最新刊期
卷 0 ， 期 2 ， 2005
- 摘要：The physiological basis of liver governing conveyance and dispersion （LGCD） was investigated from the aspect of modern information control system. The result showed that the instinctive demand was the core of LGCD. The brain limbic system, the center of motivation and emotion, was the control center of LGCD. The information path of LGCD was the hypothalamic-brainstem-autonomic nervous path and its effector was the smooth muscle system, which changed the distribution of qi, blood and body fluid through the systaltic movement to bring about LGCD, then transmitted the changes to the limbic system to get the feedback regulation through the sensory afferent system. The adrenocortical hormone played an important role in maintaining and changing the normal function of LGCD.关键词：liver governing conveyance and dispersion;information control system;Physiology
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发布时间：2021-09-15 -
- 摘要：Objective To analyse the regularities of frequency distribution of ancient and modern formulae and drugs for preventing and treating the dizziness syndrome, and to probe into the effective combination of formulae and drugs. Methods The literature research and statistics were used to collect the important medical books of past ages and modern documents since 1980 about preventing and treating the dizziness syndrome. A database of the formulae and drugs for the dizziness syndrome was established. The drugs were divided into groups by their functions and their frequency distributions were counted. The drugs with an accumulative frequency over 50% were included into a sub-database. The ancient and modern formulae and drugs for preventing and treating the dizziness syndrome were compared. Results The ancient drugs and formulae for preventing and treating the dizziness syndrome were mainly those for nourishing, exterior syndrome-relieving, heat-clearing and phlegm-resolving. The modern drugs and formulae were mainly those for nourishing, blood-activating, stagnation-resolving, liver-soothing, wind-stopping and phlegm-resolving. The drugs with a higher frequency were selected. Conclusion The therapies of nourishing yin and essence, relieving exterior syndromes, clearing heat and resolving phlegm are the guiding treatment ideas of ancient doctors to prevent and treat the dizziness syndrome. The therapies of nourishing yin and essence, resolving stagnation to dredge the collaterals, expelling phlegm and stopping wind are the guiding treatment ideas of modern doctors to prevent and treat the disease.关键词：dizziness;formulae and drugs for prevention and treatment;ancient;modern;drugs with a higher frequency
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发布时间：2021-09-15 -
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- 摘要：Objective To study the effects of Fufangbiejiarangan Tablets （FT） on the expression of transforming growth factor-β1 （TGF-β1） and mRNA in rat renal cortex. Methods To establish the rat models of renal interstitial fibrosis after unilateral ureteral obstraction（UUO）. The rats were divided randomly into 7 groups: the normal group, the pseroperative group, the model group, the Benazepril group, the treatment group 1 with high dose of FT, the treatment group 2 with middle dose of FT and the treatment group 3 with low dose of FT. After the operation for four weeks the expression of TGF-β1 and mRNA in rat renal cortex were detected respectively by immunohistochemistry and in situ hybridization. The graphic analysis system and SPSS 11.5 statistics software were used to treat the results. Results In the model group the level of TGF-β1 and the yellow granular positive reactant of mRNA was low in the renal tubular epithellal cell and renal interstitial cell. In the Benazepril group the level of yellow granular positive reactant were obviously decreased compared with the model group （P<0.01）. In the treatment groups the level of yellow granular positive reactant were obviously decreased compared with the model group （P<0.01）. The treatment group 1, 2 and 3 had different dose dependency respectively. Conclusion TGF-β1 may play an important role in renal interstitial fibrosis. FT has a protective effect on rat kidney with renal interstitial fibrosis through decreasing the levels of TGF-β1 and mRNA.关键词：Fufangbiejiaruangan Tablets;transforming growth factor-β1;unilateral ureteral obstraction;renal interstitial fibrosis;rats
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发布时间：2021-09-15 - 摘要：Objective To determine the permeation rate of effective components of Qingkailing （ECQ） through an in vitro blood-brain barrier （BBB） model. Method To establish an analog in vitro BBB by using mouse model of microvascular endothelial cells monostratal culture. The permeation rate of ECQ （including geniposide, baicalin, cholic acid, hyodeoxycholic acid and dexocholic acid） in 24 hours is detected by means of LC/MS analysis. Result The order of permeation rate is geniposide, cholic acid, hyodeoxycholic acid and dexocholic acid. Baicalin is not detected in the colature. Conclusion The effective components of Qingkailing have a higher permeation rate in an analog in vitro BBB. The mechanism and pharmacological effect are worth studying further.关键词：Qingkailing;effective components;blood-brain barrier;permeation rate
