最新刊期
卷 0 ， 期 0 ， 2020
- 摘要：The authors of this paper have made a survey of the viewpoints of traditional Chinese medical doctors in different historical periods on the TCM etiology and pathology of dementia, and the viewpoints of contemporary medical doctors on the etiology and pathology of senile dementia. On the bases of the etiology and pathology of both dementia and senile dementia, and according to the systematic TCM clinical observation and analysis of vascular dementia, the authors have given a preliminary exposition of the TCM etiology and pathology of vascular dementia. The authors point out that vascular dementia mainly develops in the patients with longstanding diabetes, obstruction of qi in the chest, and apoplexy; the deficiency of renal essence and qi, and the collateral’s obstruction caused by the combination of phlegm stagnation and blood stagnation are the etiology of vascular dementia; and the impairment of the collaterals and marrow of the brain due to the turbid toxins produced by the accumulation of phlegm and blood stasis are the pathology of vascular dementia.关键词：vascular dementia;TCM Etiology and Pathology;Turbid Toxin?
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发布时间：2021-09-15 -
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- 摘要：利用链脲佐菌素 （STZ）糖尿病SD大鼠模型 ,观察了中药复方止消通脉宁及典型的醛糖还原酶抑制剂 （Sorbinil）对大鼠肾组织醛糖还原酶 （AR）和山梨醇脱氢酶 （SDH）活性及肾脏病变的影响。结果表明糖尿病大鼠经上述两种药物治疗后 ,肾脏AR活性明显下降 ,SDH活性显著升高 ,血糖、2 4h尿白蛋白含量显著下降 ,肾重及肾重 /体重显著降低 ,且止消通脉宁组疗效优于Sorbinil组。提示中药复方止消通脉宁可改善多元醇代谢 ,为临床上使用止消通脉宁防治糖尿病肾病提供了一定的实验依据关键词：糖尿病肾病;醛糖还原酶;山梨醇脱氢酶;止消通脉宁;醛糖还原酶抑制剂
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发布时间：2021-09-15 - 摘要：This experiment is designed to study the preventive and treating effects of Jiedutongluo Decoction （JD） on delayed neuronal death caused by cerebral ischemia reperfusion in the rats which underwent bilateral common carotid blockage and intraperitoneal injection of sodium nitroprusside. The rats in the experiment were divided into control group, model group, JD treating group and nimodipine treating group. The cerebral SOD activity and MDA level were determined by photochemical method. The results showed that compared to that in the rats in the control group, the SOD activity was lower and the MDA level was higher in the rats in the model group; and both JD and nimodipine could increase the SOD activity and decrease the MDA level, but the effects of JD was stronger than those of nimodipine, which implies that the two drugs have anti-lipid-peroxidating effects, and JD is more effective than nimodipine.关键词：Jiedutongluo Decoction;vascular dementia;Anti-Lipid-Peroxidation
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发布时间：2021-09-15 - 摘要：An observation on the changes of the levels of 16 amino acids in the hippocamp of the rat with chronic fatigue induced by combined stress factors, and the regulating effects of traditional Chinese drugs on the 16 amino acids, was made in the experiment. The results showed that both Yishen Oral Liquid and Ginsenoside Tablets could not significantly decrease the increased levels of glycine, alanine, lysine, arginine, taurine and γ-aminobutyric acid in the rat, but the two drugs, especially Ginsenoside Tablets, could significantly increase the decreased ratios of Glu/GABA and excitation/inhibition.关键词：Chronic fatigue;Syndrome;Psychological Stress;Somatic Stress;animal model;Hippocamp;Amino Acid;Traditional Chinese Dru`
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发布时间：2021-09-15 - 摘要：以收缩波幅及收缩频率为指标 ,观察半夏泻心汤及其拆方各组对大鼠离体胃底肌条收缩活动的影响 ,以探讨半夏泻心汤的配伍机理 ,进一步指导临床实践。实验结果表明 ,拆方各组中 ,部分药组之间呈协同作用趋势 ,而部分药组之间则呈制约趋势。同时发现 ,苦降组能明显减小胃底肌条的收缩幅度 ,甘补组、辛开苦降组、全方组能明显增大胃底肌条的收缩幅度关键词：半夏泻心汤;方剂配伍;拆方研究;胃底肌条
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发布时间：2021-09-15 - 摘要：The effects of the total glycoside extracted from Cornus officinalis （TGECO） on T lymphocytes and T lymphocyte subgroup, and the IL 2 production of T lymphocytes were studied in healthy mice in order to explore the immunosuppressive mechanism of TGECO. The results showed that all the different TGECO doses could inhibit the multiplication of T lymphocytes （ P <0 01）, CD3 surface expression in T lymphocytes （ P <0 01）, and CD4 and CD8 surface expression in T lymphocytes （ P <0 05 or P <0 01）; besides, middle and large TGECO doses could increase the ratio of CD4/CD8, which implies that the TGECO effect of inhibiting CD8 is stronger than that of inhibiting CD4. The results also showed that all the different TGECO doses could inhibit the IL 2 production of T lymphocytes （ P <0 05 or P <0 01）, which may be one of the main causes of the immunosuppressive effects of TGECO.关键词：Total Glycoside from Cornus Officinalis;T Lymphocyte;mouse;Immunologic Funct
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发布时间：2021-09-15 - 摘要：In this experiment, different drugs including Shenyan No.3 （S No.3） were given to the rabbit first, and then the rabbit’s serum was separated and added to into the mesangial cell culture solution; afterwards, an observation on mesangial cell multiplication and mesangial cell IL 1 level was made. The results showed that S No.3 could strikingly inhibit mesangial cell multiplication and mesangial cell IL 1 secretion under both normal and pathological conditions （ P <0 01）, and the inhibiting effect of S No. 3 on mesangial cell IL 1 secretion was stronger than that of Tripterygium wilfordii （ P <0 05）. The reults implies that S No.3 may have a good effect on the chronic nephritis with mesangial cell proliferation as a main evidence in its pathology.关键词：Shenyan No.3;Mesangial cell;Interleukin-1;Chronic nephritis
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发布时间：2021-09-15 - 摘要：The histopathological changes in the guinea pigs with experimental allergic encephalomyelitis （EAE） and the effects of Wenyangbushen Decoction （WD） on them were observed by HE and Luxol Fast Blue staining methods. The results showed that the pyramidal cells in the hippocampal CA3 area were also related to the onset of EAE, and WD could reduce the pathological lesions in the guinea pigs with EAE. The results have provided some morphologic evidence for the clinical use of WD in the treatment of multiple sclerosis.关键词：Multiple Sclerosis;Wenyangbushen Decoction;Experimental Allergic Encephalomyelitis;Guinea P?
