最新刊期
卷 ， 期 3 ， 2006
- 摘要：Obesity is one of the main dangerous factors that affect people’s health. The recognition of obesity in Chinese medicine was recorded as early as the days of “Huangdi Neijing”. “Huangdi Neijing” recorded that the cause of obesity was related to the dietary habits, functions of zangfu organs and people’s constitutions. The pathogenesis of obesity was related to the condition of qi, blood, phlegm turbidity and blood stasis. The types of obesity were mainly “zhiren”, “gaoren” and “rouren”. The fatty was susceptible to stroke, so the drugs administrated to them would be strong in the property and flavour, and acupuncture would be deeper and longer in acupoints. “Huangdi Neijing” also pointed out initially the psychological characteristics of the fatty. All above-mentioned recognitions have laid a solid theoretical function for the later study of obesity.关键词：obesity;“Huangdi Neijing”;cause and pathogenesis
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发布时间：2021-08-03 - 摘要：Objective To observe the changes of GAP-43 expression in hippocampal CA1 induced by 1-42 β-amyloid （Aβ 1-42 ） and the influence of Jinsiwei （GETO）. Methods To establish the Alzheimer’s disease （AD） model by injection of agglomerated Aβ 1-42 in rat hippocampus. After 4 weeks the frozen section was taken from rat brain and the number of positive neurons of GAP-43 and optical density （OD） value in hippocampal CA1 were detected with immunohistochemistry and computer image analysis technique . Results There was no significant difference between the model group and normal group in the number of positive neurons of GAP-43 in hippocampal CA1. There was a significant difference （P<0.01） between the GETO group and model group, and it was the same between the GETO group and donepezil group （P<0.01）. There was a significant difference （P<0.01） between the model group and normal group in OD value of positive neurons of GAP-43 in hippocampal CA1, and it was the same between the GETO group and model group （P<0.01）. But there was no significant difference between the GETO group and donepezil group. Conclusion Jinsiwei （GETO） could improve the expression of GAP-43 of hippocampus in AD rats, which furnished new information about the molecular mechanism of GETO’s effects of promoting nerve growth, improving synaptic plasticity , and the ability of learning and memory.关键词：Jinsiwei （GETO）;Alzheimer’s disease;axon growth;GAP-43;rats
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发布时间：2021-08-03 - 摘要：Objective To develop a reference method of experimental design for the study of the compatibilities of different analogous decoctions. Method Banxiaxiexin Decoction and its analogous decoctions were made up and changed by the homogeneous design. Then the pharmacological data were given an analysis of progressive regression with the analysis of gastric juice as the pharmacological indexes. Result The drugs in Banxiaxiexin Decoction and Gancaoxiexin Decoction had similar effects on gastric principles and similar change trends, but they were different in degrees. There was some discrepancy between Shengjiangxiexin Decoction and above two decoctions and there were interactions among the different drugs in these decoctions. Conclution The method of experimental design is worth a reference to the study of the compatibilities of different analogous decoctions.关键词：Banxiaxiexin Decoction;analogous decoctions;gastric juice;homogeneous experimental design;rats
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发布时间：2021-08-03 - 摘要：Objective To study the influence of Fufangbiejiaruangan Formula on the expressions of NF-κB and IκBα in tubules epithelial cells （TEC） in different periods. Method The serum with Fufangbiejiaruangan Formula was prepared in rats with uniureteroligation （UUO） and then the culture with 5% serum was given to TEC in vitro. The Western blotting method was used to detect the expressions of NF-κB and IκBα at different time points. Result TEC was stimulated with LPS and 6 hours later the activity of NF-κB in cytoplasma was increased, and karyon shifted after 12 hours. The activation of NF-κB in karyon continued to 24th hour. TEC was stimulated with LPS and 2 hours later the expression of IκBα reached the lowest point, it increased after 4 hours and reached the normal level after 8 hours. Conclution Fufangbiejiaruangan Formula can inhibit the activation of NF-κB and stop the degradation of IκBα, prevent the dissociation of NF-κB from the compound of NF-κB and IκBα, and stop the karyon shift of NF-κB. This may be the mechanism of Fufangbiejiaruangan Formula for preventing and treating renal interstitial fibrosis.关键词：Fufangbiejiaruangan Formula;NF-κB;IκBα;tubules epithelial cells
