最新刊期
卷 0 ， 期 0 ， 2020
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- 摘要：The achievements in Chinese medical basic theory research were summarized in recent 50 years,the puzzle in clinic and pharmacy,which was brought by the mode of this research,was summed up from different aspects including biological characters,scientific methodology,intervention of multiple subjects and so on.The problems existed in the inheritance and innovation of Chinese medical theory were analysed from two major aspects of scientific thinking mode and practical demands.At the same time the methodology and implementation of Chinese medical theory research were brought forward（countering） the key problems in the development of the research and taking the satisfaction of clinical needs as the target,integrating closely Chinese medicine and Chinese herbal drug researches and（inheriting）,（developing） and innovating Chinese medical basic theory.关键词：Chinese medicine;basic theory;methodology;inheritance;innovation
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发布时间：2021-09-15 -
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- 摘要：Objective To compare the syndrome characteristics of two types of animal models with heart-qi insufficiency syndrome combined physical function disorder and syndromes of Chinese medicine under the non-ill condition. Methods The animal models were established by using two methods,the model of physical function disorder（PFD） was established by sleeping deprivation in rats on water stand,and the model of postinfarction heart failure（PHF） was established by ligation of the front descending coronary artery.The general state,heart rate,respiratory frequency,exhausted swimming time and hemodynamic index were observed.The two kinds of animal models were didgnosed by the clinical diagnostic standard of syndrome of heart-qi insufficiency.Results The rats of PFD model had stimulated spirit,（acute） antagonism,high heart rate and respiratory rate frequency,shortened exhausted swimming time and （hyperfunction） of heart.The rats of PHF model had listless spirit,less movement,high heart rate and（respiratory） rate frequency,shortened exhausted swimming time and hypofunction of heart.Conclusion The rat model of PFD established by functional factors has the characteristics of complicated syndrome（manifestations） and unstable changes.It differs from the model of PHF which has stable syndrome（manifestations） induced by local unself-healing organic disease.关键词：heart-qi insufficiency syndrome;sleeping deprivation;myocardial infarction;heart failure;animal model;rats
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发布时间：2021-09-15 - 摘要：Objective To observe the microecological regulative effect of Shenlinbaizhu Powder on enteric bacteria flora in the mouse model with spleen-insufficiency syndrome.Method The model was（established） by using Raix et Rhizoma Rhei with bitter-cold flavour and purgative effect.The contents of representative bacteria in stool were determined by selective culture media of anaerobe and aerobe.The statistical difference was analysed by approach paired t test.Results After the model establishment the contents of enteric bifidobacterium,lactobacillus bifidus and bacteroides were decreased significantly.（After） the administration of Shenlinbaizhu Powder the contents of above three anaerobes were recovered and content of bifidobacterium was much higher than before the model establishment（P<0.05）.The content of Escherichia coli was increased significantly after the model establishment and recovered after the administration of Shenlinbaizhu Powder（P<0.01）.The contents of enteric coccobacteria were not different（before） and after the model establishment but lower great significantly after the administration of（Shenlinbaizhu） Powder（P<0.01）.The change of staphylococcus content was not observed before and（after） the model establishment and administration of Shenlinbaizhu Powder.Conclusion The contents of enteric anaerobic flora are abnormally decreased and some aerobic flora are increased significantly in mouse with spleen-insufficiency syndrome.Shenlinbaizhu Powder has a regulative effect to help anaerobic flora and inhibit aerobic flora,especially to inhibit strongly the main resistant strain-coccobacteria,for flora regulation.关键词：spleen-insufficiency syndrome;Shenlinbaizhu Powder;microecology;anaerobic flora;(aerobic) flora;mice
