最新刊期
卷 0 ， 期 0 ， 2020
-
-
- 摘要：It was found by the authors through a systematical analysis of the past cases that there were 3 stages in the development of vascular dementia, namely the plateau, undulation and staircase descent, which showed different characteristic symptoms and developing tendencies. For diagnosing and treating vascular dementia, the authors raised the viewpoint of adopting TCM differentiation of clinical stages and using different treatments at different stages. According to the authors, when vascular dementia reaches a plateau, TCM therapies for regulating the whole function of the body should be fully used to delay its development; when it reaches the stages of undulation and staircase descent, TCM emergency treatment or combined therapies of TCM and modern medicine should be adopted in order to effectively control and prevent the staircase descent of the disease. The authors hold that vascular dementia is a multifactor disease involving biological, sociological and psychological fields; and it is important for improving the living quality and stabilizing the state of illness of the patients to control the various relative risk factors and to adopt the combined treatments involving various rehabilitating measures.关键词：vascular dementia;TCM Differentiation of Clinical Stages;Combined Treatment
- 8
- |
- 924
- |
- 5
发布时间：2021-09-15 -
-
-
-
- 摘要：The rat dementia model was established by devascularizing the left cortex of the adult Wistar rat. It was found that in the model rats, the number of BDNF positive neurons obviously decreased in the cortex and hippocampus; some of the BDNF positive neurons shrank, and the color of the their cytoplasm faded; some of the BDNF positive neurons became vacuolized, and the color of their cytoplasm became pale; and these changes were most clearly seen in the cingulate cortex and the hippocampal CA 1 area. It was seen that in the experiment, Congsheng Capsules could obviously increase the expressions of BDNF and trkB in the cortex, hippocampus and MBN in the model rats.关键词：Congsheng Capsules;BDNF;trkB
- 11
- |
- 68
- |
- 6
发布时间：2021-09-15 - 摘要：The rabbits acquired hypercholesterolemia and atherosclerotic plaques after being fed with cholesterol forage for 8 weeks, and then, some of the rabbits were fed with the forage mixed with Jiangzhitongmai Recipe （JR） from the 8th week for 16 weeks. The level of blood lipid was detected at different times and the changes in the arterial walls were observed with the optical microscope and the electron microscope in the rabbits. The results showed that JR could significantly inhibit the increase of the levels of serum total cholesterol, low density lipoprotein cholesterol and triglyceride, which suggests that JR can relieve experimental hyperlipemia and inhibit the formation of atherosclerotic plaques.关键词：Jiangzhitongmai Recipe;hyperlipemia;atherosclerosis;Experimental Study
- 9
- |
- 151
- |
- 3
发布时间：2021-09-15 - 摘要：Rat vascular dementia model was established by the repeated cerebral ischemia reperfusion method, and the model rats were treated with Huadaixingshen Decoction （HD） with the administration of hydergine as contrast. The results of the observation with the optical microscope and the electron microscope showed that in the rats of the model group, a large number of neurons in the hippocampal CA1 area exhibited degeneration, necrosis and deletion, mitochondrial tumefaction, vacuolar degeneration and synaptic degeneration; and the tissue staining and quantitative analysis found that the number of AchE positive fibers in the hippocampal CA1 area and the frontal cortex obviously decreased. It was shown that HD could obviously reduce the neuronal injury in the hippocampal CA1 area, and increase the number of AchE positive fibers in the hippocampal CA1 area and the frontal cortex, and its effects were better than those of hydergine.关键词：vascular dementia;Huadaixingshen Decoction;Cholinergic Fiber;Experimental Study
- 9
- |
- 142
- |
- 2
