最新刊期
卷 0 ， 期 11 ， 2008
- 摘要：Similar to the basic category,species,in the biological taxonomy,symptomatic units should be found in the clinical manifestations of Chinese medicine.To be a relative independent clinical phenomenon,every symptomatic unit is composed of one symptomatic anatomy and one symptomatic characteristic definitely.Based upon the clinical records in the past dynasties,415 symptomatic units were found with an accumulative frequency of 99.9%,if the symptomatic units were ordered from high frequency to low frequency.These symptomatic units include 62 symptomatic anatomies and 243 symptomatic characteristics.Furthermore,57 factors that can aggravate and relieve these symptomatic units were summarized too.All of these results may be helpful to the standardization and classification of the clinical manifestations of Chinese medicine.关键词：symptomatic units;symptomatic anatomies;symptomatic characteristics;clinical manifestations of Chinese medicine;diagnostics of Chinese medicine.
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发布时间：2021-09-15 -
- 摘要：With the development of aging of population,senile dementia has become a significant chronic disease.The prevention of chronic disease plays an important role in health program.Currently,our research focuses on the mild cognition impairment stage.The patients in the mild cognition impairment stage are not aware of the illness since the symptoms are quite slight,few patients consult specialist in hospital.We must convert concept for early detection and early intervention of mild cognition impairment.Therefore education programs and census are carried out in several communities.The medical files are recorded in the program,self-detection is acquired to be done by patients and the vascular mild cognition impairment patients are screened by the specialists.Those patients are treated with Chinese medicine and are followed up to evaluate the results.The new research method is established,with which the patients in the mild cognition impairment stage can be detected and benefit from the early intervention.关键词：mild cognitive impairment;Chinese medicine research method;prevention and treatment pattern in community
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发布时间：2021-09-15 - 摘要：Chinese surgery of traditional Chinese medicine（TCM） had developed into an important stage marked by the formation of three famous medical schools termed as "zheng zong","quan sheng" and "xin de" in the Ming and Qing dynasties.While after renaissance time,modern surgery in western medicine has been largely improved by its technologies.Through comparative studies,it was concluded that TCM addressed in internationally flouring and smoothly flowing of qi and blood,resulting in elimination of carbuncles and local devastations.These medical schools of TCM were mainly by means of pure natural herbs in healing.In contrast,modern surgery was based upon anatomy and pathology,by finding the focus and then proceeding surgical operations.The latter paid great attention to the improvement of its technology.Therefore,they make different evidently both in their medical systems and treatment methods.Possibly the two medicines in each surgery may share their advantages and enrich each other clinically in the future.关键词：surgery of TCM;modern surgery;surgical technology;medical schools of TCM;comparative study
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发布时间：2021-09-15 - 摘要：Objective To study the effect of hydroxy safflor yellow A（HSYA） on the cell cycle and apoptosis of human umbilical vein endothelial cells（HUVEC） with the stimulus of HepG2 tumor cell conditioned medium.Methods HUVEC were primarily cultured to the passage 36.The changes of cell cycle and apoptosis of HUVEC with the stimulus of conditioned medium under the inhibition of HSYA were detected by flow cytometry,and the expression of cytokine TNF-α was detected by ELISA.Results In the tumor model group,the proportion of HUVEC of G0/G1 stage was lower than in the control group（P<0.05）,the proportion of S stage was higher than the control group（P<0.01）,and the apoptosis was inhibited at the same time（P<0.01）.There were no significant differences in the proportions of HUVEC at each cell cycle stage between the HSYA and the model groups,The proportion of apoptosis was higher in the HSYA group than in the model（P<0.05）.The expression of cytokine TNF-α was higher in the model group than in the control（P<0.05）,and it is lower in HSYA group than in the model group（P<0.05）.Conclusion HSYA may remarkably promote the apoptosis of HUVEC with the stimulus of tumor cell conditioned medium.And one of the mechanisms of its promoting effect is to enhance the expression of the apoptosis related factor TNF-α.关键词：hydroxy safflor yellow A;tumor;human umbilical vein endothelial cell;cell cycle;apoptosis
