最新刊期
卷 0 ， 期 1 ， 2003
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- 摘要：Philosophy of science is a philosophic branch which analyzes and studies sciences. Based on a point of view of philosophy of science, the authors of this article have analyzed TCM basic theory from three aspects, namely the logic feasibility of TCM basic theory, the testability of TCM basic theory and the potential of TCM basic theory of explaining experience, and discussed the difference between the TCM basic theory and scientific theory, and the possibility of TCM basic theory to develop towards scientific theory. The authors’ purpose is to review TCM basic theory from a new angle of philosophy of science, try to find out some of its shortcomings and seek approaches to its improvement.关键词：TCM Basic Theory;Philosophy of Science;Theoretical Review
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发布时间：2021-09-15 - 摘要：After reviewing the present situation of the study of apoplectic etiology and therapeutics and the difficulties existing in the apoplectic treatment, the author of this article thinks that the basic causes of the undesirable curative efficacy of apoplexy are the complication and blind area of the pathology of apoplexy. The author considers that apoplectic etiology is clearly characterized by toxic heat, and has further put forward a hypothesis of the relationship between toxic heat and apoplexy. The author holds that there are messages of toxic heat in apoplectic onset and development, and that the ten distinguishing characteristics of the toxic heat exist both in the time dimension and space dimension of apoplectic development. The author concludes that the therapy of clearing heat and removing toxins should be the most important treatment of apoplexy.关键词：apoplexy;Toxic Heat;Time Dimension and Space Dimension
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发布时间：2021-09-15 -
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- 摘要：Objective To investigate the effects of medicated serum prepared with Huoxuehuayu Formula （MSPHP） on hepatic stellate cells （HSC） in vitro. Methods The experimental criteria were examined by methods such as cell culture, MTT, and immunohistochemical tests; the normal rat serum was used as a control. Results The proliferation of HSC and the expression of α SMA in HSC were significantly decreased in both MSPHP group and γ IFN group as compared with those in the control group （ P <0 05）. Conclusion MSPHP can resist hepatic fibrosis through inhibiting the proliferation of HSC and the expression of α SMA in HSC.关键词：Medicated Serum Prepared with Huoxuehuayu Formula;Hepatic Stellate Cell;α Smooth Muscle Actin
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发布时间：2021-09-15 - 摘要：Objective To investigate the physiological mechanisms of the seasonal phenomena in the reproduction in rats according to a TCM exposition saying that "the kidney originates and controls life reproduction and corresponds to the winter," which is an important part of TCM visceral theory. Method The changes in the level of luteotrophic hormone （LH） in testicular cell membrane were measured in the rat pinealectomized model by radioligand binding assay in the winter and summer. Results The maximum binding capacity and the equilibrium dissociation constant of LH receptors in the normal control group remarkably increased in the winter and decreased in the summer （ P <0 01）, and there was a significant difference between the number of LH receptors in the normal control group and that in the model group; in the model group, as far as the maximum binding capacity and the equilibrium dissociation constant of LH receptors were concerned, there was no significant difference between those in the winter and those in the summer. Conclusions The seasonal factors can regulate the expression of LH receptors in the rat testicular cell membrane, and the pineal body may be one of the media between the life reproduction and the seasons.关键词：kidney;Reproduction;Season;Pineal Body;Luteotrophic Hormone;rat
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发布时间：2021-09-15 - 摘要：Objective To investigate the influence of tetramethylpyrazine （TMP） and/or verapamil （VP） on the level of daunomycin （DNM） in the umbilical cord blood monocytes. Method According to the fluorescent property of DNM, flow cytometry was used to detect the level of DNM in the monocytes of 6 cases’ DNM containing umbilical cord blood after being incubated with TMP and/or VP in vitro. Results TMP alone could significantly decrease the level of DNM in the monocytes of umbilical cord blood; neither VP alone nor VP and TMP in combination could significantly influence the level of DNM in the monocytes of umbilical cord blood. Conclusion TMP may exert a protective effect on the normal cells by decreasing the intracellular level of anticancer drugs, of which the mechanism is waiting for being studied.关键词：tetramethylpyrazine;Umbilical Cord Blood;Daunomycin;multidrug resistance
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发布时间：2021-09-15 - 摘要：Objectives To compare the protective effects against the injury by cytohypoxia of the main cholic acid like component of porcine gall powder with those of bear gall powder, in order to provide experimental data for the possible substitution of porcine gall powder for bear gall powder for treating apoplectic syndrome in TCM clinical practice. Methods The injury by cytohypoxia was induced by sodium dithionite in the cultured cells of ECV304 cell line; MTT, LDH leakage rate test, and trypanblau staining were used to find the difference between the protective effects against the injury by cytohypoxia of hyodeoxycholic acid （HDCA）, the main component of porcine gall powder, and the same effects of tauroursodesoxycholic acid （TUDCA） and taurochenodesoxycholic acid （TCDCA）, the main components of bear gall powder. Results Sodium dithionite could induce remarkable injury in the cells of ECV304 cell line; all HDCA, TUDCA and TCDCA could relieve the injury by cytohypoxia induced by sodium dithionite significantly as compared with a control （ P <0 001） while no remarkable difference between the effects of HDCA, TUDCA and TCDCA was found. Conclusions HDCA possesses an effect against the injury by cytohypoxia of the cells of ECV304 cell line, which is similar to that of TUDCA, which suggests that porcine gall power can be used to substitute bear gall powder for treating apoplectic syndrome.关键词：ECV304 Cell Line;Injury by Cytohypoxia;Porcine Gall Powder;Bear Gall Powder
