Discussion on the microscopic syndrome differentiation of phlegm syndrome in metabolic syndrome based on gut microbiota associated with lipid metabolism

XIA Shujie; MI Lifen; SHEN Shanyi; WANG Tong; JIANG Mingqian; LI Candong

doi:10.3969/j.issn.1006-2157.2023.11.006

您当前的位置：

首页 >

文章列表页 >

Discussion on the microscopic syndrome differentiation of phlegm syndrome in metabolic syndrome based on gut microbiota associated with lipid metabolism

Theoretical Studies | 更新时间：2023-12-08

- Discussion on the microscopic syndrome differentiation of phlegm syndrome in metabolic syndrome based on gut microbiota associated with lipid metabolism
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 11, Pages: 1517-1522(2023)
- 作者机构：
  
  1.福建中医药大学中医学院　福州　350122
  2.福建省2011中医健康管理协同创新中心
  3.福建省中医健康状态辨识重点实验室
  4.福建中医药大学附属人民医院内分泌科
- 作者简介：
  
  Prof. LI Candong, Ph.D., Doctoral Supervisor. College of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, No.1, Qiuyang Road, Minhou District, Fuzhou 350122. E-mail: fjzylcd@126.com
- 基金信息：
  
  National Natural Science Foundation of China(82204977;U22A20376)
- DOI：10.3969/j.issn.1006-2157.2023.11.006
  CLC： R259.89
- Received：17 May 2023，
  
  Published Online：08 September 2023，
  
  Published：30 November 2023
- 稿件说明：
移动端阅览
XIA Shujie, MI Lifen, SHEN Shanyi, et al. Discussion on the microscopic syndrome differentiation of phlegm syndrome in metabolic syndrome based on gut microbiota associated with lipid metabolism[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(11): 1517-1522.
DOI：

XIA Shujie, MI Lifen, SHEN Shanyi, et al. Discussion on the microscopic syndrome differentiation of phlegm syndrome in metabolic syndrome based on gut microbiota associated with lipid metabolism[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(11): 1517-1522. DOI： 10.3969/j.issn.1006-2157.2023.11.006.

摘要

代谢综合征是以肥胖、高血糖、高血压、血脂异常等聚集发病为特点的代谢紊乱症候群。其中，向心性肥胖是代谢综合征重要的始发因素与临床表现，而肠道菌群失调会诱发代谢性炎症及胰岛素抵抗，其介导的脂代谢紊乱在代谢综合征的发生、发展中起到重要作用。痰为代谢综合征的重要病理因素，并与肠道菌群失调、脂代谢紊乱相关。本文从“肠道菌群-脂代谢”角度系统梳理代谢综合征痰证的病理机制，并提出代谢综合征痰证与肠道菌群介导的脂代谢紊乱关系密切，将两者联合分析并结合机器学习等方法可从整体上探索代谢综合征痰证的生物学基础，并对其进行微观辨证，可为代谢综合征痰证的科学内涵和干预靶点研究提供理论参考依据。

Abstract

Metabolic syndrome is a cluster of metabolic disorders associated with obesity

hyperglycemia

hypertension

and dyslipidemia. Central obesity is an important initiating factor and clinical manifestation of metabolic syndrome

while an imbalance in the intestinal flora can induce metabolic inflammation and insulin resistance. Lipid metabolism disorder also plays an important role in the occurrence and development of metabolic syndrome. Phlegm is an important pathological factor of metabolic syndrome that correlates with the intestinal microbiota and lipid metabolism disorders. Therefore

this paper systematically investigated the pathological mechanisms underlying metabolic syndrome with phlegm syndrome from the perspective of "intestinal microbiota-lipid metabolism"

and proposed that metabolic syndrome with phlegm syndrome is closely related to lipid metabolism disorder mediated by intestinal microbiota. Combining the two diseases and machine learning furthers our understanding of the biological basis of metabolic syndrome with phlegm syndrome and provides a mechanism for microscopically differentiating the syndromes

acting as a theoretical reference for scientific research into disease prognoses and treatment targets.

关键词

Keywords

references

中华医学会糖尿病学分会．中国2型糖尿病防治指南(2017年版) [J]. 中华糖尿病杂志， 2018 , 10 ( 1 )： 43 .

MCCRACKEN E , MONAGHAN M , SREENIVASAN S . Pathophysiology of the metabolic syndrome [J]. Clin Dermatol , 2018 ， 36 ( 1 )： 14 - 20 .

KANEKO K , YATSUYA H , LI Y , et al . Risk and population attributable fraction of metabolic syndrome and impaired fasting glucose for the incidence of type 2 diabetes mellitus among middle-aged Japanese individuals: Aichi Worker’s Cohort Study [J]. J Diabetes Investig , 2020 , 11 ( 5 )： 1163 - 1169 .

