最新刊期
卷 0 ， 期 5 ， 2003
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- 摘要：Dr. Wei Yuheng advocated the therapy of nourishing the liver in his entire life time of TCM practice. In his book entitled Continuation of the Classified Medical Records of Well known Doctors, it is recorded that he created a formula named Yiguan Decoction for strongly nourishing the yin phase of the liver, kidney and stomach and that he used Yiqi Decoction to heavily nourish the yang phase of the spleen and kidney. He carefully selected many medical records of Dr. Feng Chuzhan involving the application of Yiqi Decoction in order to give the later generations his theories that the liver is the root of internal injuries; the hepatic blood should be nourished and the hepatic qi can not be insulted; and in composing formulas for nourishing the liver, attention should be paid equally to the liver entity, the liver function, the three yin meridians of foot, and to the three elements, namely earth, metal and water.关键词：Wei Yuheng;Conception of Composing TCM Formulas;Yiqi Decoction;Yiguan Decoction
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发布时间：2021-09-15 -
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- 摘要：古往今来中成药的分类方法有很多 ,但不论是病证分类法、功效分类法、笔画分类法、剂型分类法还是混合分类法 ,都难以做到合理地分清各类中成药。目前 ,在尚无统一分类方法的情况下 ,按读者对象选择分类方法 ,可能是较妥当的办法。例如读者对象是以药剂为主的 ,就可采用剂型分类法 ,而将其他分类法做索引处理。关键词：中成药;分类;方法
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发布时间：2021-09-15 -
- 摘要：Objective To study the effects of Compound Biejia Formula （CBF） on HRCT images in the rat model of pulmonary fibrosis induced by bleomycin. Methods 54 SD male rats were involved in this experiment. 45 Rats were given bleomycin by drip via the trachea and 9 rats were given the same dose of normal saline in the same way. After 80 days of the administration, HRCT images were observed in parallel in the two groups of the animals and at the same time, a HRCT pathological comparative study was carried out. Results It was found by HRCT that in the lung of the model rats, there was consolidation, thickened lobular septa and interstitium, lobular deformity, nodular shadows, bronchiovascular abnormality, thickened pleurae, ground glass like opacity, and even honeycomb lung in some animals; pathological slices showed that there was fibroid proliferation and marked fibrosis of the interstitium. CBF could improve HRCT images of the lung in the model rats and reduce pulmonary fibroid change. Conclusion The curative effects of CBF on the rats with pulmonary fibrosis may be related with its influencing the pulmonary structure.关键词：Compound Biejia Formula;pulmonary fibrosis;HRCT;rat
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发布时间：2021-09-15 - 摘要：Objective To observe the cardiac gene expression spectrum of the rat with heart failure after myocardiac infarction （HFMI） and the effects of the formula for benefiting qi and activating blood circulation （FBQABC） on cardiac hemodynamics in the rat model of HFMI. Methods The rat model of HFMI was established by left coronary artery ligation. The total RNA was extracted from the samples of the infarct area and non infarct area of the left ventricle of the rats in the model group and from the samples of the left ventricle of the rats in the sham operation group, respectively, at the heart failure formation stage （10 days after the operation） and the heart failure stable stage （8 weeks after the operation）; the extracted total RNA was detected with 6 rat 40S gene chips （4096 genes/a chip）. From the 4th weeks after the operation, the rats in the model group were treated with FBQABC until to the 8th week, with captopril as a positive control, and the changes in the rat cardiac function were observed by an impedance method before and after the administration. Results The detection with gene chips showed that there were more than 1000 genes in 13 types, the expressions of which were either up regulated or down regulated, involving energy metabolism, the frame of the cardiac muscle cell and the cardiac muscle fiber; there were 1086 differential expression genes in the infarct area at the heart failure formation stage and 724 differential expression genes at the heart failure stable stage; and there were 196 differential expression genes in the non infarct area at the heart failure formation stage and 97 differential expression genes at the heart failure stable stage. After the treatment of captopril and FBQABC, the SV, CO and CI in the HFMI rats were all improved markedly （ P <0 01）. Conclusion The mechanism of FBQABC for treating heart failure in HFMI rats may be its regulating the cardiac energy metabolism related genes, hence, causing the improvement of the cardiac function.关键词：Formula for Benefiting Qi and Activating Blood Circulation;heart failure;gene chip;hemodynamics;rat
