最新刊期
卷 0 ， 期 4 ， 2003
- 摘要：The five zang organs model is a product of Chinese classical philosophy and the thought of mediation and integration. The five zang organs system is a polynary, multivariate and nonlinear system. The five zang organs model is not a morphological model, but a ultra morphological and relational model of function classification. The significance of the five zang organs regulation model is mainly showed by its different modes of regulation, namely external regulation, internal regulation, self organizing regulation, immediate regulation, after regulation, before regulation, unary regulation, binary regulation, and polynary regulation. The shortcomings of the five zang organs model are defects in its classification and functional relations. However, the defect in the classification of the five zang organs model is not an actual shortcoming because all the ultra morphological function models always try to classify the complicated life phenomena into some limited and simple categories, and the TCM practice proves the five zang organs model to be an optimized one. In fact, the shortcoming of the five zang organs model is in the relationship between the five zang organs functions and five zang organs relations, which can be perfected through clinical practice.关键词：Five Zang Organs;five elements;Functional Regulation;Self Organizing System
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发布时间：2021-09-15 -
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- 摘要：After analysing the existing problems in the clinical practice of making TCM formulas, the authors of this article point out that at present, there are some phenomena worth paying attention to, for example, the confused formulas and over dosage formula ingredients; although the integration of the syndrome differentiation and the disease differentiation is emphasized in making TCM formulas, it is rarely discussed how to make actual organic integration of them; and the efficacy of TCM patent medicines is not easy to be assured because their indications are not clearly understood and there is no rational combination us of them in clinical application. The authors hold that in order to meet the clinical need, it is necessary to think that the skills of making TCM formulas is a foundation of TCM clinical practice, and it is necessary to strengthen the research on the regularity of the development of TCM diseases and syndromes, carry out systematic research on the latent pathogenesis of TCM diseases and syndromes, and investigate the principles and regularity of making TCM formulas by practising the theories of the correlation between formulas and syndromes and the correlation between diseases and syndromes.关键词：Study of TCM Formulas;Clinical Practice;TCM Formula Making;Integration of Diseases and Syndromes;Latent Pathogenesis
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发布时间：2021-09-15 -
- 摘要：we obseved the effect of 3,4 oxo isopropylidene shikimic acid （ISA） on the the PGI 2 release in human umbilical vein endothelial cells. Radioimmunoassay was used to assess 6 keto prostaglandin F 1α （6 keto PGF 1α ）. Cell viability was assessed by MTT assay. The release of NO was assessed by colorimetry. The results showed that ISA increased the level of 6 keto PGF 1α in normal and H 2O 2 induced HUVEC. ISA had no effect on the viability and the NO release of the normal HUVEC So we conclude ISA incresed the PGI 2 release, which is related to the antithrombosis effect of ISA.关键词：oxo isopropylidene shikimic acid;vascular endothelial cell;6 keto PGF 1α
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发布时间：2021-09-15 - 摘要：Objective To establish a comprehensive assessment method used for analyzing the optimized dosage of the ingredients in TCM formulas on the basis of processing the experimental data from the dog with experimental acute myocardial ischemia treated by 7 different dosage combinations of danshen （Salvia miltiorrhiza） and sanqi （Panax notoginseng） in order to meet the need of analyzing and predicting the optimized dosage of ingredients when composing TCM formulas. Method A method of multi objective optimization and fuzzy comprehensive assessment was used in this study. Results The general efficacy and the tendency of efficacy of different dosage combinations of danshen and sanqi were clarified. It was found that the ratios of danshen to sanqi as 10∶6 and 10∶3 were the best of all the ratios for relieving the pathologic changes in the experiment, and the effectiveness of the two ratios was about equal to that of isosorbide dinitrate. Conclusion The method of multi objective optimization and fuzzy comprehensive assessment is suitable to be used in the comprehensive assessment of the optimized ratios of the ingredients of the TCM patent drugs under the secondary development.
