Application strategy of the " You Gu Wu Yun" theory to reduce the toxicity of traditional Chinese medicine from the perspective of " traditional Chinese medicine state"

QIAO Shijie; WEI Zongchen; CAI Ziyao; FU Chao; LI Shunan; WANG Zhanglin; HUANG Liqing; TONG Kang; TANG Wen; WANG Zhibin; HAN Hairui; LIN Duoduo; ZHANG Shaodong; LEI Huangwei; WANG Yang; LI Candong

doi:10.3969/j.issn.1006-2157.2024.11.005

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Application strategy of the " You Gu Wu Yun" theory to reduce the toxicity of traditional Chinese medicine from the perspective of " traditional Chinese medicine state"

Theoretical Studies | 更新时间：2024-12-02

- Application strategy of the " You Gu Wu Yun" theory to reduce the toxicity of traditional Chinese medicine from the perspective of " traditional Chinese medicine state"
- Journal of Beijing University of Traditional Chinese Medicine Vol. 47, Issue 11, Pages: 1506-1511(2024)
- 作者机构：
  
  1.福建中医药大学中医学院　福州　350122
  2.福建中医药大学人文与管理学院
  3.四川省南充卫生学校
  4.福建医科大学
  5.福建中医药大学办公室
- 作者简介：
  
  Prof. LI Candong, Ph.D., Doctoral Supervisor. School of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, No.1, Qiuyang Road, Shangjie Town, Minhou County, Fuzhou 350122. E-mail: fjzylcd@126.com
- 基金信息：
  
  The Second National Famous Traditional Chinese Medicine Inheritance Studio Construction Project of the State Administration of Traditional Chinese Medicine(国中医药办人教函〔2022〕245号)
- DOI：10.3969/j.issn.1006-2157.2024.11.005
  CLC： R285.1
- Received：30 April 2024，
  
  Published Online：14 September 2024，
  
  Published：30 November 2024
- 稿件说明：
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QIAO Shijie, WEI Zongchen, CAI Ziyao, et al. Application strategy of the " You Gu Wu Yun" theory to reduce the toxicity of traditional Chinese medicine from the perspective of " traditional Chinese medicine state"[J]. Journal of beijing university of traditional chinese medicine, 2024, 47(11): 1506-1511.
DOI：

QIAO Shijie, WEI Zongchen, CAI Ziyao, et al. Application strategy of the " You Gu Wu Yun" theory to reduce the toxicity of traditional Chinese medicine from the perspective of " traditional Chinese medicine state"[J]. Journal of beijing university of traditional chinese medicine, 2024, 47(11): 1506-1511. DOI： 10.3969/j.issn.1006-2157.2024.11.005.

摘要

本文基于中医“有故无殒”理论，在“中医状态”视域下，认为“有故无殒”中“故”之外延为“状态”。临床为降低中药的不良反应，应宏观、中观、微观三观并用，融宏观、中观、微观参数于一体，定性、定量结合仔细辨识人体生理特点、病理特点、体质、证、病等“状态”，突出方与“状态”之间的联系，方与“状态”相应，则会减少中药不良反应之殒患。本文希冀着重于“有故无殒”理论对中医药研究的指导作用，发挥中医药的特色优势，辩证地看待中医药的作用。

Abstract

Based on the " You Gu Wu Yun" theory in traditional Chinese medicine (TCM)

this paper believes that " Gu" in " You Gu Wu Yun" is extended to " state" from the perspective of " TCM state". In order to avoid the adverse reactions of TCM

the macro

meso

and micro three views should be used together

and macro

meso

and micro parameters should be integrated. We should also carefully identify the physiological characteristics

pathological characteristics

constitution

syndrome

and disease of human body by combining qualitative and quantitative method

highlighting the relationship between the prescription and the " state". The correspondence between prescription and the " state" will reduce the risk of adverse reactions of TCM. In this paper

we hope to focus on the guiding role of the " You Gu Wu Yun" theory in TCM research

to give full play to the characteristics and advantages of TCM

and to dialectically treat the role of TCM.