发布时间：2021-09-15 - 摘要：The mechanisms of the protective effects of Yiyuanhuoxue Pellets （YHP）, rhubarb and Xueshuanxinmaining （XXN） against myocardial injury caused by cerebral ischemia reperfusion in aged rats were studied. The aged rats were divided into the control group, model group, nimodipine group, large dose YHP group, small dose YHP group, rhubarb group and XXN group; and the changes in the levels of lactate dehydrogenase （LDH）, creatine phosphokinase （CPK）, noradrenalin （NE）, dopamine （DA）, epinephrine （E）, endotheliolysin （ET）, calcitonin gene related peptide （CGRP） and neuropeptide Y （NPY） were detected. The results showed that in the rats in the model group, levels of serum CPK and LDH, plasmatic ET and cerebral NPY were increased, and the excitability of sympathetic adrenal system was reinforced; compared with the model group, the levels of serum LDH and CPK were decreased in the rhubarb group, the level of plasmatic ET was decreased in the large dose YHP group, XXN group and the rhubarb group; the level of cerebral NPY was decreased in the rhubarb group and large dose YHP group; the level of plasmatic CGRP was increased in the small dose YHP group; and the excitability of sympathetic adrenal system was decreased in all the groups treated with the above mentioned drugs. The results suggest that the protective effects of rhubarb, XXN and YHP against myocardial injury may relate with their inhibiting the excitability of sympathetic adrenal system and regulating the imbalance between CGRP and ET.关键词：brain;Ischemia;myocardium;Monoamine Nervous Transmitter;Neuropeptide;Yiyuanhuoxue Pellets;Rhubarb;Xueshuanxinmaining;rat
- 8
- |
- 101
- |
- 5
发布时间：2021-09-15 - 摘要：In order to guide the clinical application of Banxiaxiexin Decoction （BD）, the effects of the whole ingredients and different ingredient goups of BD on the chronic gastric ulcer were studied by observing certain criteria such as the proliferating cell nuclear antigen （PCNA）, in the rats with chronic gastric ulcer. The results showed that both BD whole ingredients and BD different ingredient groups had certain effects of regulating the proliferation of gastric mucosal cells; the effects of the ingredients in some combination of the ingredient groups exhibited a coordinative tendency, and the effects of the ingredients in some other combination of the ingredient groups exhibited an antagonistic tendency; and the BD whole ingredients exhibited better effects than the ingredients in each separate group. The experimental results verified the rationality and showed the scientific features, of BD formulation by Dr. Zhang Zhongjing.关键词：Banxiaxiexin Decoction;TCM Formula Formulation;Peptic Ulcer;proliferating cell nuclear antigen
- 11
- |
- 424
- |
- 2
发布时间：2021-09-15 - 摘要：The effects of ligustrazine on the angiotensin Ⅱ induced myocardial hypertrophy were observed by using the technique of in vitro cell culture. The results showed that ligustrazine could inhibit the angiotensin Ⅱ induced increase of the content and molecular diameter of the total protein in the cultured myocardial cells and the angiotensin Ⅱ induced proliferation of the cardiac fibroblasts. The effects of ligustrazine found in this study was similar to those of losartan, which implies that ligustrazine has the effects of inhibiting myocardial hypertrophy.关键词：Ligustrazine;Angiotensin Ⅱ;Myocardial Hypertrophy
- 14
- |
- 229
- |
- 10
发布时间：2021-09-15 - 摘要：An observation was made on the effects of Xiaochaihu Decoction, Dahuangzhechong Pills and Biejiajian Pills on serum procollagen Ⅲ （Pc Ⅲ）, Hyaluronic Acid （HA） and laminin （LN） in different stages of rat hepatic fibrosis. The levels of Pc Ⅲ, HA and LN were determined in rat CCl4 hepatic fibrosis model by radioimmunoassay. The results showed that Xiaochaihu Decoction could obviously decrease the levels of serum LN and HA in the prevention of hepatic fibrosis, and could lower the level of HA in the treatment of minor hepatic fibrosis, which suggested that in the treatment of hepatic fibrosis, Xiaochaihu Decoction should be given in an early stage; Dahuangzhechong Pills could decrease the levels of serum HA, LN and Pc Ⅲ in the rats with hepatic fibrosis in every stages, which suggested that Dahuangzhechong Pills had therapeutic effects on hepatic fibrosis; although both preventive dose and therapeutic dose of Biejiajian Pills could decrease the level of serum HA, only the therapeutic dose could decrease the levels of serum LN and Pc Ⅲ, but at the same time it brought unfavorable effects on the rats, which suggested that Biejiajian Pills had no good preventive effects on hepatic fibrosis, and the measures for keeping and maintaining the vitality of the body should be adopted when to use Biejiajian Pills clinically, because they could damage the vitality of the body despite their therapeutic effects.关键词：Zhang Zhongjings Three Formulas;hepatic fibrosis;rat;serum;Hyaluronic Acid;Laminin;Procollagen Ⅲ