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发布时间：2021-09-15 - 摘要：Objective To investigate the effects of Qingfei Decoction （QD） on the level of the plasma endothelin （ET） in the mice infected by influenza virus in the respiratory tract. Methods The model was induced by the intranasal influenza virus inoculation, and the level of ET was measured by radioimmunoassay. The effects of QD were observed in the model. Results It was found that the level of ET was 91 87±18 41 pg/ml in the model mice received QD therapy, which was less than that was found in the model mice not treated by QD （ P <0 05）. Conclusion QD possesses rather good effects in relieving the respiratory symptoms and reducing the level of plasma ET.关键词：Qingfei Decoction;Virus Infection of Respiratory Tract;endothelin
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发布时间：2021-09-15 - 摘要：Objective To observe the changes in the abilities of learning and memory and the changes of （the brain derived neurotrophic factor） BDNF and （the glial cell line derived neurotrophic factor） GDNF in the of substantia nigra and hippocampus in the rat model of mimic Huntington’s disease, and to observe the interfering effects of Shenwu Capsules （SC） on these changes. Methods The SD rat model of Huntington’s disease was established by peritoneal injection of 3 nitropropionic acid, the mitochondrial respiratory chain complex Ⅱ/Ⅲ inhibitor, 20 mg/kg, once every other day, successively for 20 days. During the period of establishing the model, the rats in the treating group were intragastrically given SC successively for 25 days. The rats in the positive control group were given haloperidol on the first day when the model inducement began. The Morris water maze and step through tests were used to test the rat’s abilities of learning and memory. The immunohistochemical staining was used to detect the numbers and areas of the BDNF positive and GDNF positive neurons in the CA1 and CA4 areas of the hippocampus. Results The results of Morris water maze test showed that the swimming time and distance of the rats in the model group were markedly prolonged as compared with those in the rats in the control group, and SC could remarkably shorten the swimming time and distance of the rats. The results of the step through test showed that the latency for going into the dark chamber in the rats in the middle SC dose group and large SC dose group was prolonged for 56.69 and 54.24 seconds respectively as compared with that in the rats in the model group. The numbers of the expressions of the BDNF positive and GDNF positive neurons in the hippocampal CA1 and CA4 areas of the rats in the model group were less than those in the rats in the normal control group, and the total stained area of the positive neurons also became decreased; but the expressions of the BDNF positive and GDNF positive neurons were markedly enhanced in the same hippocampal areas in the rats in the middle SC dose （ P >0 01）. Conclusion SC can remarkably enhance the abilities of learning and memory of the rats and increase the expressions of BDNF and GDNF in the hippocampus.关键词：Nitropropionic Acid;Huntington’s Disease;neurotrophic factor;rat
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发布时间：2021-09-15 - 摘要：Objective To investigate the effects of four classical TCM formulas for mediating the spleen and stomach on cerebral neuropeptide transmitters in the rats. Methods SD rats were intragastrically given Buzhongyiqi Decoction, Dachengqi Decoction, Guipi Decoction, Wendan Decoction and double distilled water respectively for 15 days and then, the levels of SS, SP, VIP and NPY in the cerebral cortex and hippocampus were measured by radioimmunoassay. Results The results showed that Buzhongyiqi Decoction could markedly reduce the level of VIP and raise the level of NPY in the cerebral cortex, Dachengqi Decoction could decrease the levels of SS and SP in the cerebral cortex and the level of VIP in the hippocampus, Guipi Decoction could increase the level of SS in the cerebral cortex, and Wendan Decoction could lower the level of VIP in the hippocampus. Conclusion All the four formulas exert effects on the levels of cerebral neuropeptide transmitters to different degrees, which may be one part of the biological base of the psychological effects of the TCM decoctions for mediating the spleen and stomach.关键词：Buzhongyiqi Decoction;Dachengqi Decoction;Guipi Decoction;Wendan Decoction;SS;SP;VIP;NPY
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发布时间：2021-09-15 - 摘要：Objective To investigate the mechanism of the effects of Liansuzhiou Capsules （LC） against the vomit caused by Chemotherapy. Methods The pigeon model of vomit was induced by abdominal injection of cis platinum, and the radio immunity test kit was used to detect the gastrointestinal hormones. Results It was found that the large LC dose could markedly increase the level of the epidermal growth factor in the peripheral blood （ P <0 05）, both the small LC dose and large LC dose could markedly reduce the level of gastrin in the peripheral blood （ P<0 05, P<0 01 ）, and the large LC dose could markedly decrease the level of vasoactive intestinal peptide in the peripheral blood （ P <0 05）. Conclusion LC shows certain effects of protecting gastrointestinal mucosa and improving gastrointestinal peristalsis, which may be the mechanisms of the effects of LC for treating the vomit due to chemotherapy, especially for treating the delayed vomit.关键词：Liansuzhiou Capsules;Pigeon;Vomit Caused by Chemotherapy;gastrointestinal hormones
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发布时间：2021-09-15 - 摘要：Objective To investigate the antihypertensive effect and the effects of activating blood circulation and resolving stasis of Xihua Decoction No.2 （XD No.2）. Methods The influence of XD No.2 on the blood pressure, blood coagulation, fibrinolytic system, myocardial pathology, etc. was observed in the rat model of two kidney one clamp renal hypertension. Results It was found that the traditional Chinese drugs for activating blood circulation and resolving stasis could reduce blood pressure, decrease the heart rate, improve the criteria of blood rheology, relieve the disorder of microcirculation, enhance the fibrinolytic activity and the deformability of erythrocytes, increase the anticoagulant ability, prevent thrombosis, and delay the occurrence of ventricular hypertrophy, etc. Conclusion The treatment of hypertension by the therapy of activating blood circulation and resolving stasis can increase the effective rate and decrease the rate of the occurrence of complications.关键词：Xihua Decoction No.2;hypertension;Antihypertensive Therapy;Activating Blood Circulation and Resolving Stasis
