最新刊期
卷 0 ， 期 3 ， 2003
- 摘要：Objective To discuss the characteristics of TCM syndromes and the approaches to the standardization of TCM syndromes. Method The author discusses the characteristics of TCM syndromes on the concepts of dimensions and ranks, and holds that TCM syndromes are the onditions of different factors （dimensions） in different correlations （ranks）. The factors of TCM syndromes are multidimensional, and the ranks of TCM syndromes reflect the complicacy of the interrelationship between the factors. The management of the ranks of TCM syndromes mainly depends on the kinds of corresponding intervention. Results One of the important approaches to TCM syndrome standardization is the organic integration of "reducing dimensions and increasing ranks" and "reducing both dimensions and ranks" as well as the the construction of the "decision-making tree of TCM syndrome diagnostics;" that means, on the one hand, to reduce the dimensions of the main factors of TCM syndromes, in order to standardize their corresponding characteristic messages and extract their multilevel combinations of effective messages; on the other hand, to work out the strategies for selecting the factors of TCM syndromes by increasing or reducing their ranks in order to fit for the flexible TCM syndrome differentiation and the intervention of different diseases and different human subjects. The results of doing so are grasping the generality of TCM syndromes, and representing the individuality of TCM syndrome differentiation as well. Conclusion: Differentiating and analyzing the dimensions and ranks of TCM syndromes is helpful to introducing multidisciplinary methods including mathematics, physics and informatics to develop new approaches to the standardization of TCM syndromes.关键词：TCM syndrome;Dimension;Rank
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发布时间：2021-09-15 -
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- 摘要：Objective To investigate whether the total saponin from Panax notoginseng （TSPN） can promote the synthesis and secretion of bFGF and the proliferation of the neural stem cells after cerebral injury. Method To detect the expressions of Nestin and bFGF in the subependyma of the forebrain lateral ventricle in the adult rats with cortical devascularization before and after the TSPN administration, by the immunohistochemical techniques. Results Both the number of Nestin and the expression of bFGF in the subependyma of the forebrain lateral ventricle were markedly increased after the rats with cortical devascularization were give TSPN. Conclusion TSPN can promote the synthesis and secretion of bFGF in the subependyma of the forebrain lateral ventricle, which may further stimulate the proliferation of the neural stem cells.关键词：Total Saponin from Panax notoginseng;Neural Stem Cell;cell proliferation;Subependyma;Cortical Devascularization
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发布时间：2021-09-15 - 摘要：Objective To observe the effects of Qingkailing Injection （QI） on the indexes of the blood gas in the rabbits with cerebral hematoma. Method The rabbit model of cerebral hematoma was established by the intracranial burying of the autogenous clot, and the changes in the indexes of the blood gas at different times after the formation of cerebral hematoma were detected. Results The rabbits manifested overventilation after the formation of cerebral hematoma, showing a mixed acid-base dysequilibrium: metabolic acidosis complicated by respiratory alkalosis. The overventilation was relieved to some degree after the administration of QI. Conclusion QI can reduce overventilation and correct acid-base dysequilibrium to some extent.关键词：Qingkailing Injection;Cerebral hematoma;Blood Gas;Rabbit
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发布时间：2021-09-15 - 摘要：Objective To observe the preventive effects of Tongmaining Capsules （TC） on the restenosis after percutaneous transluminal angioplasty （PTA） and initially investigate the mechanism of the effects of TC. Methods The rabbit model of the restenosis after PTA was established by carotid balloon injury method. The rabbits were randomly divided into 5 groups （10 animals in each group）, namely the sham operation, control, TC large dose, TC middle dose, and TC small dose. The animals in the sham group were only given external carotid artery ligation without balloon injury. After the carotid balloon injury, the animals in the rest 4 groups were intragastrically given 0.5% suspension of sodium carboxymethyl cellulose, 10 ml/kg·d -1; TC, 1.64 g/kg·d -1; TC, 0.82 g/kg·d -1; and TC, 0.41 g/kg·d -1, respectively; and all the doses were given successively for 21 days. 1 Hour after the administration on the 21st day, the animals in each group were executed and their internal carotid arteries were isolated for observing the morphological changes of the carotid artery wall by macroscopical observation and hematoxylin-eosin staining, and for detecting collagen formation of the vascular wall and the expressions of VEGF and bFGF by Masson staining and immunohistochemical techniques, with the help of an image analysis system to make semiquantitative analyses. Results On the 21st day after undergoing PTA, the carotid arteries of the rabbits in the control group showed