Exploring the pathogenesis and treatment of myopia based on the " theory of imbalance of the essence and tendon" and biological rhythm

YAN Xin; KANG Zefeng; SUN Hongrui; WU Xinru; WANG Jianquan; HOU Xinyue; CAO Ke'er; ZHANG Lixia; YANG Yingxin

doi:10.3969/j.issn.1006-2157.2023.12.015

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Exploring the pathogenesis and treatment of myopia based on the " theory of imbalance of the essence and tendon" and biological rhythm

Clinical Studies | 更新时间：2024-01-03

- Exploring the pathogenesis and treatment of myopia based on the " theory of imbalance of the essence and tendon" and biological rhythm
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 12, Pages: 1750-1755(2023)
- 作者机构：
  
  1.中国中医科学院眼科医院　北京　100040
  2.全国中医药儿童青少年近视防治中心
  3.西安市中医院
  4.中国中医科学院
  5.首都医科大学附属北京中医医院
- 作者简介：
  
  Prof.KANG Zefeng, Ph. D., Chief physician, Doctoral Supervisor. Eye hospital, China Academy of Chinese Medical Sciences, No.33, Lugu Road, Shijingshan District, Beijing 100040.E-mail: zefeng2531@163.com
- 基金信息：
  
  National Key R&D Program of China(2022YFC3502500);Qihuang Scholar Studio Project of Kangzefeng Qihuang Project of National Administration of Traditional Chinese Medicine;Qihuang Scholar Studio Project of Kangzefeng Qihuang Project of National Administration of Traditional Chinese Medicine(SZSM201812090)
- DOI：10.3969/j.issn.1006-2157.2023.12.015
  CLC： R276.7
- Received：10 July 2023，
  
  Published：30 December 2023
- 稿件说明：
移动端阅览
YAN Xin, KANG Zefeng, SUN Hongrui, et al. Exploring the pathogenesis and treatment of myopia based on the " theory of imbalance of the essence and tendon" and biological rhythm[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023, 46(12): 1750-1755.
DOI：

YAN Xin, KANG Zefeng, SUN Hongrui, et al. Exploring the pathogenesis and treatment of myopia based on the " theory of imbalance of the essence and tendon" and biological rhythm[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023, 46(12): 1750-1755. DOI： 10.3969/j.issn.1006-2157.2023.12.015.

摘要

“精筋失衡论”是本团队在继承国医大师唐由之、国医名师庄曾源等的学术思想的基础上，结合多年临床经验所提出的创新性理论。“精”既包括先天之精，也包括后天生长发育所需的五脏六腑之精；“筋”指包括神经、软组织和结缔组织在内的综合体，既有表征特点，又有连接、支持、营养、保护等功能。目之所以能视物，精是其物质基础，筋是其功能的保障。在近视的发生、发展过程中“精筋失衡”贯穿始终，是近视发生、发展的核心环节。“失衡”二字不仅指的是精与筋的稳态被破坏，还具有生物节律失衡的内涵。现代研究认为，生物节律在近视的发生、发展中具有重要作用。本文基于“精筋失衡论”探讨其与生物节律的关系，初步提出以补真精、柔筋膜、利头目、调节律治疗近视。以“精筋失衡论”指导近视的治疗，有助于深入认识其病因病机，并拓宽临床诊疗思路。

Abstract

The "theory of imbalance of the essence and tendon" is an innovative theory proposed by our team that is based on the academic ideas of Chinese medicine master Tang Youzhi and famous master Zhuang Zengyuan and combines years of clinical experience. "Essence" includes both innate essence and the essence of the five

zang

-organs and six

-organs required for postnatal growth and development

respectively. "Tendon" refers to a complex of nerves

soft tissue

and connective tissue

which not only has characteristic features but also functions such as connection

support

nutrition

and protection. The reason why the eye can see things is that essence is its material foundation

and tendon is the functional guarantee. During the occurrence and development of myopia

the "imbalance of the essence and tendon" runs through the entire process and is the core link in the occurrence and development of myopia. The word "imbalance" not only includes the disruption of the steady state of the essence and tendon

but also carries the connotation of biological rhythm imbalance. Modern research suggests that biological rhythms play an important role in the occurrence and development of myopia. This article explores the relationship between the imbalance of essence and tendon and biological rhythms based on the "theory of imbalance of essence and tendon" and preliminarily proposes that the main treatment method for treating myopia is to replenish essence

soften tendon

benefit the head

and regulate the rhythm. Guiding the treatment of myopia with the "theory of imbalance of essence and tendon" helps to deeply understand the etiology and pathogenesis of myopia and broaden clinical diagnosis and treatment ideas.