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发布时间：2021-09-15 - 摘要：Objective To study the effects of Zhengtian Pills（ZHTP） on monoamine neurotransmitters and its protection against migraine.Methods All rats were divided into 4 groups: the normal group（saline）,the model group（saline）,the ZHTP group（16.8 mg/kg） and the flunarizine group（1 mg/kg）.The replication of migraine rat model was made by subcutaneous injection of nitroglycerin after rat treated with ZHTP for 5 days.The degree of ear rubescence and the times of scratching head were observed as evaluation index of pharmacodynamic action,then the concentration of 5-HT,NE and DA in the brain were measured by HPLC.Results Compared with the normal group,the model group showed increasing degrees of ear rubescence and times of scratching and shaking head and also the decreasing contents of 5-HT,NE and DA（P<0.05）.After preventive administration of ZHTP,the degree of ear rubescence of model rats decreased and the duration of ear rubescence got short,and the times of scratching and shaking head decreased and the contents of 5-HT,NE and DA in the rat brain somewhat increased.All these had statistical significance compared to the model group.Conclusions ZHTP could obviously decrease the attack,which may be related with the regulation on the release of 5-HT,DA and NE in the rat brain.关键词：Zhengtian Pills;migraine;neurotransmitter
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发布时间：2021-09-15 - 摘要：Objective To study the influence of berberine（Ber） on cardiac fibroblasts（CFB） proliferation and collagen protein synthesis induced by Angiotensin Ⅱ,and investigate its mechanism.Methods Purified CFB were obtained by the methods of digestive enzyme and differential adhesion.CFB proliferation was determined using MTT method.Collagen content was determined using hydroxproline method.NO content and NOS activity was determined using chemistry colorimetry method.TGF-β1 content was determined using enzyme linked immunosorbent assay（ELISA）.Result Berberine at the concentration of 1.25～10 mg/L could obviously inhibit CFB proliferation and the increased collagen protein synthesis induced by AngⅡ,and also could increase NO content and NOS activity and decrease TGF-β1 content.Conclusion Berberine has inhibitiory effects on CFB proliferation and collagen protein synthesis induced by AngⅡ,which is of positive significant to myocardial fibrosis inhibiting and ventricular remodeling improving.The mechanism might be related with increasing NO secretion and reducing TGF-β1 expression of CFB.关键词：berberine;cardiac fibroblasts;Angiotensin Ⅱ
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发布时间：2021-09-15 - 摘要：Objective To observe the pharmacodynamic action of Huiyangshengji Liposome Gel on promoting chronic dermal ulcer healing and investigate initial pharmco-mechanisms of external used drugs with the effect of restoring yang to promote tissue regeneration treating sores ulceration with yin syndrome.Methods 80 SD rats were divided 4 groups randomly: blank control group,model control group,traditional Huiyangshengji Ointmen treatment group,Huiyangshengji Liposome Gel treatment group.The chronic dermal ulcer rat model was prepared by the method of composite factor（dehydrocortisone+dermal deficiency+bacterial infection）.We observed rats common living behavior,examined lysozyme content in wound surface secretion,tested TNF-α and TXB2 levels in serum,and also observed tissue pathological alteration.Results The model group rats displayed elementary yin syndrome characteristics as same as Chinese Medicine clinical yin syndrome.The lysozyme contents in secretion were increased,TNF-α and TXB2 levels in