最新刊期
卷 0 ， 期 2 ， 2006
- 摘要：The theory of Chinese herbal nature is the key of the science of Chinese meteria medica,the base of the development of science of Chinese meteria medica and the link between Chinese medicine and Chinese meteria medica.This paper discussed the systematical significance of Chinese herbal nature and methodology of Chinese herbal nature theory development on the basis of internal mechanism of three yin-three yang system and its relationship with elementary theory of Chinese medicine from the theory of yin-yang.The paper provided a theoretical form for the research on the compatibilities of components of（Chinese） herbal drugs and a thinking train for the application of basic principles of Chinese medicine in modern life science.关键词：three yin-three yang ystem;complex system;theory of Chinese herbal nature;(compatibilities) and components
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发布时间：2021-09-15 -
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- 摘要：The establishment of syndrome model is an pressing problem in the field of Chinese medical（research）.This paper set an example of the model combined cerebral infarction with syndrome of（qi-insufficiency） and blood stasis,discussed the thinking train and method of the model establishment of syndrome manifestations of Chinese medicine,took qi-insufficiency as the initial factor or key factor（running） through the whole procedure of the model establishment.The correlative macro-signs and（biological） indexes were observed dynamically,the evaluation system was determined and the basis was provided to the material function for opening out the syndrome of qi-insufficiency and blood stasis.关键词：qi-insufficiency and blood stasis;disease and syndrome;animal model;thinking train and method of research
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发布时间：2021-09-15 - 摘要：Objective To observe the level changes of arginine vasopressin （AVP）（with the effect of（improving） learning and memory abilities） and gene expression in the brain of spleen-deficiency rat model and influence of Guipi Decoction.Methods To establish the rat model of spleen-deficiency by the（methods） of purgation with bittle and cold nature drugs,improper diet and overstrain.（Immunohistochemistry） and in situ hybridization were used to detect AVP level and gene expression in nucleus hypothalamicus（ventromedialis）,CA1 zone of hippocampus and prefrontal cortex.Result The immunity positive reactant of AVP in above brain zones decreased obviously in the model group,while increased obviously in the treatment group.AVP mRNA expressions in CA1 zone of hippocampus and prefrontal cortex decreased obviously in the model group,while increased obviously in the treatment group.Conclusion AVP（with the effect of improving learning and memory abilities） level and gene expression in the brain of spleen-（deficiency） rat model has changed.Guipi Decoction can influence the learning and memory abilities by regulating AVP level and gene expression.关键词：spleen-deficiency rat model;arginine vasopressin;gene expression;Guipi Decoction;rats
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发布时间：2021-09-15 - 摘要：Objective To investigate the regulative effect of some Chinese herbal drugs（with the effects of reinforce kidney,replenishing qi and strengthening essence） on the expression of signal transduction（molecules）-Smad2 in the bone tissue of rats after ovariectomy and the mechanism of osteoporosis occurrence.Methods The model of postmenopausal osteoporosis was established through ovariectomy in rats and then treated with Chinese herbal drugs （with the effects of reinforce kidney,replenishing qi and strengthening essence） for 12 weeks.The control group was treated with nilestriol.The bone mineral density（BMD） of rat femoral bone in vitro was detected by dual-energy X-ray densitometer and the expressions of Smad2（protein） and mRNA were detected by reverse transcription-polymerase chain reaction（RT-PCR） and（Western） blotting method respectively.Results BMD of femoral bone in vitro in rats after ovariectomy（decreased） obviously and the expressions of Smad2 protein and mRNA in bone tissue decreased averagely.The Chinese herbal drugs（with the effects of reinforce kidney,replenishing qi and strengthening essence） could increase BMD in rats after ovariectomy and improve Smad2 expression in bone tissue at the levels of protein and mRNA.Conclusion The decrease of Smad2 expression in bone tissue maybe the mechanism of primary osteoporosis.The Chinese herbal drugs（with the effects of reinforce kidney,replenishing qi and strengthening essence） can improve BMD through increasing Smad2 expression.
