最新刊期
卷 0 ， 期 0 ， 2020
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- 摘要：The toxic effects of glutamic acid on nerve cells and the treating effects of Congsheng Capsules （CC） were investigated. The method of rat cerebral cell culture was used in this experiment. Changes in the levels of LDH and MDA in the nerve cell culture fluid, and the level of Ca 2+ in the nerve cells were observed after glutamic acid and CC were used to the nerve cells respectively. The results showed that glutamic acid had toxic effects on the nerve cells; and CC could reduce the leakage of LDH and the excessive production of MDA, and decrease the level of Ca 2+ . The results suggest that CC have certain protective effects on the nerve cells.关键词：Congsheng Capsules;Nerve Cell;glutamic acid;LDH;MDA;rat
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发布时间：2021-09-15 - 摘要：The changes in the level of neuropeptide Y （NPY） in the hypothalamus and plasma were investigated in the rats with deficiency of splenic qi. The rat model of deficiency of splenic qi was established by the method of tiredness and purgation. The level of NPY was detected by radioimmunoassay and the results were compared with those from the rats with ovariotomy. The results showed that compared with that in the rats in the normal control group, the level of NPY in the hypothalamus markedly increased in the rats in all groups, especially in the ovariotomy group; and the level of NPY in the plasma was with a rising tendency in all groups, especially in the purgation group. The results indicate that there is a change in the level of NPY in the hypothalamus in the rats with deficiency of splenic qi induced by the factor of tiredness or purgation, and the extent of the change is less than that in the rats with ovariotomy; the change in the level of NPY in the hypothalamus may play an important role in the formation of the syndrome of splenic deficiency.关键词：Deficiency of Splenic Qi;hypothalamus;Neuropeptide;rat
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发布时间：2021-09-15 - 摘要：The mouse model of influenza virus pneumonia （IVP） was established with Kunming line mice and then treated by Qingfei Decoction （QD）. The pathological changes of the isolated lungs of the model animals were observed in the 6th day and 12th day of QD treatment respectively. Optical and electron microscopic examinations of the lung tissue of IVP mice showed that interstitial pneumonia characterized mainly by monocyte and lymphocyte infiltration was developed; alveoli were filled with many exudative inflammatory cells and serous fluid, alveolar wall was broadened with an unclear structure; in type I pneumcytes, many pinosomes were found in the cytoplasm of the capillary endothelial cells, and the basilar membrane of the capillaries was destroyed; in type II pneumocytes, the nuclei became irregular, mitochondria in the cytoplasm were apparently swollen, endoplasmic reticulum became distended, the arrangement of lamellar bodies was in disorder, and the joints among epithelial cells were damaged; and the situation was severer in the 12th day of the influenza virus infection of the mice, which manifesting many vacuoles in the cytoplasm, than that in the 6th day. Tissue image quantitative analysis showed that the percentage and gray scale of the disease focus in the model mice were significantly increased. It was proved that QD could obviously relieve interstitial pneumonia and decrease the percentage and gray scale of the disease focus in the model mice.关键词：Influenza Virus Pneumonia;Qingfei Decoction;pathology;Tissue Image Analysis
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发布时间：2021-09-15 - 摘要：The effects of the extract of gegen （the dried Root of Pueraria lobata or Pueraria thomsonii） on the vagina and uterus and on hormones in the pituitary sex gland axis were investigated in the ovariectomized rats. 60 Female Wistar rats with the body weight between 250 g to 260 g were randomly divided into 6 groups, namely the normal control group, model group, estradiol group, sham operation group, small dose of gegen extract group and large dose of gegen extract group. The rats in all groups except the normal control group and sham operation group, were bilaterally ovariectomized. After the administration of gegen extract for 6 weeks, the rats in each group were anesthetized for collecting carotid blood. And then, the levels of hormones such as E 2 and LH in the serum of the carotid blood were detected and the weight of the isolated vagina and uterus was measured respectively. The histomorphological changes of the uterus were observed by the use of HE staining. The results showed that gegen extract could markedly increase the weight of the vagina and uterus, relieve uterine atrophy, raise the level of E 2, and lower the level of LH. The results of the study can provide experimental evidence for developing new drugs for treating climacteric.关键词：Gegen （Dried Root of Pueraria lobata or Pueraria thomsonii） Extract;Vagina;uterus;Hormone;rat
