最新刊期
      卷 0 ， 期 0 ， 2020
      • WANG Yun~1,ZHANG Zhi-bin~2,MA Jian~2
        Vol. 0, Issue 5, Pages: 293-295(2007)
        摘要：The extraction and combination of syndrome factors is a recently proposed solution to the problem of syndrome standardization. The extracting method of syndrome factor from the established achievement in the standardization of syndrome is discussed in the present paper based on the 4 syndrome standards with authority. The importance of the representation of syndrome factors in clinical practice is emphasized and the primary scale of syndrome factors is determined through the analysis on 1653 records of syndrome. The results in this paper indicate the feasibility to standard the syndrome through the extraction of syndrome factors, which provide the basis for the further research on this subject.  
        关键词：syndrome factor;syndrome standardization;clinical diagnosis   
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      • Vol. 0, Issue 5, Pages: 296-297(2007)
        摘要：<正>随着SARS、禽流感的陆续来临,社会对流行病普通关注起来。中医在防治疫病方面有着丰富的理论和经验,但就目前来看,中医界在理论准备上还有欠缺,将各种疫病一概视为温疫乃普遍现象。本文拟依据经典文献和个人体验,就寒疫问题谈一些看法。  
        关键词：寒疫;伤寒;流感   
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      • Vol. 0, Issue 5, Pages: 298-300(2007)
        摘要：<正>“脉要精微论篇第十七”是唐代中期王冰整理、编次后《素问》第十七篇的题目,位于“卷第五”之首。1“精微”释义王冰感到当时流传的《素问》版本存在着很多的问题,他的“素问序”说:“世本纰缪,篇目重叠,前后不伦,文义悬隔,施行不易,披会亦难。岁月既淹,  
        关键词：素问;校释;脉要精微论;解精微论   
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      • Vol. 0, Issue 5, Pages: 300-307(2007)
        摘要：<正>《北京中医药大学学报》荣获“中国高校精品科技期刊”称号2006年11月14日教育部科学技术司发布《关于公布“首届中国高校精品·优秀·特色科技期刊”及“2006年高校科技期刊优秀编辑工作者、优秀编辑学论著”的通知》（科技司[2006]290号）。通知公布中国  
          
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      • Vol. 0, Issue 5, Pages: 301-304(2007)
        摘要：<正>长久以来,术语的歧义一直困扰着中医基础理论研究。要解决这个问题,现代语言学的语义分析方法可能会有帮助。本文拟以“疏泄”这个术语为例,考查其在古今中医文献中的用法、意义及其演变过程,通过源流的梳理和语义的分析,做一番澄清概念的尝试。  
        关键词：疏泄;肝脏;源流   
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      • Vol. 0, Issue 5, Pages: 305-307(2007)
        摘要：<正>明末清初,随着西方传教士来华,西方医学知识得以在中国传播,并在当时的中医学界形成了一定的影响。这一时期,中医界开始注意到了西方医学与传统中医学之间的极大差异性,并给予了一定的重视,如方以智、王宏翰等人,都曾给予专门论述。  
        关键词：明末清初;西洋医学;中医学   
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      • Vol. 0, Issue 5, Pages: 308-309(2007)
        摘要：<正>叶桂《临证指南医案》卷五中有风、寒、风温、温热、暑、湿、燥诸门医案178则,记述之医案病因病机与六淫邪气伤人有关,其中不少医案中所记述的临证表现见有外感表证,所处治疗方药亦在祛散表邪于外,但从中可以体会叶氏于治疗外感表证时,时时关注升降开合理论的应用,用药简洁严谨,值得玩  
        关键词：升降理论;文献研究;临证指南医案;外感表证   
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        发布时间：2021-09-15
      • LIU Xue-mei~1,HUANG Qi-fu~1,ZHANG Yun-ling~2,et al.
