Exploring the potential therapeutic effect of activating blood and resolving stasis in treating erectile dysfunction based on fibroblast-mediated mechanisms of penile erection

ZHANG Sizheng; CAO Yan; LUO Chenglong; CHENG Haoyang; ZHANG Qi; JIAO Yongzheng

doi:10.3969/j.issn.1006-2157.2024.11.003

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Exploring the potential therapeutic effect of activating blood and resolving stasis in treating erectile dysfunction based on fibroblast-mediated mechanisms of penile erection

Special Theme: TCM Prevention and Treatment of Male Diseases | 更新时间：2024-12-02

- Exploring the potential therapeutic effect of activating blood and resolving stasis in treating erectile dysfunction based on fibroblast-mediated mechanisms of penile erection
- Journal of Beijing University of Traditional Chinese Medicine Vol. 47, Issue 11, Pages: 1495-1500(2024)
- 作者机构：
  
  1.中国中医科学院广安门医院男科　北京　100053
  2.北京市东城区第一人民医院中西医结合科
- 作者简介：
  
  JIAO Yongzheng, Ph.D., Researcher, Chief Physician, Doctoral Supervisor. Guang′anmen Hospital, China Academy of Chinese Medical Sciences, No.5, Beixiange Road, Xicheng District, Beijing 100053. E-mail: yzhjiao@126.com
- 基金信息：
  
  National Natural Science Foundation of China(82074446)
- DOI：10.3969/j.issn.1006-2157.2024.11.003
  CLC： R277.5
- Received：29 April 2024，
  
  Online First：31 October 2024，
  
  Published：30 November 2024
- 稿件说明：
移动端阅览
ZHANG Sizheng, CAO Yan, LUO Chenglong, et al. Exploring the potential therapeutic effect of activating blood and resolving stasis in treating erectile dysfunction based on fibroblast-mediated mechanisms of penile erection[J]. Journal of Beijing University of Traditional Chinese Medicine, 2024, 47(11): 1495-1500.
DOI：

ZHANG Sizheng, CAO Yan, LUO Chenglong, et al. Exploring the potential therapeutic effect of activating blood and resolving stasis in treating erectile dysfunction based on fibroblast-mediated mechanisms of penile erection[J]. Journal of Beijing University of Traditional Chinese Medicine, 2024, 47(11): 1495-1500. DOI： 10.3969/j.issn.1006-2157.2024.11.003.

摘要

勃起功能障碍是男科常见、难治的疾病，且发病率高，目前，认为神经、内皮、平滑肌的协同作用是阴茎勃起的关键，而阴茎海绵体中大量的成纤维细胞在勃起行为中的作用往往被忽略。成纤维细胞处于阴茎海绵体内细胞分子网络的中心，可以调控海绵体微环境的动态平衡，介导阴茎勃起，从而为勃起功能障碍治疗提供新靶点。本团队认为，瘀血是导致勃起功能障碍的核心病机，是造成海绵体微环境失调的关键病理因素，且瘀血与勃起功能障碍患者海绵体微观病理改变相契合。因此，本团队积极探讨成纤维细胞介导阴茎勃起与中医学理论的相关性，将其与中医学理论相结合并运用于临床，提出活血化瘀法可以调节海绵体微环境，改善成纤维细胞介导的勃起功能障碍，为勃起功能障碍的中医药治疗提供新思路。

Abstract

Erectile dysfunction has a high incidence rate and is a difficult-to-treat condition in male urology. The synergistic effect of nerves

endothelium

and smooth muscles plays a crucial role in penile erection. However

the role of the many fibroblasts in the corpus cavernosum of the penis during erection is often overlooked. Fibroblasts are at the center of the cellular and molecular network in the corpus cavernosum of the penis

regulating the dynamic balance of the cavernosal microenvironment and mediating penile erection

thus providing a novel target for treating erectile dysfunction. Blood stasis primarily causes erectile dysfunction

thereby serving as a crucial pathological factor leading to the imbalance of the cavernosal microenvironment. Blood stasis also corresponds to the microscopic pathological changes in the corpus cavernosum of patients with erectile dysfunction. Therefore

this study explored the correlation between fibroblast-mediated penile erection and traditional Chinese medicine theories

integrating it with clinical practice. This study proposes that activating blood and resolving stasis can regulate the cavernosal microenvironment and improve fibroblast-mediated erectile dysfunction. This study also provides novel insights for treating erectile dysfunction with traditional Chinese medicine.

关键词

Keywords

references

中华医学会男科学分会勃起功能障碍诊断与治疗指南编写组．勃起功能障碍诊断与治疗指南 [J ] . 中华男科学杂志， 2022 ， 28 ( 8 )： 722 － 755 .

