最新刊期
卷 0 ， 期 0 ， 2020
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- 摘要：Recently the developed countries begin to stride forward towards to the “conceptual age” from the “information age”（based on microelectronics,information technology and internet,etc.）and get into a completely new thinking.In addition,the advanced technologies,such as pattern recognition technology,human centred synthetic integration technology,which are highly related to noetic science and the science of complexity,can be applied in TCM syndrome differentiation and treatment.It brings new opportunities for the creative development of Chinese medicine,which takes the image thinking and holism concept as its ideological core.关键词：completely new thinking;conceptual age;creative development of Chinese medicine;image thinking
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发布时间：2021-09-15 -
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- 摘要：Objective To investigate the different mechanisms of warm-purgation therapy and warm-astringing therapy in immunologic injury of ulcerative colitis.Methods Before and after the treatment the serum contents of interleukin-8（IL-8）and tumor necrotic factor-α（TNF-α）were detected by ABC-ELISA method in the warm-purgation group,warm-astringing group and control group,the expressions of IL-8 and TNF-α in colonic tissue were examined by two-step immunohistochemistry method in three groups and the changes of IL-8 and TNF-α in serum and colonic tissue were compared in three groups.Results Both warm-purgation therapy and warm-astringing therapy could induce the TNF-α level in serum and colonic tissue.The warm-purgation therapy had a better effect to decrease IL-8 level in serum and colonic tissue than warm-astringing therapy.Conclusion The effective mechanism of warm-purgation therapy may be related to that it can inhibit the expressions of IL-8 and TNF-α,prevent inflammatory cells（mostly neutrophil）from aggregation and relieve acute inflammatory reaction.The effective mechanism of warm-astringing therapy may be related to that it can prevent lymphocyte from producing TNF-α to relieve chronic inflammatory injury.关键词：ulcerative colitis;interleukin-8;tumor necrotic factor-α;warm-purgation therapy;warm-astring therapy
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发布时间：2021-09-15 - 摘要：Objective To observe the influence of salvianolic acid B and tanshinone ⅡA on the expressions of nuclear factor kappa B（NF-κB）and intercellular adhesion molecule-1（ICAM-1）in cultured vascular smooth muscle cells（VSMC）induced by tumor necrosis factor-α（TNF-α）,and to investigate the molecular mechanism of salvia miltiorrhiza monomer against atherosclerosis（AS）.Methods The rat VSMC were cultured in vitro,the mRNA and protein expression of ICAM-1 were observed by RT-PCR and immunocytochemistry technique respectively.The NF-κB expression was detected by both of immunocytochemistry technique and cell ELISA.Results The mRNA and protein expression of ICAM-1 were up-regulated and NF-κB expression was also significantly increased by TNF-α（P<0.01）.Two kinds of salvia miltiorrhiza monomer markedly inhibited the expressions of NF-κB and ICAM-1.Salvianolic acid B had a better effect than tanshinone ⅡA.Conclusion One of the molecular mechanisms of salvia miltiorrhiza monomer against AS is that it can inhibit the expressions of inflammation-related factors in VSMC.Salvianolic Acid B has a better effect in anti-inflammation than tanshinone ⅡA.关键词：tumor necrosis factor-α;intercellular adhesion molecule-1;nuclear factor kappa B;salvianolic acid B;tanshinone ⅡA
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发布时间：2021-09-15 - 摘要：The pulse and tongue examinations are important methods in the diagnosis of Chinese medicine.The modern theory and means of information science are used to collect and analyze the information from pulse and tongue examinations by integrated multi-physical parameter sensor.Through the fusion disposal on the digitalized information from four TCM diagnostic methods,the research strategy of integrated technique of diagnostic information is proposed based on the information extraction and discrimination of TCM pulse and tongue examinations.关键词：information of pulse examination;information of tongue examination;integration of equipments;research strategy