serum were decreased in the traditional Huiyangshengji Ointmen group and Huiyangshengji Liposome Gel group,with significant differences when compared with the model group.In both treatment groups,granulation tissue increased in wound surface,collagen synthesis was vigorous,dermal structure tended to integrity.Compared with the model group,play an significant role in antibiosis,anti-inflammation,promoting collagen synthesis,and so forth.Conclusion Huiyangshengji Liposome Gel exhibits good therapeutic effect on promoting chronic dermal ulcer healing through its functions in antibiosis,anti-inflammation,promoting collagen synthesis,and so forth.关键词：Huiyangshengji Liposome Gel;chronic dermal ulcer;external therapy;rats
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发布时间：2021-09-15 - 摘要：Objective To study the effect of saikosaponin a（SSa） on intracellular free calcium concentration（） and interleukin-6 in hippocampal astrocytes actived by glutamate.Methods A cell culture model of neonatal Spague-Dawley rat hippocampal astrocytes were used.After exposed to extracellular fluid with calcium,L-glutamate（0.1 mmol/L）,L-glutamate and SSa of different concentration（1.25 mg/L and 0.625 mg/L） for 12 hours,changes of i and IL-6 were observed by enzyme-linked immunosorbent assay（ELISA） and fluorescent Ca2+ indicator Fura-3/AM respectively.Results Elevation of intracellular Ca2+ fluorescence intensity and increased expression of IL-6（P<0.01） were observed in glutamate group.Compararing with glutamate group,elevation of i and IL-6 expression were decreased after astrocytes were incubated with SSa（P<0.01）.The i and IL-6 level in 1.25 mg·L-1 of SSa group and control group showed no significant differences（P>0.05）.Conclusion SSa could effectively inhibit the hippocampal astrocytes from decreasing i.and secreting IL-6,and the inhibitory effect on elevation of i and IL-6 expression may be one of the mechanisms of its anti-epilepsy effect.关键词：epilepsy;astrocyte;glutamate;Saikosaponin a;interleukin-6;Ca2+;rats
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发布时间：2021-09-15 - 摘要：Objective To investigate the curative mechanism of Kuiyangping by studying the effect of iton expressions of EGF and EGFR mRNA in gastric mucosa in rats with experimental gastric ulcer（GU）.Methods The ulcer model was prepared by modified Okabe’s method.The rats were randomly divided into 6 groups: experimental group,the model group,the low,middle and high dose of Kuiyangpin groups and the ranitidine hydrochloride group.After the 14-day treatment,the expressions of EGF and EGFR mRNA in the mucosa were measured by real-time PCR.Result Compared with the model group,the value of EGF 2-ΔΔCTT in the low,middle and high dose of Kuiyangping groups were obviously enhanced,which indicated that Kuiyangping could up-regulate the expression of EGF（P<0.01）;and the value of EGFR 2-ΔΔCT in the low,middle and high dose of Kuiyangping groups were obviously enhanced,which indicated Kuiyangpin could up-regulate the expression of EGFR（P<0.001）.Conclusion Kuiyangping can increase the expressions of EGF and EGFR mRNA in gastric mucosa in rats with gastric ulcer,which may be one of the molecular basises of its functions to accelerate ulcer healing,improve the quality of healing and reduce ulcer recurrence.关键词：Kuiyangping;gastric ulcer;EGF;EGFR;real-time PCR;rats
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发布时间：2021-09-15 - 摘要：Objective To investigate the effect of Naomaian Capsules on expression of brain-derived neurotrophic factor（BDNF） mRNA in acute cerebral infarction tissue of rats.Methods 36 SD male rats were randomly divided into 6 groups,with 6 rats in each group: low-dose Naomaian Capsules group（A）,moderate-dose Naomaian Capsules group（B）,high-dose Naomaian Capsules group（C）,west medicine（nimodipine）group（D）,sham-operation group（E）,and 24h ischemia model group（F）.The model of focal cerebral ischemia was made by thread-occluded method.In each group,the brain tissues of 3 rats were taken out 24 hours after the operation and the injuries of their cerebral cortex cells were observed by HE staining and the brain tissues of another 3 rats were taken out to extract the total mRNA for amplification of BDNF mRNA specific fragment by RT-PCR and analyze the