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发布时间：2021-09-15 - 摘要：Objective To improve the experimental methods for observing mouse gastric emptying （GE） and small intestine propulsion （SIP）. Method The black semisolid nutrient paste was intragastrically given to the mice and GE and SIP were detected at the same time. Results The results showed that improved the effects of drugs on GE and SIP could be observed at the same time. Conclusion The method can well reflect the effects of drugs on GE and SIP, decrease the consumption of the animal and increase the efficiency of experiment.关键词：gastric emptying;Intestine Propulsion;Metoclopramide
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发布时间：2021-09-15 -
- 摘要：Objective To investigate the effect of the combination use of curcumin and amiloride （CUCA） on the proliferation of rat hepatic stellate cells （HSC）. Methods HSC T6 were cultured in different concentrations of curcumin and amiloride for 24 hours. LDH colorimetry was used to observe the cytotoxicity of curcumin and amiloride on HSC T6. MTT colorimetry was used to observe the effects of the respective use and the combination use of curcumin and amiloride on the proliferation of HSC. Results It was found that the HSC proliferation rate in each drug treating group was markedly lower than that in the control group （P<0.001）; the proliferation inhibitory rate in the group treated by CUCA was the highest. It was also found that the HSC proliferation rate in the CUCA treating group was much lower than that in the curcumin treating group （ P <0 05）. The LDH activity detected in the supernate of each drug treating group showed no marked difference as compared with that in the control group （ P >0 05）. Conclusion Both curcumin and amiloride can inhibit the HSC proliferation, and the inhibitory effect of CUCA is better than that of curcumin alone; the effects of the two drugs are not of nonspecific cytotoxicity.关键词：curcumin;Amiloride;Hepatic Stellate Cells;proliferation
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发布时间：2021-09-15 - 摘要：Objective To investigate the effects of Shengui Capsules （SC） on angina pectoris of coronary heart disease. Methods The coronary artery ligation, pituitrin inducement of myocardial ischemia, reperfusion of coronary artery in the isolated heart, 86Rb measurement of myocardial nutritive volume of blood flow, and the creatine phosphate kinase （CPK） assay were adopted in the observation of the effects of SC on angina pectoris of coronary heart disease. Results It was found that SC could reduce the area of rat acute myocardial infarction caused by ligating the coronary artery, relieve the changes in ST section and T wave in the rat electrocardiogram induced by intravenous injection of pituitrin, increase the coronary blood flow in the isolated guinea pig heart, decrease the level of serum CPK in the rat, enhance the intake of 86Rb of the mouse myocardium, and increase the myocardial nutritive volume of blood flow. Conclusion SC show rather strong effects on angina pectoris of coronary heart disease.关键词：Shengui Capsules;coronary heart disease;Angina Pectoris;Pituitrin
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发布时间：2021-09-15 - 摘要：Objective To isolate and identify chemical compounds and to find active constituents from chuipencao （the ground part of the plant Sedum sarmentosum）. Methods The silica gel column chromatography was used to separate chemical compounds from chuipencao, and the UV, IR, MS and NMR methods were used to identify the structures of the compounds. Results 7 compounds were separated from the ethyl acetate part of the extract of chuipencao by 95% ethanol and identified as tricin-7-O-β-D-glucoside, luteolin, isorhamnetin, isoliquiritigenin, quercetin, dioctadecyl sulfide and palmic acid. Conclusion Among the 7 compounds, dioctadecyl sulfide, and palmic acid are separated from chuipencao for the first time.
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发布时间：2021-09-15 - 摘要：Objective To establish a method for quantitatively determining the fat soluble components in danshen （the dried root of Salvia miltiorrhiza） in Compound Danshen Formula （CDF）, and to initially investigate the rule of their changes in quantity and stability in solution when danshen and sanqi （the dried root of Panax notoginseng） were blended together. Method HPLC techniques were used: the mobile phase was methanol water （75∶25）, and the detecting wavelength was 254 nm. Results The contents of the three fat soluble components in danshen were of the order: cryptotanshinone>tanshinone IIA>tanshinone I; and their contents and stability in solution appeared to be different to a certain degree when danshen and sanqi were blended in different ratios in CDF. Conclusion The method is fast and accurate, and can be used to control the quality of the preparation of CDF; there is a nonlinear relationship between the stability and contents of the fat soluble components in danshen in CDF and the ratios in which danshen and sanqi are blended.关键词：Danshen （dried root of Salvia miltiorrhiza）;cryptotanshinone;Tanshinone I;Tanshinone IIA;HPLC
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发布时间：2021-09-15 - 摘要：Objective To optimize the technology of extracting chemical constituents from niubangzi （the fruits of Arctium lappa）. Methods With arctiin as a criterion, the water extraction and ethanol extraction technologies of extracting the constituents from niubangzi were compared by HPLC; and the L 9（3 4） orthogonal experimental design was used to optimize the conditions of the ethanol extraction technology. Results The conditions of the ethanol extraction technology of extracting the constituents from niubangzi were 70% ethanol, 1 hour of reflux, 8 fold solvent and 3 times of extraction. Conclusion With the extraction rate of arctiin as 94 98%, the optimized technology is stable and practical and worthy of a trial in pharmaceutical production.
