最新刊期
卷 0 ， 期 2 ， 2004
- 摘要：The system of diagnosis and treatment according to the indications of TCM formulas （SDTI TCMF） is completely different and special, as compared with the existing system of TCM syndrome differentiation and treatment. SDTI TCMF emphasizes making a diagnosis by carefully catching hold of the pivotal symptoms corresponding to the specific indications of a TCM formula from the anfractuous clinical symptomatic manifestations of the patients, that is to say, in treating a patient the emphasis is put on differentiating the symptoms related to the indications of a TCM formula, not on differentiating syndromes. The contents on indications of formulas in some TCM classics, such as Shanghanlun, Jinguiyaolue, and Wenbingtiaobian, are the theoretical foundation of SDTI TCMF. The proposal and establishment of the conception of SDTI TCMF not only grasp the essence of TCM diagnostics and therapeutics, and help the improvement of TCM clinical curative efficacy, but also provide a brand new theoretical approach for TCM modern research.关键词：Diagnosis and Treatment According to the Indications of TCM Formulas;TCM Syndrome Differentiation and Treatment;Study of TCM Syndrome Differentiation;Theory of Indications of Formulas
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发布时间：2021-08-10 -
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- 摘要：Objective To observe the changes in the behavior and NT 3 in the cortex and hippocampal CA 1 region in the rats irritated by the chronic stressor of restraint, and to investigate the effects of 3 TCM formulas, namely Xiaoyao Powder, Sijunzi Decoction and Jinguishenqi Pills, on the rats. Methods The rat model of chronic stress to restraint was induced by restraining the rat on a specially-designed restraint rack 3 hours each day for 7 and 21 days, respectively. The behavior of the model rats was observed and the effects of the 3 TCM formulas on NT 3 in the cortex and hippocampal CA1 region were detected by the immunohistochemical method and image analysis. Results The duration of staying at the central grille was obviously longer and the times of passing through the grille were obviously decreased in the rats undergone 21 days of irritation by the chronic stressor of restraint; the times of passing through the grille were decreased in the rats undergone 7 days of the irritation; and the times of struggling in the rats in both model groups were obviously decreased. All the 3 TCM formulas could shorten the duration of staying at the central grille, and increase the times of passing through the grille and the times of struggling. The level of NT 3 in the cortex in the model rats began to decrease after 7 days of the irritation and the decrease became significant after 21 days of the irritation, as compared with that in the control rats （ P <0.05）. The integral optical density of NT 3 in the hippocampal CA1 region in the rats in both model groups was significantly decreased, as compared with that in the control rats （ P <0.05）. All the 3 TCM formulas could increase the integral optical density of NT 3 in both cortex and hippocampus and the number of hippocampal NT 3 positive cells; and Xiaoyao Powder could increase the number of cortical NT 3 positive cells. Conclusion The decrease in the level of NT 3 in the cortex and hippocampal CA 1 region is related with the reaction caused by the chronic stressor of restraint, and Xiaoyao Powder, Sijunzi Decoction and Jinguishenqi Pills all can improve the behavior of the model rats and upregulate the level of NT 3, among which Xiaoyao Powder shows a stronger effect.关键词：Chronic Stress of Restraint;Neurotrophic Protein;Xiaoyao Powder;Sijunzi Decoction;Jinguishenqi Pills;rat
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发布时间：2021-08-10 - 摘要：Objective To investigate the effects against drug resistant tumor cells of 9 active components of traditional Chinese drugs by cell cultivation. Method MTT colorimetry was used in the detection, and KBv200 was used as the target. The cytotoxicity and enhanced sensitivity of the 9 active components were observed. Result It was found that cinnamic aldehyde, daizein, genistein and dioscin had obvious inhibitory effect on KBv200. Conclusion Cinnamic aldehyde, daizein, genistein and dioscin are worthy of further studies with respect to their inhibition of the growth of tumors.