        Vol. 0, Issue 5, Pages: 310-313(2007)
        摘要：Objective To study the protective effect and the anti-oxidation mechanism of Xinnaoshutong Capsules on neurons in rats with focal cerebral ischemia and reperfusion. Methods Rat model of focal cerebral ischemia and reperfusion was established by thread ligation in middle cerebral artery. After 24 hours, the morphological changes of rat cerebral cortical neurons （HE staining） were observed under optical microscope, apoptosis of cortical neurons was detected by TUNEL, the content of MDA、SOD、LD and LDH in ischemic cerebral brain were detected by spectrophotometry. Results Compared with the control group, there were obvious neurological deficits in the ischemia and reperfusion model groups. The significant ischemic morphologic changes in cerebral cortex were observed, such as neuronal edema and amount of apoptosis neurons. The content of MDA was much higher, whereas that of SOD was much lower in ischemia cerebra （P＜0.01）. The neurological deficits of middle cerebral artery occlusion （MCAO） rats could be improved and the neuronal edema and neuronal apoptosis of cortex could be lessened in the Xinnaoshutong Capsules group. Compared with the control group, MDA、LD and LDH were decreaced, and SOD was increased significantly in the Xinnaoshutong Capsules group （P＜0.05～0.01）. Conclusion Xinnaoshutong Capsules have the effect of lightening the injury degree of brain tissues and decreasing neuronal apoptosis after cerebral ischemia and reperfusion. The mechanism might be related to regulating oxidative stress response and elevating the free radical scavenging capability to alleviate cerebral injury.  
        关键词：ischemia;reperfusion;cortex;free radicals;apoptosis;Xinnaoshutong Capsules;rats   
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        发布时间：2021-09-15
      • YAO Jun-ying~1,HAN En-ji~
        Vol. 0, Issue 5, Pages: 314-316(2007)
        摘要：Objective To investigate the effects of Caulis Piperis Kadsruae on amyloid precursor protein （APP） gene expression in human neuroblastoma cell line SK-N-SH. Methods Cell viability was tested by MTT assay, the expressions of APP mRNA and protein isoforms were quantified by RT-PCR and Western blot analysis, respectively. Results Caulis Piperis Kadsruae caused a significant decrease in the total APP mRNA band in a dose dependent manner, and the expressions of the intraceUular immature and mature APP in SK-N-SH cells were inhibited by Caulis Piperis Kadsruae. In the experimental condition, Caulis Piperis gadsruae （0-50g/L） did not reduce the survival rate of SK-N-SH cells. Conclusion Caulis Piperis Kadsruae can selectively inhibit the expression of APP in SK-N-SH cells.  
        关键词：β-amyloid precursor protein;Caulis Piperis Kadsruae;gene expression   
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        发布时间：2021-09-15
      • PEI Ling-peng~1,HUI Bo-di~2,WANG Dong-hui~3,et al.
        Vol. 0, Issue 5, Pages: 317-322(2007)
        摘要：Objective To study the influence of trans-resveratrol on D-galactose induced osseous changes of rats. Methods Wistar rats were given injections of D-galactose for 5 months to cause aging. Osseous routine parameters were tested and compared in young group, model group, medication groups （high-does, middle-does, low-does） and normal old group. Results Compared with young group, the bone mineral density （BMD）, structural mechanics parameters of bone, biomechanics parameters of bone, bone calcium, manganese, magnesium and the content of hydroxyproline in the model group were significantly decreased （P＜0.01）. However, bone phosphorus wassignificantly raised（P＜0.01）. Those changes of the model group were the same as those of the old group, but the changes of the different medication group significantly differed with the model group. Conclusion The high does of D-galactose can cause aging and osteoporosis at the same time, and trans-resveratrol can delay D-galactose induced osseous changes.  
        关键词：osteoporosis;the bone mineral density （BMD）;hydroxyproline;trans-resveratrol;rats   
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      • ZHANG Qiu-ju,ZHANG Jian-jun,JIA De-xian,et al.
        Vol. 0, Issue 5, Pages: 323-325(2007)
        摘要：Objective To observe the effect of Semen Astragali Complanati extracts on lipid metabolism in rats with hyperfipermia, including blood fat and fat content in liver. Methods The changes of triglyeride （TG）, total cholesterol（TC）, low-density lipoprotein-c （LDL-c） and high density lipoprotein-c （HDL-c） in serum of Waster rats with hyperlipermia were observed by enzymatic method. The fat content in the liver was detected by soxhlet extraction. Results TC, TG and fat content in the liver of hyperfipormia model rats were significantly decreased after water extract, oil extract, 50% alcohol extract and 95% alcohol extract of Semen Astragali Complanati treating for 15 days （90g/kg）. HDL-c could be increased in the low dose of water extract group （20g/kg） and the middle dose of oil extract group （45g/kg）, and these effects were more significant than those in the gypenosides positive control group. There was significant difference between the treating group with the model group （P＜0.001）. Conclusion Extracts of Semen Astragali Complanati have the effect of decreasing TG, TC, LDL-c and fat content in the fiver and increasing HDL-c of hyperfipermia model rats.  