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发布时间：2021-09-15 - 摘要：Objective To observe the effects of Zengyetang Injection （ZI） on apoptosis of thymocytes induced by dexamethasone in young rats. Methods Wistar rats aged 4～5 weeks were given ZI and dexamethasone by intraperitoneal injection. DNA agarose gel electrophoresis and flow cytometry were used to analyse apoptosis of thymocytes in both the ZI group and the dexamethasone group. The electron microscope was used to observe the changes in the ultrastructure of thymocytes in both groups. Results DNA agarose gel electrophoresis showed that there was only a weak ladder strip in the ZI group. Flow cytometry showed that there was a rather big apoptotic peak in the DNA group block diagram, with an apoptotic rate of （60 74±4 86）% in the dexamethasone group; the diplokaryon peak was obviously bigger and the apoptotic peak was obviously smaller in the ZI group as compared with those in the the dexamethasone group; the apoptotic rate in the ZI group was （32 20±7 70）%. There was a significant difference between the two apoptotic rates （ P <0 01）. The observation by electron microscope showed that the chromatin of thymocytes gathered in a crescent shape or formed apoptotic corpuscles in the dexamethasone group while in the ZI group, the chromatin existed in an even status and only the volume shrunk slightly. Conclusion ZI has certain inhibitory effects on the apoptosis of thymocytes induced by dexamethasone.关键词：Zengyetang Injection;Adrenal Cortex Hormones;apoptosis;Young Rat
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发布时间：2021-09-15 - 摘要：Objective To study the mechanism of the effects of Qidantongbi Decoction （QD） on rat type Ⅱ collagenous rheumatoid arthritis （RA） and observe the effecacy of the therapy for clearing the Shaoyang meridian and nourishing the liver and kidney. Method Immunological techniques were used in this experiment. Results QD could markedly reduce the degree of rat pedal swelling and the level of PGE 2 in inflammatory tissues （ P <0 01）, exerting an analgesic effect at the same time. QD could also remarkably inhibit DTH induced by DNFB in the mouse （ P <0 01）, T cell proliferation in the spleen of DTH mouse （ P <0 01）, and IL 2 release of splenic cells （ P <0 01）. Conclusion QD can effectively relieve RA symptoms and treat RA through inhibiting type IV immune allergic reaction.关键词：Qidantongbi Decoction;rheumatoid arthritis;immunity;rat;mouse
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发布时间：2021-09-15 - 摘要：Objective To study the rat model of depressive chronic stress and to investigate the behavioral changes and the changes in the levels of monoamine neurotransmitters in the anterior cortex and hippocampus in the model rats after being treated with chlorimipramine and the active components of Sini Powder （ACSP）. Methods HPLC ECD techniques were used to analyze the influences of chronic stress and ACSP on the levels of monoamine neurotransmitters in order to understand the antidepressive mechanism of ACSP. Results In the model rats, the body weight decreased markedly and the times of defecation increased in the open chest and also, there was a reduction in the level and vertical movements, the consumption of sugar water （ P <0 01）, the levels of 5 HT in the hippocampus （ P <0 01） and DA in the anterior cortex （ P <0 05）. ACSP could increase the levels of 5 HT and DA （ P <0 01）, hence, improving the behavior of the model rats. Conclusion Regulating the levels of 5 HT and DA is one of the antidepressive mechanisms of ACSP.关键词：Sini Powder;Active Components;depression;Model of Chronic Stress;behavior;neurotransmitter;rat
