最新刊期
卷 0 ， 期 1 ， 2006
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- 摘要：Objective To discuss the establishment of animal model of postencephalorrhagia depression for further study on the post-encephalorrhagia depression.Method The injection of collagenase in caudate-putamen nucleus was used to induce rat encephalorrhagia and then chronic unpredictable mild stress was given for 21 days to establish the animal model.Result The activity,interest,hedonia,abilities of learning and memory in the model group were decreased obviously compared with that in the control group.In the model group the results of pathological sections showed the atrophia and degeneraltion of amygdaline cortex,piriform cortex,gyrus cingulatus and hypothalamic neuron,nucleolar asymmetry and decrease of Nissl bodies.Conclusion It is an ideal method for establishing the animal model of post-encephalorrhagia depression to give chronic unpredictable mild stress to rats on the basis of cerebral hemorrhage.关键词：post-encephalorrhagia depression;rats;animal model
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发布时间：2021-09-15 - 摘要：Objective To study the preventive and therapeutic effects of Qingfeiyin Decoction on influenzavirus A and B.Method To apply the histiocytic culture,cytopathic inhibition（CPE）,hemagglutiative assay（HA） and hemadsorption（HD） to study the direct,preventive and therapeutic effects of extract from Qingfeiyin Decoction on the influenzavirus.Results （1） The preventive and direct deactivated effects were as follows: The median tissue culture infective dose(TCID50) was lower over 2Log in the Qingfeiyin group than that of the virus control group with a correlation with the decoction concentration.（2） The therapeutic effect on madin darby canine kidney（MDCK） infected influenzavirus was as follows: The TCID50 was lower over 1.5Log in the Qingfeiyin group than that of the virus control group.Conclusion Qingfeiyin Decoction has the direct inhibitory,preventive and therapeutic effects on influenzavirus A and B with a remarkable dose-effect relationship.关键词：influenzavirus;Qingfeiyin Decoction;ribavirin;prevention;treatment
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发布时间：2021-09-15 - 摘要：Objective To observe the effect of Shenluotong on tubulointerstitial fibrosis in rats and try to find the mechanism.Methods The model of renal obstruction was established by unilateral ureteral obstruction（UUO） in rats,and then divided them randomly into five groups,including UUOV group（treated with Valsartan）,UUOS group（treated with Shenluotong）,UUOVS group（treated with Valsartan and Shenluotong）,UUO group and the sham-operation group.The morphological change of kidney tissue and the protein and gene expressions of MMP-1 and TIMP-1 were observed and compared with that of the sham-operation group.Results In UUO group and different treatment groups there were different degrees of lesions of kidney compared with the sham-operation group.The expressions of MMP-1 and TIMP-1 in kidney tissue were increased obviously（P<0.05）,and the expression of TIMP-1 was higher than that of MMP-1.There was no significant difference in the expression of MMP-1 between different treatment groups and UUO group（P<0.05）,while the expression of TIMP-1 decreased significantly（P<0.05）.The comparison between different treatment groups showed that the expression of TIMP-1 in UUOVS group was lower obviously than that in UUOV group（P<0.05）,but there was no significant difference between other treatment groups（P>0.05）.Conclusion After unilateral ureteral obstruction the different degrees of pathological changes in kidney tissue were seen,which was related to the unbalance of MMP-1/TIMP-1 expressions.Shenluotong and Valsartan have an inhibitory effect.The combined use of both drugs was better than only use of one drug.关键词：Shenluotong;unilateral ureteral obstruction;tubulointerstitial fibrosis;matrix metalloproteinase;rats