MARK KP , ARENELLA K , GIRARD A , et al . Erectile dysfunction prevalence in the United States: report from the 2021 National Survey of Sexual Wellbeing [J ] . J Sex Med , 2024 , 21 ( 4 ): 296 － 303 .

PANG K , PAN D , XU H , et al . Advances in physical diagnosis and treatment of male erectile dysfunction [J ] . Front Physiol , 2022 , 13 : 1096741 .

SAMIDURAI A , XI L , DAS A , et al . Beyond erectile dysfunction: cGMP-specific phosphodiesterase 5 inhibitors for other clinical disorders [J ] . Annu Rev Pharmacol Toxicol , 2023 , 63 : 585 － 615 .

MELCHIODE Z , NGUYEN T , DAWOOD O , et al . Phosphodiesterase 5 inhibitors: preclinical and early-phase breakthroughs for impotence treatments [J ] . Expert Opin Investig Drugs , 2023 , 32 ( 7 ): 635 － 642 .

GUL M , SEREFOGLU EC . An update on the drug safety of treating erectile dysfunction [J ] . Expert Opin Drug Saf , 2019 , 18 ( 10 ): 965 － 975 .

ZHAO LY , HAN S , SU HC , et al . Single-cell transcriptome atlas of the human corpus cavernosum [J ] . Nat Commun , 2022 , 13 ( 1 ): 4302 .

张思政，苏亮，罗成龙，等 . 基于“间质系统－三焦”探讨解表药在阳痿治疗中的运用 [J ] . 中医药学报， 2023 , 51 ( 11 ): 7 － 12 .

LUO C , PENG YP , GU J , et al . Single-cell RNA sequencing reveals critical modulators of extracellular matrix of penile cavernous cells in erectile dysfunction [J ] . Sci Rep , 2024 , 14 ( 1 ): 5886 .

JEVTICH MJ , KHAWAND NY , VIDIC B . Clinical significance of ultrastructural findings in the corpora cavernosa of normal and impotent men [J ] . J Urol , 1990 , 143 ( 2 ): 289 － 293 .

BELLINGHIERI G , SANTORO G , SANTORO D , et al . Ultrastructural changes of corpora cavernosa in men with erectile dysfunction and chronic renal failure [J ] . Semin Nephrol , 2004 , 24 ( 5 ): 488 － 491 .

PLIKUS MV , WANG X , SINHA S , et al . Fibroblasts: origins, definitions, and functions in health and disease [J ] . Cell , 2021 , 184 ( 15 ): 3852 － 3872 .

LENDAHL U , MUHL L , BETSHOLTZ C . Identification, discrimination and heterogeneity of fibroblasts [J ] . Nat Commun , 2022 , 13 ( 1 ): 3409 .

GUIMARAES EL , DIAS DO , HAU WF , et al . Corpora cavernosa fibroblasts mediate penile erection [J ] . Science , 2024 , 383 ( 6683 ): eade8064 .

RYU JK , KOH GY . Fibroblasts enable penile erection [J ] . Science , 2024 , 383 ( 6683 ): 588 － 589 .

LIU QW , SONG YL , CUI YB , et al . Heterogeneity of fibroblasts is a hallmark of age-associated erectile dysfunction [J ] . Int J Biochem Cell Biol , 2023 , 156 : 106343 .

张思政 . 青年男性勃起功能障碍患者生活方式相关的危险因素及中医证素分布调查 [D ] . 北京：中国中医科学院， 2023 .

张景岳．类经 [M ] . 范志霞，校注．北京：中国医药科技出版社， 2011 ： 311 .

李霄，王继升，王彬，等 . 活血通络起痿汤对糖尿病勃起功能障碍大鼠阴茎海绵体结构及sE-selectin、ET-1的影响 [J ] . 时珍国医国药， 2023 , 34 ( 12 ): 2889 － 2892 .

AYDOS K , BALTACI S , SAǦLAM M , et al . Ultrastructual changes of corpora cavernosa in vascular erectile dysfunction [J ] . Int Urol Nephrol , 1996 , 28 ( 3 ): 375 － 385 .

COSTA WS , CARRERETE FB , HORTA WG , et al . Comparative analysis of the penis corpora cavernosa in controls and patients with erectile dysfunction [J ] . BJU Int , 2006 , 97 ( 3 ): 567 － 569 .

欧阳锜．证治概要 [M ] . 北京：人民卫生出版社， 1961 ： 412 .

张玮，李萍，黄启福，等 . 几类常用外用中药成分对人皮肤成纤维细胞增殖及胶原合成的影响 [J ] . 北京中医药大学学报， 2007 , 30 ( 1 ): 36 － 39 .