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发布时间：2021-09-15 - 摘要：Objective To observe whether the conditional medium of the injured Vascular endothelial cells（VEC） induced by ox-LDL, the D （with majority of paeonioflorin） and E （with majority of total flavone ）（weight ratio 1:2）compatibility of the effective components extracted from Qixue Bingzhi Formula have any influence on the activity of Vascular smooth muscle cells（VSMC）, MAPK, PKC and the fluorescent intensity of intracellular Ca 2+. Method The VSMC normal culture fluid, the conditional medium of the injured VEC induced by ox-LDL, the conditional medium of the injured VEC induced by ox-LDL and Simvastatin, the conditional medium of the injured VEC induced by ox-LDL and the D and E compatibility of the effective components extracted from Qixue Bingzhi Formula acted on the VSMC respectively. With β-radioactivity assay the activity of the mitogen-activated protein kinase （MAPK） and protein kinase C （PKC） were assayed, and with the Liquid Cellular Technique the fluorescent intensity of intracellular Ca 2+ of VSMC was assayed too. Result In comparison with the normal cultured VSMC, it has been found that conditional medium of the injured VEC acted on VSMC, the activity of MAPK and PKC of VSMC significantly increased and the fluorescent intensity of intracellular Ca 2+ increased too; whereas after the D and E compatibility of the effective components acted on the cultured VSMC with the conditional medium of the injured VEC, in comparison with the model cultured VSMC, the activity of MAPK and PKC significantly decreased （p<0.01）, and the fluorescent intensity of intracellular Ca 2+ lowered. Conclusion The D and E compatibility of the effective components from Qixue Bingzhi Formula is able to inhibit the increase of the activity about MAPK and PKC, and increase of the fluorescent intensity about intracellular Ca 2+. The action of Qixue Bingzhi Formula in prevention and treatment of AS may be related to the paeonioflorin and total flavone （weight ratio 1:2） compatibility of the effective components, which can inhibit the activity of MAPK and PKC of VSMC induced by the conditional medium of the injured VEC and the fluorescent intensity of intracellular Ca 2+.关键词：atherosclerosis;endothelial cells;smooth muscle cells;oxidized low-density lipoprotein;Qixue Bingzhi Formula
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发布时间：2021-09-15 - 摘要：Objective To investigate the protective effects of a saponin compound from Anemarrhena asphodeloides （SCAA） on the rat undergone cerebral ischemia/reperfusion and to study the mechanism of the effects. Method The rat model of cerebral ischemia/reperfusion was induced by the thread insertion method, in which the neurological symptoms, area of cerebral infarction, and blood cell count were observed, and the activities of SOD, MPO and NOS, and the levels of MDA and NO were detected. Results It was found that when being used at doses of 20 mg/kg and 40 mg/kg, respectively, in the model rats, SCAA showed marked effects of relieving the neurological symptoms; reducing the area of cerebral infarction; decreasing the white blood cell count and neutrophil blood count in the whole blood; reducing the activities of MPO, T-NOS, and i-NOS; increasing the activity of SOD; and decreasing the levels of MDA and NO. Conclusion The mechanism of SCAA in protecting the rat from cerebral damage due to ischemia/reperfusion is its reducing the intensities of the injury caused by free radicals, inflammatory reactions, and of the NO toxic effects.关键词：saponin compound from anemarrhena asphodeloides;cerebral ischemia/reperfusion;neurological symptom;infarction area;blood cell count;biochemical assay
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发布时间：2021-09-15 - 摘要：Objective To investigate the effect and mechanism of antidepressant of Kaixin Powder （KP）.Method The mouse model of forced-swimming was established to evaluate the antidepressant effect of KP. The content of plasma cortisol were measured by RIA and the center neurotransmitter was measured by HPLC.Results The test indicated that in the KP groups with different doses the fast time of forced-swimming mice was significantly shortened and the mid-dose group showed the best result. The plasma cortisol content was significantly reduced at 5d, 7d and 14d after administration. At 3d and 5d after administration the NE content of the Desipramine group and the KP groups was obviously increased with a significant difference compared with the control group. There was no significant difference in the content of DA at different administration times among the KP groups. At 1d in the low-dose KP group the content of 5-HIAA in mouse brain was increased. The medium and high-dose KP groups showed activities at 3d and 5d and had a significant difference after administration compared with the control group. Conclusion KP can increase the contents of 5-HT and NE in mouse cerebrum, decrease the content of plasma cortisol simultaneously and has antidepressant effect.关键词：Kaixin Powder;antidepressant;CortisoL;neurotransmitter