POWELL-WILEY TM , POIRIER P , BURKE LE , et al . Obesity and Cardiovascular Disease：A Scientific Statement From the American Heart Association [J]. Circulation , 2021 ， 143 ( 21 )： 984 - 1010 .

POWELL EE , WONG VW , RINELLA M . Non-alcoholic fatty liver disease [J]. Lancet , 2021 ， 397 ( 10290 )： 2212 - 2224 .

BISHEHSARI F , VOIGT RM , KESHAVARZIAN A . Circadian rhythms and the gut microbiota: from the metabolic syndrome to cancer [J]. Nat Rev Endocrinol , 2020 ， 16 ( 12 )： 731 - 739 .

LIU JF , LIU QP , LI ZW , et al . Prevalence of Metabolic Syndrome and Risk Factors Among Chinese Adults: Results from a Population-Based Study - Beijing, China, 2017-2018 [J]. China CDC Wkly , 2022 ， 4 ( 29 )： 640 - 645 .

HIRODE G , WONG RJ . Trends in the Prevalence of Metabolic Syndrome in the United States, 2011-2016 [J]. JAMA , 2020 , 23 ( 24 )： 2526 - 2528 .

YAO F , BO YC , ZHAO LY , et al . Prevalence and Influencing Factors of Metabolic Syndrome among Adults in China from 2015 to 2017 [J/OL]. Nutrients , 2021 ， 13 ( 12 )： 4475 [ 2023-03-01 ]. https://www.mdpi.com/2072-6643/13/12/4475 .

LEMIEUX I , DESPRÉS JP . Metabolic Syndrome: Past, Present and Future [J/OL]. Nutrients ， 2020 ， 12 ( 11 )： 3501 [ 2023-03-01 ]. https://www.mdpi.com/2072-6643/12/11/3501 .

XIA SJ , CAI J , CHEN JX , et al . Factor and Cluster Analysis for TCM Syndromes of Real-World Metabolic Syndrome at Different Age Stage [J/OL]. Evid Based Complement and Alternat Med , 2020 , 2020 ： 7854325 [ 2023-03-01 ]. https://www.hindawi.com/journals/ecam/2020/7854325/ .

林小凤，王永发，林雪娟，等．代谢综合征“痰证”患者中医证素与理化指标的相关性研究 [J]. 时珍国医国药， 2018 ， 29 ( 8 )： 2035 - 2037 .

XIA SJ , GAO BZ , WANG SH , et al . Modeling of diagnosis for metabolic syndrome by integrating symptoms into physiochemical indexes [J/OL]. Biomed Pharmacother ， 2021 ， 137 ( 1 )： 111367 [ 2023-03-01 ]. https://www.sciencedirect.com/science/article/pii/S0753332221001529?via%3Dihub .

FAHED G , AOUN L , BOU ZERDAN M , et al . Metabolic Syndrome: Updates on Pathophysiology and Management in 2021 [J/OL]. Int J Mol Sci , 2022 ， 23 ( 2 )： 786 [ 2023-03-01 ]. https://www.mdpi.com/1422-0067/23/2/786 .

CATRYSSE L , VAN LOO G . Inflammation and the Metabolic Syndrome: The Tissue-Specific Functions of NF-κB [J]. Trends Cell Biol , 2017 ， 27 ( 6 )： 417 - 429 .

ECKEL RH , ALBERTI KGMM , GRUNDY SM ， et al . The metabolic syndrome [J]. The Lancet , 2005 ， 365 ( 9468 )： 1415 - 1428 .

师林，杨玉彬，黄颖娟，等 . 健脾化湿方对脾虚痰湿型肥胖2型糖尿病胰岛素抵抗大鼠骨骼肌PI3K/Akt通路的影响 [J]. 中华中医药杂志， 2018 , 33 ( 2 )： 530 - 534 .

卢文艺，刘莲，黄蔚，等 . 加味苓桂术甘汤对代谢综合征大鼠抗氧化作用及脂联素表达的影响 [J]. 中国实验方剂学杂志， 2016 , 22 ( 10 )： 97 - 101 .

王琦．痰湿体质系列研究及在代谢性慢病防控中的应用 [J]. 天津中医药， 2020 ， 37 ( 1 )： 4 - 8 .

魏佳 . 从AMPK-HIF1-PKM2信号通路探讨代谢综合征痰证大鼠的生物学基础 [D]. 福州：福建中医药大学， 2021 .

丁珊珊，廖颖，李灿东，等．基于脂质组学探讨二陈汤对高脂饮食小鼠肝线粒体功能的调节作用 [J]. 中华中医药杂志， 2022 ， 37 ( 5 )： 2531 - 2535 .

WU JY , WANG K , WANG XM , et al . The role of the gut microbiome and its metabolites in metabolic diseases [J]. Protein Cell , 2021 , 12 ( 5 )： 360 - 373 .

VALLIANOU N , STRATIGOU T , CHRISTODOULATOS GS , et al . Understanding the Role of the Gut Microbiome and Microbial Metabolites in Obesity and Obesity-Associated Metabolic Disorders: Current Evidence and Perspectives [J]. Curr Obes Rep , 2019 ， 8 ( 3 )： 317 - 332 .