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发布时间：2021-09-15 - 摘要：Objective To study the expressions of interleukin-1β（IL-1β） and interleukin-1β receptors（（IL-1βR）） of liver tissue in rats with hepatic fibrosis induced by CCl4.Method The model of hepatic（fibrosis） model was established by administration of CCl4 two times a week for 2,4,6,8 weeks respectively.The liver tissues of rats in all groups（including the control group） were stained by hematoxylin-eosin（HE） and the pathological changes and the expressions of IL-1β and IL-1βR in rat liver tissues were（observed） with immunohistochemical response.Results The expressions of IL-1β and IL-1βR in the control group was not significant.In 2 week group the pathological changes were mainly inflammation and（hepatocyte） degeneration,the expressions of IL-1β and IL-1βR were significantly increased（P<0.01）（compared） with that of the control group.In 4 week group there was a significant proliferation of interstitial substance and the expressions of IL-1β and IL-1βR were not obvious in necrosis hepatocytes and decreased compared with that of 2 week group（P<0.01）.In 6 week group the necrosis of hepatocytes was serious and the fibrotic septa formed around central vein and portal area.The positive cells of IL-1β and IL-1βR decreased obviously compared with that of 4 week group（P<0.01）.In 8 week group the pseu-lobules formed in liver tissue and the expressions of IL-1β and IL-1βR were similar to that of 6 week group.（Conclusion） In the different development phases of hepatic fibrosis the injury factors could stimulate the expressions of IL-1β and IL-1βR in liver cells.关键词：hepatic fibrosis;hepatic injury;interleukin-1β;interleukin-1β receptors;Immunohistochemistry;rats
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发布时间：2021-09-15 - 摘要：Objective To observe the influences of Qingkailing Injection（QI） on apoptosis of（hippocampal） neurons and mitochondrion membrane potential（MMP） in rat model of hypoxia-（hypoglycemia-）rexyenation（HHR）.Methods Mitochondrion activity was detected by methyl（thiazolyl） tetrazolium test（MTT）.The apoptosis percentage and MMP were detected by flow（cytometry）,and the cytomorphological changes and neuron necrotic percentage were observed with（fluorescence） microscope.Results After hypoxia-hypoglycemia treating in rats for 5 hours and reoxygenation treating for 3、12、24 hours the apoptosis rate of neurons increased significantly.There were chromatinic coacervation,（karyorrhexis） and apoptotic bodies in neurons were observed cytomorphologically.The MMP and（mitochondrion） activity decreased significantly after reoxygenation for 3、12、24 hours,and decreased（further） along with the prolongation of reoxygenation.QI could decrease obviously percentage of neuron apoptosis and necrosis and increase MMP and mitochondrion activity with a significant difference（P<0.05～0.01） compared with the HHR group.Conclusion Qingkailing Injection could inhibit the decrease of MMP induced by injury of hypoxia-hypoglycemia-reoxygenation,stabilize MMP,inhibit cell apoptosis and protect hippocampal neurons.关键词：Qingkailing Injection;neuron;apoptosis;mitochondrion membrane potential;rats
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发布时间：2021-09-15 - 摘要：Objective To investigate the mechanism of the effect of Bikangyin Mixture on rheumatoid（arthritis） and provide the theoretical basis for clinical practice.Methods To establish the model of（arthritis） induced by adjuvant and observe the regulative effects of Bikangyin Mixture and methotrexate（respectively） on interleukin-1β（IL-1β） and tumor necrosis factor-α（TNF-α） through the evaluation of（arthritis） index,X-ray radiological and pathological examination on secondary arthritis and the detection of serum cytokines.Result After the treatment with Bikangyin Mixture and methotrexate the arthritis index changed obviously with a significant difference compared with the model group（P<0.05）.The order of pathological change degree from high to low was as follows: the model group,methotrexate group and（Bikangyin） Mixture group.There was a significant difference（P<0.05） in the levels of IL-1β and TNF-α between the control group and other groups,while there was no significant difference between（Bikangyin） Mixture group and methotrexate group（P>0.05）.Conclusion The abnormal increase of IL-1β and TNF-α was related closely to rheumatoid arthritis.Bikangyin Mixture could decrease the（concentrations） of serum IL-1β and TNF-α level and control or inhibit the development of rheumatoid（arthritis）.关键词：rheumatoid arthritis;adjuvant arthritis;Binkangyin mixture;rats