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发布时间：2021-09-15 - 摘要：Objective To study the formative mechanism of pulse position property immediately,directly and quantitatively by using the modern image technology.Methods The mature and non-injury method was applied to establish the model of floating pulse and deep pulse in healthy young people aged from 20 to 30 years old.The indexes related to radial artery（cun kou）vasomotion,hemodynamics and hemodynamics of the whole circulation system were determined by NX-8 video-pulse information collective analyzer,Magnetom Avanto 1.5T superconducting magnetic resonance imaging system and SONOS-1000 color Doppler blood flow imager.Results In the floating-pulse condition the radial artery was dilated obviously,the diameter and area of radial artery cross-section were enlarged,the axial displacement was increased,the vessel tissue was changed to thinner.The maximum-portal flow velocity（Vmax）and mean-portal flow velocity（Vmean）of radial artery were decreased,heart rate was increased,and mean arterial pressure and vessel pressure were reduced.In the deep-pulse condition the diameter and area of radial artery cross-section were decreased,the axial displacement was reduced,the vessel tissue was changed to thicker,Vmax,Vmean,peak systolic velocity and peak diastolic velocity of radial artery were all reduced obviously,resistance index（R1）was increased obviously,mean arterial pressure and total peripheral resistance were risen,and the vessel pressure,stroke volume（SV）and heart index were decreased.Conclusion The formation of pulse position is related to some factors,such as cardiac output,vessel tension,peripheral resistance,blood filling of vessel system,diameter and area of radial artery cross-section of radial artery,axial displacement and vessel tissue thickness.关键词：pulse position;imaging technology;physiological basis of cardiovascular system
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发布时间：2021-09-15 - 摘要：Objective To study the influence of the rabbit serum after oral feeding Fuzhengjiedu Decoction on the proliferation of nickel-transformed cells（Nt16HBE）by cell culture.Methods Nt16HBE cells were treated with Fuzhengjiedu Decoction serum for 7 days.The influence of Fuzhengjiedu Decoction serum on the proliferation and activities of nuclear transcription factor κB（NF-κB）and telomerase of Nt16HBE were detected respectively by MTT method,flow cytometer and TRAP-PCR-ELISA.Results Different doses of Fuzhengjiedu Decoction serum（10% for concentration）inhibited the proliferation of Nt16HBE,activities of NF-κB and telomerase significantly in a dose-effect or time-effect manner（P<0.05,P<0.01）.Conclusion Fuzhengjiedu Decoction serum can inhibit significantly the proliferation of Nt16HBE.The mechanism is related to its effect of down-regulating the expressions of NF-κB and telomerase,which shows that Fuzhengjiedu Decoction has an antagonism to nickel carcinogenicity in vitro.关键词：Fuzhengjiedu Decoction;medicinal serum;nickel;cell proliferation;nuclear transcription factor κB;telomerase
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发布时间：2021-09-15 - 摘要：Objective To investigate the influence of Huoxuehuayu Formula on the mRNA expressions of transform growth factor-β1（TGF-β1）and TGF-β3 of new granulation tissue in different periods（3 days to 11 days）in diabetic rat model,and to provide a scientific base for TCM theory of “removing stasis being good for promoting regeneration”.Methods The diabetic ulcer model and general wound model were established respectively in 36 SD rats,which then were randomly divided into the Huoxuehuayu Formula group,diabetic wound control group treated with normal saline solution（NSS）and normal wound control group treated with NSS.The samples were taken respectively 3 days or 11 days after the wound healing.The changes of mRNA expressions of TGF-β1 and TGF-β3 in new granulation tissue were detected by real-time PCR method.Results After 3 or 11 days in the Huoxuehuayu Formula group the copies of mRNA of TGF β1 and TGF-β3 were higher than those in the diabetic wound control group（P<0.05）but lower than those in the normal wound control group（P<0.05）.Conclusion Huoxuehuayu Formula can up-regulate obviously the expressions of mRNA of TGF-β1 and TGF-β3 mRNA of new granulation tissue in diabetic rat model,it is beneficial to wound healing and verification of the theory of “removing stasis being good for promoting regeneration”.关键词：activating blood and removing stasis;diabetes;transform growth factor;rats
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发布时间：2021-09-15 - 摘要：Objective To observe the influence of Weikang Capsule on the morphological changes of gastric mucosa in rats with precancerous lesions of chronic atrophic gastritis.Method The rats were randomly devided into six groups:the normal control group,model group,spontaneous recovery group,high-dose Weikang Capsule group,low-dose Weikang Capsule group and Weimeisu group.Result In the model group the result of the light microscope showed that!the gastric mucosa was atrophied and thinner,the glands was getting less,the enteral epithelial metaplasia and various dysplasia were occurred.After the administration of Weikang Capsule the inflammation of gastric mucosa,enteral epithelial metaplasia and dysplasia were all relieved or disappeared.Conclusion Weikang Capsule may have a better interrupted and reversal effect on the precancerous lesions of atrophic gastritis,such as gastric mucosa atrophy,enteral epithelial metaplasia and dysplasia.关键词：Weikang Capsule;gastric mucosa;precancerous lesions;pathomorphology;rats
