最新刊期
卷 0 ， 期 5 ， 2005
- 摘要：The relationship between systems theory and reductionism in medical research was discussed. The reduced analysis with the systems meaning, the harmony of “substance to function”, or“relation to function”in the medical research should be paid more attention. The study tactics and methods which were from reduction to systems in design, computation and experiment should be advanced. In the background of new century science some developing trends of medicine and biological science were systematized. The trends in the research of information and systems and its reference significance to the modern research of Chinese medicine were analyzed in the paper.关键词：systems theory;reductionism;systems biology;medicine;Chinese medicine and pharmacology
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发布时间：2021-09-15 - 摘要：The paper reviewed the research documents on the concept of syndrome manifestations of Chinese medicine and their effects on the diagnosis and treatment, pointed out that syndrome manifestations summarized the whole condition of the pathological and physiological changes of a disease expressed in four diagnostic methods （inspection, listening and smelling, inquiry and feeling the pulse）. They have the characteristics of internal sthenia and external asthenia, multi-dimension interface and dynamic time and space. The syndrome manifestations are not the diseases or sub-types of a disease of western medicine. They are the whole reflected state of pathology and physiology in the background of a disease. They are the theory basis of "the same disease with different symptoms and different diseases with the same symptom". The syndrome manifestations have not only the diagnostic attribute but also pathological, physiological and therapeutic attributes. The target of syndrome manifestation reflects the therapeutic attributes of syndrome manifestations. That means the syndrome manifestations are not only the objective of the treatment with prescriptions of Chinese medicine, but also the effective base. This is the theory foundation of "different diseases treated with the same therapy and the same disease treated with different therapies". It is a scientific question with new significance being worth studying.关键词：syndrome manifestations;concept;attribute
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发布时间：2021-09-15 -
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- 摘要：Objective To observe the conditioned culture medium of vascular endothelial cell （VEC） lesion induced by oxidized low-density lipoprotein （ox-LDL） and the influence of compatibility of effective components of D （paeoniflorin mainly） and E （total flavones mainly, weight ratio= 1:2） of Qixuebingzhi Formula on the proliferation of vascular smooth muscle cells （VSMC） and c-myc mRNA expression. Methods The VSMC normal culture fluid, conditioned culture medium of VEC lesion induced by ox-LDL, conditioned culture medium of VEC lesion induced by simvastatin and ox-LDL, conditioned culture medium of VEC lesion induced by D, E compatibility and ox-LDL were respectively used in VAMC. The MTT method was used to detect the grown activity of VSMC and reverse transcription-polymerase chain reaction （RT-PCR） was used to detect the expression of c-myc mRNA. Results After the conditioned culture medium of VEC lesion effected on VSMC the cell grown activity obviously increased compared to normal cultured VSMC （P<0.01）, and the expression of c-myc mRNA was potentiated. After the conditioned culture medium of VEC lesion and D, E compatibility effected on VSMC the cell grown activity obviously decreased compared to the model group （P<0.01）, and the expression of c-myc mRNA was attenuated. Conclusion The compatibility of effective components-paeoniflorin and total flavones in Qixuebingzhi Formula could antagonize the VSMC proliferation and potentiated expression of c-myc mRNA effected by the conditioned culture medium induced by ox-LDL. The effect of Qixuebingzhi Formula on preventing and treating arteriosclerosis maybe related to that paeoniflorin and total flavones can inhibit VSMC proliferation and potentiated expression of relative gene induced by conditioned culture medium of VEC lesion.关键词：Arteriosclerosis;endothelial cells;smooth muscle cells;oxidized low-density lipoprotein;Oixuebingzhi Formula
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发布时间：2021-09-15 - 摘要：Objective To observe the effects of Dangguibuxue Decoction on decrease of blood lipid, lipid peroxidation and atheromatous plaque in experimental atherosclerosis formation. Methods To divide randomly 50 rabbits into the blank group, model group, low-dose group, mid-dose group and high-dose group. To establish the rabbit atherosclerosis model by feeding fat food and intravenous injection of ox seralbumin. The level of serum malondialdehyde （MDA） was determined with thiobarbituric acid （TBA） chromatoptometry, and the levels of serum superoxide dismutase （SOD）, total cholesterol （TC）, triglyceride （TG）, low-density lipoprotein （LDL） and high-density lipoprotein （HDL） were determined with hydroxylamine chromatoptometry in auto-biochemical analyzer of OLMPUS-A U600. At the same time the pathological examination was made on aorta and coronary artery. Results Dangguibuxue Decoction decreased obviously the levels of serum TC, LDL and MDA, increased the activity of SOD, and decreased the area and thickness of atheromatous plaque in experimental animals. Conclusion The antiatherosis mechanism of Dangguibuxue Decoction maybe related to its blood lipid regulation and antioxidation.关键词：Dangguibuxue Decoction;atherosclerosis;blood lipid;lipid peroxidation;superoxide dismutase
