摘要:Four steps in studying clinically effective TCM formulas are discussed on the basis of chemistry. The application of direct experiment design in screening ingredients of a formula, and the adoption of the identification by chemical model in controlling the quality of TCM preparations are briefly recounted. The effective parts of the ingredients of TCM formulas and the determination of the main chemical constituents in them, the application of stechiometry in studying TCM formulas, and computer simulation of the structures of main effective constituents in the ingredients of TCM formulas, are also related in the paper.
摘要:The model of cerebral ischemia was induced in the rat with hyperlipemia; laser diffraction method was used to determine erythrocytic deformability and radioimmunoassay was used to determine the content of plasmatic entothelin. The results showed that 1 day after re perfusion of the cerebral ischemic rat, the erythrocytic deformability was obviously decreased, the erythrocytic aggregation ability was increased, and the content of plasmatic endothelin had an increasing tendency ( P <0.05); 7 days after the re perfusion, all the criteria but the content of plasmatic endothelin, were restored to normal level; and the TCM preparation Fusheng Powder had significant effects of decreasing erythrocytic aggregation ability, improving erythrocytic deformation ability, and inhibiting plasmatic endothelin secretion, by which Fusheng Powder improved cerebral microcirculation perfusion and protected the brain from cerebral ischemic damage.
关键词:Fusheng Powder;Cerebral Ischemic Re perfusion;Erythrocytic Deformability;Plasmatic Endothelin;rat
摘要:The methods of ABC immunohistochemistry and image pattern analysis were used to observe the effects of the TCM preparation Tifukang on dynamic changes of L ENK and DYN A 1-13 in different cerebral areas in the rat with exercise induced fatigue. The results showed that the content of L ENK in caudate putamen decreased when at rest in the rat undergone 7 week’s exercise with high intensity, but increased immediately at the end of the exercise; and Tifukang had a regulating effect on the content of L ENK, making it decreased when in an acute stress state and increased when in a chronic stress state caused by exercise in rats. The results also showed that the content of DYN A 1-13 in hypothalama could be activated by exercise, and the activation was more obvious 30 minutes after the stopping of the exercise; and Tifukang could decrease the content of DYN A 1-13 in hypothalama but with no significant effect.
关键词:Tifukang;Exercise induced Fatigue;L ENK;DYN A 1-13;Immunohistochemistry
摘要:In vitro bacteriostatic experiment showed that Huangqichifeng Oral Solution (HOS) had a relatively significant inhibiting effect on 9 kinds of commonly seen bacterium, and especially a better effect on the commonly seen bacteria in the respiratory tract; in vivo bacteriostatic experiment showed that HOS had a certain protective effect on the mouse infected by Staphylococcus aureus , with a decreased death rate when the preparation was given 6 hours before the infection was induced, while the mouse could not be protected from the death due to the infection when the preparation was given after the induction of the infection.
关键词:Huangqichifeng Oral Solution;Bacteria;In Vitro Inhibiting Bacteria;In Vivo Inhibiting Bacteria
摘要:Dingfengtong Granules (DG) were found to be significantly effective in inhibiting the pain caused by both physical and chemical factors and the effectiveness could last for about 3 hours. Mouse meninges microcirculation experiment showed that DG could obviously improve cerebral circulation in mice, and rat cerebral blood flow determination showed that DG could markedly increase the volume of cerebral blood flow in the rat with incomplete cerebral ischemia. The experiment in rabbits found that DG could expand the micrangium in the bulbar conjunctiva, and improve the flow state of blood flow.
关键词:migraine;Analgesia;Microcirculation of Meninges;Volume of Cerebral blood Flow;Flow State of Blood Flow;Mouse;Rat
摘要:Cases of mild and moderate multiple infarctional dementia (MID) were chosen according to DSM III R, and were randomly divided into treating group (30 cases) treated with Jiannaoyizhi Granules (JG), and control group (15 cases) treated with Hydergine; the treating effectiveness was evaluated by using MMSE and Blessed BBS. The results showed that JG was effective for treating mild and moderate MID, especially good for mild MID, with an overall effective rate of 76.7%.
关键词:Multiple Infarctional Dementia;Disturbance of Intelligence;Tonifying the Kidney and Removing Turbidness;Jiannaoyizhi Granules