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发布时间：2021-09-15 - 摘要：Objective To observe the influence of Liujunzijiajian Formula on vasoactive fractions of （gastric） mucous coat,including nitric oxide（NO）,nitric oxide synthase（NOS） and endothelin（ET）,in rats with gastric ulcer.Method Okabe’s acetous cauterization was used to establish the gastric ulcer model in rat anterior gastric wall.The model rats were given drugs respectively for 10 days and then the contents of NO、NOS and ET in peripheral tissues of gastric ulcer were detected.Results The contents of NO and NOS in gastric tissues in different groups increased obviously compared with that of the model gronp（P<0.01）,and the content of ET in different groups decreased obviously compared with that of the model gronp（P<0.01）.The comparison between Liujunzijiajian high-dose group and two groups of western medicines is different（P<0.05）.Conclusion Liujunzijiajian Formula could increase（remarkably） the contents of NO and NOS in rat gastric tissues and decrease the content of ET.It may be the mechanism of Liujunzijiajian Formula in the improvement of gastric ulcer healing in rats.关键词：Liujunzijiajian Formula;gastric ulcer;nitric oxide;nitric oxide synthase;endothelin;rats
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发布时间：2021-09-15 - 摘要：To investigate the mechanism of Yinxingpingchuan Formula in prevention and treatment of Parkinson’s disease（PD）.Methods To establish the mouse model of PD by intraperitoneal injection of MPTP.Immunohistochemistry and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling（TUNEL） technique were used to observe the influence of Chinese herbal drugs on the loss of（mesencephalic） nigra dopamine（DA） neurons and apoptosis.Results In the model group the positive neurons of tyrosine hydroxylase（TH） in mouse nigra compact part decreased obviously than that of the normal group,which was more obvious on 14th day than on 28th day.Yinxingpingchuan Formula and its decompositions could reduce partially the loss of TH positive neurons in mesencephalic nigra compact part.In the model group the apoptosis cells in mouse mesencephalon increased obviously,which was more obvious on 14th day than on 28th day.In the different groups treated with Chinese herbal drugs the apoptosis was inhibited at different degrees.Conclusion Apoptosis maybe one of the common styles of DA neuron loss in mesencephalon of PD mice.Yinxingpingchuan Formula can prevent and treat PD by inhibiting apoptosis and reducing DA neuron loss.关键词：Yinxingpingchuan Formula;Parkinson’s disease;dopamine neurons;cell apoptosis;mouse
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发布时间：2021-09-15 - 摘要：Objective To observe the influence of Danzhixiaoyao Powder on cerebral pathological（changes） in rats with Alzheimer’s disease（AD） induced by D-galactose.Methods The AD model was established by subcutaneous injection of D-galactose [150 mg/（kg·d）] for 49 days.Acricept [0.54 mg/（kg·d）] was used as the control.The model was given Danzhixiaoyao Powder orally and then on 50th day the brain of rat was taken and stained with hematoxylin-eosin（HE） for observing histological structure under the light microscope,and stained with lead-uranium for observing the ultrastructure under the electron microscope.Results By the light microscope the neuron lesion,gliacyte proliferation and tortuosity and thickening of blood vessel wall in model’s brain were relieved by Danzhixiaoyao Powder.By the electron microscope the lesions of neuron processes and those of cerebral endothelial were relieved too,the basement membrane was completed and foot processes of gliacytes were regular after the（administration） of Danzhixiaoyao Powder.Conclusion Danzhixiaoyao Powder can relieve cerebral（pathological） changes,which may be its morphological basis for preventing and treating AD.关键词：D-galactose;Alzheimer’s disease;brain structure;Danzhixiaoyao Powder;rats
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发布时间：2021-09-15 - 摘要：Objective To observe the influence of Jiajianwenjing Decoction on rat ovarian of model with blood stasis due to cold stagnation and investigate the mechanism of Jiajianwenjing Decoction for treating gynecopathy of type of blood stasis due to cold stagnation.Methods To establish the rat model of blood stasis due to cold stagnation by putting rats into ice water（0-1℃）.The estrous（cycles） of rats were determined by vaginal smear,the weight of uterus,ootheca was measured and the uterus index and ovarian index were detected.After HE stain the histomorphological changes of rat（uterus） and ootheca were observed with the light microscope and the serum levels of generative（hormones） were detected with radioimmunoassay（RIA）.Results