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发布时间：2021-09-15 - 摘要：Objective To observe the influence of the factor of liver depression and spleen deficiency （LDSD） on the growth of tumour and the immune function of T cells in S180 tumor bearing mice. Methods Tumor cells were extracted from the abdominal cavity of S180 tumor bearing mice and adjusted to a concentration of 1×10 10 L -1 . The S180 tumor cells were inoculated into the Kunming mice by subcutaneous injection at the right oxter at a dose of 0 2 mL per mouse. LDSD syndrome was induced in the inoculated mice on the very day of the inoculation by the method of binding and an intemperate diet. At the same time, the single LDSD group, single S180 tumor bearing group and normal control group were also set up for the experiment. After the 10 th day of the inoculation, the mice were executed. The weight of tumor, the proliferation rate of T cells in the spleen, the ability to produce IL 2 and IFN γand the thymic index were measured. Results It was found that in the S180 tumor bearing mice, the LDSD factor could markedly increase the tumor weight （ P <0 01）, decrease the proliferation rate of T cells （ P <0 01） and the ability to produce IL 2 and IFN γ（ P <0 01）, and lower the thymic index. Conclusion The LDSD factor can aggravate the suppression of cellular immune function and promote the growth of tumor in the tumor bearing mice.关键词：liver depression and spleen deficiency;tumour;Cellular immunity;mouse
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发布时间：2021-09-15 - 摘要：Objective To observe the effects of Yaotongshu Capsules（YC）on apoptosis of rabbit chondrocytes induced by nitric oxide （NO） in vitro. Methods The transmission electron microscope （TEM） and the flow cytometer （FCM） were used to observe the apoptosis of the rabbit chondrocytes which were cultured with sodium nitroprusside （SNP） for 12, 24 and 48 hours, respectively; and the Annexin V/PI method was used to detect the status of apoptosis of chondrocytes induced by NO and again cultured for 24 hours in the presence of different doses of YC medicated serum. Results The FCM observation showed that the rate of apoptosis was 74 05±6 68% in the chondrocytes cultured with SNP for 24 hours, while that in the control group was 3 15±0 76% （ P <0 01）. The TEM observation revealed a typical morphological change of apoptotic chondrocytes. The rate of apoptosis was remarkably lowered by different doses of YC medicated serum, especially by the large dose of YC medicated serum. Conclusion SNP can induce apoptosis of rabbit chondrocytes in vitro and the large dose of YC medicated serum can remarkably decrease the rate of apoptosis of chondrocytes induced by NO, which suggests that YC can inhibit apoptosis of rabbit chondrocytes.关键词：Yaotongshu Capsules;Serum Pharmacology;nitric oxide;Chondrocyte;apoptosis;Rabbit
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发布时间：2021-09-15 - 摘要：Objective To investigate the mechanism of the antipyretic effects of Qingkailing Injection （QI） on the rabbits with endotoxin induced fever. Methods The rabbit model of endotoxin induced fever was established for the experiment. The digital thermograph was used to measure the colonic temperature. Radioimmunoassay was used to measure the levels of IL 1β and cAMP in the hypothalamus, cAMP in cerebrospinal fluid and AVP in the ventral septal area. Results QI exerted a marked antipyretic effect on the rabbits with endotoxin induced fever （ P <0 01）, remarkably inhibit the production of IL 1β and cAMP in the hypothalamus （ P <0 01）, and markedly reduce the levels of cAMP in cerebrospinal fluid and AVP in the ventral septal area （ P <0 01）. Conclusion The mechanism of the antipyretic effects of QI against endotoxin induced fever may be related with the inhibition of the production of endogenous pyretogens and central febrile media and the promotion of the release of antipyretic substances.关键词：endotoxin;Fever;Interleukin 1β;Adenosine Cyclic monophosphate;Arginine Vasopressin;Qingkailing Injection;Rabbit
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发布时间：2021-09-15 - 摘要：Objective To observe the effects of Xuanfudaizhe Decoction （XD） on the permeability of esophageal mucosa in the rat model of acidic reflux esophagitis. Methods The rat model of acidic reflux esophagitis was established by pyloric partial ligation and cardiac sphincter dissection. The model rats were given XD for 2, 4 and 8 days, respectively and then, the permeability of esophageal mucosa was measured. Results The permeability of esophageal mucosa was markedly improved in the model rats after being treated with XD for 4 days and there was no difference between the result from the model group and that from the sham operation group （ P >0 05）. Conclusion By inhibiting acid reflux and exerting an anti inflammatory effect, XD can remarkably reduce the permeability of esophageal mucosa, hence, promoting the recovery from the disease.关键词：Xuanfudaizhe Decoction;Reflux Esophagitis;Permeability;rat
