Study on the traditional Chinese medicine syndromes of 1, 000 male patients with androgenetic alopecia based on factor-cluster analysis

ZHUANG Mingyue; LIU Qingwu; TIAN Ziyuan; ZHONG Shiyi; YANG Dingquan

doi:10.3969/j.issn.1006-2157.2023.11.012

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Study on the traditional Chinese medicine syndromes of 1, 000 male patients with androgenetic alopecia based on factor-cluster analysis

Clinical Studies | 更新时间：2023-12-08

- Study on the traditional Chinese medicine syndromes of 1, 000 male patients with androgenetic alopecia based on factor-cluster analysis
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 11, Pages: 1574-1581(2023)
- 作者机构：
  
  1.北京中医药大学　北京　100029
  2.中日友好医院
- 作者简介：
  
  Prof. YANG Dingquan, Chief Physician, Doctoral Supervisor. China-Japan Friendship Hospital, No.2, Sakura Garden East Road, Chaoyang District, Beijing 100029. E-mail: ydqlx@163.com
- 基金信息：
  
  Capital Funds for Health Development and Research(2016-3-4064)
- DOI：10.3969/j.issn.1006-2157.2023.11.012
  CLC： R269
- Received：25 November 2022，
  
  Published Online：11 July 2023，
  
  Published：30 November 2023
- 稿件说明：
移动端阅览
ZHUANG Mingyue, LIU Qingwu, TIAN Ziyuan, et al. Study on the traditional Chinese medicine syndromes of 1, 000 male patients with androgenetic alopecia based on factor-cluster analysis[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(11): 1574-1581.
DOI：

ZHUANG Mingyue, LIU Qingwu, TIAN Ziyuan, et al. Study on the traditional Chinese medicine syndromes of 1, 000 male patients with androgenetic alopecia based on factor-cluster analysis[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(11): 1574-1581. DOI： 10.3969/j.issn.1006-2157.2023.11.012.

摘要

目的

探究男性雄激素性秃发患者的中医证候分布特点。

方法

回顾性收集2020年1—12月中日友好医院毛发医学中心收治的1 000例男性雄激素性秃发患者的临床资料。采用自行设计的中医症状调查表收集四诊信息，使用Excel软件和SPSS 26.0软件进行描述性频数分析、因子-聚类分析和卡方检验，归纳出主要中医证候及症状分布规律。

结果

1 000例男性雄激素性秃发患者中，按频数统计，排在前5位的症状依次为：头皮出油(94.6%)、头皮脱屑(73.0%)、头皮瘙痒(71.2%)、情志抑郁(67.5%)、倦怠乏力(66.3%)。根据因子-聚类分析得出的4种中医证候依次为湿热内蕴证(34.6%)、肝郁脾虚证(28.7%)、血热风燥证(22.2%)、肝肾亏虚证(14.5%)。20～

30岁患者以湿热内蕴证为主，30～

40岁患者以肝郁脾虚证为主，40～

50岁患者以湿热内蕴证为主。30～

40岁患者的中医证候分布比较差异有统计学意义(

0.05)。

结论

男性雄激素性秃发以湿热内蕴证、肝郁脾虚证为主，不同年龄段的证候分布存在差异。因子-聚类分析结果结合临床经验探讨中医证候，对男性雄激素性秃发的临床辨证论治具有参考性。

Abstract

Objective

To study the characteristics of traditional Chinese medicine (TCM) syndromes in male patients with androgenetic alopecia (AGA).

Methods

The clinical data of 1

000 male patients with AGA admitted to the Hair Medicine Center of China-Japan Friendship Hospital from January 2020 to December 2020 were retrospectively collected. A self-designed TCM symptom questionnaire was used to collect clinical information of the four examinations. Descriptive frequency analysis

factor-cluster analysis

and Chi-square test were performed using Excel and SPSS 26.0 software. The clinical data were combined to summarize the main TCM syndromes and symptoms.

Results

The top five symptoms ranked by frequency were scalp oil (94.6%)

scalp scurf(73.0%)

scalp pruritus(71.2%)

depression(67.5%)

and fatigue (66.3%). Four TCM syndromes were derived using factor-cluster analysis: syndrome of internal retention of dampness-heat (34.6%)

syndrome of liver depression and spleen deficiency(28.7%)

syndrome of blood heat and wind-dryness(22.2%)

and syndrome of liver-kidney deficiency (14.5%). Men aged 20 to

30 years were mainly syndrome of internal retention of dampness-heat

those aged 30 to

40 years were mainly syndrome of liver depression and spleen deficiency

and those aged 40 to

50 years were mainly syndrome of internal retention of dampness-heat. There was a significant difference in the distribution of TCM syndromes in patients aged 30 to

40 years (

0.05).

Conclusion

Male AGA syndromes are mainly syndrome of internal retention of dampness-heat and syndrome of liver depression and spleen deficiency

and the distribution of syndromes differs across age groups. It is feasible to evaluate TCM syndromes with factor-cluster analysis combined with experts’ experiences for the clinical syndrome differentiation and treatment of male AGA.