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发布时间：2021-08-03 - 摘要：Objective To investigate the influence of Xingnaoqizhi Capsules （XC） on acetylcholinesterase （AChE） activity of hippocampal tissue in mice. Methods To divide randomly 120 mice into the sham- operated group, model group, XC groups in large and small dose, ginkgo group and nimodipine group with 20 mice in each group. The bilateral corotid ligation and repeated cerebral ischemia reperfusion were used to establish the mouse model of vascular dementia. After 7 days the ethological experiment and pathomorphism observation in hippocampus were made and AchE activity of hippocampal tissue was detected by atomic spectrophotometry. Results ①The ethological experiment showed that the mouse learning and memory ability decreased in model group, while increased in other groups （P<0.05 or P<0.01）. ②The result of pathomorphism with the light microscope showed that there were ischemic pathogenic changes in mouse hippocampal tissue in model group, while these changes were less serious in other groups. ③The AChE activity of model group was obviously lower than that of the sham-operated group （P<0.01）, and that of other groups were higher than model group （P<0.05 or P<0.01）. Conclusion Xingnaoqizhi Capsules has a significant therapeutic effect on vascular dementia. One of this effective mechanisms is that XC can regulate AChE activity in brain tissue and relieve the injury induced by ischemia reperfusion.关键词：Xingnaoqizhi Capsules;vascular dementia;acetylcholinesterase;mice
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发布时间：2021-08-03 - 摘要：Objective To determine the active fraction with sedative effect from Juncus effuses L. Method The samples were prepared by solvent extraction. The whole Juncus effusus L.was extracted with 95% ethanol at first, and then the ethanolic extract was further separated with petroleum ether, chloroform, ethyl acetate and methanol in turn to get four fractions from large to small in polarity. The sedative and hypnotic experiment was made for active screening. The influences of extracts from Juncus effuses L. on mouse autonomic activity and sleeping time （combined with pentobarbital sodium） were observed . Result Juncus effuses L. had reliable sedative and hypnotic effects. The ethyl acetate extract had the most definite sedative effect among the four different polarity fractions of Juncus effuses L. Conclusion It is the first time that the ethyl acetate extract of Juncus effuses L. is proved to be the effective sedative fraction. On this basis the further studies are needed on active principles or principle group with sedative effect and the characteristics of this effect in Juncus effuses L.
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发布时间：2021-08-03 - 摘要：Objective To observe the inhibitory effect of resibufogenin （RBG） on transplantation tumor growth of human cervical cancer Hela cells in rude mice. Method The short and long diameter of the tumor was measured every 3 days before treatment, in treatment period （15 days） and rest period （6 days） respectively, and the approximate volume of tumor was calculated. On the 6th day after stopping treatment the tumor was weighed and observed pathologically. Results ① The large-dose of RBG （15 mg/kg） had a strong acute neurotoxicity. ② RBG had no obvious influence on weight of tumor-bearing mouse. ③ The large-dose of RBG （15 mg/kg） had an obvious inhibitory effect on transplantation tumor growth of human cervical cancer in nude mouse, but no follow-up effect after stopping treatment. RBG in dose of 15 mg/kg and Pingyangmycin in dose of 5 mg/kg were about equal in tumor-inhibitory effect. ④ The short-term neurotoxicity of RBG was not observed. Conclusion RBG has a remarkable tumor- inhibitory effect on transplantation tumor growth of human cervical cancer Hela cells in nude mice. RBG is an important principle with anti-cancer effect of Chinese herbal drug, vallicepobufagin , but it also has acute neurotoxicity. The further development of RBG should be handled with great care.关键词：resibufogenin;tumor;inhibit growth;cervical cancer Hela cells;nude mice
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发布时间：2021-08-03 - 摘要：Objective To study further the effective basic principles of Radix Salviae Miltiorrhizae through the analysis of fingerprint chromatograms of chemical constituents of Radix Salviae Miltiorrhizae. Method To set up the fingerprint chromatograms of water-soluble and liposoluble constituents at the same time in 60 minutes in gradient elution by using RP-HPLC. Results The fingerprint chromatograms with 18 common peaks were simulated with mean method and the analysis of different grades and origin places of Radix Salviae Miltiorrhizae was made after the analysis of the fingerprint chromatograms from 30 groups of Radix Salviae Miltiorrhizae in 6 provinces. Conclusion This method can be used in the qualitative control of Radix Salviae Miltiorrhizae and investigation of effective principles of Radix Salviae Miltiorrhizae .关键词：Radix Salviae Miltiorrhizae;fingerprint chromatograms;qualitative control
