最新刊期
      卷 ， 期 4 ， 2001
      • Gao Yanbin,Tang Daiyi
        Issue 4, Pages: 16-19(2001)
        摘要：In order to study the regulative effects of Zhixiaotongmaining on the mRNA expression of renal AGE receptor in diabetic rats, streptozotocin was used to induce rat diabetic model and RT PCR method was used to detect the level of renal mRNA expression of AGE receptor in the diabetic rats treated with Zhixiaotongmaining for 12 weeks. The results showed that the content of renocortical AGEs and the level of the mRNA expression of renocortical AGE receptor in the diabetic rats were higher than those in the normal rats （ P <0.01）; and Zhixiaotongmaining could decrease the content of renocortical AGEs and the overdue mRNA expression of renocortical AGE receptor in the diabetic rats （ P <0.01）. The results suggest that Zhixiaotongmaining can regulate the abnormal mRNA expression of renal AGE receptor in the diabetic rats.  
        关键词：Zhixiaotongmaining;AGEs;AGE Receptor;RAGE;rat   
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        发布时间：2021-08-03
      • Wang Yunhong,Ma Guibao,Wang Yanping,et al.
        Issue 4, Pages: 20-22(2001)
        摘要：The mechanism of the protective effects of Fusheng Powder against the lesions due to cerebral ischemia and reperfusion was studied in rats by radioimmunoassay and the in situ hybridization technique. It was found that the overdue expressions of cNOS mRNA and ET mRNA could increase the levels of NOS and ET, and Fusheng Powder could decrease the levels of NOS and ET and exert protective effects against the lesions due to cerebral ischemia and reperfusion.  
        关键词：Cerebral Ischemia;Fusheng Powder;nitric oxide;endothelin;rat   
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        发布时间：2021-08-03
      • Liu Bin,Shi Renbing,Wang Wei
        Issue 4, Pages: 23-25(2001)
        摘要：The method for the quantitative determination of total flavone in Pollen Typhae （TFPT） was developed on the basis of the comparison of ultraviolet visible absorption spectra of rutin, typhaneoside and TFPT before and after their coloration by the test solution of aluminium nitrate sodium nitrite sodium hydroxide and the reagent of aluminium trichloride. The sample was treated through a polyamide column for separation and purification, and was colorated with aluminium trichloride, and then, the content of TFPT in the sample was determined at the wavelength of 405 nm in an ultraviolet visible spectrophotometer with typhaneoside as a control. This method for the determination of TFPT was more rational than that in which the control was rutin, and the color reagent was aluminium nitrate sodium nitrite sodium hydroxide or aluminium trichloride.  
        关键词：Total Flavone in Pollen Typhae;typhaneoside;Ultraviolet visible Spectrophotometry   
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        发布时间：2021-08-03
      • Li Yan,Fan Lu,Sun Xiuhua
        Issue 4, Pages: 26-27(2001)
        摘要：In order to optimize the technology of extracting the isoflavone constituents from pueraria root, the experiment used the orthogonal experimental design （4 factors and 3 levels） with the content of puerarin as an experimental criterion in screen the factors affecting the technology of extracting the isoflavone constituents from pueraria root. The results showed that all the 4 factors designed in the orthogonal experiment signifantly affected the extracting technology. In consideration of the industrial practice, the best condition of extracting the isoflavone constituents from pueraria root was decided: reflux extraction with 80% alcohol for 3 times, i.e. extracting with 8 fold alcohol for 2 hours for the first time, with 6 fold alcohol for 2 hours for the second time, and with 4 fold alcohol for 1 hour for the third time.  
        关键词：Orthogonal Experiment;Pueraria Root;Puerarin   
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        发布时间：2021-08-03
      • Zhang Danhui,Jiang Yufeng,Huang Qifu,et al.
        Issue 4, Pages: 28-30(2001)
        摘要：The effects of Jierexingshen Injection （JI） on the body temperature and the levels of cAMP and IL 1 β were observed in the hypothalamus of the rabbits with endogenous pyrogen （EP） induced fever. The results showed that there was no obvious difference between the body temperature curve and the levels of ΔT and TRI3 in the animals in the JI group and those in the animals in the normal saline group （ P >0.05）, which implies that JI has no great influence on normal body temperature. The results also showed that the levels ofΔT and TRI3 and the levels of cAMP and IL 1 β in the hypothalamus of the animals in the JI plus EP group were significantly lower than those in the EP group （ P <0.01）, with a positive correlation between the changes in the body temperature and the changes in the levels of cAMP and IL 1 β, which implies that JI not only can inhibit the increase of the body temperature induced by EP, but also can inhibit the increase of the levels of cAMP and IL 1 β in the hypothalamus caused by EP.  
