最新刊期
卷 0 ， 期 3 ， 2002
- 摘要：The authors of this paper hold that the TCM collateral disease theory is an important part of TCM theoretical foundation, and a deep study of the TCM collateral disease theory will help the development and innovation of TCM theories of zang-fu, meridians and collaterals, pathogenic factors and pathogenesis, and diagnosis and treatment based on syndrome differentiation. The authors try to explain the pathogenesis of the TCM collateral disease on the basis of the molecular pathophysiologicaL facts, and have put forward a new hypothesis of the TCM collateral disease. By doing so, the authors intend to make one of the possible links between TCM basic theories and modern medical theories.关键词：traditional Chinese medicine;Collateral Disease Theory;Molecular LeveL;Integration of TCM and Modern Medicine
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发布时间：2021-09-15 - 摘要：<正>自1988年以来,我校“211工程”重点学科建设工作在国家教育部和国家中医药管理局的支持下,在校党委的领导下,通过全校师生员工的共同努力,取得了显著的成绩。1重点学科建设的现状我校“211工程”重点建设学科包括中医基础理论、中医诊断学、中医内科学、中医外科学、中药学、中西医结合基础等6个学科。通过近5年的学科建设,形成了26个比较稳定的研究方向。现有学科及学术带头人38名,学术骨干78名;教授93人,副教授115人,博士生导师46人;获博士学位的教师53名。共培养硕士生125名,博士生115名,博士后34
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发布时间：2021-09-15 - 摘要：<正>中医学的现代研究应从中医“证候”入手,对中医证进行规范化和客观化研究是中医研究的当务之急,对此.行业内已经形成共识。然而,中医证的研究因其复杂性和多样性很难进行深入的研究。建国50多年来,中医界对之投入了相当可观的财力、物力、人力.虽然取得了很多可喜的成果,但至今尚未能揭示证的本质。因此有必要对以往的工作进行回顾,吸取经验和教训,以利于今后的研究。关键词：中医;证候;方证;客观化;探讨
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发布时间：2021-09-15 - 摘要：<正>古代阴阳学说渗透到《内经》,并与临床实践相结合,形成了中医独特的阴阳学说。中医阴阳学说不仅包涵哲学的涵义,更重要的是赋于它医学的内容。阴阳学说贯穿于中医基础理论和临床的各个方面,历代医家对之非常重视,并作了淋漓尽致的发展。1东汉时期东汉末年著名医学家张仲景在“勤求古训,博采众方”的基础上,结合自己的实践经验,写成了重要著作《伤寒论》。首先,《伤寒论》涉及阴阳的条文很多,据统计,在全书387条中,含有“阴”关键词：阴阳学说;实践;发展
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发布时间：2021-09-15 - 摘要：<正>中风之病,历代皆有阐述,而对本病的最早认识,当首推《内经》。《内经》虽对中风病的认识未见专篇论述,但却散见于诸篇之中,涉及到病因病机、证候、治则、治法诸方面内容,尤其对中风病因的阐述,翔实而精辟,今重习温之,颇多收获。现仅就书中对中风病发病之因,核其要旨,以飨同道。1风邪乃中风病之首因《内经》所述“风邪”的致病特点概括有三,一者“善行而数变”（《素问·风论》）,风邪不仅易于引发多种病症,且病症变化迅速,如《素问·风论》所谓“风之伤人也,或为寒热,或为热中,或为寒中,或为疠风,或为偏枯,或为风也,其病各异,其名不同”;其二,关键词：内经;中风病因;研究
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发布时间：2021-09-15 - 摘要：<正>金代阎明广《子午流注针经》一书卷首所收《流注指微针赋》简称《指微赋》。其作者何若愚的籍贯,除赋文前署有“南唐何若愚撰,常山阎明广注”外,尚无其他资料。目前研究者基本认为“南唐”不是朝代名,与“常山”均为地名,并有种种推测。现据赋文作一考证。南唐,五代十国之一,公元937年,李昇代吴称帝,建都金陵,国号唐,后称南唐。曾灭闽楚,极盛时辖有今江苏、安徽淮河以南和福建、江西、湖南关键词：指微赋;籍贯;考证
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发布时间：2021-09-15 - 摘要：This paper briefly introduces some internationally recognized criteria for diagnosis, treatment and treating effectiveness assessment of vascular dementia （VaD）, and explains the sources, scoring criteria, essential contents and reasons for the adoption of some oftentimes used VaD assessment scales, in order to help further understand and apply the Criteria for Diagnosis, TCM Differentiation and Clinical Effectiveness Assessment in Treating VaD （see Journal of Beijing University of Traditional Chinese Medicine. 2000, 23（5）: 16 - 24）, and to answer the readers’ relevant questions. The criteria and scales introduced in this paper include DSM-IV criteria for dementia; NINDS-AIREN criteria for VaD; criteria for obvious effectiveness, effectiveness, ineffectiveness and exacerbation in treating VaD; Cornell Scale for Depression in Dementia （CSDD）; Mini-Mental State Examination （MMSE） and Clinical Dementia Rating （CDR）; Instrumental Activities of Daily living Scale （IDAL） which contains Physical Self-maintenance Scale （PSMS）; CGIC; and Clinician Interview-Based Impression of Change （CIBIC）. The authors of this paper state that there are still some other criteria and scales waiting for clinical trial in China because there are some cultural differences needing to be dealt with. Too, the Criteria for Diagnosis, TCM Differentiation and Clinical Effectiveness Assessment in Treating VaD need to be revised on the basis of clinical verification.关键词：vascular dementia;Diagnosis;NeuropsychologicaL Examination;Behavior Examination;Assess- ment of Daily Living Activities
