最新刊期
卷 0 ， 期 6 ， 2004
- 摘要：The retrospective study of the connotation of the TCM term Xuanfu developed in the past two thousand years shows that there are four unfavorable facts:（1） the term Xuanfu has many analogues of unclear meanings,such as the gate to qi,the mysterious gate,sweat pore,microorifice,yuanfu,fine meridian collateral,and the body interstitial structure; （2） Xuanfu is described as many uncertain morphological conformations,such as a hollow,an orifice,body texture,cleft or lumen,white membrane,and fine meridian collateral; （3） there are no accordant views on the function of Xuanfu,and it is said to be with such functions as opening and closing,unclogging and dredging,oozing and draining,and perfusing and pouring; （4） there are no accordant views on the actions of Xuanfu,and it is said to act to activate qi and dispel sweat,activate qi and lead qi downward,ooze body fluids,and to perfuse and diffuse qi and blood. It is of great significance to the TCM development and clinical practice to clarify the meaning of the TCM term Xuanfu and the historical development of the analogues of Xuanfu,and to make certain the difference and similarity between them.关键词：Xuanfu;Historical Development;TCM Term;review
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发布时间：2021-09-15 - 摘要：The pathologic changes related to the pathogenesis of TCM meridian-collateral disease, such as obstructed blood circulation, malnourished meridian-collaterals, qi and blood stagnation, aggregation of body fluid （TCM） and retention of phlegm （TCM）, and toxin accumulation in meridian-collaterals, involve many biological facts, for example, abnormal regulation and control of vasoactive substances, mechanisms for injuries of vasoendothelial cells and vascular smooth muscle cells, ECM malmetabolism, and abnormal regulation and control of cytokines and signal transduction pathway. Aggregation of body fluid denotes an increase in normally-distributed ECM, and retention of phlegm denotes the abnormal distribution of ECM. The irreversible cytomorphological and histomorphological changes are the results of toxin accumulation in meridian-collaterals, which manifest at the late stage of meridian-collateral disease. Therefore, the development of visceral fibrosis can be related with meridian-collateral disease. For example, pulmonary fibrosis can be related with pulmonary meridian-collateral disease; hepatic fibrosis, hepatic meridian-collateral disease; renal fibrosis, renal meridian-collateral disease. The diagnosis and treatment of meridian-collateral diseases can be based on to find a way for preventing and treating multiorganic fibrosis by TCM.
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发布时间：2021-09-15 - 摘要：The two reasons why the study on the treatment of miscellaneous diseases by Wenbing-formulas is going on slowly are: （1） the neglect of the study on Wenbing-formulas and the treating and diagnostic system based on Wenbing-formula-corresponding syndromes; （2） the ignorance of the study on the theories for treating and diagnosing miscellaneous diseases in the discipline of Wenbing. The study of the discipline of Wenbing in the future should be carried out at four points, namely strengthening the studies on Wenbing-formula-corresponding syndromes; deepening studies of the treating and diagnostic system based on Wenbing-formula-corresponding syndromes; putting an emphasis on the study of treatment and diagnosis of miscellaneous diseases in the discipline of Wenbing. The center of the teaching in the discipline of Wenbing should be the original text of the classics of the discipline of Wenbing, especially the original text on correlations between formulas and syndromes.关键词：Wenbing-Formulas;Miscellaneous Disease;Wenbing-Formula-Corresponding Syndrome;Diagnosis Based on the Discipline of Wenbing
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发布时间：2021-09-15 -
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- 摘要：Objective To observe the effects of liver-protective TCM drugs on the expression of TIMP-1 in HSC and HSC apoptosis on the purpose of investigating their target points for resisting hepatic fibrosis.Method First, the rat HSC was isolated and cultivated, and then, TIMP-1 expression in HSC and the interfering effects of the TCM drug-medicated serum on the TIMP-1 expression were detected by the ABC immunohistochemical method, the results of which were analyzed by a quantitative image analytic technique; and the percentage of HSC apoptosis was calculated by the Giemsa staining method and TUNEL staining method. Results There was a significant difference between the absorbency of TIMP-1 positive reactants in hepatic HSC in the TCM drug-medicated serum group and that in the control group （P<0.05）; and the apoptotic rate was 10.3% in the TCM drug-medicated serum group. Conclusion The serum mediated with TCM liver-protective drugs could inhibit the TIMP-1 expression of hepatic HSC and promote apoptosis of the activated hepatic HSC.
