最新刊期
卷 0 ， 期 1 ， 2001
- 摘要：The authors of this paper have put forward a hypothesis of the injury of brain collaterals by toxins. According to this hypothesis, the basic reason of the difficulty of apoplectic rehabilitation is that the brain collaterals are injured by the toxins of fire produced by the disharmony of ying and wei, and wei qi stagnation caused by the obstruction of brain collaterals. The authors hold that the modern pathological basis of the difficulty of apoplectic rehabilitation is the cerebral ischemic cascade in the apoplectic development, namely, the damage caused by free radicals, metabolic toxins and excitatory amino acids and so on, to the microvascular endothelial cells and nerve cells. The key points of the treatment of apoplexy, according to the authors, are to dispel the toxins and dredge brain collaterals, and to harmonize the relations between ying and wei. By doing these, the damage caused by cerebral ischemic cascade can be halted, and the repairing ability of the body can be mobilized. These effects can be seen in many aspects at the early stage and rehabilitating stage of apoplexy.关键词：Injury of Brain Collaterals by Toxins;pathogenesis;Apoplexy;Dispelling Toxins and Dredging Collaterals;Treating Principles
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发布时间：2021-09-15 -
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- 摘要：The rat model of vascular dementia was established by the cortical devascularization method. It was found in the rat model that learning and memorizing abilities were remarkably decreased, and the quantity of AchE positive fibers was significantly reduced in the cortex, the pyramidal cell layer of CA1 - CA4 subregions of the hippocampus, and in some other areas; and the quantity of Ach and ChAT positive neurons was obviously decreased in the MBN. In the rat model, atrophic cells, characterized by small sizes and less branches or even no any branches, were also found in the MBN. While in the Congsheng Capsules treated group, it was found that the learning and memorizing abilities were improved, the density of AchE positive fibers in the cortex and CA1 subregion of the hippocampus was obviously increased, and the AchE and ChAT positive neurons in the MBN were morphologically intact. The results of this study suggest that Congsheng Capsules have a protective effect against the injuries of neurons caused by the ischemia due to cortical devascularization, and an improving effect against the disturbance in learning and memorizing caused by cortical devascularization.关键词：Congsheng Capsules;vascular dementia;AchE;ChAT;Behavior
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发布时间：2021-09-15 - 摘要：The blood concentration of ferulic acid （FA） was determined by RP HPLC after the dog was intragastrically given Xiongshao Capsules （XC） which contains FA, and 3P87 Pharmacokinetics Program was used to fit the pharmacokinetic model. The results showed that the concentration time curves of FA after giving a single dose of XC to the dog intragastrically were fit to the one compartment open model, and the pharmacokinetic parameters found in the experiment were ka=0 0749±0 0202 （min -1 ）, ke=0 0159±0 0020 （min -1 ）, t 1/2Ka =9 7346±2 3774 （min）, t 1/2Ke =44 2539±5 5179 （min）, t peak =29 3386±4 1009 （min）, c max =1509 5180±275 8128 （μg/L）.关键词：ferulic acid;pharmacokinetics;Xiongshao Capsules;RP HPLL
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发布时间：2021-09-15 - 摘要：The cortical cells of the new born rat cultured for 8～12 days by the primary culture method were treated by oxygen and glucose deprivation （OGD）, and the effects of Jiunaoning Injection （JI） on the OGD injured cortical cells were observed. The results showed that the MDA level and the LDH activity in the cell supernate were significantly increased, while the SOD activity and cell survival rate were significantly decreased in the OGD group, compared with those in the control group; and the MDA level and the LDH activity were significantly decreased, while the SOD activity and cell survival rate were increased in the JI group, compared with those in the OGD group. The results suggest that the basis of the clinical effects of JI is relieving the lesions caused by lipid peroxidation and increasing the tolerance of nerve cells to OGD.关键词：Jiunaoning Injection;Oxygen and Glucose Deprivation;Nerve Cell;Lactic Dehydrogenase;Lipid Oxidation
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发布时间：2021-09-15 - 摘要：The effects of Shenkang Injection （SI） on the secretion of fibronectin （FN） in LLC PK 1 renal tubular epithelial cells were studied by enzyme linked immunosorbent assay, with a control group treated with the Rubarb Injection （RI） （in which the extract from Rheum offinale alone is its active component）. The results showed that the effects of SI could significantly inhibit the secretion of FN in LLC PK 1 renal tubular epithelial cells in a dose dependent manner, and the effects of SI were better than those of RI. The results of the experiment suggest that the inhibition of the secretion of FN in LLC PK 1 renal tubular epithelial cells is one of the mechanisms of the SI treatment for delaying the development of chronic renal failure.关键词：Shenkang Injection;Renal Tubular Epithelial Cell;LLC PK 1;fibronectin
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发布时间：2021-09-15 - 摘要：The effects of Caoguozhimu Decoction （CD）, a TCM antiepileptic, on NMDA receptor binding capacity and the expression of NMDAR1 mRNA in pentylenetetrazole kindled rat model were observerd by the ligand receptor method and in situ hybridization, with MK 801 as a contrast. The results showed that compared with model group, the level of hippocampal NMDAR1 mRNA was significantly decreased （ P <0 05） in CD group, while there was no obvious change of that in MK 801 group; and the cortical NMDA receptor binding capacity was obviously decreased but without statistical significance in CD group, while there was a significant decrease （ P <0 05） of that in MK 801 group. The results imply that CD decreases the level of NMDA receptor mainly by decreasing the expression of NMDAR1 mRNA.关键词：Caoguozhimu Decoction;Epileptic Model;In Situ Hybridization;Ligand Receptor Method;NMDA Receptor Binding Capaci?