changes of BDNF mRNA expression of each group.Results Obvious symptoms of neural function deficiency and ischemic morphological changes such as cellular edema were observed in 24h ischemia model group.Relative optical density of the amplified products of BDNF mRNA in 24h ischemia model group was obviously higher than in sham-operation group（P<0.01）.The relief of cortex neuron edema and relative optical density of amplified products of BDNF mRNA in Naomaian Capsules group with all dosages and west medicine group were obviously higher than 24h is chemia model group,and the results had statistical significances（P<0.01）.Conclusion Naomaian Capsules can up-regulate the expression of BDNF to cause the recovery of the neurological function,which contributes to its therapeutic effect for acute cerebral infarction.关键词：Naomaian Capsules;acute cerebral infarction;BDNF;rats
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发布时间：2021-09-15 - 摘要：Objective To investigate the synergy and attenuation of Liujunzi Decoction to S180 tumor bearing mouse treated by cyclophosphamide（CTX）.Methods S180 tumor bearing mice were established and then divided randomly into five groups,including tumor-bearing control group,CTX group,Liujunzi Decoction（high and low dose） plus CTX groups,and Zhenqifuzheng Capsules plus CTX group.We calculated the tumor-supression rate,measured the weights of spleen and thymus,observed the functions of liver and kidney and the change of immunoglobulin（Ig）,detected the content of nitric oxide（NO） in spleen.Results（1）The tumor-weight-inhibiting rates were higher in each Liujunzi Decoction plus CTX group than in the tumor-bearing control group（P﹤0.01）.The tumor-weight-inhibiting rates of Liujunzi Decoction high-dose plus CTX group were higher than that of CTX group（P﹤0.05）.（2） Compared with the two Liujunzi Decoction plus CTX groups,the index of spleen and thymus,and the level of IgG in the CTX group were lower,and the content of NO in spleen were higher,which revealed significant differences（P﹤0.05 or P﹤0.01）.（3） The level of serum ALT were higher in the CTX group than in the high dose Liujunzi Decoction plus CTX group（P﹤0.05）.Conclusion Liujunzi Decoction can enhance immunity and this could be the mechanism of the synergy and attenuation of Liujunzi Decoction on CTX activities in S180 tumor bearing mouse.关键词：Liujunzi Decoction;S180 mice;chemotherapy
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发布时间：2021-09-15 - 摘要：Objective To evaluate the preventive effect of Mahuang Decoction on murine acute myocarditis duo to encephalomyocarditis virus（EMC）,and to explore the best starting time to administer Mahuang Decoction.Methods A total of 116 eight-week-old C3H female mice were used in the experiments.Group N is uninfected control mice（n=29）.Group A B C were inoculated intraperitoneally with 0.01% concentration of EMC virus in 0.1 mL of saline（day0,n=29 per group）.Group A were orally administered with 0.1 mL saline starting on day 0 to day4.Group B were orally administered with 0.2mL Mahuang Decocotion（500 mg/kg·d） starting on day 0 to day4.Group C were orally administered with 0.2 mL Mahuang Decoction starting on day2 to day6.The survival rate of each group was monitored during the observation period.Body weight and organ weight and histopathological changes of heart were examined on days 0,2,4,6and 14 after infections.Results The survival rates on day 7 were 18.18% in group A and B,63.64% in group C.The survival rates on day 14 were 0% in group A and B,36.36% in group C.The increase in survival in group C was statistically significant compared with that in group A B（P<0.05）.The BW in group A and B on days 6 was significantly（P<0.05） lower than that in the group C.The HW and HW/BW ratio in groups A on days 4 were elevated compared with that of the group B and C（P<0.05）.The HW and HW/BW ratio in group C on days 6 after virus inoculation was significantly（P<0.01） lower than that in the group A.In group C,the HW/BW ratio on day 4 and day 6 were significantly（P<0.01） lower than those in group B.The LuW/BW ratio on day 4 day 6 were significantly reduced in group B and C versus group A.In group C the LuW/BW ratio on day 4 were significantly lower then those in group B,but one day6 the LuW/BW ratio were