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发布时间：2021-09-15 - 摘要：Objective To observe the effects of cholic acid and jasminoidin in combination on the levels of cerebral TNF-α, IL-1 β, ICAM-1 and serum NSE in the rats with persistent focal cerebral ischemia, in order to investigate the links at which cholic acid and jasminoidin act to inhibit the cascade of the cerebral ischemic inflammatory injury and to investigate the mechanism of the effects produced by cholic acid and jasminoidin in combination. Methods Adult male SD rats were randomly divided into the sham operation group, model group, cholic acid group, jasminoidin group, cholic acid plus jasminoidin group, and Xueshuantong group. The rat model of focal cerebral ischemia was induced by persistent middle cerebral artery occlusion for 12 and 14 hours, respectively, by a thread ligation method. RIA was used to detect the levels of TNF-α and IL-1 β in the cerebral homogenate and the level of NSE in the serum. ELISA was used to detect the level of ICAM-1 in the cerebral homogenate. Results The levels of TNF-α, IL-1 β, ICAM-1 and NSE were found increased to different degrees, respectively, under cerebral ischemia for both 12 and 24 hours. Both cholic acid and jasminoidin could markedly inhibit the increase of TNF-α and IL-1 β under both the 12-hour and 24-hour cerebral ischemia; in addition, cholic acid could also inhibit the increase of NSE under the 12-hour cerebral ischemia; but both cholic acid and jasminoidin showed no obvious effects on the levels of ICAM-1 and of NSE under the 24-hour cerebral ischemia. However, the coadministration of cholic acid and jasminoidin could not only markedly inhibit the decrease of TNF-α and IL-1 β under both the 12-hour and 24-hour cerebral ischemia, but also markedly inhibit the increase of ICAM-1 under both the 12-hour and 24-hour cerebral ischemia and the increase of NSE under 12-hour cerebral ischemia. Conclusion Cholic acid and jasminoidin and their coadministration possess good effects for repressing the expressions of inflammatory cytokines and adhesive molecules under cerebral ischemia, hence reducing the inflammatory injury. The coadministration of cholic acid and jasminoidin shows particularly good effects for interfering the inflammatory process at different times and different links and for repressing the cascade of the inflammatory injury due to cerebral ischemia, hence inhibiting the damage to neurons.关键词：cerebral ischemia;Cascade of Injury;cholic acid;jasminoidin
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发布时间：2021-09-15 - 摘要：Objective To investigate the apoptosis of myocardial cells in viral myocarditis （VMC） and the changes in the relative regulatory factors, and the effects of Shenbai Oral Solution on them. Methods The BALB/C mouse was inoculated with murine-myocardium-affinitive Coxsackie virus B 3m （CVB 3m ） to induce VMC. At 3, 17, 20 and 30 days, respectively, after the inoculation, myocardial cell apoptosis, expressions of c-myc and Bcl-2, changes in TNF-a and IL-6, were observed by TUNEL method, immunohistochemical techniques and ELISA, respectively. Results It was found that CVB3m could induce myocardial cell apoptosis in VMC, and the positive expressions of c-myc and Bcl-2 and the changes in TNF-a and IL-6 were related to the occurrence of myocardial cell apoptosis. Conclusion Myocardial cell apoptosis and the relative regulatory factors are involved in the occurrence and development of VMC, and Shenbai Oral Solution has a good effect for preventing and treating VMC.关键词：Viral Myocarditis;apoptosis;gene expression;cytokine;Shenbai Oral Solution