markedly thickened tunica intima and smooth muscle cell proliferation, rather thickened tunica media and an increase in vascular wall collagen, and increased expressions of VEGF and bFGF as well, as compared with the sham operation group （P<0.01）. The large dose of TC （1.64 g/kg·d -1） could markedly reduce the thickness of the tunica intima and tunica media, lessen the collagen in the carotid artery wall, and decrease the expressions of VEGF and bFGF, as compared with the control group （P<0.05, P<0.01）, but the values of these criteria were still higher than those found in the sham operation group （P<0.01）. The middle and small doses of TC （0.82 g/kg·d -1, 0.41 g/kg·d -1） only slightly affected some of the above-mentioned criteria without significant difference as compared with the control group （P>0.05）. Conclusion Large dose of TC exert certain preventive effects on the restenosis after PTA, which may be related to its decreasing the expressions of VEGF and bFGF in the smooth muscle cells of carotid artery wall.关键词：Tongmaining Capsules;Angioplasty;Restenosis;Rabbit
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发布时间：2021-09-15 - 摘要：Objective To investigate the effects of Jianpizhixie Granules （JG） on the intestinal flora and small intestine mucosa in the mice with diarrhea of splenic deficiency type. Methods The mouse model of diarrhea of splenic deficiency type was induced with 100% liquid rhubarb water extract, and the effects of JG on the intestinal flora and the repair of small intestine mucosa were studied in the model with the transmission electron microscope. Results JG could regulate the intestinal flora in the mice with experimental diarrhea of splenic deficiency type and markedly reduce the injury of epithelial microvilli of the small intestine. Conclusion JG exerts its curative effects by regulating the balance of intestinal micro-ecology and improving the structure of microvilli of the absorptive cells of the small intestine.关键词：Jianpizhixie Granules;Diarrhea of Splenic Deficiency Type;intestinal flora;ultrastructure
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发布时间：2021-09-15 - 摘要：Objective To induce chronic graft versus host disease （GVHD） model and observe the effects of Bushenqingredu Formula （BF） on the disease model. Methods The chronic GVHD model was induced in F1 mice （DBA/2×C57BL/6j） by injecting their female parent’s DBA/2 lymphocytes through the caudal veins, and the model was put under observation for 12 weeks. 4 Weeks after the model inducement, the mice were randomly divided into TCM drug group, prednisone group, model group. The control group was composed of the F1 mice not undergone the model inducement. 8 Weeks after the drug administration, the criteria such as auto-antibody, serum creatinine, blood urea nitrogen, and renal pathologic changes were observed in the mice after their execution. Results Only mild proliferation of mesangial cells was found and no interstitial damage was seen 4 weeks after the model inducement; while 12 weeks after the model inducement, changes in the pathologic criteria under observation were remarkable, mainly characterized by a large amount of subcutaneous fuchsinophilic deposites, renal tubular protein casts and a large area of infiltration by inflammatory cells in the renal interstitium, and focal or segmental glomerular sclerosis; and immunofluorescence showed that IgG and C3 deposited along capillary blood vessels. Both BF and prednisone could decrease the levels of urinary protein, auto-antibody, serum creatinine and blood urea nitrogen; BF also showed a cholesterol-reducing effect. Both BF and prednisone were effective for treating mild proliferation of mesangial cells. Conlusion The mouse model of chronic GVHD, which is alike to human lupus nephritis, can be used as a good model of lupus nephritis. BF exerts a curative effect in the early stage of lupus nephritis.关键词：Chronic Graft Versus Host Disease;Model of Lupus Nephritis;Bushenqingredu Formula;curative effect
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发布时间：2021-09-15 - 摘要：Objective To investigate the mechanisms of the effect of Compound Rhubarb Antiaging Preparation （CRAP） for enhancing memory. Method The changes in the levels of Ach and AchE and in the activities of various kinds of peroxydase were detected in the brain in 12-month-old mice and the mice with cerebral malfunction induced by D-galactose. Results CRAP could markedly increase, when given at a large dose to both 12-month-old mice and the mice with cerebral malfunction induced by D-galactose, the activities of cortical CAT and GSH-px, decrease the activity of AchE, and increase the level of Ach （P<0.05 or P<0.01）; and also could markedly increase the activities of cerebellar SOD, CuSOD and Mn-SOD, and decrease the level of LPO （P<0.05 or P<0.01）. When given at a small dose to both 12-month-old mice and the mice with cerebral malfunction induced by D-galactose, CRAP could remarkably increase the activity of cortical CAT （P<0.05 or P<0.01）, and decrease the level of cerebellar LPO （P<0.05 or P<0.01）. Conclusion The effect of enhancing memory of CRAP is close related with its actions of increasing the activities of CAT, GSH-px and SOD, inhibiting the activity of AchE, and increasing the level of Ach.
