最新刊期
卷 0 ， 期 5 ， 1999
- 摘要：In this review of the studies on molecular genetics and molecular biology of the association of apolipoprotein E（ApoE） ε4 allele with Alzheimer’s disease （AD） and cognitive decline, it can be found that ApoEε4 is a risk factor of AD. When ApoEε4 allele is present, the risk of AD is considerably increased, almost 3-fold risk of AD in ApoEε4 positive individuals compared to ApoEε4 negtive individuals. But ApoEε4 is far from being a diagnositic indicator or a predicator of AD. ApoEε4 may at least indicate a predisposion for dementia in memory-impaired individuals. Presence of ApoEε2 allele may be a genetic factor of differentiation between Lewy body disease（LBD） and late onset AD. ApoEε4 and cerebral vascular disease may have a synergistic effect on pathogenesis of vascular dementia （VD）.关键词：ApoEε4;Alzheimer’s disease;Genetics;Molecular Biology
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发布时间：2021-09-15 -
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- 摘要：Chronic fatigue syndrome （CFS） are most thought as the result of disturbance of neuro endocrine immune net by multi factors like the virus infection, stress, etc. Based on the TCM theory combined with earlier stage clinical practice, we thought the dysfunction of liver and spleen be one of the mechanism. The CFS animal model was established by multiple stress factors as chronic enchaining, cold swimming and electric stimulus when taking food. The praxiologic assay showed the results conformed to the clinical symptoms of CFS. Further clinical study would be under the TCM theory, using clinical epidemiology/DME method, multiple statistic method, internationally accepted statistic software SPSS or SAS, and measuring scales, discuss on the pathological mechanism from both angles of Chinese and western medicine, analyze the semiological characteristic and differentiation of syndromes and typing of CFS in China.
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发布时间：2021-09-15 -
- 摘要：Reduce the clinical symptoms that mainly belong to the cerebral apoplexy in western medicine but not to apoplexy in TCM, which characterized by sudden fall with unconsciousness, hemiplegia, inarticulateness or aphasia and hemianesthesia, to the analogous apoplexy. After comparing the clinical symptoms and physical signs between the analogous apoplexy group and apoplexy one, using American SAS statistical analysis soft ware to take logistic regression analysis on 2206 cases, combining with clinical practice, bibliography investigation and specialists’ experience, the main symptoms of analogous apoplexy were defined as: vertigo, sensory disturbance, severe headache, visual abnormality, involuntary movement, mental aberration, epileptic attack, agnosia, alexia and agraphia, etc. Thence established the basis for the further research on the analogous apoplexy.关键词：Cerebral apoplexy;Apoplexy;Analogous apoplexy;Multiple factor analysis;Symptoms and physical signs
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发布时间：2021-09-15 - 摘要：Xingyang Pills consists of Yinyanghuo, Xianmao, Roucongrong, Duzhong, Tusizi, Heshouwu, Jixueteng, Guizhi, Zexie, Wumei, Gancao, Wugong , etc. Administering Xingyang Pills to 105 cases of impotence with TCM syndromes of retention of dampness due to kidney deficiency , and contrasting to the group with Shenrongsanbian Pills, another Chinese patent medicine, results showed the total effective rate of Xingyang group was 90.48%, that of the control group was 63.33%. The experiment proved: For the animal with deficiency of the kidney yang , which induced by large dose of hydrocortisone, Xingyang Pills had good effects on the symptoms like the body temperature and weight decreasing, reduced free running and stress function. It also had a certain antagonizing action on the kidney deficiency expressions by castrated male animal such as the gonad atrophy （seminal vesicle, preputial glands）. In addition, it can also enhance the memory of normal and dysmnesia mouse induced by scopolamine.关键词：Retention of dampness due to kidney deficiency;Impotence;Xingyang pills;clinical study;Experimental research
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发布时间：2021-09-15 - 摘要：The Tiaolü solution consists of Xianlingpi （Epimedium）, Huangqi （Astragalus Root）, Sanqishen （Notoginseng）, Huangjing （Agastache）, Shanzha （Hawthorn fruit）, Tea leaves and Zhigancao （Prepared licorice）. It has the function of warming and invigorating the heart and kidney, removing blood stasis to restore pulse , which can be used in the treatment of sick sinus syndrome and the effect was better than the control group with Xinbao Pills. It indicated that this solution has effects on increasing heart rate, enhancing heart function and antagonizing the myocardial ischemia.关键词：Tiaolü solution;Sick sinus syndrome;Warm and invigorate the heart and kidney;Remove blood stasis to restore pulse