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发布时间：2021-09-15 - 摘要：Objective To study the preventive and therapeutic effects of Huaxian Decoction（with the effects of replenishing qi and activating blood）on mice with lung fibrosis induced by bleomycin（BLM）,and the influences on the levels of interferon-γ（IFN-γ）and interleukin-4（IL-4）in bronchi alveolar lavage fluid（BALD）,and then to investigate the mechanism of qi-replenishing and blood-activating therapy in the treatment of lung fibrosis.Methods The male ICR mice of 6-8 weeks old were divided into 6 groups:the model group（group1）was given BLM（5 mg/kg by nasal drip）to establish the model of lung fibrosis,the prevention and treatment group with Huaxian Decoction（group2）was given Huaxian Decoction orally 48 hours before the administration of BLM,the treatment group with Huaxian Decoction（group3）was given Huaxian Decoction orally on 14th day after the administration of BLM,the prednisone prevention group（group4）and prednisone treatment group（group5）,and all above groups were compared with the control group（group6）.On the 28th day BALF and lung tissue of the right lung were treated by HE and Masson stain and the cell ultrastructure changes were observed by the electron microscope.The content of hydroxyproline（HYP）was detected in the left lung by acidic hydrolysis and the concentrations of IFN-γ and IL-4 in BALF were examined by enzyme-linked immunosorbent assay（ELISA）.Results The comparison between group1 and other drug-treated groups showed that mouse lung coefficient decreased obviously（P<0.05）,alveolitis and lung fibrosis were relieved（P<0.05）,which was the most obvious in group2.The HYP content in the lung tissue was decreased（P<0.05）.The content of IFN-γ in BALF in group1 was decreased obviously,which would be much higher after the administration of Huaxian Decoction（P<0.05）.Prednisone had no effect on the content of IFN-γ in BALF.In group1 IL-4 content in BALF was increased obviously but decreased in all drug-treated groups（P<0.05）.There was no difference among all drug-treated groups.Conclusion The qi-replenishing and blood-activating therapy can obviously inhibit the development of mouse lung fibrosis,decrease IL-4 content,increase IFN-γ content and regulate the balance between IL-4 and IFN-γ to antagonize fibrosis.关键词：qi-replenishing and blood-activating therapy;lung fibrosis;interferon-γ;interleukin-4;mice
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发布时间：2021-09-15 - 摘要：Objective To investigate the therapeutic mechanism of Qianlietongyu Decoction in rats with chronic nonbacterial prostatitis induced by prostatic protein.Methods The rat model of chronic nonbacterial prostatitis was established by intraperitoneal injection of DPT vaccine,multiple intradermal injections of the suspension of prostatic protein purification with Freund’s completed adjuvant.Then the rats were divided into the normal group,model group,celecoxib group and different Qianlietongyu Decoction groups（in low,middle or high does respectively）.After 30 days the rats were killed and prostatic tissue was taken.In prostatic homogenate the contents of interleukin-1β（IL-1β）,cyclooxygenase-2（COX-2）,prostaglandin E2（PG E2）and β-endorphin（β-EP）were detected by enzyme linked immunosorbent assay（ELISA）.Results In the Qianlietongyu Decoction group in high dose and celecoxib group the contents of IL-1β,COX-2 and PG E2 were decreased significantly and β-EP content was increased.The comparison between these two groups was not different significantly（P>0.05）.Conclusion The therapeutic effect of Qianlietongyu Decoction is closely related to that it can inhibit prostatitis and regulate cytokine contents.关键词：chronic nonbacterial prostatitis;Qianlietongyu Decoction;cytokine;rats
