最新刊期
卷 0 ， 期 0 ， 2020
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- 摘要：Objective To study the prescription combination theory of ZHANG Zhong-jing.Methods The methodology of philology and mathematics was used to investigate and analyze the motivation and purpose,basis and principles of combined prescriptions,the"seven emotions"relationship between prescriptions after prescription combination,the effects of combined prescriptions,and the difference between two prescription preparing methods of"combining after decocting"and"decocting after combining".Results In addition to obtain a better clinical effect,the motivation and purpose of prescription combination were related to the belief and experience.The basis of prescription combination was syndrome manifestations and（pathogenesis）,and the principles of prescription combination were to potentiating effectiveness and（attenuating） toxicity.In a combined prescription there was at least a main-assist or reciprocal relation in proportion between the prescriptions.There might be a relationship similar to"seven emotions"relation in Chinese medicine formulary in the interaction between prescriptions.The effectiveness of combined（prescription） showed potentiation,cooperation and antagonism.The preparing methods,such as（combining） after decocting and decocting after combining,had the influence on the curative effect of a combined prescription.Conclusion The prescription combination is another way for the development of Chinese medicine formulary,and a new field in the study of Chinese medicine formulary.The（prescription） combination broadens the applicative scope of existing prescriptions.关键词：ZHANG Zhong-jing;prescription combination;theory;syndrome manifestations;pathogenesis
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发布时间：2021-09-15 - 摘要：The development current state of syndrome differentiation and treatment system of Chinese（medicine） was analyzed based on the term of"syndrome differentiation and treatment",the research（achievement） in the theory of syndrome differentiation of wei,qi,ying and xue and shanjiao,and some new methods of syndrome differentiation,such as micro-syndrome differentiation,differentiation of（syndrome） factors,etc.were discussed.And with the development of thehnology,science and the change of disease spectrum,macro differentiation of syndromes in TCM came to appear its disadvantage.So it is the essential tendeney to look for the commonness and individuality of syndromes,and built up a new syndrome differentiation system taking the multi-target syndrome as the object.关键词：syndrome differentiation and treatment;syndrome manifestations;micro-syndrome(differentiation;) diagnosis with Chinese medicine
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发布时间：2021-09-15 -
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- 摘要：Objective To analyze the reliability and validity of the questionnaire on screening the best（technologies） of Chinese medicine in rural areas.Method The spot-survey was used and the questionnaires were filled in by informant themselves.There are 1 387 valid questionnaires recalled.Result After the（reliability） test of internal consistency was used the reliabilities in the fields of price and selection of the best technologies of Chinese medicine were good and all above 0.6,while the reliability in the field of（general） knowledge about the best technologies of Chinese medicine was blow 0.6.The total Cronbach’s（alpha）（coefficient） was 0.9644 and the split-half coefficient was 0.9220.The factor analysis was used to analyze the structure validity and there were 6 factors collected according to the characteristic Eigenvalue above 1.The cumulative proportion was 65.46%.The structure validity accorded to the theory design.Conclusion The questionnaire has a good reliability and validity,and is applicable to the research and evaluation in related field.关键词：Chinese medicine in rural areas;questionnaire on the best technologies;reliability;validity
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发布时间：2021-09-15 - 摘要：Objective To discuss the relationship between quail model of hyperuricacidemia and Chinese medical symptomatology through the observation on ethology,tongue texture and the quantitative analysis.Methods The ethological changes of model were observed by using improved field test,and the changes of tongue texture were observed by using video and image techniques. Result The walking ability of quails in the model group were weaker than those in the normal group.There was no significant difference in flexibility to environment between two groups.The tongue texture of the normal group was red mainly and that of the model group was dark purple or light white mainly.There were no changes in tongue body and shape in the model group.Conclusion Some pathological changes in quail model were related to the cognition in Chinese medical theory.关键词：hyperuricacidemia;symptomatology;ethology;quails