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发布时间：2021-09-15 - 摘要：Objective To investigate the effects of Tongnaojing Capsules （TC） on neurological defects and insulin resistance （IR） in the rat model of IR complicated with focal cerebral ischemia （FCI）. Methods The rat model of IR complicated with FCI was established by feeding the rats with high carbohydrate forage first and then, using electrocoagulation of the middle cerebral artery to induce FCI; the effects of TC on the score of neurological defects, blood sugar, serum insulin, C peptide, insulin antibodies and insulin sensitivity indexes （ISI） were observed during the experiment. Results During the establishment of the model, the symptoms of neurological defects showed in different degrees in some rats 4 weeks after they were fed with the high carbohydrate forage; the levels of serum insulin and blood sugar markedly increased （ P <0 01）, the level of ISI remarkably decreased （ P <0 01）, and the level of C peptide lowered while the level of insulin antibodies significantly increased （ P <0 01） 2 weeks after FCI was induced in the model rats; after the treatment of TC, all the above mentioned criteria were improved in different degrees （ P <0 001）. Conclusions IR not only may cause FCI when being a possible independent risk factor, but also may play a role in the entire pathophysiological process of FCI as an FCI pathologic product; and TC can reverse IR and relieve the injuries caused by cerebral ischemia and restore the damaged neurological function to normal through reversing IR.关键词：insulin resistance;cerebral infarction;Rat;TCM;Tongnaojing Capsules
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发布时间：2021-09-15 - 摘要：Objective To investigate the effects of Kanglao Granules （KG） on mouse cellular immune function by observing thickness of thymic cortex, number of the lymphocytes in thymus gland and the spleen, and delayed hypersensitivity in mice. Methods The mice were randomly divided into 6 groups, namely the normal control, blank control, levamisole hydrochloride, KG large dose, KG medium dose, and KG small dose. After KG were given to the treating groups by intragastric administration once a day successively for 14 days, the thickness of thymic cortex and number of the lymphocytes in thymus gland and the spleen were examined in mice. The effects of KG on delayed hypersensitivity were observed in the mice with an injection of sheep red blood cells. Results KG could increase the thickness of thymic cortex and number of the lymphocytes in thymus gland and the spleen, and also enhance delayed hypersensitivity in mice. Conclusion KG can enhance mouse cellular immune function.关键词：Kanglao Granules;Cellular Immune Function;lymphocyte;Delayed Hypersensitivity;mouse
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发布时间：2021-09-15 - 摘要：Objective To investigate the effects of Ganjie Powder （GP） on the levels of procollagen Ⅲ （PCⅢ）, hyaluronic acid （HA） and laminin （LN） in the serum and hepatic homogenate in the mice with hepatic fibrosis. Methods The mice with CCl 4 induced hepatic fibrosis were treated with GP and colchicines; routine methods were used to observe the changes in liver function and the degree of hepatic fibrosis, and radioimmunoassay was used to measure the levels of PCⅢ, HA and LN in the serum and hepatic homogenate in the model mice in the 4th, 8th and 12th week respectively after the start of the treatment. Results The levels of PCⅢ, HA and LN started to increase in the 4th week and continued to increase along with the severity of liver dysfunction and hepatic fibrosis in the model mice; after the treatment of GP, the damage of liver function got relieved and the degree of hepatic fibrosis got decreased; and the levels of PCⅢ, HA and LN in the serum and homogenate got decreased remarkably （ P <0 01）. Conclusion GP may have direct effects on the sedimentation, decomposition and metabolism of extracellular matrix, such as PCⅢ, HA and LN.关键词：Ganjie Powder;hepatic fibrosis;extracellular matrix
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发布时间：2021-09-15 - 摘要：Objective To investigate, on the basis of cytokines and free radicals, the curative effects of the formula consisting of active components of Huangqin Decoction （HD） and the mechanisms of the effects on experimental ulcerative colitis in the rats. Method The rat model of ulcerative colitis was induced with 2,4,6 trinitrobenzene sulfonic acid. Results There was a significant difference between the levels of IL 1β, IL 4, SOD and MDA in the rats in the model group and those in the normal control group （ P <0.01）; the levels of IL 1βand MDA were remarkably decreased and the levels of IL 4 and SOD were markedly increased by a medium dose of HD, as compared with the results from the model group （ P <0.01）. Conclusion The formula consisting of active components of HD can cure ulcerative colitis in rats through improving and adjusting the levels of cytokines and free radicals.