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发布时间：2021-09-15 - 摘要：Objective To investigate the influence of Shenyanfangshuai Solution on the expression of kidney fibronectin（FN）in rats with 5/6 of nephrectomy.Method The model of renal fibrosis was established in SD male rats with 5/6 of nephrectomy,and then the rats were randomly divided into 8 groups:the normal group,sham-operation group,model group,benazepril group,Niaoduqing group and three Shenyanfangshuai Solution groups（in different doses）.The influence of Shenyanfangshuai Solution on kidney FN expression was detected by immunohistochemistry method taking benazepril and Niaoduqing as experimental control.Result In the model group the kidney FN expression showed intense positive with a lot of brown depositions in the mesangial matrix and renal tubular basement membrane.In the benazepril group and Niaoduqing group the FN expression showed moderate positive with some brown depositions.In three Shenyanfangshuai Solution groups the FN expressions were much lower than those in the model group with a few brown depositions in a dose-reliable manner.Conclusion Shenyanfangshuai Solution inhibits the expression of kidney FN in rats with 5/6 of nephrectomy,which may be one of the mechanisms of Shenyanfangshuai Solution retarding the development of glomerulosclerosis and renal fibrosis.关键词：Shenyanfangshuai Solution;fibronectin;5/6 of nephrectomy;rats
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发布时间：2021-09-15 -
- 摘要：Objective To establish a method for determinating the total chromone in the chromone fraction of Saposhnikovia divaricata（Turcz.）Schischk.Method The content of total chromone in chromone fraction of Saposhnikovia divaricata（Turcz.）Schischk.was determined by the chromatoptometry of molybdenum phosphotungstate-lithium sulfate:hamaudol was taken as the reference substance and molybdenum phosphotungstate-lithium as the developer.The procedure was developed in buffer with pH value of 10.6.Result Hamaudol had a good linear relationship with the absorbance in the range of 8 to 56 μg,and the linear regression equation was Y=0.203 4X-0.002 1（r=0.999 8）.The average recovery for hamaudol was 98.82% with RSD=1.97%（n=6）.Conclusion The content determination of 3 batches of sample shows that the method is simple,convenient and accurate,and can be used for the content determination of the total chromone in the chromone fraction of Saposhnikovia divaricata（Turcz.）Schischk.关键词：Saposhnikovia divaricata （Turcz.） Schischk.;content determination;total chromone;chromatoptometry;hamaudol
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发布时间：2021-09-15 - 摘要：Objective To identify the metabolites of Aconitum alkaloids from the compound formula of Chinese medicine in human urine.Method The liquid chromatography-electrospray ionization-multi-stage mass spectrometry（LC-ESI-MSn）was used.Result There were five metabolites of Aconitum alkaloids were identified in the urine of a female patient.Conclusion These five metabolites of Aconitum alkaloids from the urine of patient with the symptom of aconitine poisoning kept the skeletal structures of Aconitum alkaloids—the basis structure of Aconitum alkaloids,which can be taken as the indicator of aconitine（Aconitum alkaloids）poisoning and as a substitution for aconitine,a primary poisoning indicator,that metabolizes quickly in organism and is hard to determine.LC-ESI-MSn is sensitive,exclusive and easy for detecting the indicator of aconitine poisoning.关键词：aconitine poisoning;metabolites;LC-ESI-MSn
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发布时间：2021-09-15 - 摘要：Objective To investigate the clinical effect and mechanism of qi-replenishing,blood-activating and phlegm-removing therapy to prevent and treat chronic obstructive pulmonary disease（COPD）.Method All 76 patients were randomly divided into the treatment group and control group.The control group（n=30）was treated individually according to GOLD plan and patients’ conditions.The treatment group（n=46）was treated with qi-replenishing,blood-activating and phlegm-removing therapy besides the Western medicines as same as the control group.The living quality of COPD patents in two groups was evaluated before and after the treatment,and the serum contents of interleukin-1（IL-1）,interleukin-8（IL-8）,laminin（LN）,hyaluronic acid（HA）,procollagen Ⅲ（PⅢP）,transforming growth factor-β（TGF-β）and basic fibroblast grow factor（b-FGF）were detected.Result After the treatment the living quality of the patients in the treatment group was improved obviously,and the serum contents of TFG-β and b-FGF were decreased.In the control group the serum contents of LN,HA and PⅢP were increased.Conclusion The therapy of qi-replenishing,blood-activating and phlegm-removing can intervene the reconstruction of the air tract in COPD patients,slow the development of air limitation and improve patient’s living quality.关键词：chronic obstructive pulmonary disease;qi-replenishing,blood-activating and phlegm-removing therapy;clinical curative effect;mechanism