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发布时间：2021-09-15 - 摘要：The mechanism of chronic restrained stress （CRS） and the regulatory effects of three TCM formulas on CRS were investigated through neurological and endocrinologicaL approaches. Rat model of CRS was established and the behavior of the model rats was observed and assessed by the open field test and tail hanging-test. The levels of plasmatic ACTH, serum cortisol and hypothalamic (β-endorphin in the model rats were measured by radioimmunoassay. The effects of Xiaoyao Powder （XP）, Jinguishenqi Pills （JP） and Sijunzi Powder （SP） on the model rats were observed. The results showed that XP could increase the level of cortisol, SP could increase the level of β-endorphin in the acute stage of restrained stress, and JP could decrease the level of β-endorphin in the chronic stage of restrained stress. The results suggest that all the three TCM formulas play a certain role in the intrinsic regulation of chronic restrained stress in the model rats.关键词：TCM Formula;Restrained Stress;Behavioral Experiment;CortisoL;β-endorphin
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发布时间：2021-09-15 - 摘要：The effects of Naoluotong Capsules （NC） on behavior disorder, cerebral infarct size and the degree of cerebral edema were observed in the rats with middle cerebral artery thrombosis induced by FeCl3. The results showed that all the three doses of NC, namely 80, 40 and 20 mg/Kg, could reduce cerebral infarct size by 55% , 56% and 9% respectively, and also, could decrease cerebral water content and relieve behavior disorder. The results from the experiment on NC in the rats with acute blood stasis showed that NC could markedly reduce whole blood viscocity, enhance erythrocyte deformability and weaken erythrocyte aggregation. The mechanism of NC against focal cerebral ischemia might be related with their effects for changing certain hemorheological criteria.
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发布时间：2021-09-15 - 摘要：This experiment was designed to investigate the mechanism against rheumatoid arthritis of the total glycoside from the dried sarcocarp of Cornus officinalis （TGCO）. Modified Boyden chamber technique was used to assay chemotaxis of the supernatant of cultured primary synoviocytes of the rats with rheumatoid arthritis induced by C Ⅱto joint-invading inflammatory cells such as neutrophils, marrow-derived macrophages and lymphocytes. The results were expressed by the difference between the numbers of membrane-penetrating cells in the TGCO-treating group and that in the control group. The results showed that chemotaxis of the supernatant of cultured primary synoviocytes treated by TGCO was much weaker to the above-mentioned three kinds of cells, compared with that of the control group （P < 0.01）, which suggests that TGCO can inhibit chemotaxis of the articular synoviocytes to the inflammatory cells, and reducing the number of inflammatory cells in articular synovium is one of the mechanisms of TGCO against rheumatoid arthritis.