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发布时间：2021-09-15 -
- 摘要：Observe effects of the TCM compound preparation Xiaotang Tablets on noninsulin dependent diabetes. The tablet mainly consists of Taizishen （Pseudostellaria Root）, Maidong（Ophiopogon Root）, Shengdi（Dried Rehmannia Root）, Danshen（Red Sage Root）, Taoren（Peach Kernel）, Zhishi（Fruit of immature Citron）,etc., which mainly contribute to the TCM function of replenish qi and nourish yin and remove phlegm and blood stasis . After treating with Xiaotang Tablets for 4 weeks, the patients’ clinical symptoms, the level of blood sugar and lipid were all improved compared to the pretreatment, which were also better than the control group with XiaoKe Pills.关键词：Xiaotang Tablets;Noninsulindependent diabetes;Replenish qi and nourish yin;Remove phlegm and blood stasis;clinical study
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发布时间：2021-09-15 -
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- 摘要：Establishing the rat model with chronic atrophic gastritis, do the research through the experimental indice as free acid in gastric juice, total acidity, pepsin activity, etc. Observe the decoction’s effect on the rat model. Results showed that the decoction and each decomposed group all had the effect of adjusting gastric secretion to different degrees. In decomposed groups, some groups showed tendency in coordination while others showed restriction. The decoction group was the best through comprehensive evaluation on the overall effect, which proved the classic prescriptions rationality. At the same time, among decomposed groups, the group of tonifying with the sweet had markedly effect, which indicated the medicines with effect of reinforcing the body’s vital energy are important in this decoction.关键词：Banxiaxiexin decoction;Prescription composing;Decomposing research;Gastric secretion
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发布时间：2021-09-15 - 摘要：To further approach to the pathogenesis of chronic fatigue system （CFS）, the research based on establishing CFS animal model by complex stress factors, assayed the concentration of monoamine substance in the plasma and brain tissues, and then observe the modulating function of Xiaopiyishen on them. The results show CFS animal appears the changes of the above substances, which are perhaps one of the pathogenesis. Xiaopiyishen relieve somatic and psychological stress of CFS rat by modulating the changes of these substances so to facilitate the rehabilitation of CFS.关键词：Chronic fatigue;Model animal;Monoamine substance;Xiaopiyisheng
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发布时间：2021-09-15 - 摘要：Observed the effect on histopathology of abacterial chronic prostatitis rat model. The prostatitis suppository is consisted by Chinese medicines which are mainly Huanglian（Coptis Root）, Chishao（Red Peony Root）, Bingpian（Borneol）, etc. The results showed that the prostatitis suppository was functioned with repairing prostate tissue and recovering the secretory action.关键词：Prostatitis suppository;chronic prostatitis;Histopathology;rat
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发布时间：2021-09-15 - 摘要：The content change of M ATPase in skeletal muscles in state of spleen deficiency is explored with the histochemical method. The result shows the content of M ATPase presents regularly decreasing trend in the mouse model. It reveals that the histochemical reactive method of the M ATPase is a directly observable method used to further prove the correctness of the TCM theory that “the spleen dominates muscles".关键词：Spleen deficiency syndrome;Skeletal muscles;MATPase;Enzymatic histochemical reaction
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发布时间：2021-09-15 - 摘要：Kaixiping oral fluid （KXP） has a markedly growth inhibition action on transplantation H22 tumor in mouse. The tumor inhibitory rates at the dosage of 27.0, 18.0 and 19.0g/kg are respectively 47.6%, 47 8%and 33 8%. The action of prolonging survival time of the mouse with H 22 ascites tumor is stronger than the complex prescription "Tianxian" capsule which was taken as positive contrasting drug, and has no toxicside effect expressed by 5 Fu. It has some inhibitory action on the H 22 cell cultured in vitro, which the lowest effective drug concentration can reach 25mg/L and the time can last more than 48h. But for the T splenocyte, only when the dosage reaches 800mg/L does the proliferation inhibitory action work. It indicate that KXP has special inhibitory action on the tumor cell, which can not be induced by cytotoxicity. This experiment also show KXP can enhance proliferative ability of the T, B lymphocyte, markedly reinforce the activity of natural killer cell （NK） and the phagocytic activity of celiac macrophagocyte （MΦ）, which prove KXP’s importance in the antineoplastic immunity.关键词：Kaixiping oral fluid;H 22 tumor cell;transplantation tumor;Ascites tumor;Cellular immunity;mouse