关键词

Keywords

references

JONAS JB , ANG M , CHO P , et al . IMI Prevention of Myopia and Its Progression [J/OL]. Invest Ophthalmol Vis Sci , 2021 ， 62 ( 5 )： 6 [ 2023－05－28 ]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083117/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083117/ .

国家卫生健康委员会宣传司 . 国家卫生健康委员会2021年7月13日新闻发布会文字实录 [R/OL].( 2021－07－13 )[ 2023－05－28 ]. http://www.nhc.gov.cn/xcs/s3574/202107/2fef24a3b77246fc9fb36dc8943af700.shtml http://www.nhc.gov.cn/xcs/s3574/202107/2fef24a3b77246fc9fb36dc8943af700.shtml .

LEE SSY , MACKEY DA . Prevalence and risk factors of myopia in young adults: Review of findings from the raine study [J/OL]. Front Public Health , 2022 ， 10 ： 861044 [ 2023－05－28 ]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092372/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092372/ .

MACKEY DA , LINGHAM G , LEE SSY , et al . Change in the prevalence of myopia in Australian middle-aged adults across 20 years [J]. Clin Exp Ophthalmol ， 2021 , 49 ( 9 ): 1039 － 1047 .

CHAKRABORTY R , OSTRIN LA , NICKLA DL , et al . Circadian rhythms, refractive development, and myopia [J]. Ophthalmic Physiol Opt , 2018 ， 38 ( 3 )： 217 － 245 .

巢元方．诸病源候论 [M]. 王旭东，校注．北京：中国医药科技出版社， 2018 ： 198 .

傅仁宇．审视瑶函 [M]. 鲁兆麟，校注．沈阳：辽宁科学技术出版社， 1997 .

黄庭镜．目经大成 [M]. 汪剑，张晓林，徐梅，校注．北京：中国中医药出版社， 2016 ： 149 .

孙思邈．银海精微 [M]. 北京：人民卫生出版社， 1957 ： 77 .

侯昕玥，亢泽峰，曹珂儿，等．近视“精筋失衡论”探微 [J]. 中国中医眼科杂志， 2023 ， 33 ( 9 )： 841 － 844 .

许慎．说文解字 [M]. 殷韵初，整理．北京：中华书局， 1963 ： 91 .

林星星，董宝强，纪天一，等 . 从筋膜连续性探讨经筋实质 [J]. 中华中医药杂志， 2023 , 38 ( 5 ): 1928 － 1932 .

龚廷贤．寿世保元 [M]. 鲁兆麟，主校．北京：中国医药科技出版社， 2011 ： 432 .

李东垣．兰室秘藏 [M]. 文魁，丁国华，整理．北京：人民卫生出版社， 2017 ： 98 .

张景岳．类经 [M]. 郭洪耀，吴少祯，校注．北京：中国中医药出版社， 1997 .

吴瑭．温病条辨 [M]. 杨进，整理．北京：人民卫生出版社， 2017 ： 383 .

孙思邈．备急千金要方 [M]. 李景荣，校释．北京：人民卫生出版社， 1996 ： 199 .

李梴．医学入门 [M]. 高登瀛，张晟星，点校．上海：上海科学技术文献出版社， 1997 ： 666 .

ROCK A , WILCOCKSON D , LAST KS . Towards an understanding of circatidal clocks [J/OL]. Front Physiol ， 2022 ， 13 ： 830107 [ 2023－05－25 ]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914038/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914038/ .

STENVERS DAO , SCHEER F , SCHRAUWEN P , et al . Circadian clocks and insulin resistance [J]. Nat Rev Endocrinol ， 2019 , 15 : 75 － 89 .

NICKLA DL . Ocular diurnal rhythms and eye growth regulation: where we are 50 years after Lauber [J]. Exp Eye Res ， 2013 ， 114 ： 25 － 34 .

STONE RA , PARDUE MT , IUVONE PM , et al . Pharmacology of myopia and potential role for intrinsic retinal circadian rhythms [J]. Exp Eye Res , 2013 ， 114 ： 35 － 47 .

ZHANG P , SHIBATA B , PEINADO G , et al . Measurement of diurnal variation in rod outer segment length in vivo in mice with the OCT optoretinogram [J/OL]. Invest Ophthalmol Vis Sci ， 2020 ， 61 ( 3 )： 9 [ 2023－05－28 ]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401691/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401691/ .