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发布时间：2021-09-15 - 摘要：The effects of Buyanghuanwu Decoction （BD） and Huangqi （the root of Astragalus membranaceus or Astragalus membranaceus mongholicus） on cerebral excitatory amino acid （EAA） were investigated in gerbils undergone cerebral ischemia and reperfusion. Gerbil cerebral ischemia model was established by the method of ligating common carotid arteries. The levels of cerebral glutamate （Glu）, asparate （Asp）, γ-aminobutyric acid （GABA） and glycine （Gly） were measured in the model. The results showed that in 15 minutes after cerebral ischemia, the levels of Glu, Asp and GABA markedly increased （P <0.05, P <0.01, P < 0.05）, and BD and Huangqi could decrease the level of Glu （P < 0.05）; in 48 hours after reperfusion following 15 minutes of cerebral ischemia, the levels of Glu and Asp markedly increased （P < 0.05）, and BD and Huangqi also could decrease the level of Glu （P < 0.05）. The results suggest that the mechanism against ischemic cerebral injury of BD and Huangqi may be related with their resisting the increase of the level of EAA induced by cerebral ischemia and reperfusion.
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发布时间：2021-09-15 - 摘要：The model of experimental allergic encephalomyelitis （EAE） was successfully established in guinea pigs by using the complete Fruend s adjuvant and myelin basic protein. The immunohistochemical ABC assay revealed an increase of the expression of NF-K B p65 positive cells in the spinal cord in the animals in the model group, and a significant decrease of the expression of NF-K B p65 positive cells in the spinal cord of the animals in the Wenyangbushen Formula-treated group. The results suggest that Wenyangbushen Formula may relieve multiple sclerosis through its inhibiting the expression of NF-k B p65 in the spinal cord, and arresting or weakening the activity of immune inflammatory molecules .关键词：Wenyangbushen Formula;Allergic Encephalomyelitis;NF-k B;guinea pig
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发布时间：2021-09-15 - 摘要：The mechanism of the protective effects of Naomaikang Granules （NG）, which are prepared according to a TCM formula for benefiting qi, promoting blood circulation and inducing resuscitation, on the brain were studied in the rat undergone middle cerebral artery ischemia and reperfusion. The rat model of ischemia and reperfusion was established by Longa’s method. The levels of excitatory ammo acids （EAA）, water content and the level of Ca+2 were measured in the brains of the rats by automatic amino acid analysis, dry and wet weight method and atomic absorption spectrophotometry. Rat cerebral morphologic changes were observed by HE method. The results showed that the level of Glu decreased （P < 0.01）, the ratio of Glu/GABA tended to be normal, and both the water content and the level of Ca+2 decreased （P<0.05） in the brains in the rats in the NG-treating group. It was also found that the morphologic changes of neurons caused by ischemia and reperfusion were relieved in the NG-treating group. The results suggest that NG exerts its effects against cerebral injury through its inhibiting EAA release and Ca+2 intrinstic flow.
