最新刊期
卷 ， 期 4 ， 2005
- 摘要：Objective To evaluate the curative effect of the therapy integrated Chinese and western medicine on pulmonary inflammation at different time points with X-ray films as indexes, and to provide a scientific basis to management of the medicine-administration time in the treatment of SARS with Chinese and western medicine. Method To study 1561 X-ray films of 361 patients diagnosed as SARS in 11 hospitals （in 863 national key project of“clinical study on treatment of SARS with Chinese and western medicine） of Beijing area by using the method of multi-centered prospective cohort research, and to explain the influence of the therapy integrated Chinese and western medicine at different time points on pulmonary inflammation of SARS. Result The curative effect in the group treated with Chinese and western medicine was better than that of the group with western medicine only within 1-7 days after the invasion of SARS. There was a statistic different in the effects on serious patients. Conclusion The early intervention of the therapy integrated Chinese and western medicine has advantages in the curative effect on the absorption of pulmonary inflammation.
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发布时间：2021-08-03 - 摘要：Constitutional classification is the basis and core of constitutional research of Chinese medicine, which is formed through drawing the related laws from complicated constitutional manifestations and then set up a grouping system. The paper perfected the constitutional classification system, divided the human constitutions into nine basic groups. The grouping and naming basis, constitutional stating principle and method, connotation and document basis of different constitutional groups were explained respectively.关键词：constitutional science of Chinese medicine;study on constitutional classification;diagnosis basis
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发布时间：2021-08-03 - 摘要：<正>北京中医药大学中医诊断学科创建于建校初期,并于1981年和1991年分别被批准为硕士学位和博士学位授权点,建有博士后流动站。本学科为国家教育部重点学科、国家中医药管理局重点学科,为国家教育部“国家理科基础与人才培养基地”中医诊断学名牌课程建设单位,先后为全国中医诊断学专业委员会主任委员、副主任委员单位,为国家中医药管理局中医证候病理生理三级科研实验室、中医藏象理论研究室单位。2003年度中医诊断学课程被评为国家级精品课程和北京市级精品课程。在原学科带头人杨维益教授、季绍良教授的带领下,学科形成了高学历高质量的教师队伍。本学科现有教师10人,年龄结构50岁以上1人,40-49岁5人,30-39岁3人,30岁以下1人;职称结构教授5人,副教授2人,讲师2人,助教1人;学位结构具有博士学位者4人,博士在读1人,具有硕士学位者2人,形成了老中青结合的教师梯队;二名教师获国家教育部“高校青年教师奖”荣誉称号,一名教师博士学位论文获“全国优秀博士学位论文”。本学科有长期稳定的研究方向。在证候的病理生理基础研究方面形成特色,结合现代科学技术手段与证候动物模型,通过整体、器官组织、细胞、分子等层次,揭示常见中医证候的科学内涵;在病证相关性研究方面,对证候在疾病中的发生发展和演变的规律及症状与证候相关性进行研究;在此基础上,结合文献<正>整理与临床流行病学方法,并引入实验室指标,研究常见中医证候的规范化与客观化。“中医证候学”被确定为“十五”“211工程”重点项目,以带动本学科的发展;各研究方向由项目团队成员王天芳、梁嵘、李峰、李宇航、顾立刚等教授牵头并均有相应的科研项目为支撑,已发表相关学术论文和取得一定科研成果。
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发布时间：2021-08-03 - 摘要：There are uncertainness in science of Chinese medicine （CM） because the infiltration of Chinese ancient culture, so the quintessence of CM is difficult to grasp. The CM circles and even the whole scientific circles are paying attention to the research of standardization of syndrome manifestations along with the scientific development. Set pair analysis （SPA） is a kind of systematic theory and method with related number of a+bi+cj for processing the uncertainness caused by confused, randomly, incomplete intermediary and information. SPA takes certainness and uncertainness as a certain and uncertain sameness-difference-counter system and processes it dialectically and mathematically. SPA is used in the research of syndrome manifestations of CM from the quantitative angle to understand the essence of certainness of CM at a systematic level. The research will improve the theoretical study of standardization of syndrome manifestations and objectivity of CM to a great extent.关键词：standardization of syndrome manifestations;set pair analysis;uncertainness
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发布时间：2021-08-03 - 摘要：The paper discussed the relationship between damp-heat constitution （DHC） and syndrome of damp-heat （SDH） from the angles of the disease occurrence, differentiation, treatment and drug administration. It is found that DHC and SDH were in different degrees and had a close relation. DHC was an important factor to the occurrence of SDH, and SDH, however, reflected the characteristic of DHC. DHC should be regulated to being normal when SDH was treated. If DHC was treated with Chinese medicine and the morbidity of SDH would be decreased at the same time. Many therapeutic methods and effective prescriptions of past ages can open our thought train for looking for drugs for regulating DHC.关键词：damp-heat constitution;syndrome of damp-heat;relation with disease
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发布时间：2021-08-03 - 摘要：Objective The paper discussed the extant problems and future study thinking on the analysis basis of content and present situation of symptom standardized research in Chinese medicine. The content of symptom standardized research in Chinese medicine was reflected in the standard symptom terms and connotation, quantification and grade explain of symptom degrees, and symptom differentiation sense. According to the extant problems found in the study the research of methodology of symptom quantification and grade, symptom differentiation sense based on group investigation, and standard of symptom information collection should be improved.关键词：symptom;standardize;present situation;thinking