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发布时间：2021-09-15 - 摘要：Objective To observe the effect of serum of Rhaponticum uniflorum on PPARγ expression in formation of foam cell of U937 cells induced by oxidized low-density lipoprotein （ox-LDL）. Method U937 cells were stimulated by ox-LDL to establish the model of foam cell. The expression of PPARγ was observed by immunohistochemical stain. Result By the light microscope no brown granules were observed in foam cells of the mormal group.Many thick brown granules were observed in cell membrane and cytoplasma in the model group, while only a few light brown granules were observed in the model group. Conclusion The serum of Rhaponticum uniflorum can inhibit PPARγ expression in the formation of foam cell of U937 cells induced by ox-LDL.关键词：serum of Rhaponticum uniflorum;foam cell;PPARγ;low-density lipoprotein;U937 cells
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发布时间：2021-09-15 - 摘要：Objective To investigate the effective mechanism of Chinese drugs in cartilage cell apoptosis and the regulation of p53, Bcl-2 genes of rheumatoid arthritis （RA）. Methods The CIA model rats were divided and treated with Tonbiling, Methotrenxate Tablets （MTX Tablets） and Tripterygium wilfordii Hook respectively for 36 days. The immunohistochemical stain was used in cartilage cells and computer imagine analysis system was used to analyze the expression of p53, Bcl-2 gene proteins and cell apoptosis. The differences in different groups were compared. Results There was an excessive protein expression of p53 in CIA rat cartilage cells. Tongbiling could inhibit the excessive expression of p53, while a high-dose of MTX Tablets or Tripterygium wilfordii Hook had no obvious effect. The protein expression of Bcl-2 in CIA rat cartilage cells was in an inhibitory state. With low-dose of Tongbiling the protein expression of Bcl-2 increased obviously and that in the high-dose of Tripterygium wilfordii Hook increased too. There was an accentuation in CIA rat cartilage cells. Tongbiling could low-regulate the level of cell apoptosis. Conclusion Tongbiling can inhibit the excessive apoptosis of cartilage cells through regulating the excessive protein expression of p53 and low protein expression of Bcl-2 . The effects of MTX Tablets and Tripterygium wilfordii Hook are related closely to the regulation of gene family, but not to p53 relative gene.关键词：Tongbiling;p53 gene;Bcl-2 gene;apoptosis of cartilage cells
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发布时间：2021-09-15 - 摘要：Objective To ocserve the different methods when microdose of ferulic acid （FA） was extracted and separated from mouse plasma and the microdetermination sample was made for HPLC. Methods Ferulic acid was added into mouse plasma. Then the microdose of FA was extracted and separated respectively by the methods of carbinal, ethanol and heating, and detected with HPLC. Result The method of ethanol was the best one for HPLC detection. Conclusion The method of ethanol is simple, fast, good for repetition, stable and has a better extractive effect. It is an ideal extractive and separate method for extracting microdose of FA from mouse plasma, detecting the plasmatic FA concentration by HPLC and pharmacokinetic research.关键词：mouse plasma;microdose of ferulic acid;extract and separate;HPLC detection
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发布时间：2021-09-15 - 摘要：Objective To investigate the influence of Ruzengkang Compound Formula （RCF） on the pathomorphism of mammary tissue in the rat model of mazoplasia, and make RCF as a pathological foundation for preventing and treating cyclomastopathy. Methods The model was established by intromuscle injection of benzestrofol and then divided into groups. RCF was given to different groups orally once a day. After 30 days the pathohistological examine was made and blood sample was taken to separate the serum. The level of serum sex hormones in rats was detected by radiaimmunity assay （RIA）. Results The acinar number, secretion in catheter branches and caves decreased obviously, and acinar and catheter cave changed smaller in the high-dose group compared to that of the low-dose group, the control group and the model group. The changes in the high-dose group were more significant than that in the low-dose group and the control group. Conclusion RCF can inhibit mazoplasia and change the state of mazoplasia in the rat model of cyclomastopathy.关键词：cyclomastopathy;Ruzengkang;pathological histology;sex hormones