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发布时间：2021-09-15 - 摘要：Objective To discuss the mechanism of rat model of tracheal-fibrosis induced by two times intratrachea endotoxic-LPS drips.Methods To establish the rat model of tracheal-fibrosis by two time of intratrachea LPS drips.There was an interval of 14 days between the two time of drips. Then to observe the content changes of serum laminin（LN）,interleukin-8（IL-8）,tumor necrosis factor-α（TNF-α）,IV-collagen（IV-C） and lung hydroxyproline in different groups,analyse the total cell count and cell classification in bronchoalveolar lavage fluid（BALF）,and make the image analysis on pathological results of lung tissue.Results In the model group the contents of serum LN,IL-8,IV-C increased obviously（P<0.05） compared with that of the sham-operation group on the 56th day.The TNF-α content increased but there was no significant difference（P>0.05）.The content of hydroxyproline in lung tissue was higher than that of the sham-operation group（P<0.05）.The total white cell count of BALF in the model group increased obviously （P<0.01） with neutrophil increase mainly（P<0.01） on 28th day.The image analysis showed that in the model group the area of collagen in the whole lung was expanded obviously.The expansion of subepithelial area in alveolar ducts, bronchia（diameter below 90 μm） and bronchi（diameter over 129 μm） was not obvious,but that in medium-sized bronchia（diameter between 90 and 129 μm） was obvious.Conclusion The intratrachea LPS drips for two times（with an interval of 14 days） could induce tracheitis,neutrophil aggregation,release of inflammatory factors and extracellular matrix（ECM） sludging in subepithelial cells of medium-sized bronchi.关键词：endotoxic-LPS;chronic obstructive pulmonary disease;interleukin-8;tracheal-fibrosis;neutrophil;rats
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发布时间：2021-09-15 - 摘要：Objective To investigate the influence of melatonin（MT） ischesis on the level of sympathetic excitability,and the similar points between MT and Chinese medical concept of yin.Methods The weaning rats were illuminated continuously for 24 hours for 30 days to inhibit their MT secretion.The changes of blood MT,epinephrine（E） and norepinephrine（NE） were detected and the intervenient effect of the prescriptions with the effects of nourishing yin and purging fire were observed at the same time.Results In the illumination group compared with the normal group the level of blood MT at night decreased and the rat weight decreased too,but the levels of E and NE increased obviously.After the administration of the prescriptions the level of MT at night and rat weight were increased and the levels of E and NE were decreased in the illumination group.Conclusion MT hyposecretion can improve the sympathetic excitability in prepuberal rats,while the prescriptions with the effects of nourishing yin and purging fire can reverse these changes.There may be a relationship by inference between MT and Chinese medical concept of yin.关键词：melatonin;epinephrine;norepinephrine;nourishing yin and purging fire;rats
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发布时间：2021-09-15 - 摘要：Objective To investigate the relieving effect of panax notoginsenoside（PNS） on the disorder of the abilities of space search,learning and memory in rat model of Alzheimer’s disease（AD）.Methods The AD rat model was established by intraperitoneal injection of D-galactose resulting in subacute lesion combined with ibotenic acid injection resulting in destroy of bilateral basal nuclei of Meynert.The test of Morris water maze（MWM） was used to examine the changes of the abilities of space search,learning and memory in rats.Result All of the test indexes in MWM showed that the abilities of space search,learning and memory in different groups with different PNS doses remarkably improved compared with that of the model group（P<0.05）. Conclusion PNS has a significant relieving effect on the lesion of the abilities of space search,learning and memory in AD model rats.