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发布时间：2021-09-15 - 摘要：Objective To investigate the efficacy and mechanism of Yuantong Capsules in the treatment of experimental vascular dementia. Methods The rat model of dementia by ischemia/reperfusion was induced by repeated ligation of bilateral common carotid arteries together with an intraperitoneal injection of sodium nitroprusside. The rats in the experiment were divided into the sham operation group, model group, western-style drug control group, and TCM drug treating group （given a large, medium and low dose, respectively）. The observation of therapeutic effects of Yuantong Capsules was carried out in four aspects. Results Yuantong Capsules could reduce the degree of the injury by ischemia/reperfusion and improve learning and memorizing abilities. The capsules also showed an ability to resist lipid peroxidation. The effects of Yuantong Capsules had a dose-effect relationship, namely, the larger the dose, the stronger the effects. Conclusion The results show that Yuantong Capsules have marked effects for preventing and treating vascular dementia by ischemia/reperfusion.关键词：Yuantong Capsules;vascular dementia;animal experiment
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发布时间：2021-09-15 - 摘要：Objective To investigate the changes in the activity of xanthine oxidase in the serum and liver, and the expression of xanthine oxidase mRNA in the liver, of the quail model of hyperuricemia. Methods The quail model of hyperuricemia was induced by feeding a kind of feedstuff containing yeast. The activity of xanthine oxidase in the serum and liver of the model quails was detected by spectrophotometry, and the expression of xanthine oxidase mRNA in the liver in the liver of the quails was detected by hybridization in situ.Results A transient increase in the activity of xanthine oxidase was found in the serum, and an obvious enhancement in the activity of xanthine oxidase mRNA and in the expression of xanthine oxidase mRNA was found in the liver. Conclusion The results suggest that there is a certain relationship between the activity of xanthine oxidase and the mechanism for hyperuricemia. The changes in the activity of xanthine oxidase should be noticed in investigating the cause of hyperuricemia and the mechanism of the uric acid-decreasing drugs.关键词：xanthine oxidase;hyperuricemia;serum;liver;gene expression
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发布时间：2021-09-15 - 摘要：Objective To investigate the mechanism of the effects of Liujing Tablets （LT） for treating hysteromyoma. Methods The rat model of hysteromyoma was induced by intramuscularly injecting estrogen and progesterone. Radioimmunoassay was used to detect the level of serum sex hormones and ELISA was used to detect the levels of serum IL-2 and TNF-α. Results The levels of serum estrogen, progesterone and TNF-α were markedly increased and the level of serum IL-2 was decreased in the rats in the model group, as compared with those in the rats in the normal control group. The level of serum estrogen was markedly decreased and the level of serum IL-2 was markedly increased in the rats in the LT group, as compared with those in the rats in the model group.Conclusion The occurrence and development of hysteromyoma is related to endocrine disorder and immune hypofunction, and LT can inhibit the growth of hysteromyoma by regulating endocrine system and enhancing immune function.关键词：Liujing Tablets;Hysteromyoma;Sex Hormone;cytokine;rat
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发布时间：2021-09-15 - 摘要：Objective To observe the effects of Zidian Granules on the changes in the levels of IL-2, IL-6 and IL-8 in the peripheral blood of the mouse model of idiopathic thrombocytopenic purpura （ITP） and to investigate the relationship between ITP and the cytokines mentioned above. Method Radioimmunologic techniques were used to detect the levels of IL-2, IL-6 and IL-8. Results As compared with those in the control group, the levels of IL-2, IL-6 and IL-8 were all markedly increased in the peripheral blood of the mouse model of ITP （P<0.05）. Conclusion Zidian Granules have marked regulatory effects on the levels of the cytokines in the peripheral blood of the mouse model of ITP. The findings in the animal model suggests that IL-2, IL-6 and IL-8 are related to the occurrence, development and prognosis of ITP.关键词：Zidian Granules;Model of Idiopathic Thrombocytopenic Purpura;cytokine;mouse