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发布时间：2021-09-15 - 摘要：Objective To investigate the changes of plasma levels of prostaglandin I2（PGI2） and thromboxaneA2（TXA2） in rat model with renal hypertension and the depressor mechanism of Shouwujiangya Capsules.Method The rat model of renal hypertension was established by using 2K1C method and the plasma levels of 6-Keto-PGF1α and TXB2 were observed.Result After the（administration） of Shouwujiangya Capsules the blood pressures in group 1（with high dose of（Shouwujiangya） Capsules）,group 2（with low dose of Shouwujiangya Capsules） and group 3（with（captoril）） were lower significantly than that in the model group and the difference was significant（P<0.001,P<0.05,P<0.001）.The result showed that Shouwujiangya Capsules and captoril all had a good depressor effect.The plasma level of 6-Keto-PGF1α in he group 1 and group 2 was significantly（increased） respectively（P<0.01,P<0.05）,while the TXA2 level was decreased significantly（P<0.01,P<0.05） compared with those in the model group.Conclusion The hypertension in rat model is correlated to the decrease of plasma level of 6-Keto-PGF1α and increase of TXB2 level.Shouwujiangya Capsules can decrease effectively blood pressure and its depressor mechanism may be related to the（regulation） of plasma level of PGI2 and TXA2 level.关键词：Shouwujiangya Capsules;renal hypertension;6-Keto-PEF1α;TXA2;rats
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发布时间：2021-09-15 - 摘要：Objective To observe the effects of clearing away heat and resolving blood stasis of（Qingkailing） Injection on rabbits with endotoxin fever.Methods The rabbit model with heat-stasis（syndrome） was induced by colitoxin.The influence of Qingkailing Injection on the temperature of rabbit with fever was observed by digital thermograph.The content of tumor necrosis factor-α（TNFα） in serum was determined by radioimmunoassay.The activities of tissue plasminogen activator（t-PA） and tissue plasminogen activator inhibitor（PAI） were detected by the assay of chromogenic substrate and the（morphological） changes were observe in the lung,kidney and liver.Results In the Qingkailing Injection group the changes ofΔT \,TRI2（4.67±0.66）,serum TNFα content \ and the activity of plasma PAI \ were apparently lower than the changes ofΔT \,TRI2（8.44±0.98）,TNFα content \ and the activity of plasma PAI \ in the endotoxin group. The comprison between two groups showed a significant different（P<0.05～0.01）.The activity of t-PA \ in the Qingkailing Injection group was apparently higher than that \ in the（endotoxin） group.The comparison between two groups was significantly different（P<0.01）.The（outcome） of the light microscope showed that Qingkailing Injection relieved the morphological changes,such as dilation,engorgement and congestion of tissues and vessels in the lung,kidney and liver in（rabbits） with fever.Conclusion Qingkailing Injection exerts its effects of clearing away heat and resolving blood stasis through inhibiting the discharge of pyrogenetic cell factor and regulating the activities of plasmin and coagulant in rabbits with fever.关键词：endotoxin;clearing away heat and resolving blood stasis;Qingkailing Injection;rabbits
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发布时间：2021-09-15 - 摘要：Objective To observe the influence of Yuejubaohe Pills on gastroenteric movement and gastric secretion in experimental animals.Methods To establish the mouse model of the disorder of gastric（depletion） and small intestine advancement by using morphine and atropine,and the model of acceleration of gastric depletion and small intestine advancement by using neostigmine.The influence of Yuejubaohe Pills were observed on the gastroenteric movement in the normal model or the model with gastroenteric disorder,and on the gastric secretion,gastric acid secretion,peptic activity and gastric mucous weight in normal or water-immersion stress rats.Results ① Yuejubaohe Pills administrated orally had no（significant） influence on the gastric depletion and small intestine advancement in normal mice,but（improved） the gastroenteric movement in animal model of gastroenteric movement disorder,which（manifested） as relieving significantly the disorder of small intestine advancement induced by morphine and atropine,inhibiting gastric depletion,antagonizing significantly the acceleration of small intestine（advancement） induced by neostigmine,and had no significant influence on gastric depletion.② Yuejubaohe Pills administrated through duodenum decreased significantly gastric juice,total gastric acid secretion and mucous weight in normal rats and water-immersion stress rats.Conclusion Yuejubaohe Pills has the effects of regulating gastric secretion and gastroenteric movement.关键词：Yuejubaohe Pills;gastroenteric movement;Gastric secretion;mouse;rats
