Dynamic evolution mechanism and treatment ideas of colorectal " inflammation-mediated carcinogenesis" based on the " latent pathogens trapped in the intestinal collaterals" theory

LIU Yunze; ZHENG Haocheng; LI Yuan; DING Xia

doi:10.3969/j.issn.1006-2157.2024.10.002

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Dynamic evolution mechanism and treatment ideas of colorectal " inflammation-mediated carcinogenesis" based on the " latent pathogens trapped in the intestinal collaterals" theory

Special Theme: TCM Prevention and Treatment of "inflammation-cancer transformation" | 更新时间：2024-10-29

- Dynamic evolution mechanism and treatment ideas of colorectal " inflammation-mediated carcinogenesis" based on the " latent pathogens trapped in the intestinal collaterals" theory
- Journal of Beijing University of Traditional Chinese Medicine Vol. 47, Issue 10, Pages: 1343-1348(2024)
- 作者机构：
  
  1.北京中医药大学东直门医院　北京　100700
  2.北京中医药大学体质学院
  3.北京中医药大学中医学院
- 作者简介：
  
  Prof. DING Xia, Ph.D., Doctoral Supervisor. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No.11, Beisanhuan Donglu Road, Chaoyang District, Beijing 100029. E-mail: dingx@bucm.edu.cn
- 基金信息：
- DOI：10.3969/j.issn.1006-2157.2024.10.002
  CLC： R259
- Received：07 April 2024，
  
  Online First：08 October 2024，
  
  Published：30 October 2024
- 稿件说明：
移动端阅览
LIU Yunze, ZHENG Haocheng, LI Yuan, et al. Dynamic evolution mechanism and treatment ideas of colorectal " inflammation-mediated carcinogenesis" based on the " latent pathogens trapped in the intestinal collaterals" theory[J]. Journal of Beijing University of Traditional Chinese Medicine, 2024, 47(10): 1343-1348.
DOI：

LIU Yunze, ZHENG Haocheng, LI Yuan, et al. Dynamic evolution mechanism and treatment ideas of colorectal " inflammation-mediated carcinogenesis" based on the " latent pathogens trapped in the intestinal collaterals" theory[J]. Journal of Beijing University of Traditional Chinese Medicine, 2024, 47(10): 1343-1348. DOI： 10.3969/j.issn.1006-2157.2024.10.002.

摘要

结直肠炎症患者罹患结直肠癌的风险较普通人群明显升高。迁延日久的炎症是诱发结直肠癌变的重要因素，结直肠炎症→异型增生→结直肠癌是常见的结直肠“炎癌转化”的动态病理演变过程。中医学对于结直肠“炎癌转化”的病机尚缺乏系统共识，本文提出“邪伏肠络”理论，用以阐释结直肠“炎癌转化”动态演变过程中的病机发展规律，邪气伏藏于肠络而正气无法驱邪外出，待内外因素触发，伏邪内动，损伤肠道组织；病程迁延使得正气愈衰，邪气伏藏于肠络，与痰湿、瘀血互结，加速形成积聚，最终导致癌变。“邪伏肠络”是贯穿结直肠“炎癌转化”全过程的核心病机，应以透邪通络为治疗原则，透达伏邪，扶助正气，通畅肠络，从而截断“炎癌转化”进程。阐释“邪伏肠络”理论有助于完善结直肠“炎癌转化”的辨证论治体系，为临床治疗本病提供新思路。

Abstract

The risk of colorectal cancer is substantially higher in patients with long-term colorectal inflammation than in the general population. Prolonged inflammation is an essential factor that triggers colorectal cancer. The dynamic pathological evolution process of the classic " inflammation-mediated carcinogenesis" in the colorectum is proctocolitis→dysplasia→cancer. Traditional Chinese medicine lacks a systematic consensus on the pathogenesis of colorectal " inflammation-mediated carcinogenesis". This article proposes the theory of " pathogenic factors lurk intestinal collaterals" to explain the development law of pathogenesis in the dynamic evolution of colorectal " inflammation-mediated carcinogenesis". Internal and external factors can trigger the movement of the latent pathogenic factors

thereby damaging the intestinal tissues

when latent pathogenic factors are hidden in the intestinal collaterals

and the healthy qi is unable to expel them. The prolonged course of the disease further weakens the healthy qi

allowing the latent pathogenic factors to accumulate in the intestinal collaterals

intertwine with phlegm-dampness and blood stasis

accelerate accumulation

and lead to cancer. " Latent pathogens trapped in the intestinal collaterals" is the core pathogenesis during inflammation-mediated carcinogenesis. Thus

to prevent colorectal inflammation-mediated carcinogenesis

consideration should be given to the principle of driving away pathogenic factors and dredging the collaterals in clinical practice. The theory regarding " latent pathogens trapped in the intestinal collaterals" can provide a theoretical reference for syndrome differentiation and treating colorectal inflammation-mediated carcinogenesis and offer novel ideas for clinical treatment.

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references

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