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发布时间：2021-08-03 - 摘要：Objective To study the influences of Yinaojieyu Formula on the expressions of gliofibrillary acidic protein （GFAP）, encephalic neurotrophic factor （ENF） and basic fibroblast growth factor （bFGF） in rat model of depression after stroke. Method The model of depression after stroke was established by the methods of cortical devascularization, solitary raising and chronic stress test. The rats were given Yinaojieyu Formula orally and then their brains were separated and tested by immunohistochmistry. Result Yinaojieyu Formula obviously improved the expressions of GFAP, ENF and bFGF in the cortex and hippocampus of rat model.Conclusion Yinaojieyu Formula can improve the functions of 5-HT and NE and relieve the symptoms of depression by improving the expressions of GFAP, ENF and bFGF.关键词：Yinaojieyu Formula;immunohistochmistry;gliofibrillary acidic protein;encephalic neurotrophic factor;basic fibroblast growth factor
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发布时间：2021-08-03 - 摘要：Objective To investigate the therapeutic mechanism of Xiaoke Granules for diabetic nephropathy.Method Cultured rat mesangial cells （MCs） were exposed to the high-level glucose, and then the serum with Xiaoke Granules was added. The effect of Xiaoke Granules on the expression of tumor growth factorβ1 （TGF-β1） mRNA in MCs was observed through reverse transcriptase polymerase chain reaction （RT-PCR）. Result The high-level glucose irritated the expression of TGF-β1 mRNA, while Xiaoke Granules inhibited the excessive expression of TGF-β1 mRNA in MCs. Conclusion Xiaoke Granules can inhibit the excessive expression of TGF-βS1 mRNA, which maybe its key effect for treating diabetic nephropathy.关键词：Xiaoke Granules;rats;TGF-β1;gene expression
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发布时间：2021-08-03 - 摘要：objective To evaluate the influences of effective fractions of Sini Powder （EFSP） on the exploratory behavior, and abilities of learning and memory in rats with olfactory bulb lesion.Methods Open-field and Morris water maze were used to investigate the effects of EFSP on rat behavioural changes, such as horizontal and vertical movements, learning and memory abilities. Results Compared with the model group, high-and mid-dose of EFSP obviously improved the vertical movements in rats with olfactory bulb lesion. Of the learning and memory abilities, the latency period was obviously shortened in the treatment group. With mid-and low-dose of EFSP the movements in 20% of marginal zone were decreased and the movements in 80% of center zone were increased.Conclusion EFSP can relieve the decrease of exploratory behavior, and the disorder of memory and learning abilities in rats with olfactory bulb lesion. The improvement of memory and learning abilities may be related to the anti-depression effect of EFSP.关键词：Sini Powder;effective fractions;rat model of olfactory bulb lesion;behavioural science;anti-depression,
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发布时间：2021-08-03 - 摘要：Objective To observe the effect of diosgenin （Dio） on poor differentiated adenocarcinoma （MGC-803） cells of human stomach and discuss the mechanism. Methods MTT assay was used to determine the inhibitory effect of Dio on MGC-803 cells, and to observe the influence of Dio on the ability of cell cleavage and colony formation. The method of （）3H-TdR was used to detect the influence of Dio on DNA synthesis of MGC-803 cells. Result It was found that Dio inhibited the growth of MGC-803 cells in a dose-time dependent manner at a certain range of concentration, and inhibited obviously the cell cleavage and colony formation. IC50 was 13.17 μg/mL. Dio inhibited obviously DNA synthesis of MGC-803 cells.Conclusion The inhibitory effect of Dio on MGC-803 cells is related to its inhibitory effect on DNA synthesis.关键词：diosgenin;anti-tumor effect;colony-formation;()3H-TdR method
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发布时间：2021-08-03 - 摘要：T: Objective To observe the influence of Siduqing at different doses on mortality in mice with endotoxemia and the mechanism. Method The model of mouse endotoxemia was established by intraperitoneal injection of lipopolysaccharide （LPS） at a dose of 30 mg/kg, then the mice were given Siduqing orally at doses of 125 mg/L （group1）, 250 g/L （group 2）, 500 g/L （group 3）, 1 000 g/L （group 4） and 2 000 g/L （group 5） respectively. The mortalities of the groups were observed and the levels of tumor necrotizing factor-α （TNF-α） and interleukin-10 （IL-10） in mouse plasma were detected by ELISA. Result The mortalities in group 2, 3, 4, 5 were decreased respectively. The best dose of Siduqing was 1 000 g/L （in group 4）. Siduqing decreased the level of TNF-α and increased the level of IL-10 in mice with endotoxemia. Conclusion Siduqing decreases mortality of mouse with endotoxemia in a dose-dependent manner. One of its mechanisms may be related to its effect of decreasing the level of TNF-α and increasing the level of IL-10 in plasma.关键词：Chinese herbal drug;lipopolysaccharide;mortality;tumor necrotizing factor-α;interleukin-10
