Deconstructing the relationship between prescriptions and patterns under network image-number thinking: reflection on technological innovation from Chinese original thinking

LIU Jun; GUAN Shuang; WANG Zhong; WANG Yongyan

doi:10.3969/j.issn.1006-2157.2024.10.006

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Deconstructing the relationship between prescriptions and patterns under network image-number thinking: reflection on technological innovation from Chinese original thinking

Theoretical Study | 更新时间：2024-10-29

- Deconstructing the relationship between prescriptions and patterns under network image-number thinking: reflection on technological innovation from Chinese original thinking
  增强出版
- Journal of Beijing University of Traditional Chinese Medicine Vol. 47, Issue 10, Pages: 1367-1375(2024)
- 作者机构：
  
  中国中医科学院中医临床基础医学研究所　北京　100700
- 作者简介：
  
  Prof. WANG Yongyan, Chief Physician, Doctoral Supervisor, Member of the China Central Institute for Culture and History, Academician of Chinese Academy of Engineering.No.16, Nanxiaojie Road, Dongzhimennei Nanxiaojie Road, Dongcheng District, Beijing 100700. E-mail: wangyongyan@sina.cn
- 基金信息：
  
  National Social Science Foundation of China(21&ZD349)
- DOI：10.3969/j.issn.1006-2157.2024.10.006
  CLC： R2-05
- Received：16 April 2024，
  
  Online First：12 September 2024，
  
  Published：30 October 2024
- 稿件说明：
移动端阅览
LIU Jun, GUAN Shuang, WANG Zhong, et al. Deconstructing the relationship between prescriptions and patterns under network image-number thinking: reflection on technological innovation from Chinese original thinking[J]. Journal of Beijing University of Traditional Chinese Medicine, 2024, 47(10): 1367-1375.
DOI：

LIU Jun, GUAN Shuang, WANG Zhong, et al. Deconstructing the relationship between prescriptions and patterns under network image-number thinking: reflection on technological innovation from Chinese original thinking[J]. Journal of Beijing University of Traditional Chinese Medicine, 2024, 47(10): 1367-1375. DOI： 10.3969/j.issn.1006-2157.2024.10.006.

摘要

证候的发生发展，其实质是特定生物分子网络间错综复杂的互动关系。在研究方证关系时，不能仅局限于单一分子因素，而应全面审视复杂生物系统中各层级分子网络靶标间的相互关系。为了从微观至宏观的层次深入解析方证之间的整体关联，本文在中国传统象数思维的指导下，立足于前期提出的定性网络象思维观点，创造性地利用运数思维逻辑与定量模块药理学分析技术，将复杂生物系统宏观层面上的象与微观分子网络层面的象关联研究，建立原创的中医网络象数思维方法体系，系统地揭示方剂与人体相互作用的规律和机制。本文提出的网络象数思维，具有多种核心特性：它体现了象数相倚的辩证统一性，展现了网络系统的多维层次性与序列性、自组织性与整体涌现性的特质，又揭示了网络复杂系统生生之易的功能动态性、和合共生的自我调节性等基本特征。此外，本文进一步探讨了网络象数思维指导模块药理学开展方证研究的实用性与优越性，这一思维方法学框架为模块药理学的发展提供了新的视角，有利于彰显原创思维在中医药现代研究中的引领作用，迈向更为统一的新医药学体系。

Abstract

The occurrence and development of the pattern stem from the intricate interactions among specific biological molecular networks. Thus

broadening the perspective beyond a single molecular factor and investigating the intricate interconnections among molecular network targets across various levels within complex biological systems is essential when exploring the relationship between prescriptions and their corresponding patterns. This article integrates traditional Chinese image-number thinking with modern quantitative analysis

using qualitative " network image thinking" to innovatively apply numerical method in modular pharmacological analysis. This approach explores the connections between macro-level manifestations of complex biological systems and micro-level molecular network features

aiming to elucidate the correlations between prescriptions and patterns across different levels. An original method system of " network image-number thinking" in traditional Chinese medicine was established to systematically reveal the laws and mechanisms underlying the interaction between prescriptions and the human body. The " network image-number thinking" proposed in this paper has multiple core characteristics: it reflects the dialectical unity of " mutual reliance between image and number" and shows the multi-dimensional hierarchy

sequentiality

self-organization

and the emergence of the network system. This paper also elucidates the fundamental features of functional dynamism—which is characterized by the " ease of constant evolution" —and self-regulation

marked by " harmony and symbiosis" within complex network systems. Furthermore

we promote the practicality and superiority of using " network image-number thinking" to guide the module pharmacology when studying the relationship between prescriptions and their corresponding patterns. This thinking method framework provides a novel perspective for developing module pharmacology

effectively highlighting the leading role of original thinking in modern research on traditional Chinese medicine and moving towards a new unified medical system.

关键词

Keywords

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