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发布时间：2021-09-15 - 摘要：Mouse celiac macrophages （Mφ） were cultured with hyperlipidemic serum and drug-carried serum respectively, and the levels of nitric oxide （NO）, nitric oxide synthase （NOS） and oxidized low density lipoprotein （OX-LDL） were measured in the different culture fluids. RNA was extracted from Mφ, and the mRNA expression of macroph-age colony-stimulating factor （M-CSF） was observed by PT-PCR. The results showed that the TCM drugs for relieving hepatic depression and removing turbidness could enhance NOS activity significantly, increase the level of NO, inhibit the production of OX-LDL, and regulate the level of M-CSF, which suggests that these TCM drugs possess good effects against oxidative modification reaction, hence to prevent and treat arteriosclerosis effectively.关键词：TCM Drugs for Relieving Hepatic Depression and Removing Turbidness;nitric oxide;Macroph- age;Arteriosclerosis;Macrophage Colony-Stimulating Factor
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发布时间：2021-09-15 - 摘要：The effects of Kangdai No. 1 on the dynamic changes in the expression of GFAP of hippocampal astrocytes in the mice with injury caused by forebrain ischemia and reperfusion, and the relationship between the effects of Kandai No. 1 and ischemic neurons were investigated by the immunohistochemical method. The model group showed that there was only a small number of GFAP-expressing astrocytes in the mice in 1 day after ischemia and reperfusion, there was an increase in the number of GFAP-expressing astrocytes in 3 days after ischemia and reperfusion, the number of GFAP-expressing astrocytes reached a peak in 7 - 10 days after ischemia and reperfusion, and the number of GFAP-ex-pressing astrocytes still remained a relatively high level in 15 days after ischemia and reperfusion; while the Kangdai No. 1 group showed that there was a marked decrease in the number of GFAP-expressing astrocytes; the normal control group and sham operation group showed that there was only a few GFAP-expressing astrocytes; and the changes in the numbers of GFAP-expressing astrocytes were related with the survival state of neurons. The results indicated that there was a dynamic change in the number of GFAP-expressing astrocytes when forebrain ischemia and reperfusion happened, and Kangdai No. 1 had good protective effects against the injury of astrocytes and neurons caused by forebrain ischemia and reperfusion.关键词：Forebrain Ischemia and Reperfusion;Immunohistochemistry;astrocyte;Kangdai No. 1;GFAP
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发布时间：2021-09-15 - 摘要：The contents of total ginsenoside and 10 important monomer ginsenosides, namely Rb1, Rb2, Rc, Rd, Rg3, Rh2, Re, Rg1, Rg2 and Rh1 in the American ginseng fruit paste and its zymotic fluid were determined by macroporous resin column chromatography-colorimetry and RP-HPLC in order to make use of the American ginseng fruit paste. The results showed that the content of total ginsenoside in the American ginseng fruit paste processed by special technique for fermentation was decreased by 50% ; and the contents of monomer ginsenosides with similar structures were also changed markedly, and among them, the contents of Rg3, Rh2, and Rh1 were increased by 44.398 mg, 17.669 mg, and 13.547 mg respectively. The results suggest that the zymotic fluid of American ginseng fruit paste possesses the value of further development.关键词：American Ginseng Fruit Paste;Zymotic Fluid;Total Ginsenoside;Monomer Ginsenoside
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发布时间：2021-09-15 - 摘要：The effects of Tiaoxin Formula （TF） against Alzheimer’s disease （AD） were investigated. 68 AD patients were randomly divided into the treating group （34 cases） and control group （34 cases）, and the former was given TF and the latter, donepezil, respectively for 12 weeks. The changes in the criteria pertaining to MMSE, ADL and certain neuropsychological scales such as FOM, RVR, DS and BD were observed in the AD patients before and after the administration of the two drugs. The results showed that both TF and donepezil could normalize the criteria pertaining to MMSE, ADL, FOM, and DS （P < 0.05）, and there was no difference between the treating effectiveness rates in the patients in the two groups （P >0.05）, which suggests that TF can improve the cognition and ability to lead the daily life of AD patients and is an effective preparation for treating AD.关键词：Tiaoxin Formula;Alzheimer’s disease;Benefiting the Heart to Promote the Flow of Yang;Re- moving Phlegm to Induce Resuscitation;clinical study