关键词

Keywords

references

周荣易，王娇娇，韩新民 . 对中药毒性问题的思考 [J ] . 时珍国医国药， 2016 , 27 ( 7 ): 1679 － 1682 .

肖小河，柏兆方，王伽伯，等 . 中药安全性评价与药物警戒 [J ] . 科学通报， 2021 , 66 ( 4 ): 407 － 414 .

赵梓邯，张琳，李文斌，等 . 中药毒性与安全性评价研究进展 [J ] . 中国实验方剂学杂志， 2018 , 24 ( 20 ): 208 － 216 .

陈仁寿 . 从对中药毒性的认识与处理看本草学的反思与嬗变 [J ] . 中国中医基础医学杂志， 2024 , 30 ( 1 ): 104 － 107 .

魏湘萍，白莉，苗明三 . 毒性中药分级变化的思考 [J ] . 中华中医药杂志， 2021 , 36 ( 4 ): 2158 － 2161 .

宋亚刚，田硕，乔靖怡，等 . 基于文献分析的中药毒性分级方法及思考 [J ] . 中国比较医学杂志， 2023 , 33 ( 7 ): 149 － 154 .

钱文秀，阎星旭，张文青，等 . 计算机虚拟筛选技术在中药毒性研究中的探索与思考 [J ] . 中草药， 2023 , 54 ( 12 ): 4036 － 4043 .

王曼姝，孙思彤，袁宇，等 . 功能代谢组学在中药毒性评价中的研究策略及其应用 [J ] . 中草药， 2023 , 54 ( 2 ): 349 － 358 .

柏兆方，王伽伯，肖小河 . 中药毒性认知创新与安全精准用药 [J ] . 中国中药杂志， 2022 , 47 ( 10 ): 2557 － 2564 .

曾薇薇，陆齐天，杨冰祎，等 . 基于“有故无殒，亦无殒也”探讨活血化瘀药物在妊娠病中的运用 [J ] . 陕西中医， 2020 , 41 ( 9 ): 1289 － 1291 .

周毅萍，李祥云 . 李祥云应用活血化瘀类药治疗妊娠病验案3则 [J ] . 中华中医药杂志， 2017 , 32 ( 8 ): 3537 － 3540 .

周丽，邹宇，刘玉章，等 . 正常和血瘀证大鼠对莪术生殖发育毒性反应的差异 [J ] . 江苏中医药， 2013 , 45 ( 4 ): 69 － 71 .

浅田宗伯 . 先哲医话 [M ] . 徐长卿，点校 . 北京：学苑出版社， 2008 : 47 .

王婧，骆斌，蒋燕 . 略谈《内经》“有故无殒”及其临床意义 [J ] . 北京中医药大学学报， 2009 , 32 ( 11 ): 733 － 736 .

邢玉瑞 . “有故无殒亦无殒”思想古今应用探讨 [J ] . 中国中医基础医学杂志， 2020 , 26 ( 8 ): 1045 － 1046 .

陈士奎 . 我国开创的中西医结合科研及其启示(九)——张亭栋教授等与中药砒霜治疗急性早幼粒细胞白血病的中西医结合研究 [J ] . 中国中西医结合杂志， 2017 , 37 ( 11 ): 1292 － 1296 .

李永明 . 砒霜治疗白血病的三次高潮和创新点 [J ] . 中国中西医结合杂志， 2017 , 37 ( 4 ): 401 － 405 .

邹宝生 . “有故无殒，亦无殒也”的临床应用体会 [J ] . 陕西中医， 2007 , 28 ( 10 ): 1440 .

刘乃元，张冬梅 . “有故无殒亦无殒”临证应用举隅 [J ] . 陕西中医， 1999 , 20 ( 9 ): 411 － 412 .

张福产，王身菊 . 张志坚“有故无殒”应用验案 [J ] . 江苏中医药， 2008 , 40 ( 6 ): 21 .

王进，王旭东，吴承艳，等 . 本草学毒性理念的源流探考与论述范式的诠解 [J ] . 中草药， 2017 , 48 ( 1 ): 197 － 202 .