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发布时间：2021-09-15 - 摘要：Objective To study the relationships among immune indexes,the components of peripheral blood,symptoms and signs in AIDS patients and to provide the evidences for the clinical diagnosis and treatment.Method The clinical materials of 249 AIDS cases of Tanzania were analyzed statistically on the relationship between 11 symptoms and signs and their indexes of white blood cell count（WBC）,hemoglobin（Hb）,lymphocytes（LY）,LY%,CD4+,CD4+%,CD8+,CD8+% and CD4+/CD8+.Result The indexes of LY and WBC in different CD4+ phases were greatly different between the members of three groups,while LY% was not different.Along with CD4+ cell count decreasing,the indexes of LY,LY%,WBC and Hb tended to induce obviously.In three phases CD4+ cell count and LY count were correlated.When CD4+ cell count was below 200/mm3,CD4+ cell count and LY% or WBC was correlated significantly.In other two phases,in CD4+ cell count,LY%,WBC,Hb and CD4+ cell count there was no correlation observed.The total symptom integrals in three groups according to CD4+ phases were increased along with the decrease of CD4+ cell count,in the group with CD4+ cell count below 200/mm3,the total integral was significantly different from other two groups.The integrals of 9 symptoms and signs in three groups were increased along with the decrease of CD4+ cell count and there was a significant deference between the members of three groups,which was negatively related to CD4+,CD4+/CD8+ and CD4+%.Conclusion LY count is one of important indexes for evaluating the immunity of AIDS patient.Besides of CD4+ cell count,CD4+/CD8+ and CD4+% are also significant to the development of AIDS.The CD8+% and CD8+ count are not significant.关键词：AIDS;immune indexes;components of peripheral blood;symptoms and signs
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发布时间：2021-09-15 - 摘要：Objective To study the distribution law and symptom characteristics of fatty liver disease（FLD）and to further discuss the pathogenesis.Method The questionnaire of clinical symptoms was set up by transect method to collect the general materials from FLD patients and symptom materials from TCM four diagnostic methods,which were then analyzed statistically.Result The first four symptoms were fatigue,corpulent,discomfortable in costal region and ache-weak of the waist and knee.The first three pulse manifestations were wiry pulse,thready pulse and slippery pulse.In clinical symptom group the syndrome of spleen deficiency and liver-qi stagnation accounted for 46.79%,the syndrome of phlegm-damp accumulating in the middle for 30.77%,the syndrome of deficiency of liver and kidney for 27.56% and the syndrome of agglomeration of phlegm and stasis for 22.44%.The relationship between syndrome and disease seriousness or disease course showed:the syndrome of spleen deficiency and liver-qi stagnation was the most common in mild FLD,the syndrome of phlegm-damp accumulating in the middle was the most common in moderate FLD and the syndrome of deficiency of liver and kidney was the most common in serious FLD.Within 5 years there were more the syndrome of spleen deficiency and liver-qi stagnation and the syndrome of phlegm-damp accumulating in the middle came second.After 5 years there were more the syndrome of deficiency of liver and kidney and the syndrome of agglomeration of phlegm and stasis.Conclusion The syndrome of spleen deficiency and liver-qi stagnation is the most common in FLD,phlegm-damp is the important pathological factor of FLD and kidney deficiency is the key in FLD pathogenic development.关键词：clinical symptoms;fatty liver disease;syndrome manifestations;Chinese medical pathogenesis
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发布时间：2021-09-15 - 摘要：Objective To investigate a method for keeping dental hygiene,being simple,efficacious and accepted by patients.Method The patients were selected randomly from the orthodontic clinic and divided into Chinese medical collutory group and distilled water group（each n=30）.The indexes of bacterial plaque and bleeding were used to evaluate the effect of Chinese medical collutory on dental hygiene.Result On the 4th and 8th week after wearing orthodontic appliance the indexes of positive level index（PLI）,bleeding index（BI）and periodontal depth（PD）in Chinese medical collutory group were all improved than those in distilled water controt group with a significant difference（P<0.05）.Conclusion Chinese medical collutory,used by the patients wearing orthodontic appliance,can improve obviously the condition of patient’s periodontium and control bacterial plaque and gingivitis.关键词：periodontium;orthodontic appliance;Chinese medical collutory
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发布时间：2021-09-15
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