- 10
- |
- 159
- |
- 4
发布时间：2021-09-15 - 摘要：The experiment was to study the effects of the total glycoside from the extract of the fruit of Cornus Officinalis （TGEFCO）, TGEFCO polyphenol part Ⅰ and polyphenol part Ⅱ on the splenic lymphocytic proliferation, and to find the immunosuppressive constituents in TGEFCO and the mechanism of TGEFCO in treating rheumatoid arthritis. The JH3,D,Z TdR incorporation method was used in detecting the effects of all the TGEFCO extracts in this study. The results showed that all the TGEFCO extracts had inhibiting effects on rat splenic lymphocytic proliferation and among them, TGEFCO polyphenol part II had the strongest effects; and the effects of TGEFCO against rheumatoid arthritis may relate to its inhibiting T lymphocytic proliferation caused by the specific antigenic stimulation.关键词：Total Glycoside in the Fruit of Cornus Officinalis;Lymphocytic Proliferation;immunosuppression
- 9
- |
- 306
- |
- 5
发布时间：2021-09-15 -
- 摘要：In order to investigate the mechanism of the effects of Huoxuehuayu Recipe （HR） on the occurrence and development of hepatic fibrosis, the effects of rat HR serum on the proliferation of hepatic stellate cells were detected by the MTT method, and the effects of rat HR serum on α SMA expression of hepatic stellate cells were detected by immunocytochemical assay. The results showed that the OD and α SMA positive staining absorbance detected in the rat HR serum group were 58 8% and 51 2% of those values detected in the control group respectively （ P <0 01）. The results suggest that the effects of rat HR serum are similar to those of γ IFN, which inhibit the activation of hepatic stellate cells cultured in vitro by inhibiting the proliferation of hepatic stellate cells and α SMA expression.关键词：Traditional Chinese Drug;hepatic fibrosis;Hepatic Stellate Cell;proliferation;α Smooth Muscle Actin
- 8
- |
- 79
- |
- 7
发布时间：2021-09-15 -
- 摘要：The rat model of chronic renal failure was created by the method of cutting off 5/6 of the kidney, and the model rats were randomly divided into 5 groups, namely Zishenhuoxuejiedu Recipe （ZR）, lotensin, Baoshenkang, pathological control and normal control, in which the serum levels of Il 8, TNFα and SOD were respectively determined by radioimmunoassay. The results showed that the serum Il 8 and TNFα levels in the former 4 groups were higher than those in the normal control group, and the serum SOD level in the former 4 groups was lower than that in the normal control group; the serum Cr and BUN levels in the ZR and lotensin groups were lower than those in the Baoshenkang and pathological control groups; the serum Il 8 and TNFα levels in the ZR group were obviously lower than those in the lotensin, Baoshenkang and pathological groups, while the SOD level in the ZR group was obviously higher than that in these 3 groups. The results suggest that ZR has marked effects of improving renal function.关键词：chronic renal failure;Interleukin 8;Tumor Necrosis Factor Alpha;superoxide dismutase
- 11
- |
- 107
- |
- 2
发布时间：2021-09-15 -
- 摘要：The study was to observe the effects of garlicin on different TCM types of unstable angina pectoris （UAP）. 55 Cases of UAP were randomly divided into the garlicin group （consisting of 34 patients） and the nitroglycerin group （consisting of 21 patients）, and the changes in symptoms, ECG and blood rheology in patients of both groups were observed before the treatment and 10 days after the treatment. The results showed that there was no significant difference between the effective rates of symptomatic and ECG improvements in both groups; the effective rate of the cold type of UAP of the garlicin group was 100% while that of the nitroglycerin group was 75%. The results also showed that the effective rate of garlicin in treating the febrile type of UAP was 54% （ P <0.001）; garlicin had markedly effects of improving the state of blood rheology in cases of the cold type of UAP （ P <0.05） while it had adverse effects on the state of blood rheology in cases of the febrile type of the disease. From the results it could be seen that the effects of garlicin on the cold type of UAP was better than that of nitroglycerin on the same type of UAP; garlicin had better effects on the cold type of UAP than on the febrile type of the disease, and could also markedly improve the state of blood rheology in patients with the cold type of UAP.