丁樱 . 从《黄帝内经》 “有故无殒”谈儿童风湿免疫疾病治疗中的药“毒”及“毒”药的应用 [J ] . 北京中医药大学学报， 2023 , 46 ( 4 ): 445 － 449 .

王丽平，罗文佳，欧莉，等 . “有故无殒”理论指导下基于肝细胞Bax/Bcl-2凋亡通路的何首乌“毒－证”机制研究 [J ] . 中药药理与临床， 2019 , 35 ( 6 ): 82 － 87 .

李阳，韩姗姗，代彦林，等 . 基于“有故无殒”思想探讨雷公藤制剂对儿童的性腺毒性 [J ] . 中国中医基础医学杂志， 2023 , 29 ( 4 ): 692 － 696 .

ZENG LN , MA ZJ , ZHAO YL , et al . The protective and toxic effects of rhubarb tannins and anthraquinones in treating hexavalent chromium-injured rats: the Yin/Yang actions of rhubarb [J ] . J Hazard Mater , 2013 , 246/247 : 1 － 9 .

FANG F , WANG JB , ZHAO YL , et al . A comparative study on the tissue distributions of rhubarb anthraquinones in n ormal and CCl 4 －injured rats orally administered rhubarb extract [J ] . J Ethnopharmacol , 2011 , 137 ( 3 ): 1492 － 1497 .

涂灿，何琴，周元园，等 . 基于代谢组学的大黄对正常和肝纤维化大鼠双向作用对比研究 [J ] . 药学学报， 2018 , 53 ( 7 ): 1139 － 1147 .

李灿东 . 中医状态学 [M ] . 北京：中国中医药出版社， 2016 .

冯化驯 . “有故无殒亦无殒也”临床考实 [J ] . 河南医学院学报， 1981 ( 3 ): 494 － 496 .

黄圆圆，权琦，陈平，等 . 鼻咽癌患者91例放化疗后应用中药维持治疗的安全性报告 [J ] . 中华中医药杂志， 2020 , 35 ( 8 ): 3902 － 3905 .

乔世杰，付超，蔡姿尧，等 . “中医状态”纵向视域下方证相应理论内涵新释 [J ] . 北京中医药大学学报， 2024 , 47 ( 6 ): 760 － 764 .

邱丽丽 . 麻黄细辛附子汤“病证－量－效/毒”关系的研究 [D ] . 济南：山东中医药大学， 2019 .

李宿根，柴文若 . 万文谟谈临证得失二三事 [J ] . 浙江中医杂志， 1999 , 34 ( 1 ): 30 － 31 .

沈自尹 . 微观辨证和辨证微观化 [J ] . 中医杂志， 1986 , 27 ( 2 ): 55 － 57 .

李枝锦，吴平财 . 微观辨证论治脾虚湿浊型慢性萎缩性胃炎临床疗效及对血清胃泌素、胃蛋白酶原的影响 [J ] . 时珍国医国药， 2022 , 33 ( 3 ): 643 － 646 .

WANG JB , ZHAO HP , ZHAO YL , et al . Hepatotoxicity or hepatoprotection? Pattern recognition for the paradoxical effect of the Chinese herb Rheum palmatum L. in treating rat liver injury [J ] . PLoS One , 2011 , 6 ( 9 ): e24498 .

李春雨，李晓菲，涂灿，等 . 基于内毒素模型的何首乌特异质肝损伤评价 [J ] . 药学学报， 2015 , 50 ( 1 ): 28 － 33 .

王伽伯，崔鹤蓉，柏兆方，等 . 精准医学下的中药安全性评价策略和方法：病证毒理学 [J ] . 药学学报， 2016 , 51 ( 11 ): 1681 － 1688 .

周宜，陈钢，夏丽娜，等 . 从《内经》“有故无殒”思想看中药毒性研究 [J ] . 中国中医基础医学杂志， 2007 , 13 ( 5 ): 342 － 343 .

夏淑洁，吴长汶，李灿东 . 宏、中、微“三观并用”的中医状态辨识模式探讨 [J ] . 医学争鸣， 2020 , 11 ( 6 ): 39 － 42 .

朱文锋 . 证素辨证学 [M ] . 北京：人民卫生出版社， 2008 .

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