        关键词：Semen Astragali Complanati;hyperlipermia;adiposis hepatica;rats   
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      • CHENG Ying-wu,ZHAN Hong-sheng,LIN Xun,et al.
        Vol. 0, Issue 5, Pages: 326-328(2007)
        摘要：Objective To investigate the mechanism of treating acute soft tissue injury with GAOMO （TUINA combine together with topica）. Methods The effect of GAOMO on local histological changes in rats with acute soft tissue injury was observed. Results Circular-rubbing with holly ointment, rubbing with holly ointment, circular-rubbing with MOGAO, and rubbing with MOGAO could all relieve the swelling, degeneration and necrosis of local muscle fiber as well as inflammatory cell infiltration resulting from acute soft tissue injury, and promote regeneration of the injured muscle fiber, but rubbing with MOGAO got the most significant effect （when compared with the model group, P＜0.05）. Conclusion Rubbing with MOGAO can promote reparation of acute soft tissue injury.  
        关键词：GAOMO;rubbing;circular-rubbing;acute soft tissue injury   
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      • LU Yong-gang~1,ZHANG Tie-zhong~1,CHENG Wen-li~2,et al.
        Vol. 0, Issue 5, Pages: 329-332(2007)
        摘要：Objective To investigate the effect of Tongmaiyizhi Capsules and simvastatin on advanced unstable atherosclerotic lesions within the innominate artery of ApoeE-gene knockout mice. Methods After fed with high fat diet for 22 weeks, 8 week-old ApoeE-gene knockout mice were randomly divided into three groups, model group, Tongmaiyizhi group and simvastatin group, which were administered with Tongmaiyizhi Capsules （720mg/kg/d）, simvastatin （2.8 mg/kg/d） and SodiumChloride for 8 weeks respectively. Six normal C57BL/6 mice were set as the control group and were also administered with SodiumChloride for 8 weeks. Immunohistochemistry, Movat Pentachrome and Sirius Red-staining methods were used to evaluate the histomorphological changes of the plaque. Results Compared with the model group, the average area of AS lesion decreased and the content of collagen were significantly increased （P＜0.01, P＜0.05） in the Tongmaiyizhi Capsules group;the thickness, integrity of the fibrous cap were enhanced in the simvastatin group （P＜0.05, P＜0.05）. Conclusions Tongmaiyizhi Capsules can stabilize the vulnerable atherosclerotic plaque through decreasing AS area and increasing collagen tissue; simvastatin can stabilize the AS plaque through stabilizing the fibrous cap on plaque surface.  
        关键词：vulnerable plaque;stability of the atherosclerotic plaque;Tongmaiyizhi Capsules;gene simastafin;ApolipoproteinE-gene knockout mice   
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      • Vol. 0, Issue 5, Pages: 333-336(2007)
        摘要：Objective To study the effect of Duzhonghongjingtian Capsules （Cortex Eucommiae, Radix Rhodiolae, Radix Cyathulae, Cortex Cinnamoml, etc.） （DHC） on experimental thrombosis, thrombolysis and blood circulation promoting to provide pharmacological basis for treating ischemic cerebral apoplexy. Methods Rat’s thromboses were induced by the arteriovenous shunt and the electrical stimulation of common carotid artery respectively, then the effect of DHC on thrombus and thrombosis was studied. Turbidimetry was used to observe the effect of DHC on platelet aggregation and blood coagulation factor of normal rats induced by ADP and collagen. Effect of DHC on clotting time of aged mice was observed. Results DHC could notably lighten the wet-weight and dry-weight of thrombosis in the arteriovenous shunt model in rats; Serum with DHC showed the significant effect of thrombolysis in vivo. It could inhibit the platelet aggregation of normal rats induced by ADP and collagen. DHC could prolong thrombin time, prothrombin time, and thromboplastin time. The coagulation time of aged mice could also be prolonged. Conclusions DHC can significantly inhibit the thrombosis and has the satisfactory effect on thrombolysis, which is associated with its inhibiting the platelet aggregation and prolonging the coagulationtime.  
