最新刊期
卷 0 ， 期 0 ， 2020
- 摘要：The genomic study of TCM syndromes is one of the hot topics in TCM syndrome studies in the post-genomic era. The difficult key point in this study is the complicated relationship between phenotypic plasticity and quantitative trait loci. This paper generalizes the conception, advances in research, and the complicated relationship concerning phenotypic plasticity and quantitative trait loci. The paper holds that the studies in this field are to explain the possible direction of the specificity of TCM syndromes related to time and space.关键词：TCM syndrome;Phenotype;Genome;Quantitative Trait Loci
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发布时间：2021-09-15 -
- 摘要：Collateral vessels are the entia of structure and function on the microscopic level, and they are characterized by their superficial, deep, terminal and reticular formations. Collateral Vessels can be divided into qi collateral vessels and blood collateral vessels, which are the carriers of qi and blood in circulation. The TCM differentiation of collateral vessel diseases is an important part of TCM syndrome differentiation and treatment. This article briefly introduces the commonly-seen collateral vessel diseases and syndromes, such as collateral vessel qi-syndromes including collateral vessel qi-deficiency syndrome and collateral vessel qi-stagnation syndrome; collateral vessel blood-syndromes including collateral vessel blood-deficiency syndrome and collateral vessel blood-stagnation syndrome, collateral vessel blood-heat syndrome and collateral vessel blood-cold syndrome; collateral vessel deficiency syndromes including collateral vessel qi-deficiency syndrome, collateral vessel blood-deficiency syndrome, collateral vessel yin-deficiency syndrome and collateral vessel yang-deficiency syndrome; and collateral vessel toxin-stagnation syndrome, etc.关键词：collateral vessel;Collateral Vessel Disease;TCM Differentiation of Collateral Vessel Diseases and Syndromes
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发布时间：2021-09-15 - 摘要：The authors of this paper appeal for changing the conception of unidirectional adoption of the methods involving acoustics, optics, electrics, magnetics, etc. in the field of TCM research, and innovating the methodology of TCM research in order to conform with the principle of entirety, vitality and mutualization, find an interdisciplinary way to perform the bidirectional informational exchange between TCM and physics, informatics, system science, etc., and to carry out the systematic, simulant, coupling and intravital research on the characteristics of life information. The trans-dimensional conception and the application of the coupling method and technology are put forward for the first time in field of TCM theoretical research by the authors of this paper.关键词：traditional Chinese medicine;Life Information;Trans-dimension;Coupling
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发布时间：2021-09-15 -
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- 摘要：Objective To study the mechanism of the effects of Yiqihuoxue formula （YF） in inhibiting the proliferation of hepatic stellate cells （HSC） in vitro, and to investigate the different active extracts of the formula. Methods The proliferation of HSC was stimulated by lipopolysaccharide （LPS） in vitro, and then, the YF-medicated rat serum at different time phases （Sc1 and Sc2）, or normal rat serum, or different YF extracts were added, and cultivated for 24 hs, 48 hs and 72 hs, respectively. MTT assay was used to detect HSC proliferative rate and the flow cytometry （FCM） was used to detect HSC apoptotic rate. Results Both Sc1 and Sc2 could significantly inhibited the proliferation of HSC induced by LPS at different time phases （P<0.05, P<0.01）. The results from FCM showed that Sc2 remarkably promoted the apoptosis of HSC （P<0.01）. It was also found that different YF extracts could inhibit the proliferation of rat HSC cultured in vitro on different modes. Conclusion YF-medicated serum can restrain the proliferation of rat HSC in vitro and promote HSC apoptosis as well. YF contains different effective fractions which exert their effects on different modes.关键词：Yiqihuoxue Formula;hepatic fibrosis;Hepatic Stellate Cell;rat
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发布时间：2021-09-15 - 摘要：Objective To establish a 3-dimensional quantitative structure-activity relationship （3D-QSAR） model of small phenolic molecules in order to direct the development of the drugs with percutaneous absorptive activity of small phenolic molecules. Method The comparative Molecular Field Analysis was used to establish a series of 3D-QSAR models of small phenolic molecules with percutaneous absorptive activity. Results The models showed that the cross-validated correlative coefficient q 2=0.892, non-cross-validated correlative coefficient r 2=0.995, SE=0.036, and F=175.341. Conclusion The models possess rather good abilities of prediction, and show that the percutaneous absorptive activity can be increased if the the sizes of the substitute groups and negative charged groups are enlarged in the appointed regions.关键词：percutaneous absorption;Small Phenolic Molecule;3-Dimensional Structure-Activity Relationship