The difference of uterus index and（ovarian） index in different groups was insignificant statistically. In the model group the（histomorphological） changes were abnormal,the estrous cycle was prolonged and the serum levels of generative hormones decreased obviously compared with that of the normal group.In the treatment group the estrous cycle was shortened obviously and the serum levels of generative hormones（increased） compared with that of the model group.In the Taohong group the serum levels of estradiol（E2）,P,luteinizing hormone（LH） and follicle-stimulating hormone（FSH） increased（remarkably）.The estrous cycle was shortened and the levels of E2 and P increased in the treatment group compared with that of the Taohong group.Conclusion The endocrine is disturbance and the ovarian function was abnormal in the gynecopathy of type of blood stasis due to cold stagnation.（Jiajianwenjing） Decoction can treat gynecopathy of type of blood stasis due to cold stagnation through regulating endocrine and improve the ovarian function.关键词：Jiajianwenjing Decoction;blood stasis due to cold stagnation;generative hormones;(estrous) cycle;rats
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发布时间：2021-09-15 - 摘要：Objective To set down the quality control standard for Chunru gel.Methods Cortex Moutan and Borneolum syntheticum were identified by thin layer chromatography（TLC）,and the content of matrine was determined by HPLC.Result The result showed that the spots of TLC were fairly clear,the repeatability was good and the average sample-adding recovery of matrine was 97.94%（RSD=3.16%）.Conclusion The method is simple,accurate and qualified for the quality control of Chunru gel effectively.关键词：Chunru gel;Matrine;HPLC;paeonolum;borneolum syntheticum;Thin layer chromatography
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发布时间：2021-09-15 - 摘要：Objective To study the quality standard of Baotaiwuyou Tablets and establish a HPLC（method） for the content determination of magnolol and honokiol.Method The determination was carried out on a Hypersil ODS2 column（4.6 mm×250 mm,5 μm）,the mobile phase was methanol-water（72:28）,and the detection wavelength was 294 nm.Results The result showed that magnolol had a good linear relationship in concentrations between 0.050 751.015 μg with an average recovery of 99.1%（RSD=0.74%）,while honokiol had a good linear relationship in concentrations between（0.010 42）0.208 4 μg with an average recovery of 98.0%（RSD=0.72%）.Conclusion The method is easy,accurate,sensitive and reliable,which can be used for quality control of Baotaiwuyou Tablets.关键词：Baotaiwuyou Tablets;magnolol;honokiol;HPLC;Quantitative Detection
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发布时间：2021-09-15 - 摘要：Objective To set up a quantitative determination method of HPLC for four components in the chromone fraction of Saposhnikovia divaricata（Turcz.） Schischk,including prin-O-glucosylcimifugin,cimifugin,4′-O-β-D-glucosyl-5-O-methylvisamminol and sec-O-glucosylhamaudol.Methods The determination was carried out with Agilent Zorbax C18 column（4.6 mm × 250 mm,5 μm） and gradient elution program of methanol-water.The mobile phase at a flow rate of 1.0 mL/min and detection wavelength was 254nm.Results The average recovery of prin-O-glucosylcimifugin was respectively 102.56%,102.12% and 95.50%（RSD was 2.24%,1.33% and 0.48% respectively,n=5）,that of cimifugin,95.66%,99.60% and 97.54% respectively（RSD, 0.62%,1.23% and 0.89%,n=5）,that of 4′-O-β-D-glucosyl-5-O-methylvisamminol,98.96%,96.76% and 96.91% respectively（RSD,0.48%,2.46% and 2.74%,n=5） and that of sec-O-glucosylhamaudol,99.02%,103.40% and 103.96% respectively（RSD,2.51%,0.93% and 1.61%,n=5）.Conclusion The determination results of three batch samples showed that the method was easy,accurate and could be used in the quantitative determination of four components in the chromone fraction of Saposhnikovia divaricata（Turcz.） Schischk.关键词：Saposhnikovia divaricata（Turcz.） Schischk;chromone;HPLC;quantitative determination
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发布时间：2021-09-15 - 摘要：Objective To investigate the genomic research methods in syndrome manifestations of blood stasis syndrome of coronary heart disease CHD).Method To choose the patients with blood stasis syndrome of CHD and control patients,and screen out the genes correlated to the disease and syndrome manifestations by differential display of peripheral blood mRNA combined with the method of Reserve Northern and the genes were tested in clinic.Result There were 95 differential strips in the differential display and among them 28 were determined as the real differential fragments.After cloning,sequence examination,remove of same sequence and analysis of bioinformatics there were 5 gene sequences with more than 98% homologous gene sequence with that of mankind.They were correlated to the pathological changes of blood stasis syndrome of CHD after the analysis on related documents,materials and clinical test outcomes.Conclusion Combination of differential display,Reserve Northern and clinical test was fit for the research of screening the genes of disease and（syndrome） manifestations.关键词：coronary heart disease;blood stasis syndrome;combination of disease and syndrome（manifestations）;genome of syndrome（manifestations）;screening