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发布时间：2021-09-15 - 摘要：Objective To study the morphological characteristics of pathological changes of hepatic（sinusoid） in rats with alcoholic hepatopathy,and to investigate the relationships between these changes and"liver collateral disease".Methods The rat model of alcoholic hepatopathy was established by using a mixture solution of white spirit,vegetable oil and pyrazole（1 000∶250∶3）.After 12 weeks the liver tissue was taken.The olefin section of liver tissue was stained with Mallory method.Collagen IV（Col IV） and LN were stained with immunohistochemistry.Meanwhile the liver tissue was sliced into ultrathin sections and observed with the transmission electron microscope（TEM）.Results The collagen content in liver tissue was increased significantly（P<0.01）,and the Col IV content and LN density was increased in liver tissue（P<0.01,P<0.05） in the model group compared with those of the normal control group.The fenestra of hepatic sinusoid endothelial cells disappeared,basement membrane continued and（thickened,） and Disse diastem collagen fiber increased.Conclusion The main pathological changes of hepatic sinusoid in rats with alcoholic hepatopathy are capillarization and fibrosis,which were considered as the material basis of"liver collateral disease".关键词：alcoholic hepatofibrosis;hepatic sinusoid;morphology;rats
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发布时间：2021-09-15 - 摘要：Objective To establish the superficial sign model of syndrome of congealing cold with blood stasis.Methods The rat model of syndrome of congealing cold with blood stasis was established by multi-stimulation of ice water and the changes of rat superficial signs were taken with digital camera.（Results） The model rats showed a dark purple tongue,and thicker and longer sublingual vein,while the normal rats showed a ruddy tongue and clear sublingual vein.There was a significant difference between them.The model rats showed a ruddy auricle and clear capillaries,but dark red in colour compared with that of the normal rats.The indexes,such as whole blood viscosity,high and low shear rate of reductive（viscosity） in hemorrheology,were increased in the model rats compared with those of the normal rats（P<0.05）.The indexes,such as aggregate index and area,were higher significantly in the model rats than those of the normal rats（P<0.05）.The platelet maximal aggragation rate of the model rats was higher significantly than that of the normal rats,and the thromboplastin time（TT） and prothrombin time（PT） were shorter significantly in the model rats than those of the normal rats（P<0.05）.Conclusion After the rats were stimulated by ice water for 20 times,the superficial signs of blood stasis syndrome,（especially） dark purple tongue and thicker and longer sublingual vein,accorded with the evaluative（condition） of the superficial sign model of syndrome of congealing cold with blood stasis.The method of multi-stimulation by ice water is easy and reliable for the model establishment.关键词：syndrome of congealing cold with blood stasis;superficial sign model;evaluation;rats
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发布时间：2021-09-15 - 摘要：Objective To investigate the estrogenic effects through the study on the influence of ten kinds of Chinese herbal drugs,including Herba Epimedii on mouse body weight and uterus growth.Methods The （total） of 121 Kunming female mice were selected and divided randomly into 12 groups（including the（normal） control group,positive control group and 10 groups of Chinese herbal drugs） The mice in different groups were treated for 4 days and were killed on fifth day,and the uterus coefficient was calculated.The changes of mouse weight were observed before and after the drug administration. The serum levels of E2,LH and FSH were detected by using Elisa method.Results ①The administration of Herba Epimedii（orally） increased significantly the uterus coefficient in mice,while that of Herba Cistanches or Fructus（Psoraleae） decreased the uterus coefficient（P<0.01）.②The administration of Herba Epimedii orally（increased） significantly the rise rate of mouse weight（P<0.01）,and that of fructus lycii had the same（result）,but that of Herba Cistanches or Fructus Psoraleae decreased the rise rate of mouse weight.There was no significant difference in statistical analysis（P>0.05）.③The administration orally of Semen Cuscutae,Flos Carthami,Radix Salviae and Herba Cistanches increased the serum levels of E2 and LH and decreased FSH level,but that of Herba Epimedii,Fructus Ligustri Lucidi and Radix Cyathenlae（decreased） the serum levels of E2, LH and FSH.Conclusion Herba Epimedii has the plant estrogenic effects,such as effects of stimulating uterus growth and putting on body weight, and changes the serum levels of E2,LH and FSH.Herba Cistanches or Fructus Psoraleae has the inhibitory effects on mouse（uterus） growth and which mechanism and effective principles are needed further research.关键词：plant estrogen;uterus coefficient;body weight;sex hormone level;Herba Epimedii;mice