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发布时间：2021-09-15 - 摘要：Objective To investigate the antipyretic mechanism of Naoreqing oral solution （NOS）. Methods The rabbit model of endotoxin-induced fever was established in order to observe the effects of NOS on the rabbit body temperature. Radioimmunoassay was used to detect the changes in the contents of IL-1 and cAMP in the rabbit hypothalamus. Results NOS showed marked antipyretic effects on the endotoxin-induced fever （P<0.01） and remarkably decreased the contents of IL-1 and cAMP in the hypothalamus （P<0.01）. A correlation analysis indicated that the changes in the rabbit body temperature were positively correlated with the changes in the contents of IL-1 （r=0.962, P<0.01） and cAMP （r=0.899, P<0.01） in the hypothalamus of the rabbits in the four groups in the experiment. Conclusion One of the antipyretic mechanisms of NOS may be related with inhibiting the increased content of IL-1 and decreasing the production and release of cAMP in the hypothalamus.关键词：Naoreqing Oral Solution;endotoxin;Fever;IL-1;cAMP;rabbits
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发布时间：2021-09-15 - 摘要：Objective To investigate the mechanism of Gualouxiebai Decoction （GD） for treating and preventing pulmonary fibrosis. Methods The rat model of pulmonary fibrosis was induced by dripping bleomycin A5 into the trachea of the rats. The treating group was intragastrically given GD at a dose of 20 g/kg, once a day for 28 days, and then the levels of noradrenaline （NE）, dopamine （DA）, 5-hydroxytryptamine （5-HT） in the lung and the total number of inflammatory cells in BALF were measured and compared with between groups. Results The levels of NE, DA and 5-HT in the lung and the total number of inflammatory cells in BALF were remarkably higher in the model group than those in the normal group. The levels of NE, DA and 5-HT in the lung and the total number of inflammatory cells in BALF in the GD group were markedly lower than those in the model group. Conclusion GD can inhibit the increase of the levels of NE and DA in the lung and reduce the total number of inflammatory cells in BALF.关键词：pulmonary fibrosis;Gualouxiebai Decoction;Noradrenaline;dopamine;5-hydroxytryptamine
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发布时间：2021-09-15 - 摘要：Objective To investigate the effects of oxidized low density lipoprotein （OX-LDL）, Liqihuoxue Formula （LF） and its different ingredient pairs on the activity of the growth of human umbilical venous endothelial cells （HUVECs）. Methods First, HUVECs were incubated with OX-LDL to simulate the process in vivo of the OX-LDL injury of endothelial cells; and then, the OX-LDL-damaged HUVECs were incubated respectively with LF, the ingredient pair of Ligusticum chuanxiong and Paeoniae lactiflora （IP-LP）, and the ingredient pair of Bupleurum chinense and Citrus aurantium （IP-BC）. MTT assay was used to detect the activity of HUVECs growth. Results The activity of HUVECs growth was inhibited in different degrees after HUVECs were incubated with OX-LDL for 6 hs, 12 hs and 24 hs respectively （P<0.05, as compared with the normal incubation）. LF, IP-LP and IP-BC could increase the activity of HUVECs growth （P<0.05）. Conclusion LF, IP-LP and IP-BC can increase the activity of the growth of OX-LDL-damaged HUVECs, and the effects of LF tend to be stronger than those of the ingredient pairs.关键词：Liqihuoxue Formula;Ingredient Pair;OX-LDL;Endothelial Cell
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发布时间：2021-09-15 - 摘要：Objective To establish a method for quantitative determination of glycyrrhizic acid in the antidepressive fraction of Sini Powder by RP-HPLC. Methods YWG-C 18 chromatographic column （250 mm×4.6 mm, 10 μm） was chosen, the mobile phase was methanol-0.2 mol/L ammonium acetate-glacial acetic acid （67∶33∶1）, the detection wavelength was 250 nm, and the column was at a room temperature. Results There was a good linear relationship between the quantities of the sample of glycyrrhizic acid （0.10 μg to 0.50 μg） and the peak areas （r=0.9996）, and the average recovery was 101.71%, （RSD=1.73%, n=5）. Conclusion This method is simple, accurate and reliable, and can be used to control the quality of the antidepressive fraction of Sini Powder.