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发布时间：2021-08-03 - 摘要：Objective To study the influences of Rheum palmatum L. （administrated for a long time） and the interstitial Cajal cell （ICC） on colonic electromuscular in rats with spleen deficiency. Methods Fifty rats were randomly divided into the control group and the group administrated Rheum palmatum L. After 3 months the slow wave frequency and amplitude of colon were detected. The changes of ICC were observed by using ZIO method and the pathological changes of dynamic basic functional unit （DBFU, i.e. ENS-ICC-SMC） were observed with transmission electron microscope （TEM）. Results In rats with spleen deficiency induced by long-time administration of Rheum palmatum L. the slow wave frequency and amplitude of colon decreased. The electric rhythm of colon was abnormal. The coefficient of variation （CV） of slow wave frequency and abnormal rhythm index （ARI） increased obviously. The neurofibers of intermuscular neuroplexus were poor distributed, the connection was disorder and ICC was few in TEM vision. The vacuolar degeneration of intermusclar nervous axon and degeneration of ICC were observed by TEM. Conclusion The long-time administration of Rheum palmatum L. can induce the decrease of slow wave frequency in rats with spleen deficiency. The mechanism may be related to the pathological changes of DBFU.关键词：spleen deficiency;nervous system of colon;interstitial Cajal cell
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发布时间：2021-08-03 - 摘要：Objective To determine the contents of luteolin and hesperidin in the effective fractions of Spica Schizonepeta by using HPLC.Methods The contents of luteolin and hesperidin was determined at indoor temperature. The chromatographic conditions included TECHSPHERE ODS column （250mm×4.6mm, 5μm） and the mobile phase consisted of acetonitrile-0.2% phosphoric acid running in a gradient mode with a flow rate of 1.0ml/min. The detection wavelength was at 283nm. Results The linear rangers for luteolin and hesperidin were 0.036～0.12ug （r=0.9999） and 0.27～0.9μg （r=0.9999） respectively. The average recovery of the procedure was 100.93%, RSD=1.59%（n=6）for luteolin, and 98.15%, RSD=0.43% （n=6） for hesperidin. Conclution This procedure, which is simple, accurate and feasible, can be used as a qualitative control of the effective fractions of Spica Schizonepeta.关键词：luteolin;hesperidin;RP-HPLC
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发布时间：2021-08-03 - 摘要：Objective To discuss the methodology of Chinese medical effect evaluation through evaluating the total curative effect of treatment plan integrated Chinese and western medicine on SARS. Method Three synthetic evaluation methods （including nonlinear weighting, linear weighting and topsis） were used and combined with two forms of subjective-weighting and objective-weighting to evaluate the data in the same one group. Result An arrange in synthetic evaluation of curative effects of seven treatment plans was obtained. The synthetic evaluation was applied in the practice of effect evaluation of Chinese medicine. The characteristics and applied ranges of different methods were analyzed deeply. Conclusion A synthetic evaluation is an ideal method for the multi-index and multi-property evaluation.关键词：SARS;curative effect;synthetic evaluation
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发布时间：2021-08-03 - 摘要：Objective The technique of image analysis was introduced to the study of tongue inspection of Chinese medicine to improve the level of quantification, objectification and repeatability of tongue inspection. Methods The representative regions of tongue body and coating were separated and collected automatically in the model of tongue manifestations. Eight characteristic quantity variables of tongue manifestations, including colour, shape, wetness-dryness, etc., were computed and the tongue manifestations were analyzed in 49 patients with cerebrovascular diseases and 39 health people respectively. Results The correct rate reached 87.5% in the k-means and 92% in the method of artificial neural network respectively, which was obviously higher than that in the classification method according only to the colour characteristics of tongue body or coating. Conclusion Above eight characteristics reflect comprehensively the characteristics of tongue manifestations and are good for improving the application and research of the techniques of image analysis in tongue inspection of Chinese medicine.