关键词

Keywords

references

中华医学会皮肤性病学分会毛发学组．中国雄激素性秃发诊疗指南 [J]. 临床皮肤科杂志， 2014 ， 43 ( 3 )： 182 - 186 .

WANG TL , ZHOU C , SHEN YW , et al . Prevalence of androgenetic alopecia in China: a community-based study in six cities [J]. Br J Dematol , 2010 , 162 ( 4 )： 843 - 847 .

XU F , SHENG YY , MU ZL , et al . Prevalence and types of androgenetic alopecia in Shanghai, China: a community-based study [J]. Br J Dermatol , 2008 , 16 ( 3 )： 629 - 632 .

于晓飞，王科军，刘莹，等 . 雄激素性脱发中医病因病机浅析 [J]. 中国中医药现代远程教育， 2021 , 19 ( 5 )： 129 - 131 .

赵辨 . 中国临床皮肤病学 [M]. 2版 . 南京：江苏凤凰科学技术出版社， 2017 : 1318 .

曲舒涵，赵吉平，曲天歌，等．不同中医证候雄激素性脱发患者的皮肤镜图像特点 [J]. 世界中医药， 2019 ， 14 ( 1 )： 209 - 213 .

李斌，陈灿达．中西医结合皮肤性病学 [M]. 3版 . 北京：中国中医药出版社， 2017 : 337 - 342 .

朱文锋 . 证素辨证学 [M]. 北京：人民卫生出版社， 2008 : 88 - 245 .

张志斌，王永炎．辨证方法新体系的建立 [J]. 北京中医药大学学报， 2005 ， 28 ( 1 )： 1 - 3 .

申春悌，陈启光，陆岩，等．中医证候要素研究中潜在变量模型的应用 [J]. 北京中医药大学学报， 2010 ， 33 ( 11 )： 725 - 731 .

苏晓宇 . 数据挖掘聚类分析方法在中医临床中的运用 [J]. 实用中西医结合临床， 2010 , 10 ( 6 )： 90 - 93 .

薛飞飞，赵晖，王利敏，等 . 基于扎根理论和内容分析法的中医证候规范化和客观化研究思路探析 [J]. 中国中医药信息杂志， 2018 ， 25 ( 5 )： 10 - 12 .

秦钊 . 雄激素性脱发的临床调查与中医证型相关性研究 [D]. 南京：南京中医药大学， 2014 .

中国医师协会美容与整形医师分会毛发整形美容专业委员会 . 中国人雄激素性脱发诊疗指南 [J]. 中国美容整形外科杂志， 2019 , 30 ( 1 )： 8 - 12 .

李姝燏，杭小涵，林心然，等．从肝论治脂溢性脱发 [J]. 环球中医药， 2020 ， 13 ( 5 )： 870 - 872 .

吴承艳，周雯，任威铭，等 . 基于数据挖掘的近50年中医治疗雄激素源性脱发用药分析 [J]. 中国医药导报， 2017 , 14 ( 32 )： 166 - 169 .

王雨，刘明照 . 崔玉衡治疗脱发经验 [J]. 河南中医， 2013 , 33 ( 8 )： 1237 - 1239 .

罗莎，陈颖颖，冯放，等．杨顶权中西医结合治疗雄激素性秃发经验 [J]. 北京中医药， 2019 ， 38 ( 5 )： 442 - 445 .

刘久利，孙丽蕴．中药联合米诺地尔酊治疗肝肾亏虚证雄激素性脱发临床研究 [J]. 中国中西医结合皮肤性病学杂志， 2017 ， 16 ( 5 )： 431 - 433 .

李宏红，张广德，魏子孝 . 魏子孝教授治疗脱发经验 [J]. 世界中西医结合杂志， 2011 , 6 ( 1 )： 78 - 79 .

李灿，高晓芬．唐定书治疗脂溢性脱发的临床经验 [J]. 四川中医， 2006 ， 24 ( 1 )： 6 - 7 .

黄兰莹，唐可，高子平 . 高子平“二藤二叶”药对论治脂溢性脱发经验 [J]. 江西中医药， 2020 , 51 ( 6 )： 27 - 29 .

林葵容，江衍芳，余安胜．中医综合疗法治疗脾胃湿热型雄激素源性脱发的临床研究 [J]. 上海中医药杂志， 2014 ， 48 ( 8 )： 53 - 56 .

夏烽，刘纪青 . 自拟滋肾养血生发汤治疗脂溢性脱发疗效观察 [J]. 时珍国医国药， 2012 , 23 ( 10 )： 2645 - 2646 .

吴学春，魏跃钢，任芳，等 . 祛湿生发汤治疗湿热型雄激素源性脱发58例 [J]. 中国中西医结合皮肤性病学杂志， 2013 , 12 ( 2 )： 123 - 124 .

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