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发布时间：2021-09-15 - 摘要：Objective To establish the method of quantitative determination of salvianolic acid B in the water decoction of danshen （Salvia miltiorrhiza） and sanqi （Panax notoginseng）. Methods An Elite Spherisorb C18 column was chosen, the mobile phase was methanol-water （41.5∶58.5, the pH value was adjusted to 2.5 with formic acid） at a flow velocity of 0.8 ml/min., the detection wavelength was 280 nm, and the column temperature was 25℃. Results There was no great influence on the content of salvianolic B in the decoction when danshen and sanqi were blended in the ratio of 5∶3. Conclusion This method can be used to quantitatively determinate the salvianolic acid B in the water decoction of danshen and sanqi.关键词：Danshen （Salvia miltiorrhiza）;salvianolic acid B;HPLC
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发布时间：2021-09-15 - 摘要：Objective To determine of the content of salidroside in the 4 main species of Rhodiola used as hongjingtian, a commercial medicinal material in TCM and 5 other plants of the same genus by HPLC, in order to provide data for evaluating the quality of hongjingtian and to find the new resources of this TCM medicinal material. Method The chromatographic column of Bondclone C18 was used; the mobile phase was water-methanol-acetonitrile at a flow velocity of 0.6 ml/minute; and the detection wavelength was 223 nm. Results There was a good linear relationship with salidroside within the range of 0.100 μg to 1.000 μg （r=0.9998） and the average recovery was 99.10% （RSD=2.39%）. Conclusion As far as the contents of salidroside of the 4 main commercial species of Rhodiola are concerned, the highest is 4.5 times the lowest, and among the 4 species, Rhodiola crenulata has the highest content of salidroside. Among the 5 wild plants of the same genus, Rhodiola linearifolia has a rather high content of salidroside and enough attention should be paid to it.关键词：Rhodiola;salidroside;HPLC
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发布时间：2021-09-15 - 摘要：Objective To establish the method for the quantitative determination of 2,3,5,4’-tetrahydroxy diphenyl ethylene-O-2-β-D-glucoside in Wumai Oral Solution. Method RP-HPLC was used in this experiment. The YWG-C 18 column was chosen, the mobile phase was methanol-acetonitrile-water （50∶10∶90） at a flow velocity of 0.5 ml/minute, and the detection wavelength was 320 nm. Results There was a good linear relationship with 2,3,5,4’-tetrahydroxy diphenyl ethylene-O-2-β-D-glucoside in the range of 0.0236 μg to 0.1410 μg （r=0.9997）. The average recovery was 100.01% and RSD was 0.59% （n=5）. Conclusion The method is sensitive, accurate and simple, with a good repeatability.关键词：Tetrahydroxy Diphenyl Ethylene-O-2-β-D-Glucoside;Wumai Oral Solution;HPLC
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发布时间：2021-09-15 - 摘要：Objective To optimize the varieties and mixture ratio of the adjuvants of Xingnao dispersible tablets （XDTs）. Methods The optimization was carried out according to the dissolving time and cumulative solution percentage of the experimental adjuvants, and the solution curves were fitted by different equations. Results The best technology of XDTs was using a mixture of pregelatinized starch and lactose （1∶2） as adjuvant in a mixture ratio of 1∶1 to the effective components, crosslinking polyethylene pyrrolidone as disintegrant （added 2% internally, and 5% externally）, and magnesium stearate as lubricant （0.5%）. Conclusion Both the disintegration time limited and the fineness of dispersion of XDTs prepared according to the optimized technology satisfied the requirements of PRC Pharmacopeia of 2000 version, and the dissolving curve was close to Weibull distribution.关键词：Xingnao Dispersible Tablets;Optimization of Adjuvant;Ratio of Release in Vitro;Dissolving Curve
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发布时间：2021-09-15 - 摘要：Objective To optimize the honey-processing technologies for preparing wutou （Aconitum carmichaeli）. Methods The samples of wutou honey-processed by different technologies were chosen. The method recorded in the PRC pharmacopoeia was used to determine the content of the total alkaloid, and TLCS was used to determine the contents of aconitine, mesaconitine and hypaconitine. Results All the different honey-processing technologies affect the contents of main alkaloids in wutou. Conclusion The honey-boiling technology is the best technology for preparing crude Aconitum Carmichaeli.关键词：Aconitum Carmichaeli;Honey-Processing Technology;Alkaloid
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发布时间：2021-09-15 - 摘要：Objective To observe the clinical curative effect of TCM drugs in the treatment of SARS. Methods 65 Cases of acute SARS at early stage were randomly divided into two groups after being treated by western-style therapies, and one of the groups was then given some TCM preparations besides the western-style therapies. Results The curative effects of the combination of TCM and western-style therapies were better than those of the western-style therapies in respects of decreasing death rate, increasing cure rate, relieving symptoms, and reducing side-effects caused by hormones in 3 weeks of treatment. Conclusion The traditional Chinese drugs used in this clinical trial possess certain clinical curative effects in treating SARS.关键词：Combination of TCM and Western-Style Therapies;SARS;Clinical Curative Effect