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发布时间：2021-09-15 - 摘要：Objective To study the extractive technique of amino acid in nacre. Method To use orthogonal test to observe the influences of three factors: acid concentration （A）, acid volume （B） and hydrolytic time （C）, on amino acid content taking the nitric content and types of amino acid as the indexes. Result The optimized condition of hydrolytic extractive technique of nacre was A2B2C2. Conclusion The condition of hydrolytic extractive technique of nacre is that the concentration of sulfuric acid is 6 mol/L, the acid volume is 8 times of nacre volume, and the hydrolytic time is 8 hours.关键词：nacre;acid hydrolytic;nitric content;content of amino acid type
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发布时间：2021-09-15 - 摘要：Objective To study the method for establishing the animal model of lung lesion induced by acute cerebral hemorrhage, explain the concept of cerebral lung lesion syndrome and lay a foundation for the research of pathogenesis, prevention and treatment of this syndrome. Method To divide randomly 72 rats into the control group and the model group, and then the two groups were redivided into 6 sub-groups respectively（i.e. the groups of preoperation, postoperation for 1 hour, 6 hours, 12 hours, 24 hours and 48 hours）. The model of cerebral lung lesion syndrome was established by injecting jointly collagenase IV, heparin sodium and physiological saline. The model was evaluated according to the observation on respiration rate, blood gas analysis, leukocyte count, lung water contents, tumor necrosis factor-α （TNF-α） and the pathological changes in the brain and lung tissues. Results The model had a clear and stable cerebral hemorrhage and a series of inflammation, serious lung lesion and pathological changes in the lung tissue appeared in a short time. Conclusion The model can simulate successfully the pathological course of cerebral lung lesion syndrome induced by acute cerebral hemorrhage.
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发布时间：2021-09-15 - 摘要：Objective To observe the anti-diarrhea effect of Yunpizhixie Granules. Method To divide mice randomly into four groups: the group with low-dose of Yunpizhixie Granules （group 1）, the group with high-dose of Yunpizhixie Granules （group 2）, the blank group and the control group （with Pikexin Powder）. The groups were given Yunpizhixie Granules orally respectively for 6 days. Then the influences of Yunpizhixie Granules were observed on the stomach depletion, small intestine peristalsis in normal mice, on the mouse heperanakinesia of small intestine induced by neostigmine, and on diarrhea induced by senna. Result Yunpizhixie Granules had no effect on normal stomach depletion. The normal small intestine peristalsis and the hyperanakinesia of small intestine induced by neostigmine were inhibited in group 1 and 2. The diarrhea induced by senna was antagonized significantly in group 1. Conclusion Yunpizhixie Granules has an effect of anti-diarrhea.关键词：Yunpizhixie Granules;anti-diarrhea;stomach depletion;small intestine peristalsis;heperanakinesia of intestine
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发布时间：2021-09-15 - 摘要：Objective To observe the influence of Yuejubaohe Pills on the lesion of mucous membrane, acute and chronic inflammation of stomach in experimental animals. Methods The water-immersion-bound stress （in group 1）, pylorus ligature （in group 2） and reserpine （in group 3） were used to establish the animal ulcer models. The antiulcer effect of Yuejubaohe Pills was observed. The corrageenan （in group 4） and cotton pellets （in group 5） were used to establish the animal models of acute or chronic inflammation. The anti-infective effect of Yuejubaohe Pills was observed. Results Yuejubaohe Pills could inhibit obviously the ulcer in group 1 and group 2 through the injection in duodenum. Yuejubaohe Pills could also inhibit remarkably the ulcer in group 3 by a continuous oral administration. Yuejubaohe Pills could alleviate obviously the inflammation and decrease the toe tumid rate by oral administration in rats after 2 hours the model establishment. While Yuejubaohe Pills could also inhibit obviously the formation of granulation tissue and decrease the dry-weight and wet-weight of cotton pellets by a continuous oral administration. Conclusion Yuejubaohe Pills has an antiulcer effect and the effects on acute or chronic inflammation.关键词：Yuejubaohe Pills;stomach ulcer;stress;pylorus ligature;reserpine;inflammation