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发布时间：2021-09-15 - 摘要：ObjectiveTo observe the inhibitory effect of Sodium Ferulate Injection on H22 cell growth and angiogenesis of liver carcinoma,and the influence on the transcription of vascular endothelial growth（factors）（VEGF） mRNA in the mouse model.Methods The H22 cells of liver carcinoma were （inoculated） in KM mouse armpit hypodermically,Sodium Ferulate Injection was infected intrapertoneally,and then the tumor volume was measured every 3 days. The expressions of VEGF and proliferating cell nuclear antigen（PCNA） were detected by immunohistochemistry.The influence of Sodium Ferulate（Injection） on the proliferation of H22 cells and ECV 304 was tested by MTT method.The transcription of VEFG mRNA in tumor tissue was detected by RT-PCR.Results The volume and weight of H22 tumor grew more slowly in the Sodium Ferulate Injection group than in the control group（P<0.05）.The（capillary） vessel density and VEGF and PCNA cells in the tumor in the Sodium Ferulate Injection group were decreased significantly than those in the control group（P<0.05）.The transcription of VEGF（mRNA） in the Sodium Ferulate Injection group was decreased significantly than that in the control group（P<0.05）.The result of test in vitro showed that the Sodium Ferulate Injection group had no significant inhibitory effect on the proliferation of ECV304 and H22 cells.Conclusion Sodium Ferulate Injection can inhibit significantly the H22 tumor growth,angiogenesis and the expression of VEGF,but not on the proliferation of ECV304 and H22 cells.The mechanism of anti-H22 tumor and anti-angiogenesis by （Sodium） Ferulate Injection may be related to that Sodium Ferulate Injection can inhibit VEGF expression in tumor tissue.关键词：Sodium Ferulate Injection;tumor;angiogenesis;vascular endothelial growth factors;mice
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发布时间：2021-09-15 - 摘要：Objective To observe the pharmacokinetic characteristics of ferulic acid（from Radix（Angelicae） Sinensis） of decocted Jiaweixiaoyao Powder in patients with liver-qi stagnation and spleen（insufficiency.） Methods Ten patients with liver-qi stagnation and spleen insufficiency were chosen and given（Jiaweixiaoyao） Powder orally.At the time of 5,10,15,30,60,90 and 120 min,the concentration of ferulic acid in the serum samples was determined.Results The concentration-time curve of ferulic acid in serum of patients with liver-qi stagnation and spleen insufficiency was shown to fit a double（compartment） open model,t1/2Ka was（15.61±9.77） min,t1/2α was（41.54±23.95） min,and t1/2β was（91.01±64.14） min.Conclusion The pharmacokinetic characteristics of ferulic acid is（understood） in the serum of patients with liver-qi stagnation and spleen insufficiency,which will play a reference role in clinical application.关键词：ferulic acid;Jiaweixiaoyao Powder;syndrome of liverqi stagnation and spleen insufficiency;(pharmacokinetics)
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发布时间：2021-09-15 - 摘要：Objective To study the effect of Yiqihuoxuejiedu Formula composed of panaxoside,（arasaponin） and berberin on the spontaneous metastasis of mouse Lewis lung carcinoma and to discuss the mechanism.Methods The mouse model of Lewis lung carcinoma was established and then the mice were given Yiqihuoxuejiedu Formula by intraperitoneal injection.After 20 days the number of metastatic nodes on lung surface was counted,the number and size of metastatic focus in lung Paraffin section stained by HE were observed.Immunohistochemistry was used to detecte the expressions of E-cadherin,CD44,matrix metalloproteinase-2（MMP-2） and tissue inhibitor of metalloproteinase-2（TIMP-2） in tumor cells or tissue.Results Yiqihuoxuejiedu Formula decreased the number and size of metastatic focus.The size of metastatic focus was significantly smaller in Yiqihuoxuejiedu Formula group than that in the control group.Furthermore Yiqihuoxuejiedu Formula increased E-cadherin expression,and inhibited CD44（expression,）and decreased the ratio of MMP-2 to TIMP-2 in the tumor tissue.Conclusion Yiqihuoxuejiedu Formula can inhibit the spontaneous metastasis of Lewis lung carcinoma in mice.The mechanism may be related to that Yiqihuoxuejiedu Formula can prevent the exuviation of tumor cells from primary carcinoma,inhibit the adhesion of tumor cells to extracellular matrix（ECM） and endothelial cells,and degradation of ECM by regulating the expression of cell adhesion molecules in tumor cells,and to prohibit the invasion and metastasis of tumor cells.关键词：Yiqihuoxuejiedu Formula;Lewis lung carcinoma;metastasis;E-cadherin;matrix（metalloproteinase）-2;mice
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发布时间：2021-09-15 - 摘要：Objective To observe the influences of Caoguozhimu Decoction and its modified or decomposed formulae on PTZ kindling rats,in order to reduce the herbs and find out the law of Chinese medicinal（compatibility.） Method The behavioral method was used in the model of PTZ kindling rats to screen（different） groups of Caoguozhimu Decoction,its modified and decomposed formulae and select the group with a better anti-epileptic effect and then the influences of above formulae on hippocampus Glu and GABA（contents.） Result There were differences among the groups of Caoguozhimu Decoction and its modified or decomposed formulae.There was a significant effect respectively in the group of regulating spleen-stomach qi motion and the group of clearing and astringing liver combined with clearing heart to restore（consciousness,） but the best effect in the whole formula of Caoguozhimu Decoction. Conclusion Caoguozhimu Decoction and its modified or decomposed formulae all had an influence in varying degrees on convulsion onset and hippocampus Glu and GABA contents in PTZ kindling rats,but the whole formula of Caoguozhimu（Decoction） had the strongest effect.The result proves that the whole formula of Caoguozhimu Decoction is combined most scientifically and reasonably.关键词：Caoguozhimu Decoction;study on decomposed formula;epilepsy;kindling model;rats