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发布时间：2021-09-15 - 摘要：To research antiviral effect of Rheum offinicale extraction on coxsackievirus B 3 （CVB 3 ） and elucidate its antiviral mechanism. Cytopathic effect （CPE） was observed and infectious virus was titered by micro well cells culture, CVB RNA was detected by reverse transcription polymerase chain reaction （RT PCR） in Hep 2 cells supernatant. The results showed CPE can not be observed, infectious viral titer is less than 1 logarithm unit and CVB RNA is detectable in 10 -3 dilution of viral titered microwell at 8 μg/mL. These results suggested that Rheum offinicale extraction can interrupt viral biosynthese other than killing directly CVB 3 or interfere in viral absorption and penetrance, especially can interrupt viral nucleic acid amplification or/and the last stage of viral replication cirle.关键词：Rheum offinicale extraction;Coxsackievirus B 3;Micro well cells culture;Antiviral activity
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发布时间：2021-09-15 - 摘要：The experiment is devised to research the immunoregulatory action of HuayuJuanbiZhitong （HJZ） Granules on delayed hypersensitivity induced by DNFB. The experiment examines swollen degree of ears of experimental mice, proliferous reaction of splenocytes induced by ConA and LPS, the level of IL 1 and IL 2 in serum. The results show that HJZ Granules can relieve the swollen degree grossly, depress the proliferous reaction of splenocytes induced by ConA, reduce the level of IL 1 and IL 2 in serum. It suggests that HJZ Granule has a good immunorepressive action, which positively relates to the dosage.
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发布时间：2021-09-15 -
- 摘要：Objective: Approach to the effect of composed Chinese drug 892 on inducing the apoptosis of SPC A1. Methods: According to the basic TCM theory, the pathologic characteristic of lung cancer is stagnation of phlegm and turbid qi . Drug 892, composed of Banxia （Rhizoma Pinelliae）, Tiannanxing （Rhizoma Arisaematis）, and Sanqi （Radix Notoginseng）. After incubating SPC A1 and drug-bearing rabit serum which at different concentration with serologic pharmacological method, observed and detected the growth and apoptosis of cells, cell cycle and apoptosis rate. Results: By the action of drug bearing rabit serum, SPC A1 grew against the wall and then peeled off gradually; fluorescence microscope showed the nucleus broke into pieces, and cell split into apoptosis bodies in different size; FCM showed a typical peak of apoptosis, which was most obvious after 48 hours’ action with 5% drug bearing rabit serum at the rate of 42.82%. Conclusion: One of the antineoplastic molecular mechanism of composed Chinese drug 892 may be its effect on inducing the apoptosis of SPC A1 by serologic pharmacological method.关键词：Drug 892/Chinese drug;Serologic pharmacological test;SPC A1;apoptosis
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发布时间：2021-09-15 - 摘要：The research was carried on with pharmacological effective method and analgesic effect （number reduction of maximum body twisting） was taken as drug effect index. Observe internal metabolism of the capsule, compute out the correlation parameter through computer program. It proved the capsule’s pharmacodynamic model was two compartment open model.关键词：Kebitong capsule;Pharmacodynamic;Drug effect index;Atrioventricular model of fit;Pharmacokinetics parameter
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发布时间：2021-09-15 -
- 摘要：Identify the Huangqi, Chishao, Fangfeng and Jinyinhua in Huangqichifeng granules through TLC method. Results show that spots in the chromatogram is clear with good repeatability. This method can be used in the ready products qualitative identification.关键词：Huangqichifeng granules;chlorogenic acid;Astragalin A;Paeoniflorin;Thin layer chromatography
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发布时间：2021-09-15 - 摘要：The experiment on the Maoxucao （Clerodendranthus spicatus （Thunb.）） showed that: the chemical composition differs in different habitat and the content of ursolic acid differs very much as well. So attention should be paid to the habitat resource and inherent quality when using Maoxucao in clinic.关键词：Maoxucao;Habitat;ursolic acid
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发布时间：2021-09-15 -
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