Discussion on " inflammation-cancer transformation" of inflammatory bowel disease from the perspective of " deficiency-toxin" theory

WEI Xiunan; LIANG Junwei; SUN Dajuan; ZHANG Miaomiao; CHI Lili

doi:10.3969/j.issn.1006-2157.2024.10.003

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Discussion on " inflammation-cancer transformation" of inflammatory bowel disease from the perspective of " deficiency-toxin" theory

Special Theme: TCM Prevention and Treatment of "inflammation-cancer transformation" | 更新时间：2024-10-29

- Discussion on " inflammation-cancer transformation" of inflammatory bowel disease from the perspective of " deficiency-toxin" theory
- Journal of Beijing University of Traditional Chinese Medicine Vol. 47, Issue 10, Pages: 1349-1354(2024)
- 作者机构：
  
  1.山东中医药大学第一临床医学院　济南　250014
  2.山东中医药大学附属医院
- 作者简介：
  
  Prof. CHI Lili, Ph.D., Chief Physician, Doctoral Supervisor. Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No.16369, Jingshi Road, Lixia District, Jinan 250014. E-mail: chililiyl@163.com
- 基金信息：
  
  National Natural Science Foundation of China(81673969;82205057)
- DOI：10.3969/j.issn.1006-2157.2024.10.003
  CLC： R259
- Received：23 April 2024，
  
  Published Online：21 August 2024，
  
  Published：30 October 2024
- 稿件说明：
移动端阅览
WEI Xiunan, LIANG Junwei, SUN Dajuan, et al. Discussion on " inflammation-cancer transformation" of inflammatory bowel disease from the perspective of " deficiency-toxin" theory[J]. Journal of beijing university of traditional chinese medicine, 2024, 47(10): 1349-1354.
DOI：

WEI Xiunan, LIANG Junwei, SUN Dajuan, et al. Discussion on " inflammation-cancer transformation" of inflammatory bowel disease from the perspective of " deficiency-toxin" theory[J]. Journal of beijing university of traditional chinese medicine, 2024, 47(10): 1349-1354. DOI： 10.3969/j.issn.1006-2157.2024.10.003.

摘要

“虚”“毒”作为中医理论的重要概念，自《黄帝内经》以来不断丰富发展。本文通过追溯、梳理“虚”与“毒”，归纳二者关系，并结合临证实践，分析阐释其基本内涵，并探讨其外延。“虚毒”学说有静态与动态两层含义，既涵盖人体正气虚馁、邪毒亢盛的病理状态，又指代“虚”与“毒”相互推进的病理演变过程。基于“虚毒”学说的内涵及动态病机观点，该学说可适用于传染性疾病及虚损性疾病的防治，炎症性肠病“炎癌转化”亦在其列。本文以炎症性肠病为例，结合其西医学背景，阐述炎症性肠病“炎癌转化”的病机及治法，提供“虚毒”学说指导临床科研的范式。

Abstract

As essential concepts of the traditional Chinese medicine theory

" deficiency" and " toxin" have been enriched and developed continuously since

Huangdi Neijing

. By tracing back and combing " deficiency" and " toxin"

this paper sums up their relationship

analyzes and explains their basic connotation

and discusses their extension. The " deficiency-toxin" theory has two meanings: it covers the pathological state of the human body with deficiency of vital qi and excess of pathogenic toxin

and it also refers to the pathological evolutionary process in which " deficiency" and " toxin" promote each other. Based on the connotation and dynamic pathogenesis of the " deficiency-toxin" theory

it is pointed out that this theory can be applied to the prevention and treatment of infectious diseases and chronic debilitating diseases

including the " inflammation-cancer transformation" of inflammatory bowel disease. Taking inflammatory bowel disease as an example and combining its Western medical background

this paper expounds on the pathogenesis and treatment of the " inflammation-cancer transformation" of inflammatory bowel disease

and provides a paradigm of " deficiency-toxin" theory guiding clinical research.

关键词

Keywords

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