Discussion of the pathogenesis and treatment of patients on coronary heart disease with depression based on the "depression due to deficiency, toxin due to accumulation of depression, and heart damage due to toxin"

LEI Shuyang; WANG Liying; ZHU Aisong

doi:10.3969/j.issn.1006-2157.2023.11.017

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Discussion of the pathogenesis and treatment of patients on coronary heart disease with depression based on the "depression due to deficiency, toxin due to accumulation of depression, and heart damage due to toxin"

Thought and Method | 更新时间：2023-12-08

- Discussion of the pathogenesis and treatment of patients on coronary heart disease with depression based on the "depression due to deficiency, toxin due to accumulation of depression, and heart damage due to toxin"
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 11, Pages: 1605-1610(2023)
- 作者机构：
  
  1.浙江中医药大学基础医学院　杭州　310053
  2.中国中医科学院中医临床基础医学研究所
- 作者简介：
  
  WANG Liying, Ph.D., Researcher, Doctoral Supervisor.Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, No.16, Dongzhimennei Nanxiaojie Road, Dongcheng District, Beijing 100700.E-mail: coldmoon_ly@163.com
- 基金信息：
  
  National Natural Science Foundation of China(81904325)
- DOI：10.3969/j.issn.1006-2157.2023.11.017
  CLC： R259.414
- Received：25 May 2023，
  
  Published Online：25 August 2023，
  
  Published：30 November 2023
- 稿件说明：
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LEI Shuyang, WANG Liying, ZHU Aisong. Discussion of the pathogenesis and treatment of patients on coronary heart disease with depression based on the "depression due to deficiency, toxin due to accumulation of depression, and heart damage due to toxin"[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(11): 1605-1610.
DOI：

LEI Shuyang, WANG Liying, ZHU Aisong. Discussion of the pathogenesis and treatment of patients on coronary heart disease with depression based on the "depression due to deficiency, toxin due to accumulation of depression, and heart damage due to toxin"[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(11): 1605-1610. DOI： 10.3969/j.issn.1006-2157.2023.11.017.

摘要

在现代“生物—心理—社会”医学模式下，冠心病伴发抑郁状态的“双心”疾病已成为研究热点，其核心病机要素可以概括为“虚、郁、毒”，即因虚致郁、因郁化毒、因毒损心。其中，“虚”主要责之于心胆气虚，为发病的根本内因；“郁”既包含广义的气机郁滞，又包含狭义的情志三郁(怒郁、思郁、忧郁)，为病情进展的关键因素；“毒”为痰饮、瘀血等病理产物蕴久化生的“伏毒”，并在情志之郁的影响下暴发，继而损伤心脉、败坏形质，造成不可逆的心功能损伤，为冠心病伴发抑郁状态的最终结局，并以益气强心、调神壮胆，理气解郁、加强意疗，痰瘀毒同治、透达血脉为主要治法，以期为临床诊治冠心病伴发抑郁状态提供新思路。

Abstract

Under the modern "biology-psychology-society" medical model

coronary heart disease with depression has become a research focus

and its core pathogenesis elements can be summarized as "deficiency

depression

and toxin"

that is

depression due to deficiency

toxin due to accumulation of depression

and heart damage due to toxin. "Deficiency" mainly refers to the qi deficiency of heart and gallbladder

the fundamental internal cause of the disease. "Depression" includes both the broad sense of qi stagnation and the narrow sense of three depression-related emotions (anger

depressive thinking

and anxiety)

which are key factors in the progression of the disease. "Toxin" refers to the accumulation and transformation of pathological products

such as phlegm and static blood

into the "latent toxin". Toxins emerge under the stimulation of emotional depression and damage the heart channels

corrupt the shape

and cause irreversible cardiac functional lesions

the final outcome of coronary heart disease with depression. The main treatment methods include supplementing qi

strengthening heart

regulating the mind and strengthening the gallbladder

regulating qi to relieve depression

strengthening mental therapy

treating phlegm

stasis

and toxins together to smooth the blood vessels. We hope to provide new ideas for the clinical diagnosis and treatment of coronary heart disease with depression.

关键词

Keywords

references

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Distribution characteristics of TCM composite patterns of 312 patients with coronary heart disease with depression based on cross-sectional survey and latent structure model

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Related Institution

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