摘要:Pneumonectasis by the aerosol inhalation spray of velardon and TCM syndrome of kidney asthenia was induced on the same mouse, in order to simulate the TCM dyspnea of deficiency type caused by asthenia of lung and kidney. Observing the endurance, cold tolerance and changes of the three parameters in free time which are SOD、GSH PX and MDA, the results show the three parameters are in accordance with those in clinic. Then treat with the prescription of “regulating and nourishing the lung and kidney” to prove the reliability of the model.
关键词:Syndrome of dyspnea of deficiency type;Animal pattern;Counterevidence of treatment
摘要:The prescriptions in the Treatise on Febrile Disease which are represented by the Zhizichi Decoction, have not been brought into full play in the clinic as well as other classic prescriptions like Decoctions of Guizhi and Chaihu . It is due to the inadequate understanding of the syndrome and treatment in theory. The Zhizichi Decoction mainly treats the “vexation and restlessness” caused by the “pathogenic heat lingering in the stomach”, not the “restlessness of deficiency type” caused by the “disturbance of the chest and diaphragm by heat”. In fact, the “vexation and restlessness” means the gastric discomfort. A further analysis on the pathological changes from the “Yangming visceral substantive syndrome” caused by the “pathogenic heat lingering in the stomach”, to the “Yangming syndrome of jaundice” due to “damp heat”, indicates that the Zhizichi Decoction is the first important prescription on the “Yangming heat syndrome”.
摘要:Injecting colitoxin to caudal vein was used to duplicate rat model of endotoxin shock. Examine blood pressure, cerebral coefficient, nitrous oxide synthetase (NOS) activity of hippocampal tissue and morphological modification in the CA1 section of the hippocampal tissue, to discuss the mechanism of action of Xinmailing Injection on the endotoxin shocked rat. Results: Compared with the pathologic group, after injecting Xinmailing 1h and 6h respectively, the blood pressure was increased, cerebral coefficient decreased, NOS activity of hippocampal tissue markedly accentuated, the injured neurons of the CA1 section of hippocampal tissue markedly relieved. It suggests that Xinmailing Injection can improve the hypotension and venous edema caused by endotoxin shock, protect neurons of the CA1 section of hippocampal tissue, enhance the NOS activity of hippocampal tissue, so to take an effection of anti endotoxin shock.
摘要:From the perspective of Chinese and Western medicine, review the status quo of the research on the alcoholic liver disease. Chinese medicine has a lot of studies on this disease in the name, pathological changes and “the treatment according to syndrome differentiation". However, most of them were limited in clinical practices, not intensively and systematically. Till now there has not been any basic research to test and verify the mechanism of action and the target of the Chinese medicine prescriptions. On the other hand, western medicine has studied the pathogenesis in immunology, genetics, virology, etc., and created some curative drugs, but the side effects make most of the drugs difficult for widespread usage. It also need further research.
关键词:Alcoholic liver disease;pathogenesis;Treatment according to syndrome differentiation;diagnosis;basic research;clinical research
摘要:There are many schools of thought in the Canon of Internal Medicine . The classifications of them can be concluled into two methods: one is utilizing medical scholars’ name as guiding principle and another is taking doctrines of schools in each special subject as guiding principle. However, both of them are inadequate. The guiding principle of the study should be based on the theory of Yinyang and Five Elements .
关键词:Canon of Internal Medicine;Schools of thought;Differentiation of the schools;Survey
摘要:Objective: to observe the effects of Saikosaponin, an effective component of Bupleurum, on activating the primary cultured Fat Store Cells (FSC) and synthesizing extracellular matrix (ECM). Method: utilizing ultrastructure, immunocytochemistry and image pattern analysis to examine contents of collagen type 1, 3, 4 and fibronectin (FN) in FSC; using flow Cytomater to determine content of DNA and measure 3H-Proline incorporation volume so as to detect collagen protein volume in FSC. Result: positive reaction of the desmin was markedly weakened in the groups of TKCnem, TKCtem and TKCnem plus Pcnem. For the transformation of cell phenotype, the morphological character was improved. In other treatment groups on FSC, DNA synthesis and 3H-Proline incorporation volume were decreased at different levels. In all treatment groups, volume of collagen type 1 was decreased markedly, especially groups of TKCnem and TKCtem. Conclusion: Saikosaponin can protect the hepatocytes. It could inhibit the DNA synthesis and the FSC activation so to inhibit the ECM synthesis.