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发布时间：2021-09-15 - 摘要：Objective To investigate the gastric adaptive cytoprotection of ammonia and its mechanisms. Methods Ammonia of different concentrations was given by intragastric administration to mice at different times in order to observe the time effect and dose effect relationships in the gastric homocytoprotection of ammonia; acute damages of gastric mucosa were induced by absolute alcohol in mice in order to observe the cross cytoprotection of ammonia of different concentrations against the damages; and indomethacin, N nitro L arginine methyl ester and capsaicin were given to the mice in advance in order to observe the influence of these drugs on the gastric homocytoprotection of ammonia. Results 15 mmol·L -1 and 30 mmol·L -1 ammonia showed remarkable effects of homocytoprotection on gastric mucosa; 15 mmol·L -1 , 30 mmol·L -1 and 60 mmol·L -1 ammonia showed no effects of cross cytoprotection against the damages of gastric mucosa; and indomethacin, N nitro L arginine methyl ester and capsaicin showed marked effects against the gastric homocytoprotection of ammonia. Conclusion Ammonia has the effects of gastric homocytoprotection in mice, which may be related with its activating the passways of sensory nerves, endogenous prostaglandin and nitric oxide.关键词：Ammonia;Cytoprotection;mice;Gastric homocytoprotection
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发布时间：2021-09-15 - 摘要：Objective To investigate the chemical constituents of the aqueous extract of Rhaponticum uniflorum （L.） DC. Methods The chemical constituents of the aqueous extract were isolated and purified by various chromatographic techniques and their structures were elucidated by their physicochemical properties and spectral data. Results 4 compounds including arctic acid, ecdysterone, turkesterone and liquiritin were isolated and identified. Conclusion All the four compounds are isolated from the aqueous extract of Rhaponticum uniflorum for the first time and liquiritin is first found in Rhaponticum genus.关键词：Rhaponticum uniflorum;chemical constituent;liquiritin
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发布时间：2021-09-15 - 摘要：Objective To establish a method for determining puerarin quantitatively in the active part of the extract of Shenshaoxinxin Formula. Method A HPLC method was designed, which was performed under the following conditions: YWG G 18 column （250 mm×4 6 mm, 10 μ） as the chromatographic column, methanol water （15∶85） as the mobile phase at a flow velocity of 1 ml/min, and the wavelength of 250 nm as the detecting wavelength. Results The average recovery was 103 4%, and RSD was 1 16% （ n =5）. Conclusion This HPLC method is easy and accurate, and can be used as one of the methods for controlling the quality of the active part of the extract of Shenshaoxinxin Formula.关键词：Shenshaoxinxin Formula;puerarin;HPLC;Quantitative Detection
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发布时间：2021-09-15 - 摘要：Objective: To observe the correlation between TCM syndromes and the levels of plasmatic endothelin （ET） and nitric oxide （NO） in the patients of acute cerebral infarction （ACI）. Method: The ACI patients involved in the clinical study were divided into the ACI group of phlegm heat （PH）, ACI group of qi yin deficiency （QYD）, ACI group of yang hyperactivity due to yin deficiency （YHYD） and ACI group of qi deficiency （QD）; the levels of ET and NO were detected in the four groups. Results: It was found that there was a significant difference between the level of NO in the ACI group of PH and the ACI group of QYD, and that in other ACI groups; there was a significant difference between the level of ET in the ACI group of YHYD and that in other ACI groups while there was no significant difference between the level of ET in the ACI group of （QD） and that in the ACI group of （QYD）; and there was a significant correlation between the level of ET and that of NO. Conclusion: The results suggest that the levels of ET and NO correlate to the TCM syndromes in ACI patients with certain specificity, and can be used as a microcosmic criterion for diagnosing ACI by TCM syndrome differentiation.关键词：cerebral infarction;TCM syndrome;nitric oxide;endothelin
