最新刊期
卷 0 ， 期 0 ， 2020
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- 摘要：The cerebral ischemia model was established by repeated ischemia and reperfusion of common carotid arteries and tail bloodletting in the presenile mice. The contents of 3 kinds of AMP in the mouse brain homogenate were determined by HPLC and the brain energy charge was calculated. The effects of Congsheng Capsules （CC） on the brain energy charge and the levels of LA and LDH were observed. The results showed that doses of 3 g /kg and 9 g/kg of CC could markedly improve the brain energy charge, and doses of 1 g/kg, 3 g/kg and 9 g/kg of CC could remarkably decrease the level of LA and increase the activity of LDH in the model mice.关键词：Congsheng Capsules;cerebral ischemia;energy metabolism;Lactic Acid;mouse
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发布时间：2021-09-15 - 摘要：Effects of Xinmailing Injection （XI） on SOD and MDA, the two criteria for the lipid peroxidation in the cerebral tissue, were observed in the rats with endotoxic shock. The results showed that XI had good antishock effects, including stabilizing the mean arterial pressure, reducing the water content of cerebral tissue, lowering the 6 hour mortality, controlling or reducing the decrease in the level of SOD, and decreasing the production of MDA. The results suggest that XI may relieve cerebral injury caused by endotoxic shock through inhibiting or reducing the effects of lipid peroxidation in cerebral tissue.关键词：Endotoxic Shock;lipid peroxidation;Xinmailing Injection;rat
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发布时间：2021-09-15 - 摘要：Data mining is designed to cope with the situation of "rich data and poor knowledge." Under the instructions of the experts in relevant fields, it may be used to carry out the intelligent analysis of mass data, to grasp the essence of things, and to predict the tendency and implicit patterns or regularity of the development of things. The application of advanced information processing techniques, the data mining for example, in the modernization of the traditional Chinese medicine （TCM） and traditional Chinese pharmacy （TCP）, for acquiring the knowledge characterized by its implicit nature, will speed the update of the knowledge of TCM and TCP and lay sound theoretical and practicable foundations for building modern TCM and TCP theories. It is an effective way for speeding the modernization of TCM and TCP to establish a general intelligent decision support system for multi level intelligent analysis of TCM and TCP data by using a combination of a variety of data mining techniques, data warehousing techniques, online analytical process technology and expert systems.关键词：data mining;TCM;Warehousing;Expert System;Intelligent Decision Support System
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发布时间：2021-09-15 - 摘要：The rat model of bile reflux gastritis was induced by B Ⅱ gastrojejunostomy; the effects of Chaiqinpingwei Capsules （CC） on gastrointestinal hormones and pH value of gastric juice were observed in the model rats, and the mechanism of CC in treating residual gastritis was analyzed. The results showed that as compared with those in the rats in the blank control group, the levels of serum gastrin and PGE 2 in gastric mucosa were significantly decreased （ P <0 01）, and the pH value of gastric juice was remarkably increased （ P <0 01） in the rats in the model group; and the small and medium doses of CC could increase the levels of serum gastrin, EGF in the gastric juice and PGE 2 in gastric mucosa as compared with those in the model group （ P <0 05） while the 2 doses of CC had no great effects on the pH value of gastric juice. The results suggest that a long term of bile reflux can cause the disorder of gastrointestinal hormone secretion and damage the nutritional and defensive mechanisms, which causes the injury of gastric mucosa; and CC may exert their curative effects though affecting the secretion of gastrointestinal hormones.关键词：Bile Reflux Gastritis;B Ⅱ Gastrojejunostomy;gastrin;EGF;PGE 2;rat
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发布时间：2021-09-15 - 摘要：Male Wistar rats were randomly divided into the sham operation （SO） group, model group, Aima Oral Solution （AOS） group and Juhongzhike Oral Solution （JOS） group, and each group consisted of 9 animals. The rat model of chronic bronchitis was induced by the intratracheal injection of a small dose of lipopolysaccharide. Optical and transmission electron microscopic methods and image analysis were used to observe airway pathomorphological changes in the rats in the above 4 groups. The results showed that there were no obvious abnormal morphological changes in the airway of the animals in the SO group; but in the animals in the model group, the secretion in the airway was obviously increased, the glands of the airway were thickened, the epithelium of the airway was damaged, tracheal mucous and submucous layers were infiltrated by a large quantity of inflammatory cells, and the peribronchial lymph follicles were formed. Image analysis revealed that the thickness of the tracheal wall and tracheal glands was significantly increased in the animals in the model group as compared with that in the SO group （ P <0 01）. The observation of the lung ultrastructure revealed that the alveolar cavities were infiltrated by a large quantity of inflammatory cells and the alveolar interstitium was thickened in the animals in the model group; but the airway pathologic injuries were obviously relieved in the AOS group as compared with those in the model group. Image analysis showed that the thickness of the tracheal wall in the animals in the AOS group was significantly decreased （ P <0 05）. Although the airway pathologic injuries were also relieved by JOS as compared with those in the model group, the efficacy of JOS was not as good as that of AOS.关键词：Lipopolysaccharide;chronic bronchitis;Aima Oral Solution;pathology;Image Analysis;rat
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发布时间：2021-09-15 - 摘要：First, the mice were given intraperitoneal injections of myleran for 5 weeks to induce their bone marrow injury and hematopoietic function disorder, and then, were given Busuishengxue Granules （BG） by gastric perfusion for 3 months for an intervention treatment. During the experiment, the mice were observed by peripheral blood test, bone marrow smear examination and biopsy. The results showed that the mouse bone marrow injury induced by myleran conformed to the pathologic changes manifested by aplastic anemia; and BG could significantly promote the repair of marrow hematopoietic cells and the structure of microcosmic hematopoietic environment, and increase the funtional levels of red cell series, granulocyte series and megakaryocytic series in the peripheral blood.关键词：Busuishengxue Granules;aplastic anemia;Pathologic Changes;mouse