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发布时间：2021-09-15 - 摘要：Objective To observe the effects of Tongmaiyizhi Capsules （TC） on apoptosis of mouse hippocampal neurocytes induced by the injury due to ischemia reperfusion and investigate the mechanism of the nerve protective effects of TC. Methods 40 Male ICR mice were randomly divided into the sham operation group, model group, TC group and hydergine control group. A mouse model of repeated cerebral ischemia and reperfusion was established for the experiment. The optical microscope and transmission electron microscope were used to observe apoptosis of mouse hippocampal neurocytes. TUNEL labeling was used to label the apoptotic neurocytes and then the apoptotic index was calculated. Results The pathologic injuries were markedly reduced in the TC group, and the apoptotic index in the TC group was remarkably lower than that in either the model group or the hydergine control group. Conclusion TC can markedly inhibit the apoptosis of mouse hippocampal neurocytes induced by the injury due to cerebral ischemia and reperfusion, hence, exerting certain nerve protective effects.关键词：cerebral ischemia;Injury due to Reperfusion;apoptosis;Tongmaiyizhi Capsules;mouse
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发布时间：2021-09-15 - 摘要：Objective To establish a method for quantitatively determining the content of crocetin in the active fraction of Huanglianjiedu Decoction （HD）. Methods Both HPLC and TLCS were used in the experiment. For HPLC, the YWG C 18 column was chosen, the mobile phase was methanol water glacial acetic acid, and the detection wavelength was 423 nm. For TLCS, the silica gel G plate was chosen, the developing agent was chloroform methanol formic acid, the scanning was carried out by reflection sawtooth scanning, the incident wavelength （λR） was 410 nm, and the reference wavelength （λS） was 560 nm. Results For HPLC, the average recovery was 101 68% and RSD was 1 16% （ n =5）; and for TLCS, the average recovery was 98 54% and RSD was 0 83% （ n =5）. Conclusion The results achieved by the two methods are basically the same. Both methods are simple and accurate and can be used in the quality control of the active fraction of HD.关键词：Huanglianjiedu Decoction;Crocetin;HPLC;TLCS;quantitative determination
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发布时间：2021-09-15 - 摘要：Objective To investigate the method for the quantitative determination of paeoniflorin in Yinlianqinggan Mixture （YM）. Method HPLC was used in this experiment. The YWGC 18 chromatographic column （250 mm×4 6 mm, 10 μm） was chosen, and the experiment was carried out at the room teperature. The mobile phase was methanol water （30∶70） at a flow velocity of 1 mL/minute. The detection wavelength was 230 nm. Results There was a linear relationship with paeoniflorin within the range of 0 15 μg to 1 5 μg （r=0 9998, n =5） and the average recovery was 99 16% （RSD=0 87%）. Conclusion This method is accurate and practicable, and can be used in the quality control of YM.关键词：Yinlianqinggan Mixture;paeoniflorin;HPLC
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发布时间：2021-09-15 - 摘要：Objective To establish the clinical observation scales for the syndrome represented by Xiaoyao Powder （XP）. Methods The macroscopic indications related with the syndrome represented by XP were collected according to the XP literature in both ancient and modern times and the analyses made by experts; the macroscopic indications were then processed by statistical methods. 58 Clinical cases （involving 25 diseases） were divided into the positive control group and XP-treating group in order to investigate the effects of XP on the macroscopic indications related with the syndrome represented by XP, on SDS and on SAS. Results XP could improve 27 macroscopic indications to different degree and the effects of XP were age and sex dependent. Conclusion The syndrome represented by XP is related with emotions, for example, anxiety; the syndrome can correspond to a common status of many diseases.