KO GYP . Circadian regulation in the retina: From molecules to network [J]. Eur J Neurosci ， 2020 ， 51 ( 1 )： 194 － 216 .

MCMAHON DG , IUVONE PM , TOSINI G . Circadian organization of the mammalian retina: from gene regulation to physiology and diseases [J]. Prog Retin Eye Res , 2014 ， 39 ： 58 － 76 .

WEISS S , SCHAEFFEL F . Diurnal growth rhythms in the chicken eye: relation to myopia development and retinal dopamine levels [J]. J Comp Physiol A ， 1993 , 172 ( 3 )： 263 － 270 .

NICKLA DL , SARFARE S , MCGEEHAN B , et al . Visual conditions affecting eye growth alter diurnal levels of vitreous DOPAC [J/OL]. Exp Eye Res ， 2020 , 200 : 108226 [ 2023－05－26 ]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655675/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655675/ .

LOU L , OSTRIN LA . Effects of monocular light deprivation on the diurnal rhythms in retinal and choroidal thickness [J/OL]. Invest Ophth Vis Sci ， 2022 ， 63 ( 8 )： 6 [ 2023－06－11 ]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284467/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284467/ .

STONE RA , MCGLINN AM , CHAKRABORTY R , et al . Altered ocular parameters from circadian clock gene disruptions [J/OL]. PLoS One ， 2019 ， 14 ( 6 )： e0217111 [ 2023－06－18 ]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581257/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581257/ .

NICKLA DL , TOTONELLY K . Brief light exposure at night disrupts the circadian rhythms in eye growth and choroidal thickness in chicks [J]. Exp Eye Res ， 2016 ， 146 ： 189 － 195 .

RIDDELL N , CREWTHER SG , MURPHY MJ , et al . Long-wavelength-filtered light transiently inhibits negative lens-induced axial eye growth in the chick myopia model [J/OL]. Transl Vis Sci Technol , 2021 ， 10 ( 9 )： 38 [ 2023－05－30 ]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411858/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411858/ .

ULAGANATHAN S , READ SA , COLLINS MJ , et al . Daily axial length and choroidal thickness variations in young adults: Associations with light exposure and longitudinal axial length and choroid changes [J/OL]. Exp Eye Res ， 2019 , 189 : 107850 [ 2023－05－18 ]. https://pubmed.ncbi.nlm.nih.gov/31639338/ https://pubmed.ncbi.nlm.nih.gov/31639338/ .

BLASIAK J , REITER RJ , KAARNIRANTA K . Melatonin in retinal physiology and pathology: The case of age-related macular degeneration [J/OL]. Oxid Med Cell Longev ， 2016 ， 2016 ： 6819736 [ 2023－06－05 ]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027321/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027321/ .

SMOLENSKY MH , SACKETT-LUNDEEN LL , PORTALUPPI F . Nocturnal light pollution and underexposure to daytime sunlight: Complementary mechanisms of circadian disruption and related diseases [J]. Chronobiol Int , 2015 ， 32 ( 8 )： 1029 － 1048 .

HA NH , LONG J , CAI Q , et al . The circadian rhythm gene Arntl2 is a metastasis susceptibility gene for estrogen receptor-negative breast cancer [J/OL]. PLoS Genetics , 2016 , 12 ( 9 ): e1006267 [ 2023－05－22 ]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033489/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033489/ .

LI Y , SHAN Y , KILARU GK , et al . Epigenetic inheritance of circadian period in clonal cells [J/OL]. eLife , 2020 , 9 : e54186 [ 2023－05－27 ]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289596/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289596/ .

GU F , ZHANG H , HYLAND PL , et al . Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia [J]. Int J Cancer ， 2017 , 141 ( 9 ): 1794 － 1802 .

NICKLA DL . The phase relationships between the diurnal rhythms in axial length and choroidal thickness and the association with ocular growth rate in chicks [J]. J Comp Physiol A Neuroethol Sens Neural Behav Physiol ， 2006 ， 192 ( 4 )： 399 － 407 .

唐秀平，唐知进，黄再红，等．睫状肌与近视相关研究进展 [J]. 国际眼科杂志， 2023 ， 23 ( 3 )： 439 － 442 .

曹珂儿，亢泽峰，孙宏睿，等．巩膜生物力学特性及其近视关系的研究进展 [J]. 中国中医眼科杂志， 2023 ， 33 ( 8 )： 781 － 784 .

王清任．医林改错 [M]. 鲁兆麟，主校．沈阳：辽宁科学技术出版社， 1997 ： 4 .

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