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发布时间：2021-09-15 - 摘要：The influence and effects of Tongmaiyizhi Capsules （TC） on rabbit experimental atherosclerosis were investigated in this experiment. 21 Healthy Japanese male rabbits were divided into 3 groups according to their body weight. The duration of the experiment was 12 weeks. The levels of blood lipid, NO, MDA, GSH Px, TXB 2 and 6 keto PGF 1α were detected during the experiment. The pathologic changes in the rabbit aorta, coronary artery and middle cerebral artery were observed by the optical microscopy, and the pathologic changes in the rabbit aortal endothelial cells were observed by the scanning electron microscopy. The results showed that as compared with those in the animals in the cholesterol induced model group, in the TC treated group, the levels of blood total cholesterol, triglyceride and LDL were significantly decreased, and the level of HDL was significantly increased; the levels of blood NO and GSH Px were markedly increased, and the level of MDA was markedly decreased; the level of blood TXB 2 was remarkably decreased, and an obvious increasing tendency was found with the level of 6 keto PGF 1α . The results also showed that TC could significantly reduce the fat deposit in the rabbit aorta and coronary artery, diminish the plague area and protect aortal endothelial cells.关键词：Tongmaiyizhi Capsules;atherosclerosis;pathology;Biochemistry;rabbit
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发布时间：2021-09-15 -
- 摘要：The extracts of the 4 species of plants in Shandong Province used as tusizi, a traditional Chinese drug, were dialysed for determining their polysaccharide contents by the phenol concentrated sulphuric acid method. The results showed that the polysaccharide contents of the 4 plants were from 4 41% to 12 73%; the highest polysaccharide content, 10 18% on the average, was found in Cuscuta japocica Choisy, and the lowest polysaccharide content, 5 39% on the average, was found in Cuscuta australis R. Br.; and the reducing sugar contents of the plants in subgenus Monogyna were higher than those of the plants in subgenus Crammica. Conclusion: the average polysaccharide contents of the plants in subgenus Monogyna were nearly twice as high as those of the plants in subgenus Crammica while the polysaccharide contents of the plants in the same subgenus were about at the same level.关键词：Cuscuta;Polysaccharide Content;Place of Production
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发布时间：2021-09-15 - 摘要：The technology of extracting the active components from Chuanxiong （the dried rhizome of Ligusticum chuanxiong） in preparing Suxiaoxingnao Gutta Pills was investigated. The technique of percolation was used to extract the active components from Chuanxiong; the concentration and the amount of the percolation solvent （alcohol） and the time for the immersion of Chuanxiong in the solvent were determined by the orthogonal design; and HPLC was used to determine the contents of ferulic acid and ligustrazine, the two main active components of Chuanxiong. The results showed that ferulic acid and ligustrazine in the extract could reach their highest concentrations when being extracted by percolation on condition that the 70% alcohol was used as percolation solvent, the time for the immersion of Chuanxiong was 24 hours, and the amount of percolation solvent was 8 times the amount of the crude drug.关键词：Suxiaoxingnao Gutta Pills;ferulic acid;Ligustrazine;HPLC
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发布时间：2021-09-15 - 摘要：The study of TCM risk factors of stroke is an important part of stroke etiology and therapeutics. The confirmation of the TCM risk factors of stroke needs the support of a certain amount of epidemiological material and relevant data mining techniques and skills. In this article, the field investigation material （3909 cases） and retrospective material （4065 cases） were analyzed with the Cronbach α and split half reliability; and then, to meet the statistical demand of the 1:2 case control study, the values of χ 2, Ρ , OR and 95% CI of each TCM risk factor of stroke were calculated. The logistic regression analysis, cluster analysis and principal component analysis of the data of those important TCM risk factors of stroke were carried out on the basis of variable correlation and multiple colinearity analyses, literature meta analysis and the clinical experience by using the SAS software; and the roles those risk factors played in the occurrence of stroke were objectively evaluated.关键词：stroke;risk factors;epidemiology;Biostatistics
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发布时间：2021-09-15 - 摘要：Patients of acute ischemic cerebral infarction of the collateral phlegm and blood stagnation type were divided into the Shuxuetong Injection （SI） treating group and the Xuesaitong Injection （XI） control group, and the changes in the scores for clinical symptoms of apoplexy and clinical symptoms of blood stagnation syndrome were observed before and after the treatment in the patients. The results showed that both SI and XI were effective in the treatment, the effectual rate was 38 46% and the total effective rate was 88 46% in the SI treating group while the effectual rate was 33 33% and the total effective rate was 91 67% in the XI control group, and there was no significant difference between the rates in the two groups （ P >0 05）; and after the treatment in the SI treating group, the score for clinical symptoms of apoplexy was decreased significantly as compared with that before the treatment （ P <0 01）, and the score for clinical symptoms of blood stagnation syndrome was also significantly improved as compared with that before the treatment （ P <0 01）. The results suggest that SI is very effective in treating the patients of acute ischemic cerebrovascular disease and can markedly relieve the clinical symptoms of apoplexy and the symptomatic state of blood stagnation syndrome by exerting its remarkable effects for activating blood circulation and resolving blood stasis.关键词：Ischemic Cerebral Infarction;Blood Stagnation Syndrome;Activating Blood Circulation and Resolving Blood Stasis;Shuxuetong injection
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发布时间：2021-09-15 -
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