最新刊期
卷 0 ， 期 0 ， 2020
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- 摘要：The influence of multiple cerebral infarction on learning and memory, and the protective and curative effects of the TCM formula 9601 on learning disorder and dysmnesia, were studied in the rat model of learning disorder and dysmnesia resulted from multiple cerebral infarction by stepthrough test, stepdown avoidance test and water maze task performance. The results showed that multiple cerebral infarction caused by microemboli could markedly change the behavior of the model rats and cause learning disorder and dysmnesia in them, and the TCM formula 9601 could improve and increase the learning ability and memory of the model rats. The results also showed that the administration of the TCM formula 9601 to the rats before the inducing of multiple cerebral infarction, could remarkably increase the retention of memory, which provides experimental data for the application of the TCM formula 9601 in the prevention and treatment of vascular dementia.关键词：Multiple Cerebral Infarction;Model of Learning Disorder and Dysmnesia;TCM Formula 9601;rat
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发布时间：2021-09-15 - 摘要：The effects of gastrodine on the expression of glial fibrillary acidic protein （GFAP）, the transuding amount of lactic dehydrogenase （LDH）, and the activity of nitric oxide synthase （NOS） in cultured astrocytes of young rats with lesions caused by simulated cerebral ischemia and reperfusion, were determined in this experiment. The results showed that in both the large dose gastrodine group and small dose gastrodine group, GFAP fibroid changes were reduced with less astrocytes being in an intense positve reaction, LDH transuding amount was lessened and NOS activity was decreased. The results suggest that gastrodine has very good protective effects against lesions caused by simulated cerebral ischemia and reperfusion in cultured astrocytes, and its inhibiting the increased activity of NOS may be one of its mechanisms of effect.关键词：Gastrodine;cell culture;astrocyte;Glial Fibrillary Acidic Protein;Lactic Dehydrogenase;Nitric Oxide Synthase
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发布时间：2021-09-15 - 摘要：The anticancer effects of genistein was studied on the NF-κB level in this experiment. MTT method was used to determine the anticancer effects of genistein, and immunohistochemical method, Western Blot method and electrophoretic migration rate analysis were used to determine the expression of p65 and IκBα in human hepatic cancer cell strain Bel 7402 before and after the genistein administration. The results showed that genistein could markedly inhibit the growth of cancer: and after its administration, p65 expression decreased and IκBα expression increased in human hepatic cancer cell strain Bel 7402. The results implies that the anticancer mechanism of genistein is related with its inhibiting of NF-κB function resulting from its halting IκBα degradation.关键词：genistein;NF-κB;Neoplasm;IκBα
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发布时间：2021-09-15 - 摘要：The effects of Qingkailing Injection on body temperature, on the level of cAMP in hypothalamus and cerebrospinal fluid and on the level of arginine vasopressin in ventral septal area, were observed in endotoxin fevered rabbits, in order to study the antipyretic mechanisms of Qingkailing Injection. The results showed that the levels of ΔT and TRI 1, the level of cAMP in hypothalamus and cerebrospinal fluid, and the level of arginine vasopressin in ventral septal area in endotoxin given rabbits, were higher than those in the rabbits given normal saline or given Qingkailing Injection plus endotoxin, with a positive correlation between body temperature and the level of cAMP in hypothalamus and cerebrospinal fluid. The results also showed that there was a positive correlation between body temperature and the level of arginine vasopressin in ventral septal area in all animals in the experiment, which implies that lowering the level of cAMP in hypothalamus and cerebrospinal fluid and at the same time promoting the release of arginine vasopressin in ventral septal area, may be an important antipyretic mechanism of Qingkailing Injection.
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发布时间：2021-09-15 - 摘要：The effects of TCM drugs on rat postoperative intestinal adhesion were observed in this experimental study. Wistar male rats were used to induce intestinal adhesion by ligating mesenteric blood vessels. The rats with postoperative intestinal adhesion were then divided into the model control group, and several dfferent treating groups to which TCM drugs for purging the bowls （PB）, activating blood circulation （ABC） and PB plus ABC were given respectively. After 96 hours, laparotomy was performed on all the animals in the experiment for the observation of pathological changes, including intestinal adhesion, intestinal distension and edema, angiectasis and hemorrhage in each enteric layer, and inflammation of mesentery and serous coat. The results showed that compared with the model control group, there was a significant relief of intestinal adhesion, intestinal distension and edema, angiectasis and hemorrhage in each enteric layer, and inflammation of mesentery and serous coat in the animals in the PB plus ABC group （ P <0.01）. Therefore, it can be concluded that the PB plus ABC formula has curative effects on intestinal adhesion and intestinal injuries caused by intestinal ischemia.