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发布时间：2021-09-15 - 摘要：Objective To study systemically the chemical components from the effective fraction of（Qingnaoxuanqiao） Formula.Methods The isolation were carried out by the chromatographic methods of macro-reticular resin,polyamide and silica gel.The structure was identified with spectroscopy method.Result There were 12 chemical components isolated from the effective fraction of Qingnaoxuanqiao（Formula） respectively,including ①20（S）-protopanaxatriol,②gensenoside-Rd,③notogensenoside-R4,④2α,3β,19α,23-tetrahydroxy olean-12en-28-oic acid,⑤6``-O-p-coumaroyl genipin-gentiobioside,（⑥Galioside）,⑦6α-Hydroxygeniposide,⑧quercetin,⑨3,3’,5,5’-tetramethoxy-4,4’-di-β-D-gluco（pyranosyl） lignan,⑩Crocetin,B11stigmastanol,and B12β-sitosterol.Conclusion All these 12 chemical components,as known compounds,are isolated for the first time from the effective fraction of（Qingnaoxuanqiao） Formula.关键词：Qingnaoxuanqiao Formula;chemical components;structure identification
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发布时间：2021-09-15 - 摘要：Objective To find an analytical method of fingerprint of Aconitum vilmorinianum Kom.by HPLC.Method In the HPLC procedure the chromatography column was Agilent Zorbax SB-C18（4.6 mm×250 mm,5 μm）,the mobile phase was solution of acetonitrile and triethylamine phosphate in（gradient） elution with a flow velocity of 1.0 mL/min,and the detection wavelength was 267 nm.Result The fingerprint in this HPLC procedure had a good repeatability.There were 15 common peaks in（Aconitum） vilmorinianum Kom.grown in different areas（RSD≤3%,n=15）.The relative areas peak of common peaks were different.Conclusion This procedure has a good outcome which is stable and（reliable）,and can be a reference for the standard of qualitative control of Aconitum vilmorinianum Kom.关键词：Aconitum vilmorinianum Kom.;HPLC;fingerprint
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发布时间：2021-09-15 - 摘要：Objective To optimize the preparation process for preparing lung-targeted sophoridine（microsphere）（SR-MS）.Methods The preparation process of SR-MS was optimized by using emulsive solidified method and systemic observation taking entrapment efficiency and particle diameter of（microsphere） as the observing indexes.Results The optimized process parameters were: The microsphere was prepared by emulsive solidified method,SR:BSA was 1:10,rotation speed was 1 500 r/min,（emulsive） temperature was below 40℃,emulsive time was 10 min,and solidified temperature was 110℃.SR-MS prepared in this preparation process was symmetrical and round,the average diameter was ranged from 20 to 30 μm and the entrapment efficiency was 80.06% averagely.Conclusion This process is stable and feasible and can be a reference for the preparation process of lung-targeted sophoridine（microsphere）.关键词：sophoridine;microsphere;lung-targeted
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发布时间：2021-09-15 - 摘要：Objective To investigate the alcohol extractive technique of hyperin from Hypericum（perforatum） Linn.Method With the content of hyperin as criteria,the orthogonal design was used to（optimize） the factors influencing the alcohol extractive technique.Result The best extractive condition was to extract hyperin with 10-fold of 90% alcohol for 2 times and for 1.5 hours each time.ConclusionThe best optimization outcome has a good repeatability after using in the test experiment.关键词：Hypericum perforatum Linn.;hyperin;HPLC;orthogonal design