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发布时间：2021-09-15 - 摘要：Objective To investigate the clinical effects of the nourishing qi and activating circulation therapy （NQACT） on frequent transient ischemia attack （TIA） and study their mechanisms. Methods 58 Cases of TIA patients were chosen and randomly divided into the group of NQACT and the group of activating circulation and removing stasis therapy （ACRST）. Before and after the treatment by NQACT and ACRST, the levels of endothelin （ET） and nitric oxide （NO）, the values of prothrombin time （PT） and activated partial thromboplastin time （APTT）, and the level of fibrin （FIB） were detected in the TIA patients involved in the clinical trial; and the results were compared with those from the normal control subjects. Results Before the treatment by NQACT and ACRST, the levels of ET and NO were found markedly increased in the TIA patients （ P <0 01）; after the treatment, the level of ET was lowered, the level of NO was found to be only with a rising tendency, and the ratio of ET/NO was decreased; the degree of the decrease of above mentioned criteria was found bigger in the NQACT group than that in the ACRST group （ P <0 01） while the values of PT, APTT and FIB were not changed so much. Conclusion The results suggest that one of the main mechanisms of the effects of NQACT in treating TIA is protecting TIA patients against the damages of cerebral ischemia by improving vascular endothelial function and adjusting the dynamic balance between ET and NO.
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发布时间：2021-09-15 -
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- 摘要：Objective To investigate the effects of electroacupuncture of shuigou point with or without the help of venoruton on the level of calmodulin in the cerebral ischemic region in rats. Method The rat model of cerebral ischemia and reperfusion was used to observe the changes in the level of calmodulin after puncturing shuigou point with electric needles alone, or puncturing shuigou point with electric needles and orally giving venoruton at the same time. Results The level of calmodulin was found increased in the model rats, and both electroacupuncture and electroacupuncture plus oral administration of venoruton could markedly lower the increased level of calmodulin in the cerebral ischemic region; and the effects of electroacupuncture plus oral administration of venoruton were better than those of electroacupuncture alone. Conclusion Venoruton can enhance the effects of puncturing shuigou point with electric needles.关键词：Shuigou Point;Combination of Acupuncture and Drug Therapy;cerebral ischemia;Calmodulin
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发布时间：2021-09-15 - 摘要：Objective To investigate the skin electric resistance time and plasmatic drug concentration time changes after applying the aminophylline sticking film to the common antiasthmatic acupoints, the influence of different antiasthmatic acupoints on the transdermal absorption of aminophylline, and the difference between the effects of acupoint drug administration of different antiasthmatic acupoints. Methods HPLC UV method was used to detect the level of aminophylline in the plasm and the electric resistance detecting apparatus was used to measure the electric resistance of the skin in rabbits. Results The electric resistance time curve was coincident with the second function. As far as the values of electric resistance were concerned, feishu point, shanzhong point and geshu point were extremely different from the non acupuncture points （ P <0 01）; dingchuan point was markedly different from the non acupuncture points （ P <0 05）; and there was no remarkable difference between different antiasthmatic acupoints （ P >0 05）. The plasmatic drug concentration time curve was approximately coincident with zero order release. As far as the plasmatic drug concentration after applying the aminophylline sticking film was concerned, feishu point and shanzhong point were extremely different from the non acupuncture points （ P <0 01）; geshu point was markedly different from the non acupuncture points （ P <0 05）; feishu point and shanzhong point were extremely different from geshu point （ P <0 01）; and feishu point was remarkably different from shanzhong point （ P <0 05）. In addition, there was a negative correlation between the plasmatic drug concentrations and the values of the skin electric resistance related with the various antiasthmatic acupoints. Conclusion The results of the experiment can provide data for clinical acupoint drug administration.
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发布时间：2021-09-15
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