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发布时间：2021-08-10 - 摘要：Objective To observe the effects of TCM warm purgative therapy and warm astringing therapy on the level of MIP 1αin the ulcerative colon of the rats. Methods The rat model of ulcerative colitis was established by TNBS/ethanol enema. The model rats were treated experimentally with Wenpi Decoction （WD） and Zhenrenyangzang Decoction （ZD）, respectively, by gastric perfusion; and the changes in the level of MIP 1αin the ulcerative colon were detected in the first, second and fourth weeks after the treatment, respectively. Results In the first week after the treatment, the level of MIP 1αwas significantly decreased in the WD group while it was not so in the ZD group, as compared with that in the model group; in the second week after the treatment, along with that the level of MIP 1αin the model group went down, there was no obvious difference found among the levels of MP 1αin all the treating groups in the experiment. Conclusion WD can decrease the expression of MIP 1αand relieve the inflammatory reactions at an earlier time than ZD.关键词：ulcerative colitis;Warm purgative Therapy;Warm astringing Therapy;MIP 1α;rat
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发布时间：2021-08-10 - 摘要：Objective To investigate the antifebrile mechanism of Naoreqing Oral Solution （NOS）. Method Established by the injection of endogenous pyrogen （EP） was the rabbit model of fever, with which the effect of NOS on the rabbit body temperature was observed; and the effects of NOS on the levels of cAMP in the hypothalamus and cerebrospinal fluid and arginine vasopressin （AVP） in the ventral septal area were detected by the radioimmunoassay. Results The body temperature and the levels of TRI 4, cAMP in the hypothalamus and cerebrospinal fluid and AVP in the ventral septal area in the rabbits in the EP group were significantly higher than those in the rabbits in the EP plus NOS group （ P <0 01）. The change in the body temperature was in a positive correlation with the change in the levels of cAMP in the hypothalamus and cerebrospinal fluid and AVP in the ventral septal area in all the four animal groups in the experiment （ P <0 01）. Conclusion The antifebrile mechanism of NOS may be both inhibiting the production and release of cAMP in the hypothalamus and promoting the release of AVP in the ventral septal area.
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发布时间：2021-08-10 - 摘要：Objective To investigate the pathogenic factors of chronic fatigue syndrome （CFS） in China on the basis of both TCM and western style medicine. Method The case control study and multi factor Logistic regression analysis were adopted to analyze the intensity of the correlation between the relevant factors and the onset of CFS. Result It was found that there were 8 indirect factors and 5 direct factors related with the onset of CFS, and the direct factors played a more important role in the development of CFS, as compared with the indirect factors. Conclusion CFS is a result of multi factor interference and easy to be induced by weakness and emotional depression.关键词：chronic fatigue syndrome;Pathogenic Factor;Case control Study;Logistic regression analysis
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发布时间：2021-08-10 - 摘要：Objective To observe the effect of the medicated serum prepared with the entire formula of Tongmaining capsules （TC） and different TC ingredient combinations on the calcium overload in the vascular smooth muscle cells （VSMC） induced by Ang II and LPC. Methods The primary explant method was used to cultivate VSMC, and the three groups of medicated serum were prepared with TC entire formula （EF）, TC qi benefiting ingredients （QI） and TC blood activating ingredients （BI）, respectively, by using the serum pharmacology method, with 10 -6 mol/l AngII and 10 -8 mol/l LPC as stimulants. The Fluo 3 staining fluorescent probe technique was used to detect the fluorescent intensity of Ca 2+ . Results It was found that all three groups of the medicated serum had marked interfering effect on the calcium overload in VSMC induced by Ang II and LPC, with the effect of EF medicated serum being better than that of QI medicated serum or BI medicated serum.Conclusion The experimental results have revealed,at the cellular molecular level, that the inhibition caused by the TC medicated serum of VSMC proliferation induced by Ang II and LPC is related with the partial obstruction of the signal transmission path in the Ang II and LPC cells, which may be one of the mechanisms of TC medicated serum in inhibiting VSMC proliferation induced by Ang II and LPC.关键词：Tongmaining Capsules;angiotensin II;Lysophosphatidyl Choline;Vascular Smooth Muscle Cell;Calcium Overload