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发布时间：2021-09-15 - 摘要：The effects of Zhixiaotongmaining Granules （ZG） on the components of glomerular extracellular matrix （ECM） were observed in the rats with diabetes induced by streptozotocin. The results showed that ZG could significantly decrease the accumulation of the type IV collagen, fibronectin and laminin, and inhibit ECM proliferation. The results imply that ZG can delay the onset and development of diabetic nephropathy.关键词：Zhixiaotongmaining Granules;Experimental diabetes;Components of Glomerular Extracellular Matrix;Immunohistochemistry;Semi-quantitative Analysis;rat
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发布时间：2021-09-15 - 摘要：The results of the experiments of antifertility and genetic toxicology of Dianthus Superbus Decoction （DSD） in pregnant mouse showed that all DSD doses of 10 g/kg, 15 g/kg and 30 g/kg had a rather obvious effect of causing abortion and dead fetus in the nidation period and early gestational period, and DSD doses of 15 g/kg and 30 g/kg manifested the same effect in the intermediate gestational period, in a dose-effect manner with partial absorption of necrotic embryo. The experiments also showed that all the above DSD doses manifested no genetic toxicity.关键词：Dianthus Superbus;Antifertility;Genetic Toxicology
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发布时间：2021-09-15 - 摘要：The effects of electroacupuncture （EA） on the subcortical components, cortical components and pain components of the somatosensory evoked potentials （SEPs） induced by electrical stimulation of the median nerve were studied, and the characteristics of different central SEPs were summarized. The results showed that （1） 1～2 V EA of different frequencies （20 Hz and 40 Hz） had an obvious inhibiting effect on the amplitude of the thalamic components P 14 N 16 , still keeping the amplitude on a relatively low level after 20 minutes of EA performance; （2） 2～5 V EA of 20 Hz had an obvious inhibiting effect on the cortical components P 14 N 20 , P 25 N 30 and P 45 N 60 ; （3） 2～5 V EA of different frequencies （2 Hz, 20 Hz, 40 Hz and 60 Hz） had an obvious inhibiting effect on the pain components P 200 N 300 , and a especially stronger effect was observed when the EA was on 20 Hz, with a strong and lasting aftereffect.关键词：Somatosensory Evoked Potentials;electroacupuncture;frequency;Median Nerve
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发布时间：2021-09-15 - 摘要：Aim: to observe the levels of von Willebrand factor （vWF）, endothelin （ET）, thromboxane A 2 （TXA 2） and prostacyclin （PGI 2） in the plasma of the rabbit model of hyperglycemia combined with hyperlipidemia, and the effects of chicory extract on the vWF, ET, TXA 2 and PGI 2. Method: the rabbit model was established by using high fat diet and intravenous injection of alloxan, and the levels of the vWF, ET, TXA 2 and PGI 2 were determined by radioisotope immunoassay. Results: the results showed that the levels of the vWF, ET, TXA 2 were increased and the level of the PGI 2 was decreased in the model rabbits, compared with those in the healthy rabbits. The chicory extract had the effects of decreasing the levels of the vWF, ET, TXA 2 and increasing the level of the PGI 2 with improvement of the ratio of PGI 2/TXA 2. Conclusion: the effects of chicory extract may be related with the antiatherosclerotic mechanism.关键词：Chicory;Pharmacology;von Willebrand Factor;endothelin;Prostacyclin;Thromboxane Ah
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发布时间：2021-09-15 - 摘要：A subjective symptomatic material scale and an objective symptomatic material scale for TCM melancholia of both heart and spleen deficiency type, have been designed by the authors of this paper, by consulting the quantitative and standardization methods from SAS and HAMA, the two anxious syndrome scales in modern medicine for handling symptomatic materials.关键词：TCM Standardization;TCM Melancholia;Symptomatic Scale;Discriminatory Analysis?
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发布时间：2021-09-15 -
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