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发布时间：2021-09-15 - 摘要：It has a long history that the epidemic diseases treated with Chinese medicine. Before the finding and application of penicillin Chinese medicine made a contribution to the treatment of epidemic diseases in the world. This contribution reached the top with the formation and improvement of "the doctrine of epidemic diseases" in the Ming and Qing Dynasties. The knowledge of the causes of epidemic diseases in Chinese medicine was not only about pathogens, but also about the interaction between cause and organism. Chinese medicine is to understand cause through the symptoms presented after the cause effecting on an organism, which is the method of differentiating symptoms to find the cause. The method is reliable proved by Chinese prosperity. In modern times Chinese medicine did not play its role fully in prevention and treatment of epidemic diseases because it was ignored at the beginning of epidemic situation, and then it would be involved in as the situation was pressing. It shows that the Party and state policy of Chinese medicine needs further implementation seriously. It may be rated as a good example that Yijing （epidemic encephalitis B） was prevented and treated with contemporary Chinese medicine. This paper introduced in detail the experiences on treating Yijing with Chinese medicine, emphasized the advantages of Chinese medicine to the treatment of epidemic diseases and expected to be a reference for future epidemic situation.关键词：epidemic diseases;Yijing （epidemic encephalitis B）;treatment with Chinese medicine
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发布时间：2021-09-15 - 摘要：Objective To discuss the influence of the software of life quality assessment on the evaluation of the fractionation and curative effect of chronic obstructive pulmonary disease （COPD）. Method To analyze the correlation between life quality score and fractionation of lung function in 71 patients with COPD before and after the treatment. Result The score of life quality was correlated to the fractionation of lung function before and after the treatment. The changes of scores before and after the treatment was not correlated to the fractionation of lung function. Conclusion The assessment of life quality can be taken as the index for determining the disease degree. It needs to be improved that life quality is used to evaluate the curative effect.关键词：chronic obstructive pulmonary disease;life quality;assessment
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发布时间：2021-09-15 - 摘要：Objective To discuss the influence of the therapy of strengthening healthy qi, resolving stasis and relieving asthma on plasma endothelin （ET）, tumor necrosis factor-α （TNF-α） and immunity in children with asthma attacks. Method To divide randomly 95 children with asthma attacks into the treatment group and the control group. The treatment group （n=49） was treated with the therapy of strengthening healthy qi, resolving stasis and relieving asthma and inhaled seretide, and the control group （n=46）, inhaled seretide only. To observe the curative effects of two groups, the contents of plasma ET, TNF-α, interleukin-5 （IL-5）, Interleukin-8 （IL-8） and the changes of immunity and the first second of forced expiratory volume （FEV1） and the percent of forced expiratory volume （FEV%） before and after the treatment. Result The curative effect, the decrease of contents of plasma ET, TNF-α, IL-5, IL-8 and the improvement of the immunity and lung function （FEV1 and FEV%）were better significantly in the treatment group than that in the control group （P<0.05）. Conclusion The therapy can effectively decrease the contents of plasma cytokines and alleviate the inflammatory reaction of air tube in children with asthma attacks.关键词：bronchitic asthma;therapy of strengthening healthy qi, resolving stasis and relieving asthma;cytokines;immunity
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发布时间：2021-09-15 -
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- 摘要：Objective To study by modern rehabilitation evaluation the curative effect of acupuncture method of easing joint movement and opening orifices on early hemiparalysis induced by ischemic stroke. Method To divide randomly 60 cases of ischemic stroke into the treatment group （n=30） and the control group （n=30）. The control group was treated according to BNC Practice Guidelines of Cerebrovascular Diseases and the treatment group was treated with acupuncture method of easing joint movement and opening orifices besides above treatmentThe treatment course was 30 days. The evaluation of Fugl-Meyer score and Barthel index were given to two groups before and after the treatment. Results On 15th day there was a significant difference in Fugl-Meyer score between two groups （P<0.05）, but no difference in Barthel index （P>0.05）. On 30th day Fugl-Meyer score of the treatment group was increased significantly （P<0.01） and there was a significant difference in Barthel index between two groups （P<0.05）. Conclusion The acupuncture method of easing joint movement and opening orifices has a better effect combined and cooperated with BNC Guidelines on early hemiparalysis induced by ischemic stroke.
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发布时间：2021-09-15
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