刘琳 . 血竭素高氯酸盐对成纤维细胞增殖的调控及其机制研究 [D ] . 哈尔滨：东北农业大学， 2018 .

孙涛 . 云南白药对A-PRF促牙周膜干细胞及牙龈成纤维细胞增殖、成骨分化及细胞迁移作用的研究 [D ] . 昆明：昆明医科大学， 2020 .

YANG J , LIU ZS . Mechanistic pathogenesis of endothelial dysfunction in diabetic nephropathy and retinopathy [J ] . Front Endocrinol (Lausanne) , 2022 , 13 : 816400 .

刘学 . 肺纤维化大鼠全转录组测序分析及加味补阳还五汤调控Notch/Jagged通路抗纤维化的机制研究 [D ] . 济南：山东中医药大学， 2020 .

李双娣 . 基于Notch-Dell4信号通路探讨宣痹通瘀胶囊保护心肌损伤及干预血管新生作用机制的研究 [D ] . 长春：长春中医药大学， 2018 .

刘晓莹 . 基于Notch1信号通路探讨丹酚酸A对人胚肺成纤维细胞MRC-5抗纤维化作用机制的研究 [D ] . 济南：山东中医药大学， 2018 .

王思童 . 血府逐瘀汤对果蝇细胞迁移、肿瘤侵袭的影响及其机理初探 [D ] . 唐山：华北理工大学， 2021 .

APTE RS , CHEN DS , FERRARA N . VEGF in signaling and disease: beyond discovery and development [J ] . Cell , 2019 , 176 ( 6 ): 1248 － 1264 .

RYU JK , CHO CH , SHIN HY , et al . Combined angiopoietin-1 and vascular endothelial growth factor gene transfer restores cavernous angiogenesis and erectile function in a rat model of hypercholesterolemia [J ] . Mol Ther , 2006 , 13 ( 4 ): 705 － 715 .

LEE YC , HUANG SP , TSAI CC , et al . Associations of VEGF gene polymorphisms with erectile dysfunction and related risk factors [J ] . J Sex Med , 2017 , 14 ( 4 ): 510 － 517 .

方敏，杨成龙，刘建和 . 从祛瘀生新探讨心肌梗死后血管新生 [J ] . 中西医结合心脑血管病杂志， 2023 , 21 ( 4 ): 758 － 760 .

ZHAI S , ZHANG XF , LU F , et al . Chinese medicine GeGen-DanShen extract protects from myocardial ischemic injury through promoting angiogenesis via up-regulation of VEGF/VEGFR2 signaling pathway [J ] . J Ethnopharmacol , 2021 , 267 : 113475 .

张博伦，王丽，胡雅光，等 . 阿魏酸钠通过ERK信号通路干预大鼠心肌缺血再灌注损伤的实验研究 [J ] . 中国医学工程， 2021 , 29 ( 7 ): 6 － 10 .

许辉，苏新平，谭旭仪，等 . 桃红接骨汤对实验性骨折愈合中VEGF表达的影响 [J ] . 湖南中医杂志， 2016 , 32 ( 8 ): 195 － 196 .

孙宁，邓洋洋，孙鑫，等 . 补肾、活血复方对骨质疏松症模型大鼠VEGF表达的影响 [J ] . 中国骨质疏松杂志， 2016 , 22 ( 9 ): 1096 － 1100 .

唐洁 . 探讨血塞通注射液对MCAO大鼠静脉溶栓后血清ET－1、VEGF水平的影响 [D ] . 长沙：湖南中医药大学， 2022 .

ALBERSEN M . From bystanders to vital contributors: cavernosal fibroblasts′ transformative role in erectile physiology and therapeutic prospects [J ] . J Sex Med , 2024 ， 21 ( 6 ): 509 － 510 .

程皓洋，苏亮，罗成龙，等．新冠病毒感染相关勃起功能障碍的中医辨治思路探析 [J ] . 中华男科学杂志， 2023 ， 29 ( 8 )： 746 － 750 .

鹿燕敏，李兰芳，霍海如，等 . 4种活血化瘀中药有效成分对血管紧张素Ⅱ诱导的血管外膜成纤维细胞增殖及胶原合成的影响 [J ] . 中国实验方剂学杂志， 2008 , 14 ( 11 ): 68 － 70 .

王东，张江，何立群 . 活血化瘀方有效单体对活化的肾成纤维细胞株和系膜细胞株增殖的影响 [J ] . 北京中医药大学学报， 2013 , 36 ( 11 ): 762 － 767 .

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