not significantly reduced with group B.In group B the SpW/BW on day2 were significantly（P<0.01） higher than that in the group A.The SpW/BW ratios on days 6 in group C were significantly（P<0.05） higher than those in group A.Scores of myocardial necrosis were significantly lower in group C than in group A and B.Conclusion Two days later orally administration of Mahuang Decoction is beneficial to mice infected with the EMC virus and with subsequent active viral myocarditis..The present study supports the observations that Mahuang Decoction promotes temperately adaptive immune responses in thymus,spleen,and heart muscle,and the consequent attenuation of viral replication when Mahuang Decoction is administered two days later with the virus.关键词：Mahuang Decovtion;antiviral;viral myocarditis;mice
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发布时间：2021-09-15 - 摘要：Objective To establish the content determination method for astragaloside in Buyishujin Granules by HPLC-ELSD.Methods HPLC with Phenomenex C18（150 mm×4.6 mm,5 μm）column was used.Acetonitrile-water（30∶70）was taken as a mobile phase,flow rate was 1.0mL/min,diift-tube temperature was 60℃,N2 pressure was 150 kPa.Results The linear range of astragaloside was 0.5～10.26μg,the correlation coefficient（r） was 0.999 5,the average recovery rate was 98.08%,RSD was 1.97%.The method is suitable for the formulate of the quality standard with sufficient accuracy,stability and reappearance.Conclusion The method has characteristics of sufficient accuracy,stability and good reappearance,and can be used for quality control in Buyishujin Granules.关键词：astragaloside;Buyishujin Granules;HPLC-ELSD
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发布时间：2021-09-15 - 摘要：Objective To establish a content determination method for saikosaponin a,c and d to lay the foundation for quality evaluation of Altai Bupleurum Root.Methods The determination was carried out by HPLC with ZORBAX SB C18 column（4.6 mm× 250 mm,5μm）,mobile phase: acetonitrile∶water,flow velocity: 0.8 mL / min,detection wavelength: 210 nm.Result The average recoveries were 98.0% for saikosaponin a（RSD=2.4%,n=6）,98.4% for saikosaponin b（RSD=2.5%,n=6）,98.9% for saikosaponin d（RSD=2.0%,n=6）.Conclusion The determination of three batches of samples shows that this method could be used to determine the contents of saikosaponin a、c、d in Altai Bupleurum Root.关键词：Altai Bupleurum Root;HPLC;content determination;saikosaponin a,c,d
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发布时间：2021-09-15 -
- 摘要：Objective To compare and analyze the symptoms and syndrome characteristics of early and late onset narcolepsy.Methods The clinical data of 88 consecutive patients with narcolepsy,61 of which with an onset age of 9.36±2.69 on average and 27 with an onset age of 19.78±6.11 on average.Epidemiological survey was adopted in the study,including inquiry to 88 narcolepsy patients,according to unified standards,filling out questionnaire for TCM symptoms and signs,statistical data processing by using SPSS12.0 software.Unified standards were set out and adopted to assist the clinical study and the comparision and analysis of the results of syndrome patterns.SPSS12.0 was adopted in data analysis.Results ①All 88 patients showed lethargy.There were no significant differences in the rates of amyasthenia,cataplexy,sleep paralysis,hypnagogic hallucination,and disrupted sleep patterns bwtween the two groups（P>0.05）.②The main clinical syndrome type of the early onset group was stagnation of dampness due to splenic asthenia（83.6%）,but only two cases of this type were involved in the late onset group.The rates of dampness and heat in the spleen,splenic asthenia and liver sthenia,turbid phlegm disturbing brain,and phlegm-fire disturbing gallbladder in the late onset group were significantly higher than those of the early onset group（P<0.05）.There were no significant differences in the rates of spleen and kidney Yang deficiency and blood stasis in the brain.Conclusions The disease nature of early onset narcolepsy was root deficiency present with pleen deficiency and branch excess present with phlegm dampness.The key reason for occurrence of this disease is closely related to TCM constitution.关键词：Narcolepsy;TCM syndrome;TCM constitution.