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发布时间：2021-08-10 - 摘要：Objective To establish the mouse model of Lewis lung carcinoma and detect the carcinoma inhibiting rate of Weimaining. Methods The flow cytometry and immunohistochemical staining were used to investigate the effects of Weimaining on the cell cycle of carcinoma and the expression of cyclin D1 in the model mice. Results It was showed that the carcinoma inhibiting rates of Weimaining were 19 14%, 33 59%, 40 63% and 51 56%, respectively when it was given at the doses of 100 mg/kg/d, 150 mg/kg/d, 200 mg/kg/d and 250 mg/kg/d, respectively to the model mice, and the effects were exerted in a dose dependent manner. Weimaining could halt the growth of the carcinoma cells in the G 0-G 1 phase and decrease the expression of cyclin D 1 （ P <0 01）. Conclusion One of the Lewis lung carcinoma inhibiting mechanisms of Weimaining may be decreasing the expression of cyclin D 1 in the carcinoma cells and halting the growth of the carcinoma cells in the G 0-G 1 phase, and hence, making them unable to develop into the S phase for DNA replication.关键词：Weimaining;Lewis lung carcinoma;Cyclin D 1;mice
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发布时间：2021-08-10 - 摘要：Objective To study the effects of Jinguishenqi Pills （JP） on the differentially expressed genes in the mice with kidney deficiency induced by frightening by the technique of suppression subtractive hybridization （SSH）. Methods The experiment included the model group, treating group and control group. The mouse model of kidney deficiency was induced by the methods of using the cat to frighten the mouse and suspending the mouse over the water. The mice in the treating group were treated with JP. SMART technique was used in the reverse transcription and amplification in order to get the total cDNA in full length in the blood cells in the model mice and the model mice prior to and after JP treatment. And then, SSH was applied in both positive and negative directions to gain 6 groups of the differentially expressed cDNA profiles in the model mice, the model mice treated with JP, and in the normal mice. Results 6 Differentially expressed cDNA libraries were acquired in the experiment. Conclusion There is a relationship between the kidney deficiency induced by frightening and the differential expression of some genes, and JP can influence this change in gene expression, inducing the differentially expressed cDNA profiles back to their normal physiological state. The results of the experiment have established a foundation, on which it is able to identify and screen the target genes in a large scale.
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发布时间：2021-08-10 - 摘要：Objective To investigate the relationship between the change in the levels of serum NO, sex hormone as well as SOD and the aging phenomenon by carrying out a comparative study of the effects of Guhanyangshengjing Solution （GS） and livial in the 20 month old female rats. Methods The nitrate reducase method and radioimmunoassay were used to detect the change in the levels of serum NO, sex hormone and SOD. Results GS could effectively increase the levels of serum NO, sex hormone and SOD and decrease the level of LPO. Conclusion GS possessing the effects of generating body essence and nourishing kidney qi can favorably change the level of hormone and some biochemical indexs in the 20 month old female rats.关键词：Guhanyangshengjing Solution;aging;NO;Sex Hormone;SOD;rat
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发布时间：2021-08-10 - 摘要：Objective To observe the effects of Bupishenhuoxue Therapy （BT） on the level of advanced glycation end products （AGEs） and on the mRNA expression of AGEs receptors （RAGE） in the renal cortex in the diabetic rat, and to investigate the mechanism of the effects of BT in preventing and treating diabetic nephropathy （DN）. Methods The rat diabetic model was induced by an intraperitoneal injection of streptozotocin in the left lower abdomen of the rat. The model rats were divided into the diabetic group, BT group and aminoguanidine group. And there was a normal control group as well in the experiment. The fluorescence spectrum method was used to detect the level of AGEs, and the RT-PCR technique was used to detect the expression of RAGE mRNA. Results It was found that the level of AGEs was significantly increased and the RAGE mRNA was over expressed, in the renal cortex of the rats in the diabetic group; and the level of AGEs was markedly lowered and the expression of RAGE mRNA was markedly downregulated in the renal cortex of the rats in the BT group after being treated with BT for 12 weeks, as compared with the results from the diabetic group （ P <0 01）. Conclusion BT can prevent and treat DN by decreasing the accumulation of AGEs and downregulating the over expression of RAGE mRNA in the renal cortex.关键词：diabetic nephropathy;Advanced Glycation End Products;Bupishenhuoxue Therapy;rat