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发布时间：2021-09-15 - 摘要：Objective To investigate the curative effects of Mangan Mixture （MM） on hepatic fibrosis in chronic hepatitis B. Methods 45 Patients with chronic hepatitis B were randomly divided into the MM treating group and control group. The criteria, such as clinical symptoms and signs, indexes of hepatic function, hepatic and splenic indexes of ultrasonic wave B, HBVM, HA, LN and CIV were observed before and after the treatment in both groups. Results The degree of improvement in all above criteria in the MM treating group was obviously larger than that in the control group （P<0.01）. The effective rate with the MM treating group was 93.3%, and that with the control group was 66.7%. Conclusion MM is an effective TCM formula for treating hepatic fibrosis in chronic hepatitis B.关键词：Mangan Mixture;chronic hepatitis B;hepatic fibrosis;clinical research
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发布时间：2021-09-15 - 摘要：Objective To observe the influence of Xiaoyao Powder （XP） on some nervous, endocrine and immune criteria in order to investigate the pathologic mechanism of the TCM syndrome represented by XP on the basis of the nerve-endocrine-immune system. Methods All clinical cases were randomly divided into the test group （given XP） and control group （given Zhibaidihuang Pills） in the ratio of 3:1, and the course of the treatment was 1 month. The levels of serumal noradrenaline （NE）, epinephrine （E） and dopamine （DA） were measured by HPLC, the levels of serumal β-endorphin （β-EP）, ACTH, estradiol （E 2） and testosterone （T） were detected by radioimmunoassay, and the levels of IgA and IgG were detected by laser nephelometry. Results There was a significant difference between the levels of β-EP, E and DA in the test group and those in the control group （P<0.01） before and after the treatment. There was an obvious increase in the level of β-EP （P<0.01） and a obvious decrease in the levels of E and DA （P<0.01） after XP treatment. Conclusion The results suggest that the levels of β-EP, E and DA can reflect some microscopic changes in the TCM syndrome represented by XP.
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发布时间：2021-09-15 - 摘要：Objective To investigate the features of the mental symptoms with depression of different TCM types. Methods 59 Patients with depression of different TCM types were assessed by using Beck Depression Inventory and Hamilton Depression Rating Scale in order to analyze the similarities and differences of their mental symptoms. Result It was found that there were certain differences among the psychic manifestations of the patients with depression of different TCM types. Conclusion It is necessary and feasible to study the significance to TCM syndrome differentiation in investigating the features of mental symptoms with depression by using neuropsychological symptom rating scales.关键词：Mental Symptom;TCM syndrome;depression;scale
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发布时间：2021-09-15 - 摘要：Objective To observe the effects and mechanism of Jingxuanning Instant Granules （JIGs） in the treatment of cervical spondylosis of vertebral artery type. Methods 130 Cases were randomly divided into the treating group （100 cases ） and the flunarizine group （30 cases）. The transcranial color doppler （TCD） was used to detect the blood flow rate after one course of the treatment, and the main symptoms were evaluated. The results of the experiment were statistically analyzed. Results There was a significant difference between the total effective effects in the treating group and flunarizine group （P<0.05）. TCD procedure showed that there was also a significant difference between the blood flow rates of the internal carotid artery and vertebral artery （P<0.01, P<0.05）. Conclusion JIGs can exert the effects of expanding blood vessels, improving cerebral blood circulation, relieving cervical muscular spasm, so as to improve the clinical symptoms of cervical spondylosis of vertebral artery type.关键词：Cervical Spondylosis;Vertebral Artery;Jingxuanning Instant Granules
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发布时间：2021-09-15 - 摘要：Objective To observe the antidepressive effects of 2 Hz and 100 Hz electroacupuncture （EA） in the forced swimming test with rats. Methods The male SD rats were divided into the model group, 2 Hz EA group and 100 Hz EA group. After puncturing the baihui point and yointang point, the swimming immobility time test and the open field test were carried out to observe the swimming immobility time and the degree of mobility in the rats in the EA groups. Results In the 2 Hz EA group, the immobility time was significantly decreased as compared with that in the model group （P<0.05） while the degree of mobility in the rats remained unchanged （P>0.05）; however, the change in the immobility time in the 100 Hz EA group was not remarkable as compared with that in the model group （P>0.05）. Conclusion The results suggest that 2 Hz EA may possess a possible antidepressive effect.关键词：electroacupuncture;frequency;Forced Swimming Test;depression
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发布时间：2021-09-15 -
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