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发布时间：2021-09-15 - 摘要：The effects of Naotongjing Capsules （NC） against the neurological deficit and insulin resistance caused by acute cerebral infarction （ACI） were studied. 64 Patients were randomly divided into the treating group （34 cases） and treating control group （30 cases）, and the former was given NC and the latter, nimodipine, respectively for 3 weeks. Some criteria, such as the severity of neurological deficit, the levels of blood sugar （empty stomach and 2 hours after meal）, level of insulin （Ins）, insulin sensitivity index （ISI） and the level of blood lipid, were measured before and after the administration. The results showed that before the administration, the level of Ins （empty stomach）, and the levels of blood sugar and Ins （2 hours after meal） were markedly higher （P < 0.01）, and the value of ISI was markedly lower （P < 0.01） in the patients of the above-mentioned two groups, compared with those in the healthy subjects in the normal control group; after the administration, the level of Ins （empty stomach） and the levels of blood sugar and Ins （2 hours after meal） were markedly decreased （P < 0.05, P<0.01）, the value of ISI was markedly increased （P < 0.05）, and the lipid metabolic disturbance was markedly relived in the patients in the treating group; NC showed better effects for decreasing the level of Ins （empty stomach） and increasing the value of ISI, compared with nimodipine （P < 0.05, P < 0.01）. The results suggest that NC not only may relieve the severity of ACI neurological deficit significantly, but also may control the insulin resistance accompanied by lipid metabolic disturbance in the acute stage of cerebral infarction .关键词：cerebral infarction;insulin resistance;TCM;Tongnaojing Capsules;clinical study
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发布时间：2021-09-15 - 摘要：The curative effects of Bushenqingredu Formula （BF） combined with western-style drugs （WD） in treating lupus nephritis were investigated. 80 Patients in the treating group were treated with BF （which exerts the effects of tonifying the kidney, clearing away heat and toxins, and promoting blood circulation and removing blood stasis） and WD （which was used for controlling autoimmune reaction）; 30 patients in the control group were treated with WD alone; and the changes in symptoms, signs and laboratory criteria were observed before and after the treatment. The results showed that the total effective rate in the treating group was 91.25% while that in the control group was 82.56%, and there was a significant difference between the two effective rates （P < 0.05）; and too, the values of laboratory criteria, such as autoantibody, complement, blood lipid, 24-hour urinary albumin excretion, renal function and renal pathologic changes, were all markedly improved （P< 0.05 or P < 0.01） after the BF and WD treatment. The results suggest that the effects of BF combined with WD in treating lupus nephritis were better than those of single WD.关键词：Lupus Nephritis;Bushenqingredu Formula;renal function;Renal Pathology