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发布时间：2021-09-15 - 摘要：Gastric mucosal atrophy caused by bile reflux was observed and its pathogenesis was analysed in the model of chronic atrophic gastitis induced by bile reflux. The model was established by performing Gastrojejunostomy and duodenum transsection on rats. The results showed that compared with the control group, there appeared gastric mucosal atrophic changes after 14 and 20 weeks with elevated histopathologic accumulative scores （ P <0.01）, an increase in gastric juice pH value and in the levels of total bile acid and serum gastrin （ P <0.01）, and a decrease in the level of gastric mucosal PGE 2 （ P <0.01, P <0.05） in the animals in the model group. The results imply that long term bile refux may cause gastric mucosal atrophic changes, and the gastric mucosal atrophic changes at its early stage may be related with the impairment of gastric mucosal defensive mechanism due to the decrease in the level of PGE 2 and the disorder of gastrointestinal endocrine hormones caused by bile reflux.关键词：Bile Reflux;chronic atrophic gastritis;Gastrojejunostomy;Histopathologic Accumulative scores;gastrin;PGE 2
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发布时间：2021-09-15 - 摘要：MTT method and the soft agarose colony forming test were used in this study to observe the effects of the total saponin of Panax notoginseng （TSPN） on the proliferation of the immortalized human gastric mucosal epithelial cell line （IHGMECL） GES 1 and MNNG transformed IHGMECL GES 1, in comparison with the effects of retinoic acid. The results showed that TSPN could obviously inhibit the proliferation of both IHGMECL GES 1 and MNNG transformed IHGMECL GES 1 with a tendency towards a dose effect relationship, and exhibit a marked inhibitory effect on the soft agarose colony forming ability of the MNNG transformed IHGMECL GES 1. The results also showed that althouth retinoic acid exhibited similar effects on both the IHGMECL GES 1 and MNNG transformed IHGMECL GES 1, it was different from TSPN in the time of action and the morphological changes induced in the cells. The results imply that the mechanism of the effects of TSPN may be different from that of retinoic acid.关键词：Total Saponin of Panax Notoginseng;Human Gastric Mucosal Epithelial Cell Line GES 1;Cell Transformation;cell proliferation
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发布时间：2021-09-15 - 摘要：The effects of Tongluoxifeng Injection （TI） on leukocyte adhesion in piamatral microcirculation and the level of endothelin 1 in the plasma and brain in the rat model of cerebral ischemia and reperfusion were investigated. In the model control group, the blood flow speed of microcirculation became obviously higher at first and then gradually lower, and the leukocyte labeling test revealed that it was because of the leukocyte adhesion on the surface of micrangium endothelial cells and the formation of minute thrombus in venulae, hence causing the mechanical obstruction of microcirculation; furthermore, the endothelin 1 determination revealed that the level of endothelin 1 in the plasma and brain became obviously higher. It was found that a relatively large dose of TI could markedly obstruct leukocyte adhesion on the surface of micrangium endothelial cells, inhibit the formation of minute thrombus, lower the level of endothelin 1 in the plasma and brain, remove the obstruction caused by ischemia and reperfusion in microcirculation, hence exerting protective effects against the lesions due to ischemia and reperfusion.关键词：Benefiting Qi and Resolving Blood Stasis;Tongluoxifeng Injection;cerebral ischemia and reperfusion;Leukocyte Adhesion;Endothelin 1
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发布时间：2021-09-15 -
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- 摘要：The effects of Zhixiaotongmaining （a preparation consisting of traditional Chinese medicinal ingredients） on the cardiac function of the patients of subclinical diabetic heart disease with microvascular complication were studied. 63 Patients of type II diabetes with microvascular complication were divided into the control group （20 cases） and the treating group （43 cases）; the control group was given a routine treatment and the treating group was given the routine treatment plus Zhixiaotongmaining, for 4 weeks; and the changes in cardiac function, ocular fundus, and in the quantity of urinary protein in 24 hours, were observed. The results showed that Zhixiaotongmaining plus the routine treatment could significantly improve cardiac function and decrease the quantity of urinary protein. The results suggest that Zhixiaotongmaining intervention treatment may improve the abnormal cardiac function of the patients of subclinical diabetic heart disease with microvascular complication, hence preventing and curing diabetic heart disease.关键词：Zhixiaotongmaining;diabetes;Microvascular Complication;cardiac function
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发布时间：2021-09-15 - 摘要：A prospective study on child viral encephalitis was carried out. All the patients involved in this study were randomly divided into the TCM drug treating group （49 cases） and the virazole control group （32 cases）. The results showed that the effective rate from the TCM drug treating group was 95 9% and that from the virazole control group was 81.3%, and there was a significant difference between them （ P <0 05）. The results of the follow up survey of 64 patients showed that the incidence of sequelae in those treated with TCM drugs was 15 0%, while that in those treated with virazole was 25 0%, and there was no significant statistical difference between them. It could be concluded that TCM drugs have relatively good effects on child viral encephalitis but have no marked effects on the occurrence of sequelae, which is worth further studies.
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发布时间：2021-09-15 -
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