        关键词：Jierexingshen Injection;Fever;Endogenous Pyrogen;Interleukin 1;Cyclic Adenosine Monophosphate;hypothalamus   
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        发布时间：2021-08-03
      • Sun Liping,Sun Chenglin,Okada Takamitci,et al.
        Issue 4, Pages: 31-34(2001)
        摘要：The effects of Medicinal Herbal Liquor （MHL） the blood coagulation and fibrinolysis were observed in mice and rats by the in vivo platelet aggregation test, the tissue plasminogen activator （t PA） and plasminogen activator inhibitor 1 （PAI 1） detection and the thrombosis test. The results showed that MHL could relieve the in vivo platelet aggregation and the disturbance of automatic activities in the mice; increase the level of t PA and decrease the level of PAI 1 in the rats with hypercholesterolemia, and make the ratio of t PA/PAI 1 restored nearly to normal; and delay the in vivo thrombosis in the rats. The results suggest that MHL has the effects of relieving blood coagulation and increasing fibrinolytic activity, and they comply with TCM theory of activating blood circulation and resolving stagnation.  
          
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        发布时间：2021-08-03
      • Wang Wenping,Jiang Liangduo,Wang Chuijie,et al.
        Issue 4, Pages: 34-36(2001)
        摘要：In order to study the inductive effects of Changantai Capsules on T and NK cells of the immune system of the Intestinal Mucosa, the mouse model of pulmonary cancerometastasis of colorectal cancer was established, and ABC immune staining method was used in the correlation analysis of the immune factors of the small and large intestines. The results showed that compared with those in the normal group, T and NK cells manifested an increasing tendency in the small and large intestines in the cancer carried control group; and compared with those in the cancer carried control group, T and NK cells significantly increased in the small intestine （ P < 0.01） in the treated cancer carried group. The results imply that the mechanism of the preventive effects of Changantai Capsules on pulmonary cancerometastasis of colorectal cancer may relate to their inducing T and NK cells of the immune system of the Intestinal Mucosa.  
          
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        发布时间：2021-08-03
      • Li Min,Wang Shuoren,Zhao Mingjing,et al.
        Issue 4, Pages: 37-39(2001)
        摘要：The rat model of heart failure due to cardiac infarction was established by the method of the ligature of the coronary artery. Huoxue Injection （HI）, Yiqi Injection （YI） and Qixue Injection were then administered to the model rats, 4 and 8 weeks for the early stage administration, and 4 weeks for the late stage administration. After the administration, the cardiac function of the model rats was observed by the impedance method, with that of the rats in the captopril treated group as a control. The results showed that the early stage administration of HI to the model rats exhibited better effects than the early stage administration of other 2 injections; and after the early stage administration for 4 weeks, there was no difference between the effects observed in the HI treated group and those in the sham operation group, and after the early stage administration for 8 weeks, there was a significant difference between the effects observed in the HI treated group and those in other groups （ P <0.01 or P <0.05）. The results also showed that the late stage administration of YI to the model rats exhibited better effects than the late stage administration of the other 2 injections, but there was no difference between the effects observed in the YI treated group and those in other groups. The results suggest that HI administration to heart failure at early stage exerts better effects against heart failure and its exacerbation.  
          
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        发布时间：2021-08-03
      • Huang Yufang,Bian Huimin,Liu Tao,et al.
        Issue 4, Pages: 40-41(2001)
        摘要：Mouse model of acquired dysmnesia induced by scopolamine was used to study the mechanism of the effects of reinforcing memory and benefiting mentality of Kaixin Powder, with the contents of cerebral nitric oxide （NO）, nitric oxide synthase （NOS） and cholinesterase （ChE） as experimental criteria. The results showed that the cerebral NO and NOS contents and the ChE activity were higher in the mice in the model group than those in the mice in the control group; and the cerebral NO and NOS contents and the ChE activity were significantly decreased in the mice in the model group after being treated with Kaixin Powder. The results suggest that Kaixin Powder may adjust the activity of cholinergic nervous system, protect nervous cells and reinforce memory through decreasing the NOS activity and inhibiting the formation of NO.  
          
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        发布时间：2021-08-03
      • Ren Xiujun,Tu Ya,Guo Yi,et al.