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发布时间：2021-09-15 - 摘要：Objective To study the chemical compositions in the spikes of Schizonepeta tenuifolia Briq.Methods The chromatography was used to isolate and purify the compositions and spectroscopic methods were used to identify the structure of the spikes of Schizonepeta tenuifolia Briq.Result There were ten compounds isolated and identified as follows: luteolin（I）,apigenin（II）,trans-cinnamic acid（III）,β-sitosterol（IV）,ursolic acid（V）,hesperidin（VI）、3-hydroxy-4（8）-ene-p-menthane-3（9）-lactone（VII）,tilianin（VIII）,hesperitin—7—O—glucoside（IX） and schizonepetosides B（X）.Conclusion The compounds VIII and IX were isolated from the spikes of Schizonepeta tenuifolia Briq.for the first time.关键词：spikes Schizonepeta tenuifolia Briq.;flavonoids;chemical compositions
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发布时间：2021-09-15 - 摘要：The model of differentiation of physique,disease and syndrome was a clinical diagnostic and treatment model which took the physique differentiation and treatment as a key point to combine physique,disease and syndrome differentiations.The model summarized and distillated the constitution theory,scientific experiment and clinical practice.In this model the physique differentiation and treatment,the theory of "physique relating to disease" and "physique being recuperable" were the basis,the internal relationship between disease,syndrome manifestations and physique was promoted,the clinical thinking was opened and multiple clinical demands were satisfied.In clinical practice the emphasis was lain in prevention more than in recuperation,or treatment more than recuperation,or treatment and recuperation were given consideration together.If there was no any syndrome for differentiation the physique differentiation could be taken as a remedial measure.The diagnostic and therapeutic methods in this model included giving treatment after differentiation of physique condition, or giving treatment after differentiation of physique type,or administrating drugs after differentiation of physique difference.The questions were answered through clinical cases.关键词：model of differentiation of physique,disease and syndrome;physique differentiation and treatment;theory on relationship between physique and disease;theory on physique being recuperable
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发布时间：2021-09-15 - 摘要：Objective To evaluate the comprehensive therapeutic plan with a core of syndrome differentiation and treatment for acute ischemic stroke（AIS）,and try to establish an evaluation system of Chinese medical curative effect on stroke.Methods To divide randomly 42 patients into the treatment group（n=20） and the control group（n=21）.The treatment group was given the comprehensive therapeutic plan with the basic treatment of internal medicine,herbal medicine orally after the syndrome differentiation,intravenous drip of herbal medical preparation,acupuncture,normal nurse and rehabilitation measures respectively at different time points in different disease development stages.The control group was given the treatment of thrombolysis,defibrinogen anticoagulation,antiplatelet,decrease of intracranial pressure（ICP）,improvement of cerebral circulation and nutritive metabolism.Results （1） The nervous afunction was relieved obviously in two groups（P<0.05） and the difference between two groups at different time points was not statistically significant.（2） In the treatment group the patient ability of daily life was improved gradually from 14th day to 3rd month（P<0.05）.In the control group the difference at different time points was no statistically significant although the patient ability of daily life was improved.（3） The patient living quality was improved from 28th day to 3rd month in two groups（P<0.05）.（4） In the treatment group the scores of wind syndrome,fire-heat syndrome and phlegm syndrome at different time points had a trend of durative decrease（P<0.05）.The scores of qi-insufficiency syndrome and syndrome of hyperactivity of yang due to yin-deficiency decreased gradually after 28 days（P<0.05）.In the control group the scores of wind syndrome decreased continuously at different time points（P<0.05）.The fire-heat syndrome and phlegm syndrome were relieved gradually（（P<0.05））.The fire-heat syndrome on 7th day and phlegm syndrome on 14th day were relieved obviously in the treatment group compared with the control group（P<0.05）.（5） The cases of mental deficiency in two groups deceased along with the disease development.（6） In the control group there were 2 recurrent cases.There were 4 cases had bad results,2 in the control group with a relation to the therapeutic plan and other 2 in the treatment group without relation to the therapeutic plan.All cases had no hepatosis or renal insufficiency.Conclusion The comprehensive therapeutic plan with the characteristics of syndrome differentiation and treatment has the best result to acute ischemic stroke.It is worth spreading in clinic.An evaluation system of the clinical curative effect on stroke with Chinese medical features was set up initially.关键词：Chinese medicine;ischemic stroke;cerebral infarction;evaluation of curative effect;comprehensive therapeutic plan