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发布时间：2021-09-15 - 摘要：Objective It was found that the saccharide content of yishoucao （the dried root or the whole plant of Pterocephalus hookeri） is comparatively high. The present experiment is to determine the contents of reducing sugar and polysaccharide of yishoucao in order to investigate the quality of yishoucao and provide scientific evidence for establishing its quality control criteria. Method phenol sulfonic acid chromatometry was used in the experiment. Results It was found that the saccharide content of yishoucao was comparatively high and different parts of yishoucao had different saccharide contents. Conclusion The saccharide content may be used as a criterion for the quality control of yishoucao.
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发布时间：2021-09-15 - 摘要：Objective To investigate the relationship between splenic deficiency syndrome （SDS） and biological behavior in patients with gastric carcinoma, and to observe the effects of Shenqifuzheng Injection （SI） on the gastric carcinoma of SDS type. Methods 102 Patients of gastric carcinoma were divided into non SDS group and SDS group according to the criteria of TCM syndrome differentiation. The depth of infiltration, degree of differentiation, metastatic lymph nodes, and PTNM calssification of gastric carcinoma were evaluated by the statistical method. The patients in the SDS group were further divided into the operation group and the operation SI group; and the red blood cell C3b receptor rosette （RBC C3bRR）, red blood cell immune complex rosette （RBC ICR）, T lymphocyte Ag NORs and NK cell activity were detected. Results Of 102 patients with gastric carcinoma, 63 cases were complicated by SDS in different degrees. As compared with non-SDS group, the SDS group showed that more patients with T3 - T4, with poorly-differentiated adenocarcinoma, in station 3 and station 4 lymphocytic metastasis, and in stage Ⅲ and stage Ⅳ according to PTNM classification （ P <0 01）. As compared with those in the patients in the operation group, RBC C3bRR, T lymphocyte Ag NORs and NK cell activity markedly increased, and RBC ICR markedly decreased （ P <0 01） in the patients in the operation SI group. Conclusion There is a close relationship between SDS and the clinical biological behavior in the patients with gastric carcinoma. The prognosis of the patients complicated by SDS is not as good as that of the patients without the syndrome; SI can markedly improve the immune functions in the patients with gastric carcinoma of SDS type after their operation.关键词：gastric carcinoma;Splenic Deficiency Syndrome;Cellular immunity;Shenqifuzheng Injection
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发布时间：2021-09-15 - 摘要：Objective To investigate the changes of nutritional state of the senile patients with pneumonia before and after treatment. Methods Before and after treatment, the changes in the anthropometric criteria and in the levels of albumin （Alb）, transferring （TRF）, cortisol （Co）, triiodothyronine （T 3）, tetraiodothyronine （T 4）, thyroid stimulating hormone （TSH）, interleukin 1β（IL 1β） and insulin like growth factor Ⅱ（IGF Ⅱ） were detected in 30 senile patients of pneumonia, with 19 healthy young subjects and 20 healthy aged subjects as the control. Results It was found that the anthropometric criteria showed an increasing tendency both before and after treatment in the pneumonia group. The levels of TRF, T 3, T 4, TSH, Co and IGF Ⅱ were lower in the senile control group than those in the young control group. The levels of TRF, T 3 and IGF Ⅱwere lower in the pneumonia group than those in the senile control group, but the levels of Co and IL 1βwere higher in the pneumonia group than those in the senile control group. After treatment, the levels of TRF, T 3 and IGF Ⅱ increased in the pneumonia group, but levels of Co and IL 1βdecreased. Conclusion The senile patients of pneumonia are with malnutrition of different degrees, which is related with certain disorders of the synthesis of hormones and secretion of cytokines. The anthropometric criteria reflecting the nutritional state and the levels of hormones and cytokines can be all improved to a certain degree by the treatment.关键词：Penumonia;Senile People;Nutritional State;clinical research
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发布时间：2021-09-15 -
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