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发布时间：2021-09-15 - 摘要：The mechanism of huangqin （the dried root of Scutellaria baicalensis） and zhizi （the dried fruit of Gardenia jasminoides） used in combination for treating ischemic apoplexy was investigated by analyzing the characteristics of the effects of huangqin and zhizi used in combination in inhibiting the cerebral ischemic cascade reaction. The rat model of ischemia and reperfusion of middle cerebral artery was established by the thread occluding method; and the effects of huangqi and zhizi used in combination on neural symptoms, the levels of SOD, MDA, NOS and Na + K + ATPase in the brain and the level of vWF in the plasma were observed. The results showed that both the single use of huangqin or zhizi and the combinative use of huangqin and zhizi could improve the symptoms of neural function defect; the single use of huangqin or zhizi had no obvious effects on SOD, MDA and vWF, while the combinative use of huangqin and zhizi could enhance the activity of SOD and lower the levels of MDA and vWF, at the same time, showing an effect diminishing and attenuating tendency toward the activities of NOS and Na + K + ATPase. The results suggest that the effects of the combinative use of huangqin and zhizi are not the simple addition of their respective effects but some complicated biological phenomena.关键词：Huangqin （Dried Root of Scutellaria baicalensis）;Zhizi （Dried Fruit of Gardenia jasminoides）;Combinative Use of Traditional Chinese Drugs;Injury Caused by Ischemia and Reperfusion;Ischemic Cascade Reaction
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发布时间：2021-09-15 - 摘要：The influence of the factors of liver depression and spleen deficiency （LDSD） on the occurrence of hepatocarcinoma induced by diethylnitrosamine （DEN） and on the function of T lymphocytes, and the treating and preventing effects of the Shuganjianpi Formula （SF） were investigated in the model rats. All rats in the experiment were stimulated with the factors of LDSD for 19 weeks, and simultaneously, given by gastric perfusion a dose of DEN, 70 mg/kg, once a week for 8 weeks; the rats in the preventing and treating group were given a dose of SF, 1 5 g/ kg; and then, the abilities of T lymphocytic proliferation and IFN γ and IL 2 production were detected in the isolated spleen of the rats in the 9th, 14th and 19th weeks respectively. The results showed that the abilities of T lymphocytic proliferation and IFN γ and IL 2 production were significantly lower in the rats stimulated with both the factors of LDSD and DEN than those in the rats stimulated only with DEN （ P <0 05）; but after the rats were given SF, the abilities of T lymphocytic proliferation and IFN γ and IL 2 production were significantly restored. The results suggest that SF can significantly improve immunological function in the rats with DEN induced hepatocarcinoma plus the stimulation of the LDSD factors, and at the same time, can relieve the severity of hepatocarcinoma.关键词：liver depression and spleen deficiency;Experimental Hepatocarcinoma;T Lymphocyte;Shuganjianpi Formula
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发布时间：2021-09-15 - 摘要：The effects of Xiaolong Mixture （XM） on hyperplasia of prostate induced by testosterone propionate （TP） were studied in mice. The mice were randomly divided into the control group, model group, XM large dose group, XM medium dose group, and XM small dose group. A dose of TP, 5 mg/kg, was given by subcutaneous injection to all the mice except those in the control group, and at the same time, XM was given once daily to the mice by gastric perfusion. At the end of the third weeks, the measurement of the body weight, prostatic weight and prostatic index was carried out; HE and Feulgen’s staining of prostatic tissue were made; and the level of DNA was detected by image analysis. The results showed that as compared with those in the mice in the model group, the prostatic weight and prostatic index were significantly lower （ P <0 01）, adenomatosis was inhibited, and the secretion in the lumen of gland was decreased in the mice in all the three XM treating groups; both the single karyon acreage and integral grey value were also lower in all the three XM treating groups, and especially, significantly lower in the XM large dose group （ P <0 01）. The results suggest that XM can inhibit the occurrence of hyperplasia of prostate induced by TP in mice.关键词：Xiaolong Mixture;Testosterone Propionate;Hyperplasia of Prostate;mouse
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发布时间：2021-09-15 - 摘要：Hydroxypropyl methylcellulose （HPMC） was used as the main sustained release excipient of Naoluotong Sustained Release Capsules, and the formula was optimized by the orthogonal experimental design. The optimizing of the formula was done according to the requirements of PRC pharmacopeia and the amount of the accumulative release of ginsenoside was used as a criterion. The results showed that the best formula was composed of 216 mg of HPMC, 24 mg of ethylcellulose and 132 mg of mixed dilutent, and its release curve accorded with Higuchi kinetic model.关键词：Naoluokang Sustained Release Capsules;hydroxypropyl methylcellulose;Release Rate in Vitro;Technological Optimization;Ginsenoside Re
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发布时间：2021-09-15 - 摘要：The mouse model of immunosuppression induced by JC60,D,Zo irradiation was used to observe the effects of Shengjingbuxue Decoction （SD） on immunologic function. The results showed that SD could increase the amount of hemolysin released by the splenic antibody forming cells, promote the production of serum hemolysin in the peripheral blood, increase delayed hypersensitivity and T lymphocyte proliferation, enhance phagocytosis of abdominal macrophages, and promote the production of IL 1 and IL 2. It suggests that SD may antagonize the immune injury caused by radiation and promote the restoration of damaged immunologic function. The results of this experiment can provide some evidence for further studying the mechanism of the effects of SD.关键词：Shengjingbuxue Decoction;Immunologic function;Radiation Damage