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发布时间：2021-09-15 - 摘要：Objective To observe the curative effect of the therapy integrated Chinese and western（medicine） on hemiplegia induced by cerebral vascular disease（CVD）.Methods To divide randomly 177 cases of hemiplegia induced by CVD into two groups.The treatment group（n=119） was treated with（Chinese） herbal drugs,acupuncture,massage,fuming-washing therapy and rehabilitation.The control group（n=58） was treated with rehabilitation only.The curative effects in two groups were evaluated by Ashworth Scale of Spasm,Fugl-meyer Assessment（FMA） and Barthel Index（BI）.Results The total effective rate of arm spasm relief in the treatment group was 49.6% and had a significant difference（compared） with the control group（P<0.05）.The leg spasm,motion function and daily life ability were（relieved） or improved but without significant difference（P>0.05）.Conclusion The therapy integrated Chinese and western medicine can relieve effectively the hemiplegia and spasm induced by CVD and（improve） the recovery of motion function.关键词：hemiplegia;spasm;Chinese medicine;rehabilitation
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发布时间：2021-09-15 - 摘要：Objective To review the therapeutic outcome of 132 cases of small-cell lung cancer（SCLC） treated with the therapy integrated Chinese and western medicine.Methods All cases were given（differentiation） and Chinese herbal drugs in the treatment principle of expelling phlegm and resolving（stagnation）,expelling wind and dredging collaterals,and dispersing accumulation and moistening lung.At the same time all the cases took Feiliuqing Electuary（prepared in this hospital） orally with a dose of 15g once and three times a day,and chemotherapy（including mainly the plan of COA,COME,EP and CAP alternately,group 1）.There were 53 cases（group 2） were given local radiotherapy with total amount of 40-70 Gy besides the above treatment.Results All the cases were visited until December 30,2004.There were 19 cases survived,20 missed and 93 died.The survival time was started from the first day of the treatment and stopped on the day of death or missing.The average and median survival times were 20.6 months and 11 months respectively in all cases.The survival rates in 1st,2nd,3rd and 5th years were 46.97%,18.94%,11.36% and 5.30% respectively.In group 2 the average and median survival times were 34.9 months and 16 months and the survival rates in 1st,2nd,3rd and 5th years were 67.92%,32.07%,22.64% and 9.43%.In group 1 the average and median survival times were 11.6 months and 8 months and the survival rates in 1st,2nd,3rd and 5th years were 32.91%,10.13%,3.79% and 2.53%.The comparison of survival rates of 2nd and 3rd years between two groups was much significantly different and that of 5th year was significantly different.The survival rates of 5th year in two groups were all higher than that reported in documents.Conclusion The therapy combined Chinese herbal drugs,chemotherapy and radiotherapy had a reliable curative effect on SCLC,which was worth further random control research.关键词：small-cell lung cancer;integration of Chinese and Western medicine;average survival time;median survival time;survival rate
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发布时间：2021-09-15 - 摘要：After an analysis of early medical documents and modern researches and a comparison（between） traditional Chinese medicine and culture and other ancient civilized systems especially the ancient Greece,it is concluded that the ancient Chinese medical practitioners discovered the phenomenon of channels and collaterals by applying moxibustion on the hands and feet of the human body.And the（unique） Chinese concept and practice of qi and divination has played an important role during the process of this important discovery.关键词：moxibustion;channels and collaterals;sequential channel transmission;signs of（moxibustion）;history
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发布时间：2021-09-15 -
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