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发布时间：2021-08-10 - 摘要：Objective To observe the protective effects of Kangdai I on the cultivated rat cortical neurons damaged by mimic cerebral ischemia and reperfusion. Method the neuronal activity, survival rate, death rate, LDH leakage rate, the change in NOS activity, and the effects of Kangdai I were observed in the cultivated rat cortical neurons damaged by mimic cerebral ischemia of 4 hours and reperfusion for 3, 18, 24, 48 and 72 hours, respectively. Results Along with the ischemia and the prolonging of the time for reperfusion, a gradual decrease in the survival rate, a gradual increase in the death rate and in LDH leakage rate were found in the rat cultivated neurons; and an obvious increase in the NOS activity was found at 4 hours of ischemia and 3 hours of reperfusion. Kangdai I could affect the changes in these criteria. Conclusion Kangdai I maybe exert its protective effects on neurons by protecting the mitochondria from oxidative phosphorylation decoupling, protecting the cell membrane through halting lipid peroxidation and the increase in the permeability, and preventing the damage of NO and NO-derived toxic free radicals through inhibiting the enhance in the NOS reaction.关键词：Kangdai I;cerebral ischemia;Cultivated Neuron;MTT;LDH;NOS;rat
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发布时间：2021-08-10 - 摘要：Objective To explore the effects of Zhongjiling Tablets （ZT） on the levels of NO and NOS in the rats with experimental autoimmune myasthenia gravis （EAMG）. Methods The rat model of EAMG was induced by immunization with N 2 AchR extracted from the Torpedo electric ray’s electrical organ and complete Freund’s adjuvant （CFA） in Lewis rats. ELISA was adopted to detect the levels of IFN γin the serum and supernate of the cell culture fluid the 7th week after the immunization of the model rats. Colorimetry was used to detect the levels of NO and NOS in the serum, lymphocytic culture liquid and muscular tissue. Results The levels of IFN γ, NO and NOS were increased in the model group, as compared with those in the CFA group （ P <0.01） while the levels of these criteria were decreased in the ZT group （ P <0.01）. Conclusion ZT reduces the myoneural damage caused by NO through downregulating the levels of IFN γ and AchRab and causing a decrease in the synthesis of NO and NOS, in the rat model of EAMG.关键词：Experimental Autoimmune Myasthenia Gravis;Zhongjiling Tablets;IFN γ;nitric oxide;Nitric Oxide Synthase;rat
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发布时间：2021-08-10 - 摘要：Objective To study the anti tumor mechanism of the effects of Pingfei Oral Solution （POS） in the treatment of transplanted human pulmonary squamous cell carcinoma. Method The nude mouse model of transplanted human pulmonary squamous cell carcinoma was used in the experiment. The model mice were randomly divided into 3 groups, namely the normal saline group, POS group and cisplatinum group. The tumor tissue was isolated from the mice by aseptic manipulation 20 days after administration to observe the size of tumor, the proliferation of the tumor cells, the tumor vascular density, and the expression of VEGF. Results POS had remarkable effect of inhibiting the proliferation of carcinoma cells, but the effect was not as potent as that of cisplatinum. Cisplatinum could reduce the number of carcinoma vessels, but the effect was not as obvious as that of POS. The carcinoma vascular density was found to be higher in the cisplatinum group than that in the POS group. The area and the mean visual density of VEGF positive cells in the POS group were markedly decreased, as compared with those in the control group, while the intensity of the staining with respect to VEGF positive cells in the cisplatinum group was increased to a certain degree. Conclusion The POS representing the Yangyinqingfei therapy has a marked curative effect against transplanted human pulmonary squamous cell carcinoma. The results of this research initially prove that one of the mechanisms of the anti tumor effects of POS is inhibiting the proliferation of carcinoma cells and interfering neoplastic angiopoiesis.关键词：Yangyinqingfei Therapy;Pulmonary Squamous Cell Carcinoma;Neoplastic Angiopoiesis;mice
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发布时间：2021-08-10 - 摘要：Objective To investigate the effects of the honey boiled parent root of Aconitum carmichaeli （HBPRAC） on the immune function in the H 22 bearing mice. Methods Different doses of HBPRAC were given to the model mice, and then, the proliferation state of T cells and B cells in the spleen and the phagocytic activity of celiac macrophages were detected. Results It was found that the medium dose of HBPRAC could promote the proliferation of T cells, inhibit the proliferation of B cells, and enhance the phagocytic activity of celiac macrophages, in the H 22 bearing mice. Conclusion A medium dose of HBPRAC can affect the immune function in the H 22 bearing mice.关键词：Honey Boiled Parent Root of Aconitum Carmichaeli;H 22 Bearing Mice;immune function
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发布时间：2021-08-10 - 摘要：Objective To carry out an anti inflammatory study on, and an acute toxicity test with, Pterocephalus hookeri. Methods The rat acute paw swelling test, mouse tampon granulation swelling test, mouse acute ear swelling test, and mouse acute exudation test were performed in the experiment. Results Pterocephalus hookeri could significantly inhibit inflammation with lesser toxicity. Conclusion The total saponin of Pterocephalus hookeri possesses rather strong effects against inflammation without obvious toxicity.关键词：Pterocephalus Hookeri;Anti inflammatory Effect;Acute Toxicity Test