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发布时间：2021-09-15 - 摘要：The mechanism of the effects of the extracts of liquorice （the dried root and rhizome of Glycyrrhiza uralensis or Glycyrrhiza inflata or Glycyrrhiza glabra）, shengma （the dried rhizome of Cimicifuga heracleifolia or Cimicifuga dahurica or Cimicifuga foetida）, gouqi （Dried fruit of Lycium barbarum） and xiaohuixiang （dried fruit of Foeniculum vulgare） on liver lipid metabolism was studied in ovariectomized rats. After the rats were given the above 4 extracts and estrogen by gastric perfusion for 5 weeks, the levels of liver total cholesterol and triglyceride and the levels of estradiol, progesterone, testosterone and prolactin were detected. The results showed that at the end of the 6th weeks after the rats were ovariectomized, the levels of total cholesterol and triglyceride increased and the uterus became atrophic; after the ovariectomized rats were given the above 4 extracts, the levels of total cholesterol and triglyceride decreased and the uterus became larger, and gouqi and liquorice extracts were more effective in this regard; and the level of estradiol was markedly higher in the ovariectomized rats given estrogen and liquorice extract, as compared with those in the rats in the model group （ P <0 05）. The results suggest that all the 4 extracts can lower the levels of total cholesterol and triglyceride in the liver in different ways and only liquorice extract has an estrogen like effect.关键词：Chinese Herbal Drug Extract;Live Lipid Metabolism;Ovariectomized Rat;estrogen
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发布时间：2021-09-15 - 摘要：A pilot study of the scientific meaning of the composition of TCM formulas for treating diabetes was carried out by the association rule analysis technique. 106 Formulas in the TCM literature were collected and the database was established after analyzing the formulas; the association mode of ingredients in the formulas was studied on the platform of SAS’s Enterprise Miner by the use of the association rule analysis. The results showed that as far as the drugs used in combination for treating diabetes was concerned, different experts have similar ideas and principles for treating diabetes. The results indicate that there is a certain scientific rule in the composition of the TCM formulas for treating diabetes; the data mining as a kind of powerful tool for acquiring knowledge may express the composition rule of the TCM formulas in an understandable way, and provide technical supports for the modernization of traditional Chinese drugs.关键词：Diabetes;TCM Formula;Rule of Composition of TCM Formulas;data mining;Association Rule
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发布时间：2021-09-15 -
- 摘要：The mechanism of the acupunctural treatment of depression and the influence of depression on the central nervous system were investigated by puncturing the acupoints of yintang and baihui with electric needles in the rats with depression. The level of monoamine neurotransmitters in the isolated hypothalamus, hippocampus and prefrontal cortex was detected by HPLC ECD after yintang and baihui in the rats with learned helplessness were stimulated with electric needles, 20 minutes each day continuously for 4 days. The results showed that electroacupuncture of yintang and baihui could raise the level of 5 HT and lower the level of 5 HIAA in the rats with learned helplessness. The results suggest that the mechanism of the regulative effects of electroacupuncture of yintang and baihui on depression may be related with the changes in the metabolism of 5 HT and 5 HIAA.关键词：depression;Model of Learned Helplessness;Yintang;Baihui;monoamine neurotransmitter
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发布时间：2021-09-15 -
- 摘要：Hemodynamic parameters of the cunkou pulse were observed by ultrasonic color Doppler blood flow image analysis and Doppler pulse technique in 60 healthy subjects. The hemodynamic parameters of cunkou pulse （at the radial artery）, such as the peak blood flow speed in the systolic phase, blood flow speed in the late diastolic phase, mean blood flow speed, accelerating time, acceleration, decelerating time, deceleration, resistance index, pulsating index, blood flow speed ratio, mean blood flow volume, etc., were examined. The extent of the normal values of cunkou blood flow speed and time, blood flow indexes and mean blood flow volume were initially clarified by observing the healthy subjects by using Doppler techniques. The present study not only provides quantitative criteria for studying the situations of the tone and fluency of TCM pulsation patterns and the changes in the degree of the tension of the cunkou artery, but also possesses certain value for studying the diseases relating with the changes of TCM pulsation patterns.关键词：TCM Pulsation Pattern;Radial Artery;Ultrasonic Doppler;hemodynamics
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发布时间：2021-09-15 - 摘要：The diagnostic significance of the obstruction of subglossal superficial venules （OSSV） in the patients of chronic prostatitis （CP） was investigated. A group of 200 CP patients were involved for studying the relationship between the severity of OSSV and the onset of CP, with 40 healthy subjects as a control group. The examination of OSSV and prostatic fluid was conducted in the patients before and after treatment. The results showed that of the 200 CP patients, 180 manifested OSSV with different severity, while of 40 healthy subjects, only 6 manifested OSSV with different severity and among them, 4 persons were proved to be CP patients by the examination of prostatic fluid. There was a significant difference between the two groups concerning their situation of OSSV （ P <0 005）, which suggests that OSSV possesses the significance of directing the diagnosis of CP.关键词：Chronic Prostatitis;Examination of the Tongue;Subglossal Superficial Venule;Obstruction of Blood Vessel;Collaterals Being Invaded by Persistent Diseases
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发布时间：2021-09-15 -
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