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发布时间：2021-09-15 - 摘要：Objective To study the immunoregulatory effects of Zhongjiling （ZJL）, a TCM compound preparation, in the rats with experimental autoimmune myasthenia gravis （EAMG）. Methods Lewis rat was used to establish the EAMG model. There were 4 rat groups in the experiment, namely the normal control, CFA, model, and ZJL. The immunoregulatory effects of ZJL on EAMG were observed through detecting the changes in the N 2AchR-induced specific proliferation reaction of the lymphocytes in lymph nodes, serum AchRab titer, and the levels of serum IL-4 and IFN-γby JH3,D,Z-TdR permeation method and ELISA. Results In the ZJL-group, as compared with the model group, the N 2AchR-induced specific proliferation reaction of the lymphocytes in lymph nodes was inhibited （P<0.01）, the serum AchRab titer was lowered （P<0.01）, and the levels of serum IL-4 and IFN-γ were downregulated （P<0.01）. Conclusion The mechanism of the immunoregulatory effects of ZJL may be downregulating the levels of serum IL-4 and IFN-γ, inhibiting the specific proliferation reaction of the lymphocytes in lymph nodes, and restraining the production of AchRab.关键词：Model of Experimental Autoimmune Myasthenia Gravis;Zhongjiling;Immunoregulation
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发布时间：2021-09-15 - 摘要：Objective To investigate the effects of Guominkang Capsules No.2 （GC-2） on male immune infertility and to initially study the mechanism of the effects of GC-2. Methods NIH male mouse was used to establish the antisperm antibody （AsAb）-positive model by active immunity method. Prednisone acetate and GC-2 were intragastrically given to the mice during the establishment of the model, respectively, to observe the effects of the two drugs on the serum AsAb in the mice. Results The serum AsAb absorption values measured in the mice in all the three groups with different GC-2 doses were remarkably lower than that measured in the mice in the model group （P<0.01）. Conclusion GC-2 can inhibit the production of AsAb. The results of the experiment provide evidence for using GC-2 to treat AsAb-positive immune infertility.关键词：Guominkang Capsules No.2;Antisperm Antibody;TCM Treatment
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发布时间：2021-09-15 -
- 摘要：Objective To observe the protective effects of Honghua Injection （HI）, which is prepared from a traditional Chinese drug named honghua （the flower of Carthamus tinctorius）, on rat isolated hearts. Methods Isolated rat hearts were preserved in a modified Euro-Collins solution （mEC） containing HI for 20 hours with pure mEC as a control. Langendorff’s isolated rat heart reperfusion method was adopted to re-perfuse the preserved isolated hearts. 40 Minutes after the repersusion, the cardiac functions, coronary flow condition, myocardial water content, activities of LDH and CK in the coronary fluid, and myocardial SOD activity and MDA level were measured. Results In HI-mEC group, the cardiac functions and coronary flow condition were markedly better （P<0.01）, myocardial water content was lower but with no statistical significance, LDH and CK activities were remarkably lower （P<0.01）, SOD activity was higher （P<0.05）, and MDA level was lower （P<0.01）, as compared with the criteria measured in mEC group. Conclusion Honghua can exert very good effecs for preserving isolated rat hearts, the mechanism of which maybe relates to its actions of resisting oxygen free radical injuries and expanding coronary arteries.关键词：Honghua （the Flower of Carthamus tinctorius）;Langendorff’s Isolated Rat Heart Model;Isolated Heart Preservation;Euro-Collins Solution
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发布时间：2021-09-15 - 摘要：Objective To establish a RP-HPLC method for quantitatively determining baicalin and puerarin in the effective fraction of Gegenqinlian Decoction. Method The YWG-C 18 column （250 mm×4.6 mm, 10 μm） was used. The mobile phase for determining baicalin was methanol-water-phosphoric acid （47∶53∶0.2） at a flow rate of 1.0 ml/minute, and the detecting wavelength was 280 nm; and the mobile phase for determining puerarin was methanol-water （25∶75） at a flow rate of 1.0 ml/minute, and the detecting wavelength was 250 nm. Results The average recovery of baicalin was 98.61%, and RSD was 2.77% （n=5）; and the average recovery of puerarin was 102.4%, and RSD was 2.70% （n=5）. Conclusion This method is easy and accurate, and can be used for controlling the quality of the effective fraction of Gegenqinlian Decoction.关键词：Gegenqinlian Decoction;baicalin;puerarin;RP-HPLC;quantitative determination