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发布时间：2021-09-15 - 摘要：Objective To investigate the protective effects of the effective fraction of Huanglianjiedu Decoction （EFHD） on lipid peroxidation damage in the rat with multiple cerebral infarction （MCI）.Method The rat was used to induce the model of MCI by injecting sterile naturally-dried blood clot from the same species of animal into the common carotid, and the effects of EFHD on melondialdehyde （MDA）, superoxide dismutase （SOD）, Cu-Zn-SOD, glutathione-SH （GSH）, glutathione peroxidase （GSH-PX）, glutathione S-transferase （GSH-ST） and catalase （CAT） were observed in the brain of the model rats.Results EFHD could increase the activities of SOD, Cu-Zn-SOD, CAT, GSH-PX and GSH-ST; increase the level of GSH, lower the levels of MDA and LD; and decrease the activity of LDH （P<0.05,P<0.01）. Conclusion EFHD possesses significant protective effects against lipid peroxidation damage in the rat with MCI.关键词：Effective Fraction of Huanglianjiedu Decoction;Multiple Cerebral Infarction;lipid peroxidation
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发布时间：2021-09-15 - 摘要：Objective To observe the efficacy of TCM drugs for treating eczematous dermatitis and to investigate the mechanism of their effects on delayed-type hypersensitivity.Methods The mouse model of experimental contact dermatitis was established by sensitizing the skin of ICR mice with 2,4-dinitrochlorobenzen （DNCB）. The treating groups were given Piyan Decoction No.1 and No.2, respectively, the positive control group was given hydrocortisone sodium succinate, and the negative control group was given normal saline. Statistical methods were used to analyze the severity of skin injury of the auricular concha, the magnitude of the increase in the weight of the injured auricular concha, and the changes in the inflammatory cell count in the auricular concha with skin injury. Results Piyan Decoction No.1 and No.2 and hydrocortisone sodium succinate showed marked inhibitory effects on erythema, edema and infiltration in the model group, hence lowering the increase in the weight of the auricular concha due to focal skin damage caused by congestion and edema, and reducing the inflammatory cell infiltration at the site of skin damage. The results had statistical significance, as compared with those in the negative group which was given normal saline （P<0.01）. Furthermore, Piyan Decoction No.1 showed stronger effects than Piyan Decoction No.2 （P<0.05）. Conclusion Piyan Decoction has marked inhibitory effects on the mouse contact dermatitis caused by delayed-type hypersensitivity.关键词：Piyan Decoction;Contact Dermatitis;Delayed-Type Hypersensitivity;Mouse Model
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发布时间：2021-09-15 - 摘要：Object To observe the effects of Bishu Dropping Pellets （BDPs） on the regulation of T lymphocyte subgroup, IL-4, IL-12 and IgE in the guinea pig model of allergic rhinitis （AR）, and to investigate the mechanism of BDPs against AR. Methods The guinea pig model of AR was induced with 2,4-tolylene diisocyanate. The radioimmunologic method was used to detect the total levels of IgE and IL-4 in the serum; the immunohistochemical method was used to detect the levels of CD4 and CD8 of the T lymphocytes in the peripheral blood; and ELISA was used to detect the level of IL-12 in the serum. Results BDPs could markedly decrease the levels of IgE and IL-4 in the serum of the model animals, and markedly increase the ratio of CD4/CD8 and the level of IL-12. Conclusion BDPs can exert an effect against AR by decreasing the levels of IgE and IL-4, and by increasing the ratio of CD4/CD8 and the level of IL-12.