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发布时间：2021-08-03 - 摘要：Objective To further study the distribution of syndrome manifastations of IgA nephropathy with the research method of clinical epidemiology.Method A cross-sectional investigation was used in questionnaire of case report and 308 case reports were collected. Then the factor statistics was used to analyze the results. Results There were 6 community factors, or 6 analogous syndrome manifestations, collected as followings: analogous syndrome of qi-yin deficiency, analogous syndrome of kidney-yang deficiency, analogous syndrome of wind-heat attacking lung, analogous tongue-pulse syndrome and analogous syndrome of damp-heat in large intestine. Among them the analogous syndrome of qi-yin deficiency accounted the most. Conclusion It is significant to research the syndrome manifestations with the method of clinic epidemiology.
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发布时间：2021-08-03 - 摘要：Objective To investigate the influences of kidney tonics on bone mineral density （BMD） and level of estrogen （E2） of osteogonarthritis combined with osteoporosis after menopause. Method The patients with osteogonarthritis combined with osteoporosis after menopause （n=50） were divided randomly into two groups and given respectively Bushenzhuanggu Granules and Celecoxib Capsules for 3 months. The symptom integral, BMD and level of E2 were detected before and after the treatment. Result In the treatment group the symptom integral, JOA integral were obviously alleviated （P<0.01） and BMD and level of E2 were increased （P<0.01） after the treatment then that before the treatment. In the control group JOA integral was obviously alleviated （P<0.01） but symptom integral, BMD and level of E2 were not changed after the treatment compared with that before the treatment （P>0.05）. Conclusion Kidney tonics have a synthetic therapeutic effect on osteogonarthritis combined with osteoporosis after menopause.关键词：kidney tonics;osteogonarthritis;osteoporosis;bone mineral density;estrogen （E2）
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发布时间：2021-08-03 - 摘要：Objective To study the relationship between erectile dysfunction （ED） and the constitutions.（Method The） methods of group-sampling, cross-sectional study and case-control study were used in this research. Results According to the epidemiological analysis on 1564 samples of cross-sectional study and 962 samples of case-control study, the results showed that the gentle type of constitution had a protective effect on ED, sthenia type and asthenia type were the material bases of ED, melancholia type below the age of 30, dampness-heat type at ages of 31-50, phlegm-dampness type over the age of 50 and blood stasis type over the age of 31 had a higher morbidity of ED. The syndromes of liver depression and kidney deficiency, liver depression and spleen asthenia, liver depression and qi stagnation, liver depression and gallbladder-qi deficiency, and liver depression transforming into fire were common in the melancholia type. The syndromes of deficiency of liver-kidney yin, kidney-yin deficiency, disharmony between heart and kidney, and liver-yin insufficiency were common in yin asthenia type. The syndromes of downward flow of dampness-heat, dampness-heat of liver meridian, dampness-heat in spleen and stomach, dampness-heat combined with stasis, and dampness-heat due to yin deficiency were common in dampness-heat type. The syndromes of deficiency of both spleen and kidney, and deficiency of liver-kidney yang were common in yang asthenia type. The syndromes of abundant phlegm-dampness, and liver depression and phlegm stasis were common in phlegm-dampness type. The syndrome of qi stagnation and blood stasis was common in blood-stasis type. Conclusion ED is related to the constitutions. The constitutional types of ED is related to ages, and the syndrome manifestations of ED is related to the constitutional types.关键词：erectile dysfunction;epidemiology;biotypology of Chinese medicine;syndrome manifestations of Chinese medicine