        Issue 4, Pages: 51-53(2001)
        摘要：The effects of the Bloodletting of the 12 hand Jing points on the level of nitric oxide （NO） in the brain were studied in the rat model of cerebral ischemia induced by coagulating the left middle cerebral artery. The model rats were divided into the bloodletting （BL） group and the non bloodletting （NBL） group. The results showed that the cerebral NO 2- （the metabolic product of NO） level increased in the rats in both BL group and NBL group after being induced into cerebral ischemia for 10 minutes; the cerebral NO 2- level continuously increased in the rats in the NBL group after being induced into cerebral ischemia for 30 minutes, and there was a significant difference between the cerebral NO 2- level in the rats in the NBL group and that in the rats in the NBL auto control group （ P <0 05）; and the cerebral NO 2- level decreased in the rats in the BL group after being induced into cerebral ischemia for 30 minutes, and there was a significant difference between the cerebral NO 2- level in the rats in the BL group and that in the rats in the BL auto control group （ P <0 05）. The results suggest that the bloodletting of the 12 hand Jing points has the effects of decreasing the increased cerebral NO 2- level due to cerebral ischemia, and hence may relieve NO neurotoxicity and protect cerebral nerve cells.  
        关键词：Acupuncture;Jing points;cerebral ischemia;nitric oxide;rat   
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        发布时间：2021-08-03
      • Fan Yongping,Li Yan,Hu Yiming,et al.
        Issue 4, Pages: 59-62(2001)
        摘要：Patients with craniotomy were involved in the study on the causes of postoperative fever （PF）, especially PF of damp heat type. The factors of the drug administration, volume of fluid infusion, seasons, age, sex, primary disease, and the body temperature were taken into consideration in the study. The results showed that the morbidity of PF was above 50% in all the four seasons and there was no significant difference between any of two seasons （ P >0 05）; the morbidity of PF was higher in the patients below the age of 20 （ P <0 05）; there was no significant difference between the morbidity of PF in the male patients and that in the female ones （ P >0 05）; the morbidity of PF was higher in the patients with glioma than that in the patients with meningioma （ P <0 05）; the cases of PF of damp heat type accounted for 75% of all the cases of PF, among which, the morbidity was a little lower in autumn and winter than that in spring and summer, but without significant difference （ P >0 05）; the volume of fluid infusion received by the patients with PF of damp heat type was larger than that received by the patients with PF （ P <0 20）; and the body temperature of the patients with PF of damp heat type was significantly higher than that of the patients with PF （ P <0 05）.  
        关键词：Craniotomy;Postoperative Fever;Etiology;Internal Breeding of Damp heat   
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        发布时间：2021-08-03
      • Lu Yan,Chen Fang,Yang Yan
        Issue 4, Pages: 63-65(2001)
        摘要：The effects of Xiaodianyishen Decoction （XD） for the treatment of the patients with Henoch Schnlein purpura nephritis were observed. The disease was divided into two types according to the theory of traditional Chinese medicine （TCM）, namely the internal breeding of toxic heat, and the deficiency of the spleen and kidney. 67 Patients were included in the treating group and 30 patients, in the control group. The treating group was given XD No.1 or XD No.2 according to the TCM type of the disease. The results showed that the total effective rate of the treating group was 86.6% and that of the control group was 63.3%, with a significant difference （ P <0.01）. The laboratory tests found that the patients were with disorder of immunologic function, manifesting abnormality in immune globulin, T cell subpopulation and in circulating immune complex; and the results of the clinical observation suggest that XD can improve the immunologic function in the patients.  
        关键词：Henoch Schnlein Purpura Nephritis;TCM Differentiating Diagnosis;Clearing away Heat and Toxin;Nourishing the Spleen and Kidney   
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        发布时间：2021-08-03
      • Weng Chaoming
        Issue 4, Pages: 66-68(2001)
        摘要：Cases of cerebral infarction complicated by hyperlipemia and hyperviscosity of the blood were randomly grouped in order to carry out a controlled study of the effects of the therapy for activating blood circulation and resolving blood stagnation on blood rheology and blood lipid level. The treating group was treated with Xuefuzhuyu Capsules and simvastatin, and the control group, with simvastatin alone, for 3 weeks. The results showed that there was a significant difference between the effects of lowering blood-lipid level and blood viscosity of the combination of Xuefuzhuyu Capsules and simvastatin and those of simvastatin alone. The results suggest that the application of the principle of activating blood circulation and resolving blood stagnation in the development of medicines for treating hyperlipemia and lowering blood lipid level, may greatly increase the clinical effects of the medicines in development.  
        关键词：Activating Blood Circulation and Resolving Blood Stagnation;Xuefuzhuyu Capsules;cerebral infarction;Blood Viscosity;Blood lipid   
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        发布时间：2021-08-03
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