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发布时间：2021-09-15 - 摘要：objective To explore the correlation between Chinese medicine syndrome characteristics and immunological cyctokines of IL-8、TNF-αin patients with chronic prostatitis（CP）.Method Total of 52 cases of CP patients were selected for study,including 27 cases with the syndrome characteristics of downward flowing of damp-heat and 26 cases with the syndrome characteristics of stagnancy of qi and blood stasis.12 normal people were taken as control.The levels of TNF-α and IL-8 in succus prostaticus were detected by radioimmunoassay.Result Patients with the syndrome of stagnancy of qi and blood stasis or of downward flowing of damp-heat showed higher IL-8 contents than normal people,with significant differences,but the content between two types of patients had no difference.There were significant differences in IL-8 levels between two types of patients with abnormal leucocytes in succus prostaticus or normal leucocytes in succus prostaticus.The TNF-α contents had no difference among the normal people and two types of patients.There were not significant differences in IFN levels between two types of patients with abnormal leucocytes in succus prostaticus or normal leucocytes in succus prostaticus.Conclusion CP patients with the syndrome characteristics of downward flowing of damp-heat and with the syndrome characteristics of stagnancy of qi and blood stasis all present abnormally increased local immune reaction.关键词：chronic prostatitis;stagnancy of qi and blood stasis;downward flow of damp-heat;IL-8;TNF-α
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发布时间：2021-09-15 - 摘要：Objective To study the effect of different personalities of parturient women on the electroacupuncture analgesia（EA）.Methods 175 primiparas were grouped into the stability group,and the instability group,according to the scores of Eysenck personality questionnaire（EPQ）;into the extraversion group,and the introversion group according to the scores of introversion and extraversion.Statistic analysis was adopted to compare the scores of VAS before and after EA so as to study the effect of psychological characteristics and personality factors on EA.Results Personality stability could distinctly affect the parturient women’s satisfaction and the effectiveness of EA.Extraversion-introversion didn’t have statistically significant effect.But by combining the two factors,we found the effect of analgesia can be arranged from higher to lower as follows: introversion-stability,extraversion-stability,extraversion-instability,introversion-instability.Conclusions Psychological factors had significant effect on EA,then knowing psychological characteristics and personality style of the parturient woman before delivery may have a certain guiding significance for selecting analgesia ways of labor pain relief.关键词：electroacupuncture;analgesia for labor pain;Eysenck personality typing
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发布时间：2021-09-15 - 摘要：Objective To investigate the clinical therapeutic effect of electrical pulse on diabetic peripheral neuropathy（DPN）.Methods 82 cases of DPN were randomly divided into two groups.The control group were treated with intravenous injection of mecobalamin,one time a day.The treatment group were treated with the same therapy of the control group plus electrical pulse on acupoint.After 15 days,the effective rate of symptom improving was taken down,and the sensory nerve conduction velocities of median nerve and peroneal nerve were measured,and all these results were compared with the data taken before the treatment.Result There were significant differences in the improvement of symptoms and the nerve conduction velocities between the treatment group and the control group（P<0.05）.Conclusion Treatment with electrical pulse on acupoints has obvious curative effect on DPN.关键词：acupoint;electrical Pulse;diabetic peripheral nevropathy
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发布时间：2021-09-15 - 摘要：<正>学院概况 2000年7月,经教育部批准北京中医药大学成立网络教育学院（2002年10月更名为"远程教育学院"）,开展现代远程教育试点工作。并于2000年底进行第一次试招生。自成立以来,学院一直致力于开展面向在职从业人员的中医药学历教育,运用现代远程教育科技手段开展实践,为国家培养合格的中医药专业人才。现有校外学习中心28个,在校生人数达1.1万人,已毕业学生人数约9500人。
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发布时间：2021-09-15
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