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发布时间：2021-09-15 - 摘要：Objective To research into the factors affecting the ephedrine extraction from the ephedra stems used as an ingredient in the recipe of the Chuankeping Granules, and to optimize the technology of ephedrine extraction. Method With ephedrine as an experimental criterion, the orthogonal design （4 factors and 3 levels） and HPLC were used to optimize the technology of ephedrine extraction from the ephedra stems. Results It was found that alcohol was important for the extraction technology. Conclusion The best technology of the ephedrine extraction from the ephedra stems is extracting with 70% alcohol for 3 times: the first time, extracting with 8-fold 70% alcohol for 2 hours; the second time, with 6-fold 70% alcohol for 1 hour; and the third time, with 4-fold 70% alcohol for half an hour.关键词：Chuankeping Granules;orthogonal test;Ephedrine;Technology of Extraction
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发布时间：2021-09-15 - 摘要：Objective To compare the contents of total flavone and ursolic acid in the fresh and dried-in-the-shade paotonghua （flower of Paulownia tomentosa）. Method Spectrophotometry was used to determine the contents of total flavone in the fresh and dried-in-the-shade paotonghua, and TLC-scanning was used to determine the contents of ursolic acid in the fresh and dried-in-the-shade paotonghua and in the water extract of the fresh paotonghua. Results The contents of total flavone and ursolic acid in the dried-in-the-shade paotonghua were 3.081% and 426.21 mg/100 g, respectively; the contents of total flavone and ursolic acid in the fresh paotonghua were 1.231% and 62.35 mg/kg, respectively. Conclusion The contents of total flavone and ursolic acid in the dried-in-the-shade paotonghua are higher than those in the fresh paotonghua.关键词：Paotonghua （Flower of Paulownia tomentosa）;Total Flavone;ursolic acid;TLC-Scanning
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发布时间：2021-09-15 -
- 摘要：Objective To investigate the correlation between the cognitive impairment and TCM syndromes after the onset of basal ganglia infarction. Methods 82 patients with cognitive impairment after the onset of basal ganglia infarction were assessed by using the neuropsychological examination scales and TCM syndrome differentiation. 30 Cases without basal ganglia infarction approved by cranial CT were included in the coutrol group. The analysis of the correlation between the relevant criteria was carried out by Logistic regression analysis. Results The most TCM syndromes of the cognitive impairment manifested after the onset of basal ganglia infarction were kidney-essence deficiency, phlegm-turbidness, and blood stagnation. It was found that there was a negative correlation between the cognitive scores and the following two syndromes, namely the syndrome of mentality obstruction by phlegm-turbidness and the syndrome of fu-organ turbidness stagnation, i.e. the severer the two syndromes were, the lower the cognitive scores tended to be. It was also found that the interaction of the exuberance of internal heat toxin and fu-organ turbidness stagnation enlarged the risk of the onset of dementia after basal ganglia infarction. Conclusion There is a correlation between the cognitive impairment after basal ganglia infarction and the two TCM syndromes, namely the syndrome of mentality obstruction by phlegm-turbidness and the syndrome of fu-organ turbidness stagnation; and the analyisis verifies the existence of the two TCM syndromes in the course of the development of vascular dementia.关键词：Basal Ganglia Infarction;Cognitive Impairment;Neuropsychology;TCM syndrome
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发布时间：2021-09-15 - 摘要：Objective Based on the efficacy of pelvic cavity administration （PCA） of Tongyu Injection （TI） given by fallopian tube under indirect vision for the treatment of external endometriosis （EEMs）, to investigate the mechanism of the TCM therapy of activating circulation and removing stasis for the treatment of EEMs, and to study the advantage of PCA. Methods 60 EEMs cases were randomly divided into TIgroup and danazolgroup, and the course of treatment for both groups was 3 months. The positive rates of the changes in clinical symptoms and signs, endocrine hormones, blood rheology, CA 125 and endometrial antibody （EMAB） were detected before and after the administration. Results The positive rates of the changes in the clinical symptoms and signs, blood viscosity and packed cell volume, CA 125 and EMAB were decreased, and the levels of follicule-stimulating hormone, luteotropic hormone, estradiol and progestogen were regulated in the TIgroup; the results were statistically significant as compared with those from the danazol-group. The endocrineregulative effects of TI were found to be weaker than those of danazol, but they were of a mild and balanced nature. Conlusion TI exerts its effects on EEMs by clearing out the menstruous blood stasis and edema in ectopic endometria, improving microcirculation and tissue oxygen supply, and regulating immune dysfunction and endocrine disorder. TI shows weaker side effects than does danazol, and acts mainly on the cause of the disease. TI given by PCA can make the drug directly act on the focus and exert fast effects.关键词：Tongyu Injection;External Endometriosis;Pelvic Cavity Administration;clinical trial