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发布时间：2021-09-15 - 摘要：Objective To investigate the characteristics of syndrome manifestations and pathogenesis in patients with vascular dementia（VaD）.Mehtods To select VaD patients（n=66） and the patients with cerebral infarction（without cognitive lesion as the stroke group,n=51）by the New Psychometric Test Battery used in Bristol Memory Disorders Clinic Revised（BMDC-NPTB-CR,Chinese edition） and the Blessed Behavior Scale（BBS）.VaD diagnosis was made based on the Diagnostic and Statistical Manual of Mental Disorders,4th edition（DSM-IV）,the standards of the National Institute of Neurological Disorders and Stroke of USA and Association of International Research of Neuroscience of Switz.（NINDS-AIREN） and Clinic Dementia Rating（CDR）.The Hachinski Ischemia Scale and the Cornell Scale of Depression Disease（CSDD） were used for differential diagnosis.The questionnaire was used for the investigation of syndrome manifestations and the Syndrome Differentiation Scale of Vascular Dementia（SDSVD） was used for diagnosis of syndrome manifestations.Results The positive rate of single-syndrome increased in the syndromes of asthenia of kidney essence and turbid phlegm clouding orifices of the VaD group compared with that of the stroke group.The total integral of SDSVD increased obviously,and the integrals in the syndromes of kidney essence asthenia,turbid phlegm clouding orifices and internal excessive heat increased too.Conclusion The syndromes of asthenia of kidney essence,turbid phlegm clouding orifices and internal excessive heat have a higher morbidity and more serious manifestations in VaD patients.These syndromes are important nosogenic factors of vascular dementia.关键词：vascular dementia;stroke;syndrome manifestations;cause and pathogenesis of a disease
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发布时间：2021-09-15 - 摘要：Objective To investigate the distributive law of syndrome types of menopause women and provide the basis for the standardized research on clinical symptom classification according to syndrome differentiation.Method The questionnaires were given to 250 menopause women and the data from the results were analysed.Result The symptoms and signs in menopause women according to the occurrent rate were as follows in turn: fever and sweating,wakefulness,impetuosity and susceptibility to rage,palpitation,fatigue,dizziness and headache.The common three syndrome types in menopause women were the syndrome of liver depression and qi stagnation,syndrome of liver insufficiency and syndrome of kidney insufficiency.Conclusion The syndromes of kidney insufficiency and liver depression were the most common syndrome types in menopause women.The attention in treatment should be paid to soothing liver to relieve depression on the base of regulation and nourishment of liver and kidney.关键词：menopause syndrome;science of syndrome manifestations;classification according to syndrome differentiation
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发布时间：2021-09-15 -
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- 摘要：Objective To observe the effective law of routine moxibustion on the changes of blood lipid and weight of climacterium rat.Method The routine moxibustion was given to the female rats ten months after birth on the acupoint of Guanyuan（CV4） twice a week for 8 weeks.The changes of the blood lipid level and weight in 12th,14th and 16th months were observed respectively.Results The routine moxibustion on CV4 could prevent effectively the weight increase of climacterium.The effect was more obvious in 12th and 14th months.The effect of routine moxibustion on plasma total cholesterol（CHO） and triglyceride（TG） was similar.Comparison between the moxibustion group and the control group the levels of plasma CHO and TG increased a little in 12th month and decreased in 14th and 16th months.In 14th month CHO decreased more（P<0.05） and in 16th month TG decreased more（P<0.05）.The effect of routine moxibustion on plasma high-density lipoprotein（HDL） and low-density lipoprotein（LDL） was similar.Comparison between the moxibustion group and the control group the levels of HDL and LDL increased a little in 12th and 14th months and decreased in 16th month.The decrease of LDL level in 16th month had a significant difference（P<0.05）.Conclusion The routine moxibustion can prevent effectively the dyslipidosis in climacterium rats.It has an obvious follow-up effect on blood lipid.The law of this effect is that the blood lipid level was increased at first and then decreased. The decreasing effect has a statistically significance.关键词：routine moxibustion;climacterium;blood lipid;rats
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发布时间：2021-09-15 -
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