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发布时间：2021-09-15 - 摘要：Objective To investigate the effect and mechanism of Gualouxiebai Decoction for preventing and treating the pulmonary fibrosis. Method The rat models of pulmonary fibrosis was established by bleomycinA5 and then divided into 3 groups. The treatment group was given Gualouxiebai Decoction daily for 28 days. The histopathological changes and the expression of transforming growth factor-β1 （TGF-β1） in rat lung were observed and compared.Result The degree of the alveolitis and pulmonary fibrosis in the model group was more serious than that of the normal control group and the treatment group （P<0.05）. The level of TGF-β1 in rat lung tissue in the model group was also significantly higher than that of the normal control group and the treatment group （P<0.05）. Conclusion Gualouxiebai Decoction can significantly alleviate the degree of alveolitis and pulmonary fibrosis in rats and inhibit the excessive expression of TGF-β1.关键词：pulmonary fibrosis;transforming growth factor-β1;Gualouxiebai Decoction;rat
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发布时间：2021-09-15 - 摘要：Objective To observe the effect of safflor yellow made with the chromatography of macroporous resin on rat cardiac insufficiency induced by myocardial ischemia （MI）. Method The rats were given daily safflor yellow injection then injected isoprenaline （ISO） to establish the MI model. After three days a catheter was inserted through the right carotid of model. The ventricular pressures before and after the model establishment and the injection were recorded and analysed. The tissue sections of rat apex were stained with PTH and observed with the microscope. Result The increase of left ventricle end-diastolic pressure of MI rat induced by repeated ISO injection could be remitted obviously by safflor yellow （P<0.05）. safflor yellow could also control the decrease of some indexes, such as +dp/dtmax, -dp/dtmax, VPP, DP, Vpm and VPP×HR. The inhibition of safflor yellow on the myocardial metamorphosis had not been observed. Conclusion safflor yellow is effective to inhibit the cardiac insufficiency with MI induced by ISO injection.关键词：safflower luteolin;myocardial ischemia;heart function;left ventricle end-diastolic pressure
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发布时间：2021-09-15 - 摘要：Objective To observe the effects of Xifengjingning Granules （XG） on the model of experimental tourette syndrome （ETS） and the levels of dopamine in corpus striatum and homovanillic acid （HVA）. Method The ETS model was established by using ip apomorphine and injecting locally 6-oxydopamine to lesion the black substance. The contents of dopamine and HVA were determined by HPLC.Result XG could inhibit the mold and rotation induced by ip apomorphine of ETS model （P<0.01）, and increase the content of HVA in corpus striatum （P<0.01）. The effect of XG was as the same as haloperidol. Conclusion XG can relieve the symptoms of ETS model and its mechanism may be related to the brain dopamine nerve.
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发布时间：2021-09-15 - 摘要：Objective To observe the preventive and therapeutic effects of Yiqihuoxuejieduhuatan Formula （YF） on rat hepatic fibrosis induced by dimethylni-trosamine （DMN）. Methods The model of hepatic fibrosis was established by using DMN then they were divided into two groups. Group 1 was given YF at the beginning （prevention） and the end （treatment） of hepatic fibrosis induced respectively. Group 2 was injected with recombinant human interferon α2b as the control group. The activities of ALT and AST, levels of TBiL, TP, Alb, LN in rat serum were detected 90 days later. The contents of Ⅳ-C, HA and PCⅢ were measured by radioimmunoassay method. The histopathological changes of liver cells in rats were observed with the optical microscopy after the stain of hematoxylin-eosin and picric acid-sirius red. Results In group 1 the activities of ALT, AST and levels of TBiL and LN were decreased significantly （P<0.05）, and the levels of TP and Alb were increased significantly （P<0.05） in the prevention. The levels of Ⅳ-C and HA were decreased significantly （P<0.05） in the treatment. The damage of liver cells and the fibrosis degree were relieved after both the prevention and treatment. The fibrosis scores were reduced significantly （P<0.05） in the prevention. Conclusion YF has a preventive or therapeutic effect on rat hepatic fibrosis induced by DMN. In addition the prophylactic of YF can arrest the formation and development of rat hepatic fibrosis.关键词：Yiqihuoxuejieduhuatan Formula;dimethylnitrosamine;hepatic fibrosis;prevention;treatment;rats