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发布时间：2021-09-15 - 摘要：Objective To observe the effects of Xinmaian Tablets （XT） on ventricular premature bearing in the patients with coronary heart disease. Methods 60 Cases of coronary heart disease with ventricular premature bearing were randomly divided into the treating group （40 cases） and the control group （20 cases）; the former was given XT and the latter, Wenxin Granules （WG）. The 24-hour dynamic electrocardiogram was observed before and after the treatment in the patients. Results The total effective rates of XT in treating ventricular premature bearing and the ventricular premature bearing frequency were 70% and 60%, respectively; and those of WG, 65% and 55%, respectively. There were no significant differences between the effective rates and total effective rates in the two groups （P>0.05）. Conclusion XT exerts a rather good effect on the ventricular premature bearing in the patients with coronary heart disease of qi-yin deficiency and cardiac blood stagnation type.关键词：Coronary Artery Disease;Ventricular Premature Bearing;Xinmaian Tablets
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发布时间：2021-09-15 - 摘要：Objective To investigate the effects of Feikang Formula （FF） on chronic obstructive pulmonary disease （COPD） complicated by pulmonary hypertension and the mechanism of the effects of FF. Methods 60 Cases of COPD complicated by pulmonary hypertension were randomly divided into the FF-group and the nifedipine-group （30 cases in each group）. The changes in the mean pulmonary artery pressure, major clinical symptoms, pulmonary functions, blood gas, blood rheology, and the levels of endothelin （ET） and calcitonin gene-related peptide （CGRP） were observed in both groups. Results Both FF and nifedipine could decrease pulmonary hypertension, regulate the balance between ET and CGRP. In addition, FF showed effects of improving pulmonary functions and the indexes of blood gas and blood rheology while nifedipine showed no such effects. Furthermore, FF showed better effects in reducing such symptoms as cough, cough with sputum, and lack of strength, as compared with nifedipine. Conclusion The effects of FF in the treatment of COPD complicated by pulmonary hypertension are better than those of nifedipine, and FF shows a rather good future in clinical application.关键词：Feikang Formula;chronic obstructive pulmonary disease;Pulmonary Hypertension;clinical trial
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发布时间：2021-09-15 -
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- 摘要：Objective To investigate the effects of the combination of acupuncture and drugs on the levels of serum calcitonin gene-related peptide （CGRP） and endothelin （ET） in the rats with vascular dementia. Methods The rat model of vascular dementia was induced by the bilateral carotid ligation-reperfusion method. The changes in the behavior of the rat model were observed by platform jumping test, and the changes in the levels of serum CGRP and ET were detected by radioimmunoassay. Results There was a significant difference between the changes in the experimental criteria in the model group and those in the control group. The results showed that both the combination of acupuncture and the western-style drug （CAWD） and the combination of acupuncture and the TCM drug （CATCMD） were effective, but the effects of the former were better than those of the latter. Conclusion The fact that acupuncture, the TCM drug and western-style drug all showed some kind of effect, respectively, on the experimental criteria implies that the mechanisms of their effects are different; but both CAWD and CATCMD showed synergistic effects in the experiment, and especially, better effects were found with CAWD, which might be related to their changing the levels of CGRP and ET, and improving the blood supply to the brain.关键词：acupuncture;vascular dementia;calcitonin gene-related peptide;endothelin
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发布时间：2021-09-15
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