MAIFELD A , BARTOLOMAEUS H , LÖBER U , et al . Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients [J/OL]. Nat Commun , 2021 ， 12 ( 1 )： 1970 [ 2023-03-01 ]. https://www.nature.com/articles/s41467-021-22097-0 .

SINGER-ENGLAR T , BARLOW G , MATHUR R . Obesity, diabetes, and the gut microbiome: an updated review [J]. Expert Rev Gastroenterol Hepatol , 2019 ， 13 ( 1 )： 3 - 15 .

YU Y , RAKA F , ADELI K . The Role of the Gut Microbiota in Lipid and Lipoprotein Metabolism [J/OL]. J Clin Med , 2019 ， 8 ( 12 )： 2227 [ 2023-03-01 ]. https://www.mdpi.com/2077-0383/8/12/2227 .

CANFORA EE , JOCKEN JW , BLAAK EE . Short-chain fatty acids in control of body weight and insulin sensitivity [J]. Nat Rev Endocrinol , 2015 , 11 ( 10 )： 577 - 591 .

王彬，周欢，章清华，等．基于肠道微生态探讨代谢综合征之“浊毒”病机 [J]. 北京中医药大学学报， 2019 ， 42 ( 5 )： 374 - 377 .

杜含光，陈霞波，顾颖杰，等．基于16SrRNA基因测序技术分析痰证糖耐量减低患者的肠道菌群特点 [J]. 浙江中医杂志， 2020 ， 55 ( 11 )： 784 - 786 .

景彩，肖宁，张昕，等．基于16S rDNA测序技术研究痰湿质受试者肠道菌群的组成及丰度 [J]. 中医杂志， 2019 ， 60 ( 23 )： 2045 - 2049 .

张玮 . 糖尿病前期痰证与肠道菌群的相关性研究 [D]. 福州：福建中医药大学， 2022 .

严晓丹，张斐，郑雪花，等．二陈汤对高脂饮食诱导的肥胖小鼠肠道菌群的影响 [J]. 时珍国医国药， 2021 ， 32 ( 8 )： 1868 - 1871 .

刘先璐，刘悦，王洋，等．基于多元统计的痰证相关客观指标本质分析 [J]. 辽宁中医杂志， 2020 ， 47 ( 5 )： 8 - 12 .

沈自尹 . 微观辨证和辨证微观化 [J]. 中医杂志， 1986 , 42 ( 2 )： 55 - 57 .

夏淑洁，王义军，朱龙，等．知识图谱视角下微观辨证的研究主题及演化趋势 [J]. 中国中西医结合杂志， 2022 ， 42 ( 9 )： 1063 - 1071 .

夏淑洁，陈淑娇，代莲，等．代谢综合征中医常见证的生物学研究概况 [J]. 天津中医药， 2020 ， 37 ( 6 )： 603 - 608 .

MASOODI M , GASTALDELLI A , HYÖTYLÄINEN T ， et al . Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests [J]. Nat Rev Gastroenterol Hepatol , 2021 , 18 ( 12 )： 835 - 856 .

夏淑洁，李书楠，林雪娟，等．从“因发知受”到中医状态辨识 [J]. 中华中医药杂志， 2020 ， 35 ( 1 )： 27 - 30 .

李灿东．中医状态学 [M]. 北京：中国中医药出版社， 2016 ： 60 - 84 .

Views

228

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Mechanism of Qishen Yiqi Dropping Pills in regulating gut microbiota and ROS/TXNIP/NLRP3 signaling pathway to improve chronic heart failure in rats

Exploration of the pathogenesis of metabolic syndrome based on the theory of " yang transforming qi and yin shaping up body"

Characteristics of traditional Chinese medicine pattern distribution of metabolic syndrome based on latent class analysis and latent structure analysis

Study on the mechanism of calming the heart and tranquilizing the mind in treating premature ejaculation from the perspective of gut microbiota

Jianpi Shengqing Decoction alleviates non-alcoholic fatty liver disease in rats by regulating lipid metabolism through the FXR/SHP/SREBP-1c and FXR/ApoC Ⅱ pathways

Related Author

LYU Lifei

ZHU Tingting

DING Fan

LU Yingdong

CUI Xiangning

WANG Chunyu

CHENG Jialin

HAN Jinhua

Related Institution

Guang′anmen Hospital, China Academy of Chinese Medical Sciences

School of Traditional Chinese Medicine, Beijing University of Chinese Medicine

Graduate School, Beijing University of Chinese Medicine

Department of Traditional Chinese Medicine, Shenzhen Bao′an People′s Hospital

College of Traditional Chinese Medicine, Xinjiang Medical University

AI问答

Postal code：100029
Tel：(010)53911857 Email：jbutcm@bucm.edu.cn
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