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发布时间：2021-09-15 - 摘要：Objective To study the anti-depressant effect of Qiweikaixin Granulae. Method The mice were given the forced swimming test, tail suspension test and antagonistic test to depressant symptoms induced by reserpine. To observe the anti-depressant effect of Qiweikaixin Granulae. Result Qiweikaixin Granulae significantly shortened fast time in the forced swimming test and tail suspension test in mice, and prevented the depressant symptoms induced by reserpine （P<0.05）, such as descent of body temperature, blepharochalasis and acinesia. Conclusion Qiweikaixin Granulae have an anti-depressant effect in mice.关键词：Qiweikaixin Granulae;tail-suspention test;forced-swimming;reserpine;mice
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发布时间：2021-09-15 - 摘要：Objective To investigate the protective effect of Qihong Capsules on mouse viral myocarditis.Method To establish the viral myocarditis model in vivo by infection with 100LD 50 coxsackie virus, then divide model into the control group, the experimental group and the infected group. The appetite, weight and body temperature of model were detected daily for 21 days. Then the ratio of death in three groups was counted respectively. The content of serum myocardium enzyme （SME） was determined at different times from the blood taken from mouse orbit in three groups.Results The ratio of death in the control group and the experimental group was below 50%, that in the infected group, 71.0%（P<0.01）. There was a significant difference between the infected group and the experimental group in weight, body temperature and appetite （P<0.01）, and in the content of SME at the 5th day. Conclusion Qihong Capsules have a protective effect on the mouse model of viral myocarditis.
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发布时间：2021-09-15 - 摘要：Objective To investigate the effect of Naoshuning on permeability of blood-brain barrier （BBB） and protein expression of matrix metalloproteinase-9 （MMP-9） in rats with traumatic brain injury （TBI）, and to discuss the protective mechanism of Chinese medicine on BBB. Method The model of TBI was established by bumpiness of free falling body. Immunohistochemistry was used to observe the brain protein expression of MMP-9.Result BBB was damaged and the hydrous content of brain and the protein expression of MMP-9 were significantly increased at 24h after TBI in contusion tissue in the model group. The permeability of BBB, hydrous content of brain and the MMP-9 expression were significantly decreased in the Naoshuning group （P<0.01, P<0.01, P<0.01）.Conclusion A higher MMP-9 expression can damage BBB and induce the cerebral edema after TBI. Naoshuning can protect BBB and decrease the hydrous content of brain. The mechanism may be related to its inhibiting effect on the expression of MMP-9 of TBI.
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发布时间：2021-09-15 - 摘要：Objective To observe the ultrastructure of colonic wall in rat model of slow transit constipation （STC） and to find the pathogenesis of STC. Method Rhubarb was used to establish STC rat model. The ultrastructural changes of colonic wall in model were observed with the electron microscope. Result With the light microscope the chronic mucositis in colon, panmural infiltration of a large number of oxyphilic granulocytes, accrementition of muscularis collagen fibers, vacuolar degeneration of nerve cells of myenteric phexus were observed in the rhubarb group. With the electron microscope the disappearance of Cajal’ cells of myenteric phexus, spondylosis of neurons and neuroglia cells, disorganization of smooth muscle fiber and infiltration of oxyphilic granulocytes were observed in the rhubarb group. Conclusion There are distinct pathologic changes of colonic myenteric plexus in STC rat model. The production and transmission interference of neurotransmitter are thought as the pathologic base of STC. Stimulant cathartic like rhubarb can injure the enteric nervous system.关键词：slow transit constipation;colon;ultrastructure;Rhubarb;rat model;rat
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发布时间：2021-09-15 - 摘要：Objective To determine the active principle and study the content standard for rhizoma of chuanxiong（RC）. Method TLC was used to identify the content of ligustilide and HPLC was used to assay the contents of ligustilide and ferulic acid in RC. Result Ligustilide could be identified in RC.The contents of ligustilide and ferulic acid should not be lower than 1.50% and 0.05% respectively. Conclusion TLC is a specialized method and HPLC has a higher accurate and better repeated character for the assay.They can be used in the qualitativequantitative control of RC.关键词：rhizome of chuanxiong;qualitative standard;TLC;HPLC;ligustilide;ferulic acid