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发布时间：2021-09-15 - 摘要：Objective To examine the procedure for the chemical extraction of the root of Coptis chinensis used as one of the ingredients of Qingretonglin Suppository. Method The procedure for the extraction was performed with berberine hydrochloride as a general criterion for reference. Results It was found that the procedure could achieve a good result when the sample was infiltrated with 0.5% sulphuric acid solution and 7-fold of infiltrating solution was collected. Conclusion The procedure examined for the chemical extraction of the root of Coptis chinensis is technologically stable and applicable.关键词：Qingretonglin Suppository;Extraction Procedure;Infiltration;berberine hydrochloride
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发布时间：2021-09-15 - 摘要：Objective To investigate the chemical constituents of the aqueous extract of Rhaponticum uniflorum （L） DC. Methods First, the aqueous extract of Rhaponticum uniflorum was processed with macroporous adsorbing resin for absorption and purification, and then, silica gel chromatography was used to isolate the constituents of the extract. Finally, the spectral analytic technique and 2D-NMR technique （including 1H- 1H COSY, HMQC, HMBC, NOESY, TOCSY, etc.） were used to elucidate the chemical structure of the constituents. Results A diterpenoid compound, diosbulbin-B （V） was isolated from the aqueous extract of Rhaponticum uniflorum and its structure was identified. Conclusion Diosbulbin-B （V） has been found in Rhaponticum uniflorum for the first time, and it is also the first time to find Diosbulbin-B （V） existing in a plant of the Rhaponticum genus.关键词：Rhaponticum uniflorum;diterpenoid;Diosbulbin-B
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发布时间：2021-09-15 - 摘要：Object To quantitatively determine gentiopicroside in the root of Gentiana marophylla, one of the ingredients of Kangfengshi Granules. Method The HPLC procedure was used in the determination: the chromatographic column was YWG-C 18 （250 mm ×4.6 mm, 10 μm）, the mobile phase was methanol-water （30:70） at a flow velocity of 1.0 mL/min, and the detection wavelength was 254 nm. Results It was showed that gentiopicroside had a good linear relationship when its concentration was between 1.04 μg - 5.20 μg （r=0.9994, n=5）; and the sample recovery of the procedure was 100.06% （RSD = 1.08%, n=5）.Conclusion This procedure, which is quick, accurate and easy to be performed, can be used in the quantitative determination of gentiopicroside.关键词：Gentiana marophylla;Gentiopicroside;HPLC
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发布时间：2021-09-15 - 摘要：Objective To establish a method for quantitative determination of the total alkaloids in the root of Sophora flavescens used as one of the ingredients of Rouku Capsules.Methods The content of the total alkaloids in the root of Sophora flavescens was determined by solvent extraction and acid dye colorimetry, with oxymatrine as a control criterion and bromothymol blue as the acid dye. Under a condition in which the pH value of the buffer solution is equal to 7.6, the total alkaloids in the root of Sophora flavescens were extracted with chloroform, and their content was detected at the wavelength of 417 nm. Results Oxymatrine showed a good linear relationship with absorbance when its concentration was between 0.698 mg/L-13.96 mg/L, and the regression equation established was C=20.243A-1.5136, （r=0.9993, n=5）. The recovery of oxymatrine was 102.67% （RSD=0.74%, n=5）. Conclusion This procedure, which is easy, accurate and specific, can be used in the quantitative determination of the total alkaloids in the root of Sophora flavescens in Rouku Capsules.关键词：Rouku Capsules;Acid Dye Colorimetry;oxymatrine;Total Alkaloids in the Root of Sophora flavescens;quantitative determination
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发布时间：2021-09-15 - 摘要：Objective To assess the states of the autonomic nervous function in and emotions in the patients with TCM liver depression. Method Case-control study method was used to investigate the states of the autonomic nervous function and emotions in the patients with TCM liver depression. 96 Subjects involved in the assessment were divided into the liver depression group （49 cases）, non-liver-depression group （28 cases） and the normal control group （19 cases）. All the subjects were examined by some physical load tests and asked to fill in the forms of Zung Self-Rating Anxiety Scale （SAS） and Zung Self-Rating Depression Scale （SDS）. The results of the examination of autonomic nervous function were judged according to the criteria recorded in the related literature, and the total standard scores calculated according to the scales were compared among the groups. Results No statistically significant changes in autonomic nervous function in the patients in the liver depression group were found as compared with those in the non-liver-depression group and the normal control group （P>0.05）, and the total standard scores based on SAS and SDS concerning the emotions of the patients in the liver depression group were higher than those in the normal model, showing a markedly difference as compared with those in the non-liver-depression group and the normal control group （P<0.05）. Conclusion The results of this assessment provide meaningful data for the study of depression.关键词：Liver Depression;Autonomic Nervous Function;Zung Self-Rating Anxiety Scale;Zung Self-Rating Depression Scale