摘要:patients with acute bronchial asthma, mild or moderate degree, were randomly divided into two groups: the therapeutic group with Xiaochuanning and the control group with aminophylline. Observe the changes of the main symptoms, physical signs, pulmonary function, blood gas analysis, peripheral blood EOS counting, T subpopulation quantity and the ECP of blood serum. The results show that: the control & excellent effective rates and the total effective rate of the therapeutic group were 63.33% and 90.00% respectively, while 66.67% and 86.67% of the control group. The study indicates that, Xiaochuanning can not only inhibit the immediate reaction of the asthma, but can antagonize the inflammation of the airway, decrease the high reactivity of the airway and inhibit the delayed reaction of the asthma.
摘要:Cerebral cortex of the newborn rat was used for neurons culture in vitro. An isolated pattern of injured neuro by glutamic acid was built up. Observe the effect of gastrodine on the neurotoxicity of excitatory amino acid. The results show that: Glutamic acid can cause the expiration of cultured neurons in large quantities and the amount of lactic dehydrogenase (LDH) in the nutrient solution can be markedly increased. By adding gastrodine or ketamine into the nutrient solution, mortality rate of the neurons can be significantly decreased and the transudation of LDH also diminished, which suggests gastrodine can antagonize the neurotoxicity of excitatory amino acid.
摘要:To discuss the mechanism of preventive and curative action of the Chicory Capsule on diabetes, taking test in vivo, we observe the effects on the normal mice and the different hyperglycemic mice models respectively. The results show the medicine has no significant effect on the blood glucose of normal mice, but could markedly decrease it of the alloxan and adrenalin mice model and at the same time increase the amount of hepatic glycogen of the adrenalin mice model. It preliminarily indicates that, the blood glucose lowering action of the Chicory Capsule correlates with the extra-pancreas route, especially it can increase the amount of hepatic glycogen and inhibit the decomposition.
摘要:Radioimmunologic method was used to evaluate the influence of the complex prescription of regulating the spleen and stomach on the pentylenetetrazole (PTZ) kindled rats and changes of the opioid peptides concentration in the brain. In the hippocampus of the PTZ kindled rats, the leucine-enkephalin (L ENK) and β endorphin (β EP) were increased and dynorphin A1-13 (DYN A1-13 ) decreased. After treated with the complex prescription, the L ENK andβ EP were markedly decreased, while DYN A1-13 increased. It indicates that the epileptic attack and the antiepileptic effect of the complex prescription may relate with the changes of the L ENK、β Ep and DYN A1-13 in the brain.
摘要:By analyzing 2003 clinical data of resident patients suffered acute cerebrovascular disease which attacked within 72 hours, it was found that the occurrence of apoplexy correlated closely with the age and gender, the attack rate of infarctus was increased and a mild trend in the apoplectic stroke existed. By order, the concomitant diseases and past history were hypertension, smoking, ST-T change of electrocardiogram, hyperlipemia, obesity, hyperglycosemia, heart dilatation and thickening, proiosystole, fever and minimal trachitis. Most were induced by emotional instability, strenuous exercise and climatic sudden change. The representative signal symptoms of the apoplexia were heaviness sensation in the limbs and fatigue, dizziness, numbness, headache, slurring of speech and blurring of vision.
摘要:After two-week preimmunization, Sprague-Dawley rats were daily injected with cationized bovine serum albumin (C-BSA) intraperitoneally. It was found that, after two-week C-BSA intravenous injection, granular deposits of IgG along glomerular capillary walls was shown by fluorescence microscopy, the formation of crescent shown by light microscopy and a large amount of subepithelial electron-dense deposits shown by electron microscopy; after four weeks, subepithelial electron-dense deposits fused into large patches; after six weeks, glomerular sclerosis was found in most rats.