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发布时间：2021-09-15 - 摘要：Objective To study the chemical component of the effective fraction of Qingnaoxuanqiao Formula. Method The chromatography with macroporous resin, polyamide and silica gel and the spectrum were used to isolate and identify the component and structure of Qingnaoxuanqiao Formula. Result Nine compounds were isolated and identified from Qingnaoxuanqiao Formula as （1） ursolic acid （2） ginsenoside-Rg1, （3） ginsenoside-Rh1 （R）, （4） ginsenoside-Rh1 （S）, （5） ginsenoside-Re, （6） ginsenoside-Rb1, （7） geniposide, （8） notoginsenoside-R1, （9） Genipin-1-O-β-gentiobioside. Conclusion All of above compounds were isolated from the effective fraction of Qingnaoxuanqiao Formula for the first time.关键词：Complex prescription;Qingnaoxuanqiao Formula;chemical component
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发布时间：2021-09-15 - 摘要：Objective To establish a method for assay of gastrodin in Jingshu Gutta Pills. Method Gastrodin was separated by HPLC and gradient elution with a solvent system consisting of methonal-water with methanol 4%-6% for 0-15min, with 6%-30% for 15-18min. The wavelength of detection was set at 221nm by 3D spectrum. Result To create the condition for gastrodin assay in Jingshu Gutta Pills by HPLC. There was a good linear in the range of 0.100 4 to 0.502 0 mg/L, r=0.999 9. The average recovery was 101.84%, RSD=1.97%. Conclusion The method is accurate, simple and quick, and can be used in the assay of gastrodin in Jingshu Gutta Pills.关键词：gastrodin;Assay;HPLC;gradient elution
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发布时间：2021-09-15 -
Clinical Observation of Mood Disorders in Convalescence of SARS Treated with Chinese Medical Therapy
摘要：Objective To investigate the curative effect of the integrated therapy of Chinese and western medicine on the patients with anxiety and depression in the convalescence of SARS in Xiaotangshan Hospital. Method The patients with anxiety and depression in convalescence of SARS were divided into the treatment group（n=61） and the control group （n=60）. The treatment group was treated with basic western medical treatment integrated with Chinese medicine. All patients were examined by HAMD and HAMA before and after the treatment.Results The result showed that the improvement of the total score of HAMD and HAMD parameter Ⅵ （disturbed sleep）, the total score of HAMA and HAMA parameterⅡ （psychiatric anxiety） in the treatment group was much better than that in the control group. The curative effect of the treatment on mood disorders in convalescence of SARS was improved after using Ciwujia Injection. Conclusion The integrated therapy of Chinese and western medicine for the treatment of the patient with anxiety and depression in convalescence of SARS can relieve the symptoms, speed up the recovery and raise the life quality of the patients.关键词：SARS;mood disorders;Chinese medical therapy- 8
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发布时间：2021-09-15 - 摘要：Objective To evaluate further the curative effect of Pushen Capsules on primary hyperlipidemia.Method The clinical test of multicentric random parallel control was used. The patients （n=448） were divided randomly into the treatment group （n=336） given Pushen Capsules and the control group （n=112） given Zhibituo Tablets. Two groups were all treated for 4 weeks. The main indexes of curative effect were TC, TG, LDL-C and HDL-C. Result Pushen Capsules could decrease averagely the level of TC to 0.6246mmol/L, TG, to 1.5343mmol/L, LDL-C, to 0.5764mmol/L and HDL-C, to 0.4406mmol/L. Pushen Capsules had a better curative effect to decrease the level of TG in the treatment group than that in the control group.Conclusion Pushen Capsules has a lipid-regulating function for the patient with primary hyperlipidemia especially with a higher level of TG.关键词：Pushen Capsules;primary hyperlipidemia;clinical test
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发布时间：2021-09-15 - 摘要：Objective To differentiate and classify the infertility induced by oviduct blockage, analyse the related factors of oviduct blockage, and study the relationship between the factors and syndrome types of traditional Chinese medicine （TCM）. Methods To divide 230 patients into the blockage group （n=142） and the non-blockage group （n=88）, and compare the proportion among different TCM syndrome types in the blockage group. The relationship between the times of miscarriage, history of pelvic operation, abdominal operation, ectopic pregnancy, endometriosis and TCM syndrome types were analysed. The relationship between TCM syndrome types and times of miscarriage, disease course and age was studied. Results The proportion of the syndrome of qi stagnation and blood stasis in two groups had significant difference （P<0.001）. The times of miscarriage and disease course had a relationship with TCM syndrome types but the common diseases of gynaecology and age had no evident relation with TCM syndrome types after the analysis on the possible factors inducing oviduct blockage. Conclusion The syndrome of qi stagnation and blood stasis is the most common syndrome type in the infertility induced by oviduct blockage.关键词：infertility;oviduct blockage;TCM pathogenesis;syndrome types
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发布时间：2021-09-15 -
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