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发布时间：2021-08-03 - 摘要：Objective To discuss the correlation between syndrome manifestations （SM） of Chinese medicine and metabolic disturbance of blood lipid in presenium and senium, and the relationship between SM and the levels of total cholesterol （TC）, triglyceride （TG）, low-density lipoprotein C （LDL-C）, high-density lipoprotein C （HDL-C）, apoliporotein AⅠ （Apo AⅠ） and apoliporotein B （ApoB）. Method To investigate and record the general conditions （including sex, age, stature and weight） of 100 patients with hyperlipidemia, and their syndrome manifestations and levels of TC, TG, LDL-C, HDL-C, Apo AⅠ and ApoB. Results There were 23 patients with the syndrome of phlegm-turbidity stagnation （group 1）, 22 with the syndrome of spleen-kidney yang deficiency （group 2）, 21 with the syndrome of liver-kidney yin deficiency （group 3）, 18 with the syndrome of yin deficiency with exuberant yang （group 4）, 9 with the syndrome of qi stagnation and collateral stasis （group 5）, and 7 without any syndromes （group 6）. The levels of TC, HDL-C in group 1 was the lowest compared with other groups, and had a significant difference compared with group 3 and 4.Conclusion In the constitutional proportion of syndrome type, group 1 was 23% （the highest） and group 5 was 9% （the lowest）. The level of TG was a unipolar increase in group 1 and the levels of TC and TG were diphasic increases in group 2, 3, 4 and 5.关键词：syndrome differentiation and pattern;hyperlipidemia;correlation study
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发布时间：2021-08-03 - 摘要：Objective To investigate the value of tongue coating in determination of stress reaction degree induced by acute myocardial infarction （AMI） and the prognosis of the disease. Method To choose 32 patients with AMI, and record their thickness of tongue coating, degrees of symptoms, and the levels of cortisol （CO）, plasma motilin （MTL）, serum gastrin （GAS）, plasma epidermal growth factor （h-EGF）, and serum thyroxin （T3, T4） at 1st, 3rd, 5th, 7th and 14th day after the hospitalization, then to observe the relationship between the thickness of tongue coating and stress changes in AMI. Results The levels of CO, GAS, h-EGF increased and T3, T4 decreased at 1st day. At the same time the average thickness of tongue coating was the highest （11.56±4.64）. The integral of the group with the syndrome of phlegm-dampness obstructing internally was high from beginning to end compared with the other groups. There was a correlation respectively between the thickness of tongue coating and the levels of h-EGF, T3 and number of AMI days, and T4 and symptom integral. Conclusion There is a close relationship between the thickness of tongue coating and the changes of excitable hormone induced by AMI.
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发布时间：2021-08-03 - 摘要：Objective The primary study has confirmed that moxibustion preconditioning （MP） had a protective action on rats with adjuvant arthritis （AA）. This paper investigated the protective mechanism of MP through an analysis of hypothalamic HSP70. Methods To observe the changes of hypothalamic HSP70 in AA rats before model established, at early stage and secondary stage after model established respectively by using immunohistochemistry, and to analyze these changes with image analysis technique. Results The expression of hypothalamic HSP70 was limited positive in the normal group, and that in AA group of early stage and secondary stage was strong positive compared with the normal group, but had a decreasing trend along with the disease course. In the groups with MP the abnormal high expressions of hypothalamic HSP70 were relived not only at early stage but also at secondary stage compared with AA group. MP also improved the expression of hypothalamic HSP70 in normal rats. Conclusion The protective action of MP on AA rats may be related to that it can improve the positive expression of hypothalamic HSP70 in normal rats, and decreases obviously the abnormal high expression of hypothalamic HSP70 in AA rats. Hypothalamic HSP70 may be one of important factors for MP actions of preventing and relieving the disease and strengthening the constitution.关键词：moxibustion;preconditioning;heat shock protein 70;rats;preventing and relieving disease
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发布时间：2021-08-03 - 摘要：Objective To study the influence of natural moxibustion （NM） on mRNA expression of nm23-1 gene in mice with lung cancer. Method The mRNA expression of nm23-1 gene was detected by the technique of real-time fluorescence quantitative reverse transcriptase-polymerase chain reaction （RT-PCR）. Result There was no significant difference in the chemiotherapy group compared with the control group in mRNA expression of nm23-1 gene （P>0.05）. The mRNA expression of nm23-1 gene was obviously improved and Lewis lung cancer was obviously inhibited in the NM group and the group of NM combined with chemiotherapy. Conclusion One of the anti-cancer mechanisms of NM may be that it can improve mRNA expression of nm23-1 gene through helping chemiotherapy.关键词：natural moxibustion;Lewis lung cancer;">
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发布时间：2021-08-03
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