        关键词：Duzhonghongjingtian Capsules;thrombosis;thrombolysis;platelet aggregation;anticoagulated blood;rats;mice   
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      • LU Li,BAI Li-min,SUN Hong-mei,et al.
        Vol. 0, Issue 5, Pages: 337-339(2007)
        摘要：Objective To investigate the effect of the serum collected from rats with electroacupuncture stimulation on the proliferation and the expression of brain-derived neurotrophic factor （BDNF） of astrocytes. Methods Baihui （GV20）, fengfu （GV16） were stimulated with 100Hz high frequency electroacupuncture in rats. Serum was collected two weeks later from the stimulated rats and added into the culture medium of astrocytes. Cell viability was detected by MTT assay and the expression level of BDNF was tested by immunohistochemistry. Results The serum derived from the rats stimulated by electroacupuncture could promote the activity of astrocytes, but it was not in an obvious dose-dependent manner. The optimal concentration of the serum was 10%. The cell viability of astrocytes increased in a time-dependent manner with the peaking OD value of 0.372 48hours after the cells were cultured in the medium containing the 10% serum. BDNF expression in astrocytes increased significantly 5 days after astrocytes were treated by the 10% serum. Conclusion The serum from electroacupuncture stimulated rats could promote the activity of cultured astrocytes and enhance the astrocytes proliferation. The activated astrocytes pretect neuron by BDNF secretion.  
        关键词：electroacupuncture;astrocyte;brain-derived neurotrophic factor   
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        发布时间：2021-09-15
      • DONG Yu,SHI Ren-bing,LIU Bin
        Vol. 0, Issue 5, Pages: 340-342(2007)
        摘要：Objective To establish the assay method for quantitative determination ofα,β-asarone in effective fraction of A. tatarinowii Schott. Method The chromatographic column was kromasil ODS C18（250 mm×4.6mm, 5μm）,the mobile phase was methanol: water（56:44） with a flow velocity of 1.0 mL/min,and the detection wavelength was 257 nm in the reverse phased-high performance liquid chromatography （RP-HPLC） procedure. Result The average recoveries ofβ-asarone andα-asarone was 98.57% （RSD=0.35%） and 99.75% （RSD=1.30%）, respectively. Conclusion The procedure,which is easy and accurate,can be used as a quality control method for the effective fraction of A. tatarinowii Schott.  
        关键词：effective fraction of A. tatarinowii Schott.;β-asarone;α-asarone;high performance liquid chromatography;quantitative determination   
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        发布时间：2021-09-15
      • ZHANG Lan-zhen,QIN Wen,ZHANG Xiao-hua,et al.
        Vol. 0, Issue 5, Pages: 343-345(2007)
        摘要：Objective To establish the method for the determination of the contents of two components, caffeic acid and rosmarinic acid in the different parts of Prunella vulgaris L. by HPLC. Methods The determination was carried out with Agilent Zorbax C18 column（4.6 mm×250 mm, 5μm）, gradient MeOH-0.1% acetic acid solution was taken as the mobile phase at a flow rate of 1 mL/min, and the detection wavelength was 330 nm. Results The average recoveries of caffeic acid and rosmarinic acid were 101.0% and 100.5% respectively （RSDs were 2.30% and 1.79% respectively, n=6）. Conclusion The determination of the contents of caffeic acid and rosmarinic acid showed that the method was easy and accurate, and could be used to determine the contents of two components in the different parts of Prunella vulgaris L.  