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发布时间：2021-09-15 - 摘要：Presenile mice were used to establish the vascular dementia model characterized by disturbance in learning and memorizing by the method of cerebral ischemia reperfusion and blood pressure reduction through tail bloodletting. The therapeutic effects of Congsheng Capsules （CC） on disturbance in learning and memorizing and cerebral pathological injuries were observed. The results showed that the learning and memorizing abilities could be obviously decreased by performing repeated ischemia reperfusion of bilateral common carotid artery and reducing blood pressure through tail bloodletting; after the treatment of CC in different doses for 45 days, it was found that to a certain degree, every dose of CC could improve the learning and memorizing abilities and reduce the cerebral pathologic injuries.关键词：Congsheng Capsules;Cerebral ischemia reperfusion;Disturbance in Learning and Memorizing;Behavior Test;Brain Pathomorphological Injury
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发布时间：2021-09-15 -
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- 摘要：The Changes of the contents of 15 volatile components of dried ginger, one of the ingredients of Banxiaxiexin Decoction （BD）, when decocted with other different ingredients of BD, were studied by capillary GC MS method. The ingredients other than dried ginger of BD were divided into different groups according to the four natures and five tastes theory, and dried ginger was decocted in combination with the different groups in turn. The results showed that every ingredient combination had an influence on the output of the volatile components of dried ginger by decocting. This experiment was an attempt to study the formulation and the formulating principles of TCM formulas by the chemical method.关键词：Banxiaxiexin Decoction;Dried Ginger;Volatile Component;GC `
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发布时间：2021-09-15 - 摘要：Rat fatty liver model was established by feeding high fat food and intragastrically giving a Chinese spirit, and the effects of the tianjiu therapy were observed in the model. The parameters observed in this study included the body weight, liver weight, the ratio of liver weight and body weight, liver lipid, blood lipid, transaminase, alkaline phosphatase, lactic dehydrogenase, gamma glutamyltransferase, and the liver pathologic changes. The results showed that the tianjiu therapy could regulate the fat metabolism of the liver and the whole body, reduce the fat deposit in the liver, inhibit fatty degeneration of liver cells, and help liver cells to restore their normal functions. The results also showed that the recovery speed of the rat with fatty liver treated by the tianjiu therapy was higher than that of the rat with the same disease not treated by the therapy.关键词：rat;fatty liver;Tianjiu Therapy;Ganshu;Pi?
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发布时间：2021-09-15 -
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- 摘要：The cause of postoperative fever, especially postoperative damp-heat, in the cases of craniotomy was studied by investigating the TCM symptoms in the peri operative period. The questionnaire was used to record the general materials and the symptoms appeared 3 days before the operation and 1～7 days after the operation of the patients. The frequencies of the symptoms before and after the operation in different seasons were compared. The results showed that before the operation, the symptoms located at the first 10 places by their frequencies were similar in spring and summer, while they were different in autumn and winter; and after the operation, the symptoms were reduced and their frequencies became less different, and there were differences between the frequencies of the main symptoms appeared in the period of spring and summer and those in the period of autumn and winter. Before the operation, the main symptoms were headache, abnormal vision, dizziness and fullness of head, vomiting and nausea. According to TCM theories, these symptoms were produced by the depression of yang qi, and the stagnation of qi and body fluid. During the operation, there was the heat produced by depression of yang and the dampness produced by the stagnation of body fluid. After the operation, there was the damp-heat syndrome with fever, dry mouth, greasy mouth, abdominal distension, constipation, headache and anorexia as its main symptoms.关键词：Craniotomy;Peri Operative Period;TCM symptoms;Fever;Damp H
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发布时间：2021-09-15 - 摘要：The study on quantitative TCM differential diagnosis of cerebral arteriosclerosis （CAS） was made on the basis of the physical examination data of 630 retired veteran cadres once worked for the departments directly under Fujian provincial government. Based on the background data, a discriminatory function formula for quantitative TCM differential diagnosis was established by using the multivariate stepwise analysis model. The diagnostic efficiency of the formula in diagnosing the syndrome of hyperactivity of yang due to deficiency of yin and the syndrome of stagnation of blood due to deficiency of qi was evaluated by the DME method according to 15 parameters reflecting diagnostic capacity and overall applicable value of the formula. The results showed that the discriminatory function formula for quantitative TCM differential diagnosis of CAS possessed rather high diagnostic efficiency and was worthy of clinical use.关键词：Cerebral Arteriosclerosis;TCM Differential Diagnosis;Quantitative Diagnosi$
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发布时间：2021-09-15 - 摘要：The changes of CD11b, CD54 and T cell subset were observed in the patients with acute cerebral infarction treated with Xingnaojing Injection （XI）. 2 Milliliters of blood drawn from the patients and treated with anticoagulant before and after the XI treatment, was used to determine the changes of cell adhesion molecules CD11b and CD54, and CD4 and CD8 in the T cell subset by RACS method. The results showed that before the XI treatment, the expressions of CD11b and CD54 were obviously increased, those of CD4 and CD8 were decreased, and the ratio of CD4 +/CD8 + was lowered; after the XI treatment for 2 weeks, the expressions of CD11b and CD54 were obviously decreased, those of CD4 and CD8 were restored to a certain degree, and the ratio of CD4 +/CD8 + was relatively increased. The results suggest that the effects of XI for relieving cerebral lesions may be related with its decreasing the expressions of CD11b and CD54, increasing the ratio of CD4 +/CD8 +, and restoring the immune function.
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发布时间：2021-09-15 -
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