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发布时间：2021-09-15 - 摘要：Objective To investigate the influence and protective mechanism of routine moxibustion on the acupoint of Guanyuan（CV4） on uterus structure,hormones and receptor in natural climacterium rats.Methods To divide randomly 128 SD female rats into 8 groups.The changes of histomorphology,（hormones） and receptor in uterus were observed by using immunohistochemistry,radioimmunoassay and HE staining in 12th,14th and 16th month after routine moxibustion was given to rats aged ten months.（Results） There was obvious catagenesis in rat uterus sructure in all model control groups and the contents of estradiol（E2）,progestagen（P） in uterus were decreased at the same time.After the routine（moxibustion） on CV4 in rats aged 10 months the catagenesis of uterus in different groups relieved compared with that of the control group.Routine moxibustion improved the expressions of E2 and receptor in uterus.The increase of E2 content was mainly observed in 14th and 16th month groups（all P<0.05）.The（increase） of ER-α expression was mainly observed in 12th and 14th month group（P<0.01,P<0.05）.Routine moxibustion had regulated P content in uterus, which was mainly observed in 16th month group（P<0.05）.Conclusion Routine moxibustion on CV4 can prevent climacterium rat from retrograde changes of uterus.The effect may be related to that routine moxibustion can regulate the contents of E2,P and ER-α expression in uterus.关键词：routine moxibustion;Guanyuan（CV4）;uterus histomorphology;hormones;receptor;rat climacterium
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发布时间：2021-09-15 - 摘要：Objective To investigate the catgut-embedding therapy on the contents of γ-aminobutyric acid（GABA） and glutaminc acid（Glu） in hippocampus and cerebral cortex in rats with experimental（epilepsy）.Method To divide randomly 50 rats into the normal group（group 1）,model group（group 2）,catgut-embedding therapy group（group 3）,acupuncture group（group 4） and valproate sodium group（group 5）,after 3 days pretreatment,and then the introperitoneal injection of benzylpenicillin（sodium） was given to different groups（besides group 1） to establish the model.After 90 minutes the rats were killed and the（hippocampus） and cerebral temporal cortex were taken from one hemisphere of brain.The contents and ratio of GABA and Glu were determined and calculated by HPLC.Result In group 2 the contents and ratio of GABA and Glu were all higher than those in group 1（P<0.05,P<0.01）,the content of GABA and ratio of GABA and Glu in group 3 were all higher than those in group 2（P<0.01）,but the content of Glu in group 3 was obviously lower than that in group 2（P<0.01）.The（influence） of the catgut-embedding therapy in group 3 was stronger than that in group 5 and group 4.The therapy had more significant effect on hippocampus than on cerebral temporal cortex.Conclusion The catgut-embedding therapy has the antagonism on epilepsy through regulating brain excitability and（inhibiting） amino acids level.关键词：catgut-embedding therapy;epilepsy;γ-aminobutyric acid;glutaminc acid
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发布时间：2021-09-15 - 摘要：Objective To observe the regulative effect of Minkang Tablets on juvenile atopy.Mehtod The patients with pollinosis,asthma or atopic dermatitis were selected and treated with Minkang（Tablets） for 6 months and the relief of clinical symptoms were observed.IgE and relative genes were（detected） in laboratory.Result The symptoms,IgE and gene expressions all changed after the（treatment）.Conclusion Chinese herbal drugs can alleviate the symptoms of juvenile atopy and regulate the high sensitized state.关键词：atopy;Minkang Tablets;pollinosis;asthma;atopic dermatitis;IgE;gene
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发布时间：2021-09-15 - 摘要：Objective To validate the repeatability of discriminant function formula（DFF） of cerebral ateriosclerosis（CAS） metrodiagnosis.Method The double-blind prospective test was proceeded in Neurological Department of Dongzhimen Hospital of Beijing University of Chinese Medicine,and then the prospective test result and outcomes of metrodiagnosis DFF were compared and evaluated.Result DFF had a better repeatability.The sensitivity,specificity,misdiagnosis rate and missed diagnosis rate in DFF were similar to those in retrospective test.Conclusion Discriminant function formula is well worth spreading.关键词：cerebral ateriosclerosis;metrodiagnosis;prospective study
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发布时间：2021-09-15 -
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