        关键词：Prunella vulgaris L;caffeic acid;rosmarinic acid;quantitative determination   
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        发布时间：2021-09-15
      • WANG Zhan,HAN Li-wei,REN Tian-chi
        Vol. 0, Issue 5, Pages: 346-349(2007)
        摘要：Objective To prepare solid dispersions of puerarin with polyethylene glycol 6000 （PEG6000） to improve its dissolution and solubility. Methods The solid dispersions of puerarin were prepared by the fusion method with PEG6000 as the carrier. Evaluation of the properties of the dispersions was performed using dissolution studies, ultraviolet spectroscopy （UV）, infrared spectroscopy （IR） and differential scanning calorimetery （DSC）. Results The rate of dissolution and the solubility of puerarin in the solid dispersions prepared by the optimized preparing process were incresced 3 times and 17 times respectively as compared with crude puerarin. The data of UV, IR and DSC showed the absence of well-defined drugpolymer interactions. Conclusion The dissolution and solubility of puerarin could be improved significantly in solid dispersions with PEG6000.  
        关键词：puerarin;polyethylene glycol 6000;solid dispersions;dissolution rate;solubility   
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      • LI Gui,WANG Xiao-jun,LI Xue-zeng,et al.
        Vol. 0, Issue 5, Pages: 350-353(2007)
        摘要：Objective To study the effect of Wubi Capsules on immune function in patients with systemic scleroderma（SSc） and its mechanism of action. Methods 93 SSc patients were randomly divided into treatment group （33 cases） and control group （32 cases）. The patient’s T lymphocyte subpopulation （CD3+, CD4+, CD8+, CD4+/CD8+）, immunoglobulin （IgG, IgA, IgM）, complement （C3, C4）, plasma endothelin （ET）, and transforming growth factor-β（TGF-β） were prospectively and contrastively analyzed and compared with those of the 15 cases of healthy person. Results Patients with SSc showed disorder of T lymphocyte subsets. Compared with the healthy persons, immunoglobulins （IgG, IgA, IgM）, ET and TGF-βwere increased and complement level was decreased significantly （P＜0.05, P＜0.01）. There were significant improvements in above aspects in both groups after treatment（P＜0.05, P＜0.01）. Compared with the control group, the treatment group showed better effects, and there was significant difference between the two groups （P＜0.05, P＜0.01）. Conclusion Patients with SSc show abnormal immunoregulation, high autoantibody and immunocomplex accumulating. Wubi Capsules can correct the state of abnormal immunoregulation in patients with SSc, increase the function of immune homeostasis, eliminate antigen, suppress antibody production, lessen the formation of immune complex, and decrease the content of ET and TGF-β. Wubi Capsules can influence prognosis of patients with SSc, which is related with suppressing Th’function and improving above mentioned indexes.  
        关键词：systemic scleroderma;Immunologic function;Wubi Capsules   
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      • Vol. 0, Issue 5, Pages: 354-356(2007)
        摘要：<正>阿尔茨海默病（Alzheimer’s disease,AD）是一种以进行性智能衰退为特征的中枢神经系统退行性疾病,其确切的发病机制人们尚不清楚。长期以来,科学家一直认为AD的病因是Alois Alzheimer在1907年鉴定的一种蛋白质团块或缠结,并于1985年首次从AD老年斑中分离出β淀粉样蛋白(Beta  
        关键词：ADDLs;阿尔茨海默病;突触   
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      • Vol. 0, Issue 5, Pages: 357-358(2007)
        摘要：<正>急性软组织损伤,在中医学上属于“伤筋”等范畴,临床上主要表现为肿、痛、瘀等,故而患者运动受限,甚至关节功能障碍。西医学认为肿胀是由于毛细血管破裂、出血或血管壁通透性增加,血管内液外渗到组织间隙所致;而疼痛则是由于创伤性血肿或炎性反应物质刺激局部末梢神经引起。因此采用  
        关键词：急性软组织损伤;活血消肿;外敷   
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      • Vol. 0, Issue 5, Pages: 359-360(2007)
        摘要：<正>百草茶是由多种药草混合煮成的一种饮品。百草茶在台湾民间流传年代已久,但大多数口耳相传,大量百草茶治疗温热病证的资料,都散在中医诊所、草药店、家庭中,文字记载有效案例不多见。从现代文献资料来看,百草茶可用于防治的温热病证包括流行性感冒、上呼吸道感染、肺炎(包括细菌性肺  
        关键词：百草茶;温热病证;民间验方   
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