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发布时间：2021-09-15 - 摘要：<正>1临床资料我们选择了1998年1月～2001年8月间在我院放疗科行口腔放疗的鼻咽癌、鼻咽部恶性淋巴瘤、口腔肿瘤病人共50例,随机分为两组,对照组20例,其中男性16例,女性4例,年龄19～68岁,平均39.8岁;治疗组30例,其中男性21例,女性9例,年龄21～70岁,平均42.6岁。治疗组鼻咽癌25例,鼻咽部恶性淋巴瘤4例,口腔硬腭癌1例,对照组鼻咽癌18例,鼻咽部恶性淋巴瘤2例。以上两组病例均经我院病理证实,诊断明确,一般状况较好,Kamof-sky评分>60分,能坚持完成放疗全过程。关键词：放射性口腔粘膜炎;中药含漱;大黄黄连泻心汤
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发布时间：2021-09-15 - 摘要：<正>乳腺增生症是妇女常见的乳房疾病,它可分为乳痛症（乳腺组织增生症）和乳腺囊性增生症等。主要临床表现是乳房随月经周期的改变出现周期性疼痛,以及乳房内大小不同的肿块和压痛。目前西医除了必要时手术治疗外,尚无理想的治疗方法,笔者近年自拟“蜈蛇达络散”治疗本病,收到了较满意的效果。1临床资料108例女性患者,均为门诊病人,年龄22～59岁,平均41岁,病程1个月～25年。108例患者诊关键词：乳腺增生症;蜈蛇达络散;专方专药
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发布时间：2021-09-15 - 摘要：<正>焦虑症是以广泛和持续焦虑或反复发作的惊恐不安为主要特征的神经症性障碍。其焦虑或恐惧往往无实质内容或与现实处境不符,常伴有头晕、胸闷、心悸、呼吸急促、口干、尿频尿急、出汗、震颤等植物神经症状和运动性紧张。本病包括广泛性焦虑（GAD）和惊恐障碍（PD）。临床以GAD、16～40岁年龄段,女性多见。调查表明,我国GAD发病率为2％～4.7％,PD终生患病率为1.5％～3.5％;某些特定人群（如冠心病患者、临考学生）发病率可高达10％以上。随着现代社会工作、人际关系、经济压力等诸多出素作用的加剧,发病率还在上升。现代医关键词：焦虑症;中医药疗法;病因病机;综述
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发布时间：2021-09-15 - 摘要：<正>消化性溃疡（pephic ulcer,PU）是临床上常见病、多发病,中医的辨证分型较多,有的分3型,有的分5型,有的分7型,但寒热辨证是其根本。寒热既反映病证的基本性质,又是鉴别疾病属性的两个纲领,巳对于治疗有重大的指导意义。如何结合现代医学的指标研究消化性溃疡的寒热辨证是很多学者的课题,因此笔者对其研究近况综述如下。1消化性溃疡临床与寒热辨证溃疡病在临床可以以寒热证的形式表现出来,很多学者对此作了研究。近代秦伯未根据自己的临床经验,认为溃疡病的根本在于脾胃虚寒[1]。有学关键词：消化性溃疡;寒热辨证;综述
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发布时间：2021-09-15 - 摘要：<正>强直性脊柱炎（AS）是一种病因不明的、慢性、全身性、炎症性疾病。它主要以侵犯中轴关节为主,影响患者的身心健康,并波及外周关节及眼、心、肺、肾等脏器,致残率较高。目前西医对本病尚无确切有效的治疗方法。而近年来中医在对本病的诊治方面取得了较大成果,现将有关报道综述如下。1病因病机在对AS的病因病机的认识上,大多数医家都以素禀不足,肾督亏虚、风寒湿邪乘虚入侵,内外合邪而发病为共识而兼有其他见解。尹氏[1]认为AS多属肾精不足,太阳经疏,督脉失养,风寒湿热诸邪由足太阳膀胱经而入,内舍督脉,消伐肾精。黄氏[2]认为气血肝肾内虚是致痹的内因和本质,风寒湿邪外袭是致痹的外因和表象,经络瘀阻是痹证的发病机理。焦氏3]认为本病的主要病机是肾虚督寒。许氏[4]认为AS是经络气血受风寒湿三气侵犯闭塞而关键词：强直性脊柱炎;中医药;诊疗进展;综述
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发布时间：2021-09-15 - 摘要：<正>糖尿病是一种与遗传因素有关又与多种环境因素相关的全身性慢性内分泌代谢疾病。主要是由于胰岛素绝对或相对不足而引起的糖、脂肪、蛋白质代谢紊乱,临床上以血糖升高为主要特征,且容易并发多种疾患,从而严重危害人类健康。属中医学消渴病范畴。中国中医药学会消渴病（糖尿病）学会认为消渴病为糖尿病的同义词。在消渴病的中医辨治方面,历来多从阴虚燥热的角度出发。国家中医药管理局发布的《中医病证诊断疗效标准》中,对消渴病的概念、诊断依据。辨证分类方面均强调了阴虚燥热[1]。在全国高等医学院校教材《中医内科学》中,关键词：糖尿病;脾虚湿滞;辨证论治
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发布时间：2021-09-15 - 摘要：The effects of puncturing different Jing acupoints with electric needles on the level of calmodulin in the ischemic region of the brain were investigated in the rats undergone ischemia and reperfusion. The results showed that the level of active calmodulin in the ischemic brain in the rats increased markedly, while it decreased when the Jing acupoints on the forepaws, or hind paws, or on all the four paws of the rats were punctured with electric needles, which suggests that Jing acupoint electric needling exerts a certain protective effect on the brain. The results also showed that there was no difference among the effects on active calmodulin exerted by the Jing acupoint electric needling on the forepaws, hind paws, and all the four paws.关键词：Electric Needle;cerebral ischemia;Jing Acupoint;Calmodulin
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发布时间：2021-09-15 - 摘要：<正>李学武教授出生于一个中医世家,从事中医针灸的临床、教学、科研工作30余年,在治疗脑血管病、胃肠病、眼病及其他多种疑难杂症方面有丰富的经验。李老针刺手法娴熟、见解独到,对于常用的穴位经常根据病情需要采取特殊的进针角度与深度,尤其擅用深刺法,以增强针感、提高疗效。现将李老临床常用的穴位深刺方法介绍如下。1夹脊穴深刺治疗腰腿痛夹脊穴包括颈椎、胸椎、腰椎、骰椎两旁的所有夹脊穴。其针刺深度、方向与疗效有着明显关系。李老取夹脊穴一般是刺在督脉旁开20mm左右,这关键词：名老中医;临床经验;针刺方法
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发布时间：2021-09-15 - 摘要：<正>我科自1998～2000年对收住院的急性脑出血95例患者,采用北京中医药大学药厂生产的地坛牌清开灵注射液,结合西医常规治疗,取得了满意疗效,现报道如下:1临床资料病例选择均符合国家中医药管理局制定的中风病诊断标准,共95例。治疗组55例,男性36例,女性19例,其中60岁以下23例,60岁以上32例,平均年龄62.4岁;对照组40例,男性26例,女性14例,平均年龄59.8岁。95例患者全部CT扫描,其中合并高血压86例,合并感染25例,合并糖尿病15关键词：脑出血;清开灵注射液;临床观察
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发布时间：2021-09-15
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