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发布时间：2021-09-15 - 摘要：Objective To study the ratios of the costs to efficacies of three treatment schemes for chronic congestive heart failure. Method An approach based on medication economics was used to evaluate and analyze the ratios of the costs to efficacies of three treatment schemes for chronic congestive heart failure, namely （1） scheme consisting of cardiac stimulants （CS）, diuretics （D）, beta adrenergic receptor blockers （ARB） and angiotensin converting enzyme inhibitors （ACEI）, （2） scheme consisting of CS, D, ARB, ACEI plus Shengmai Injection, （3） scheme consisting of CS, D, ARB, ACEI plus Xinjiening Mixture. Result The scheme consisting of CS, D, ARB, ACEI plus Xinjiening Mixture showed the best ratio of the cost to efficacy.Conclusion The approaches based on medication economics are important for evaluating the treatment schemes consisting of drugs.关键词：Chronic Congestive Heart Failure;Treatment Schemes;Cost-Efficacy
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发布时间：2021-09-15 - 摘要：Objective To investigate the effects of Shengjing Pills in the treatment of male sterility. Method 120 Cases of male sterility were randomly divided into the treating group （60 cases） and the control group （60 cases）. The treating group was given Shengjing Pills and the control group was given Wuziyanzong Pills. The sperm parameters were analyzed by the WLJY-9000 Weili Color Spermatozoon Quality Examining System, and the level of blood testosterone and the side effects of Shengjing Pills were also observed. Results It was found that the spermic density, spermic survival rate, spermic activity, spermic motion parameters, and the level of testosterone were markedly higher than those detected in the control group （P<0.05）, and furthermore, no notable side effects with found with Shengjing Pills in the patients during administration. Conclusion Shengjing Pills can generally adjust sperm abnormality and increase sperm quantity, sperm quality and the level of testosterone, with assured effects and without notable side effects.关键词：Shengjing Pills;Male Sterility;Supplementing Body Essence and Marrow;Nourishing Yin and Helping Yang
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发布时间：2021-09-15 - 摘要：Objective To investigate the efficacy of the integrated therapy of autologous bone marrow mononuclear cell transplantation and TCM drugs in the treatment of lower limb ischemia. Method 6 Cases of lower limb ischemia were involved in the clinical study. Before the operation, granulocyte colony stimulating factor （G-CSF） was used in the patients for making their bone marrow be in an active proliferation state. And then, the bone marrow fluid was aspirated for the separation of mononuclear Cells. The amount of the mononuclear cells in the separated fluid was over 1×10 9. The transplantation of the mononuclear cells was performed by the method of multipoint injection in the ischemic lower limb, and the TCM drugs were given to the patients from the first day after the operation. The efficacy of the integrated therapy was assessed by scoring lower limb pain intensity, poikilothermia, ankle-brachial index （ABI）, and the area of the ulcerative surface in the patients before and after the operation. Results The scores of the lower limb pain intensity and poikilothermia markedly decreased in the patients one week after the treatment, then rebounded to some degree two weeks after the treatment, and went down again one month after the treatment. ABI increased gradually after the treatment, and the average value of the increased ABI was 0.23 one month after the treatment. After the treatment, the ulcerative area markedly shrank in the 3 cases with ulcerative surface; and toe amputation was performed in the 2 cases with severe putrescence one month after the treatment, and the incision got healed by first intention. Conclusion The integrated therapy of autologous bone marrow mononuclear cell transplantation and TCM drugs can relieve the clinical symptoms and signs in the patients of lower limb ischemia.关键词：Bone Marrow Transplantation;Mononuclear Cell;Lower Limb Ischemia;TCM Drug Therapy
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发布时间：2021-09-15 -
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