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发布时间：2021-08-03 - 摘要：Objective To establish a gas chromatography method for the quantitative determination of cinnamicaldehyde in distilled oil of Rammlus Cinnamomi. Method A capillary quartz column HP ultra-1 （25 m×0.2 mm×0.33 μm） was used as the chromatographic column. The temperature of the column was increased continuously from 60 ℃ to 250 ℃,and the temperature of sampler was 250 ℃ in splitless sampling. The splitless cycle was 0.4 min. The detector （FID） was 250 ℃. The carrier gas （mobile phase） was as follows: helium was 1 ml/min, hydrogen was 0.2 kg/cm2, and air was 0.4 kg/cm2. The integrator was HP 3396A. Result It was showed that cinnamicaldehyde had a good linear relationship in concentrations between 0.082～1.640 g/L （r=0.999 4）, and the average recovery was 100.69%, the contents of cinnamicaldehyde in different time points were almost equal when acetonitrile was used as a solvent. Conclusion The gas chromatography method is easy and accurate with a good repeatability.关键词：Rammulus Cinnamomi;cinnamicaldehyde;gas chromatograghy;acetonitrile
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发布时间：2021-08-03 - 摘要：Objective To study the distribution of qi-insufficiency constitution in different people groups. Method The epidemiological method was used to investigate the distribution of qi-insufficiency constitution of 395 individuals aged over 16 years in the population of Beijing city proper, suburbs, towns and villages. Results The frequency of qi-insufficiency constitution occurrence was 19% in the sample of adult group. Qi-insufficiency constitution was more liable to occur in the population of town and village than in city population, more liable to occur in females than in males. The occurrence rate increased obviously in males after the age of 40 than those in different age groups before 40, but it had no tends to increase with increasing age in different age groups before 40. The occurrence rate was remarkable higher in the group of 41-48 than in different age groups before 40 and the group of 49-56, and it was the highest in the group of 57-64 and tended to decrease in the group of over 64. There were a few cases in females before the age of 22 but the occurrence rate of qi-insufficiency constitution increased progressively in the group of 29-35, 36-42, 43-49 and over 50.Conclusion The distribution of qi-insufficiency constitution is different in different people groups.关键词：qi-insufficiency constitution;people group;distribution
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发布时间：2021-08-03 - 摘要：Objective To discuss the correlation between acute cerebrovascular disease （ACD） and change of myocardia enzymogram （ME）. Methods The retrospective investigation was made in 206 cases of ACD, which included ME, sex, age, consciousness, degree of paralysis, previous history of coronary heart disease （CHD）, pathogenic factors of Chinese medicine （wind, fire, phlegm, stagnation and deficiency）, cerebral hemorrhage, cerebral infarction, change of electrocardiogram （ECG）, cerebral edema, infection in the lung, hemorrhage of digestive tract, and so on. Then above materials were put into the computer after digital treatment and the correlation between the change of ME and other factors analysed with SPSS 11.0 software. Results The increase of the change of ME in the patients with ACD was correlated to cerebral hemorrhage （r=0.185, P<0.05）, and to fire, one of the factors of Chinese medicine （r=0.215, P<0.05）. It was correlated significantly to disturbance of consciousness （r=0.256, P<0.001）, to occurrence of complications （r=0.251, P<0.001）, to death （r=0.312, P<0.001）. It was correlated to wind（r=0.139）,and negative correlated to stagnation （r=-0.174）.It was not correlated to age, degree of paralysis, previous history of CHD and other factors of Chinese medicine （phlegm and deficiency）, cerebral infarction and change of ECG. Conclusion The patients with ACD, especially cerebral hemorrhage complicated disturbance of consciousness have an increase tends in change of ME and poor prognosis.关键词：cerebral hemorrhage;cerebral infarction;myocardia enzymogram
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发布时间：2021-08-03 - 摘要：Objective To investigate the therapeutic effect of Xiaofengzhiyang Granules on chronic urticaria . Method To divide randomly 160 cases of chronic urticaria into the treatment group and control group and give Xiaofengzhiyang Granules and Loratadine respectively. Result The total symptom integrals, levels of serum IgE decreased obviously （P<0.01） in two groups. The improvement of the total symptom integral, significant effective rate, total effective rate, security index and recurrent situation in the treatment group were all better than the control group （P<0.01 or P<0.05）. Conclusion Xiaofengzhiyang Granules has a good curative effect on chronic urticaria without remarkable side effects.关键词：Xiaofengzhiyang Granules;chronic urticaria;observation of curative effect
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发布时间：2021-08-03
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