Discussion and treatment of late onset hypogonadism in male based on " tian gui out of time sequence"

WU Hui; NING Gang; LI Bonan; PENG Ajian; WANG Haoyu; SHI Ruobing; ZHOU Xing

doi:10.3969/j.issn.1006-2157.2024.11.004

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Discussion and treatment of late onset hypogonadism in male based on " tian gui out of time sequence"

Special Theme: TCM Prevention and Treatment of Male Diseases | 更新时间：2024-12-02

- Discussion and treatment of late onset hypogonadism in male based on " tian gui out of time sequence"
- Journal of Beijing University of Traditional Chinese Medicine Vol. 47, Issue 11, Pages: 1501-1505(2024)
- 作者机构：
  
  1.湖南中医药大学研究生院　长沙　410208
  2.长沙市第四医院
  3.湖南中医药大学第一附属医院
- 作者简介：
  
  Prof. ZHOU Xing, Ph.D., Chief Physician, Doctoral Supervisor. The First Hospital of Hunan University of Chinese Medicine, No.95, Shaoshan Middle Road, Yuhua District, Changsha 410007. E-mail: zhouxing@hnucm.edu.cn
- 基金信息：
  
  National Natural Science Foundation of China(82074444;82474525)
- DOI：10.3969/j.issn.1006-2157.2024.11.004
  CLC： R277.5
- Received：14 July 2024，
  
  Published Online：04 November 2024，
  
  Published：30 November 2024
- 稿件说明：
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WU Hui, NING Gang, LI Bonan, et al. Discussion and treatment of late onset hypogonadism in male based on " tian gui out of time sequence"[J]. Journal of beijing university of traditional chinese medicine, 2024, 47(11): 1501-1505.
DOI：

WU Hui, NING Gang, LI Bonan, et al. Discussion and treatment of late onset hypogonadism in male based on " tian gui out of time sequence"[J]. Journal of beijing university of traditional chinese medicine, 2024, 47(11): 1501-1505. DOI： 10.3969/j.issn.1006-2157.2024.11.004.

摘要

随着中医学对男性迟发性性腺功能减退症的认识及研究的不断深入，中医药论治男性迟发性性腺功能减退症的独特优势逐渐凸显。时序是对自然生长及运行规律的总体概括，天癸与睾酮均有其正常的时序，且可能存在相关性。生理状态下，男子天癸遵循以“八”为期、由“至”到“竭”的正常时序；“天癸失于时序”包括天癸盛失于时序(以肝为主的脏腑功能失调)和天癸竭失于时序(以肾为主的脏腑病理性虚损)，最终导致“天癸竭”提前于“八八”发生。基于天癸与睾酮是男性迟发性性腺功能减退症重要的中、西医学发病生理基础，本团队认为，“天癸失于时序”与男性迟发性性腺功能减退症肝郁肾虚证的核心病机有重要联系，提出恢复天癸正常时序，肝肾同治，分时论治男性迟发性性腺功能减退症，临床运用雄蚕益肾方取得良好疗效，以期为男性迟发性性腺功能减退症的中医药认识及治疗提供新的思路与借鉴。

Abstract

The unique advantages of traditional Chinese medicine (TCM) in treating late onset hypogonadism in male have gradually emerged with the continuous deepening of the understanding and research on late onset hypogonadism in male. Time sequence is a general summary of the natural growth and operational laws. Tian gui and testosterone have their normal time sequences

and they may be associated with each other. A man′s tian gui follows the regular time sequence from " inception" to " exhaustion" throughout " eight" under normal physiological conditions. " Tian gui out of time sequence" includes the loss of tian gui exuberance (dysfunction of viscera dominated by the liver) and exhaustion in the time sequence (pathological deficiency of viscera dominated by the kidney)

resulting in " tian gui exhaustion" in advance of " eight eight". Tian gui and testosterone are key concepts in Chinese and Western medicine for understanding late onset hypogonadism in male. The theory of " tian gui out of time sequence" may be closely related to the core pathogenesis of this condition

particularly in cases of liver depression and kidney deficiency. This study suggests that restoring the normal time sequence of tian gui while treating the liver and kidney simultaneously through time-sh

aring treatment should be effective. The use of

Xiongcan Yishen

Formula has shown promising therapeutic result

offering new insights and references for treating late onset hypogonadism in male using TCM.

关键词

Keywords

references

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