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发布时间：2021-08-10 - 摘要：The flowering branch, anthotaxy and lamina of Artemisia annua L. were taken as the explants; and the MS culture medium was chosen as the basic culture medium to be used in different combinations with hormone, in order to investigate the callus induction and the regeneration of the plant of Artemisia annua L. The results showed that the sequence of the ability to generate the callus was flowering branch > anthotaxy > lamina, and the best result of plant regeneration was with the cultivation of the flowering branch.关键词：Artemisia Annua;Tissue Cultivation;Plant Regeneration
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发布时间：2021-08-10 - 摘要：Objective To find a method for the determination of the content of total alkaloid in the effective fraction of the extract of Kushen Decoction （KD）. Methods The content of total alkaloids in the samples was determined by the acidic dye colorimetry, which was performed with matrine as the reference substance, dibromothymolsulfonphthalein as the acidic dye, and CHCl 3 as the extractant, under the condition of a buffer solution （pH=7.6）. Results Matrine had a good linear relationship with the absorbance in the range of 1.67 μg/mL - 8.33 μg/mL, and the regression equation was C=0.076A+0.0068 （r 2=0.9995）. The average recovery for matrine was 103.84%, with RSD=0.75% （ n =5）. Conclusion The determination of the content of the total alkaloid in five batches of sample shows that the method is simple, convenient and accurate, and can be used for the determination of the content of the total alkaloid in the effective fraction of the extract of KD.
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发布时间：2021-08-10 - 摘要：Objective To investigate the relationship between the heating time and the quality of the product in processing heshouwu, the traditional Chinese drug （the root of Polygonum multiflorum）. Method Crude heshouwu was processed by steaming in different heating times at a high pressure. Samples of the processed and crude heshouwu were taken for the experiment, and HPLC was used to determine the contents of free emodin and free physcion as well as the contents of the total emodin and total physcion in the samples. Result The heating time in processing of the heshouwu had a rather great influence on the content of anthraquinones. Conclusion The extent of the changes in the content of anthraquinones in the processed heshouwu can be controlled by the heating time in its processing.关键词：Processed Heshouwu;emodin;physcion;HPLC
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发布时间：2021-08-10 - 摘要：Objective To make an initial observation on the clinical effects of Qingnao Gutta Pills （QGP） on lacunar Infarction （LI）. Methods 40 Cases of LI were randomly divided into the QGP treating group （including 20 patients treated with QGP plus cytidine diphosphate choline） and the control group （including 20 patients treated with enteric aspirin tablets plus cytidine diphosphate choline） according to the principles of the prospective, random and parallel controlled studies. The nerve function defect scale and TCM clinical symptoms scale were used to evaluate the treating efficacy. Results Statistically, the QGP treating group showed better improving effects against TCM clinical symptoms, especially against amnesia and torpor, headache, dizziness, oral bitter feeling and dry throat, constipation, and yellow furred tongue, as compared with the control group. Although no statistical significance of the effects against the nerve function defect and of the total clinical effective rate was found in the QGP treating group, the clinical effects of the QGP were markedly manifested, as compared with the effects found in the control group. Conclusion The treatments for both groups have remarkably clinical effects. The treatment for the QGP treating group shows better effects on the TCM clinical symptoms than the treatment for the control group.关键词：Qingnao Gutta Pills;Lacunar Infarction;clinical efficacy
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发布时间：2021-08-10 - 摘要：Objective To investigate the clinical curative effects of the combination usage of BuzhongYiqi Decoction （BD） and Xiaochaihu Decoction （XD） in the treatment of chronic fatigue syndrom （CFS） manifesting the TCM syndrome of hepatic stagnation and splenic deficiency （HSSD）. Method 72 Patients of CFS manifesting HSSD were randomly divided into the treating group and control group. The treating group was given BD in combination with XD, with certain modification of the formulas; the control group was orally given ATP; and the clinical curative effects were observed in both groups. Result The total effective rate was 89.5% in the treating group while that was 26 5% in the control group, and there was significant difference between the two rates （ P <0 05）. Conclusion BD in combination with XD can markedly relieve the clinical symptoms of the patients with CFS manifesting HSSD, and raise immune function of the organism, with significant clinical efficacy.
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发布时间：2021-08-10 -
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