- 8
- |
- 147
- |
- 1
发布时间：2021-09-15 - 摘要：The study was to observe the effects of Bushen Compound Instant Granules （BCIG） on the bone marrow hematopoietic progenitor cells （BMHPC） in the patients with aplastic anemia of the kidney yang deficiency type. 30 Cases were treated with BCIG, 15 cases with Compound Zaofan Pills （CZP）, and 15 cases with stanozolol; the changes in the levels of BMHPC in the 3 groups were observed before and after the treatment by the methyl cellulose culture method, with a control group consisting of 15 healthy human subjects. The results showed that the clinical effective rate of the BCIG group was 80%, obviously higher than those of the CZP group （40%） and stanozolol group （46.67%）; the recovery of the levels of bone marrow BFU E and CFU GM in the effective cases in the BCIG group was more obvious than that in the effective cases in the CZP group and stanozolol group; and there were no obvious changes in the levels of bone marrow BFU E and CFU GM in the ineffective cases in all the 3 groups. It could be seen from the results that the effective rate of BCIG in treating aplastic anemia of the kidney yang deficiency type was higher than those of CZP and stanozolol, and the hematological recovery of the patients responding to BCIG was more complete.
- 8
- |
- 127
- |
- 1
发布时间：2021-09-15 -
-
-
-
-
-
- 摘要：In order to study the mechanism of acupuncture and drugs against early pregnancy, the rat early pregnancy model and an indirect intrauterine pressure recording method were used, with the frequency and intensity of the uterine contraction as experimental criteria for evaluating the changes in uterine contraction. By doing so, the changes in the intrauterine pressure and uterine contraction could be scientifically, simply, sensitively and objectively recorded. The results showed that the intensity of uterine contraction was reinforced by mifepristone and misoprostol used in combination; and the random uterine contraction was effectively inhibited and the effective uterine contraction was strengthened by acupuncture. The results can help the clinical practice of treating early pregnancy.关键词：acupuncture;Mifepristone;Misoprostol;Intensity of Uterine Contraction
- 8
- |
- 111
- |
- 6
发布时间：2021-09-15 - 摘要：The mechanisms of the treatment of depression by electroacupuncture was investigated on the neuroendocrinal basis. The effects of puncturing the acupoints of baihui and sanyinjiao by electric needles on the levels of plasmatic cortisol and adrenocorticotropic hormone （ACTH） were observed by radioimmunoassay in the rats with chronic stress induced depression （CSD）. The quantitative comparison of arginine vasopressin positive neurons （AVN） of paraventricular nucleus of the hypothalamus was made in each group of rats by immunohistochemical method and computer image pattern analysis. The results showed that the plasmatic cortisol and ACTH levels and the number of AVN of paraventricular nucleus of hypothalamus were obviously higher in the CSD model group than those in the normal control group, and obviously lower in the electroacupuncture treating group than those in the CSD model group, which were near to the normal. The results suggest that the regulating effects on the hyperactivity of the function of HPA axis were one of the mechanisms of the treatment of depression by electroacupuncture.
- 13
- |
- 583
- |
- 14
发布时间：2021-09-15 -
-
- Postal code：100029
- Tel：(010)53911857 Email：jbutcm@bucm.edu.cn
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
0