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发布时间：2021-09-15 - 摘要：Objective To optimize a method for extraction of RNA from different organs of Radix（Glycyrrhizae） and to provide a base for the study on synthetic enzyme gene clone and gene expression of medicinal components of Radix Glycyrrhizae.Methods The purity and yield were compared of RNA（extracted） from the xylem,phloem,rhizome and leaf of Radix Glycyrrhizae by methods of guanidine isothiocyanate or sodium citrate respectively.Results RNA could be extracted from the xylem,phloem,rhizome,but not from the leaf of Radix Glycyrrhizae by using guanidine isothiocyanate method,and RNA could be extracted from the leaf of Radix Glycyrrhizae by using sodium citrate method.Conclusion The method of guanidine isothiocyanate or sodium citrate is respectively an effective extractive method for RNA from the xylem,phloem,rhizome,and leaf of Radix Glycyrrhizae.关键词：Radix Glycyrrhizae;organ;RNA extraction
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发布时间：2021-09-15 - 摘要：Objective To study the characteristics of the sequences of internal transcribed spacers（ITS） of ribosomal DNA（rDNA） from Cuscuta.Methods The sequences of rDNA ITS region（including ITS-1,5.8S rDNA and ITS-2） were determined from 7 species of Cuscuta by the direct or clone sequencing of PCR products.Results The results showed that the full length of Cuscuta ITS was about 612 bp,the GC contents of ITS-1,5.8S rDNA and ITS-2 were 53%63%,48%55% and 46%56%（respectively,） and there were three variable sites found in 3 populations of C.approximata.The（phylogenetic） tree based on the neighbor-joining（NJ） method indicated that the branch including（Cuscuta.）japonica was in basal position of the phylogenetic tree,and C.chinensis C.cupulata had a close relationship with the tree successively.In the branches of other 5 species,one was consisted of C.campestris and C.pentagona,and another,of C.australis C.approximata.Conclusion The phylogenetic tree based on NJ method corresponds with the morphological classification,which provides an important molecular basis for the classification and determination of Cuscuta genus.关键词：Cuscuta;molecular identification;sequences of internal transcribed spacers;ribosomal DNA
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发布时间：2021-09-15 - 摘要：Objective To identify the medicinal plant group of "Taibai Qiyao",which was unique in Shaanxi Province,by using Fourier fingerprint chromatogram by powder X-ray diffraction.Method The（identification） method of Fourier fingerprint chromatogram by powder X-ray diffraction was applied to test and analyze 12 samples of herbal materials from the medicinal plant group of "Taibai Qiyao".Result The Fourier fingerprints chromatogram by powder X-ray diffraction were obtained from 12 herbal materials,including qiaomaiqi,tao’erqi,zhushaqi,fengweiqi,hongmaoqi,niuziqi,tieniuqi,yangjiaoqi,panlongqi,huluqi,xieziqi and dengtaiqi.Conclusion The identification method of Fourier fingerprint chromatogram by powder X-ray diffraction is practicable for the identification of medicinal materials in "Taibai Qiyao"plant group.关键词：identification of Chinese medicinal materials;Fourier fingerprint chromatogram by powder X-ray diffraction;"Taibai Qiyao"
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发布时间：2021-09-15 - 摘要：Objective To observe the curative effect of Jianpiqingrehuayu Formula on gastric ulcer and its recrudescence.Method The patients（n=80） with gastric ulcer（syndrome of spleen insufficiency and heat stagnation in Chinese medicine） were divided by single-blind random method into the treatment group（n=40）,the ranitidine control group（n=20） and the Weinai`an Tablets control group（n=20）.The effects of gastroscope and Chinese medical syndrome manifestations,the symptoms before and after the treatment,recurrent rate and symptoms 6 months after stopping the treatment were observed （respectively）.Result There was no significant difference in the effects of gastroscope,Chinese medical syndrome manifestations and anti-HP between the treatment group and control groups.In the alleviation of main symptoms,recurrent rate and the main symptoms after the treatment for 6 months the results of the treatment group were much better than those of the control groups.Conclusion Jianpiqingrehuayu（Formula） has a significant curative effect on gastric ulcer and its recrudescence.关键词：Jianpiqingrehuayu Formula;gastric ulcer;spleen insufficiency and heat stagnation;(syndrome) manifestations of Chinese medicine;gastroscope;recurrent rate
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发布时间：2021-09-15
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