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发布时间：2021-09-15 - 摘要：Objective To investigate the curative effect of the integrated therapy of TCM and western style medicine for treating SARS. Methods 80 cases of SARS in the restoration stage were chosen and divided into the treating group and control group. The control group was treated by the four step cascade therapy with western style drugs and the treating group was given the TCM drugs for benefiting qi and nourishing yin on the basis of the treatment of western style drugs. Results The curative effect in the treating group was better than that in the control group as far as the improvement of symptoms and abnormal laboratory criteria, the absorption of pulmonary shadows, the reduction of the time for withdrawing or reducing the use of hormones and reduction of the average time for hospitalization were concerned. Conclusion The integrated therapy of TCM and western style medicine for treating SARS possesses certain superiority.关键词：Integrated Therapy of TCM and Western Medicine;SARS;Benefiting Qi and Nourishing Yin
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发布时间：2021-09-15 -
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- 摘要：Objective To compare the effects of puncturing different points on the level of blood lipid in the serum in rats. Methods 32 SD rats were randomly divided into the normal group, model group, fenglong group, dazhui group and non acupoint group （at the middle point of the dorsal part of the tail）. The rat model of hyperlipemia was established for the experiment. Acupuncture was performed at fenglong, dazhui and non acupoint in the model rats, respectively and then, the levels of TC, TG, LDL c and HDL c were measured. Results It was found that puncturing fenglong, dazhui and non acupoint could markedly decrease the levels of TG, TC and LDL c; dazhui had superiority reducing TC, and fenglong had superiority in reducing LDL c. It was also found that fenglong and non acupoint, especially fenglong, could increase the level of HDL c while dazhui could decrease the level of HDL c. Conclusion Although all the pionts punctured have certain effects on the level of blood lipid in serum, different points have different effects on the components of blood lipid. Fenglong has been proven to be virtuous and specific in regulating blood lipid.
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发布时间：2021-09-15 - 摘要：Objective To investigate the effects of puncturing zusanli acupoint on the absorption of zinc in rats. Methods 30 Young male Wistar rats were randomly divided into the normal group, group of zinc depletion （ZD） and group of zinc depletion plus acupuncture （ZDA）. The observation criteria used in this experiment were zinc content in the kidney, zinc content in the liver, zinc content in the testicle, the organ weight of the kidney, the organ weight of the liver, the organ weight of the testicle, zinc content in the serum, change in the body weight of the rats in each group, and the titer of the forage. Results There was no marked difference between the zinc content in the rat serum in the group of ZDA and that in the normal group （ P >0.05） while there was remarkable difference between the zinc content in the rat serum in the normal group of ZD and that in the group of ZD （ P <0 05）; the last three day intake of forage of the rats in the group of ZDA was obviously larger than that in the group of ZD （ P <0 05）; the zinc content in the testicle in the group of ZDA was markedly higher than that in the group of ZD （ P <0 05） and the weight of the testicle in the group of ZDA was also markedly larger than that in the group of ZD （ P <0 01）. Conclusion Acupuncture can increase the zinc content in the serum, the titer of the forage and the body weight of the rats, which suggests that puncturing zusanli acupoint may promote the absorption of zinc, which might be related with the maintaining of the normal synthesis and metabolism of protein and the normal physiological function of testosterone.关键词：Zinc;Trace Element;acupuncture;rat
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发布时间：2021-09-15 -
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