最新刊期
卷 0 ， 期 0 ， 2020
- 摘要：It is a better way to establish a mathematical model of formula-syndrome correspondence for investigating therapeutic laws.The formula-syndrome correspondence is a complex system.The mathematical model of formula-syndrome correspondence should be matched with the characteristics and complexity of the subject in the research,and balanced between the fidelity and cost of modeling.Currently two key problems should be resolved in the research,which are modeling subject with moderate scale,complexity and sufficient representativeness,and the algorithm of syndrome-formula quantitative association accorded with clinical demand.The paper selected the examples of formula-syndrome correspondence from Shanghanlun as the modeling basis centered on above two key problems.The coupling model of formula-syndrome correspondence was established based on analytic hierarchy process（AHP） for analyzing complex system,which provided the scientific base for the study on formula-syndrome correspondence systematically.关键词：formula-syndrome correspondence;mathematical model;Shanghanlun;analytic hierarchy process
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发布时间：2021-05-20 - 摘要：Objective To investigate the mechanism of Ruanganshengbai Granules in anti-hepatofibrosis through observing its influences on the expressions of hepatocyte growth factors（HGF） and C-Met-mRNA in mice with hepatic fibrosis.Methods BABL/c mice（n=80） were fed with 0.03% thioacetamide water for 20 weeks for establishing the model of hepatic fibrosis,and then all mice were randomly divided into four groups（each n=20）.Group A was given Ruanganshengbai Granules [11.2 g/（kg·d）],group B was given Ruanganshengbai Granules [5.6 g/（kg·d）] and group C was given Biejiaruangan Tablets [1.12 g/（kg·d）].The model group（group D） and the control group（group E,n=20） were given equivalent normal saline solution once a day,respectively.On the 4th and 8th week,10 mice were killed in each group for detecting liver function indexes.The hepatic tissue were collected from all groups for histological observation after HE staining.The expressions of HGF and C-Met-mRNA were detected by using RT-PCR.Results There was significant difference in liver function indexes and histological observation before and after treatment.The expressions of HGF and C-Met-mRNA were higher significantly in the treatment groups than those in the control group（P<0.05）.Conclusion Ruanganshengbai Granules can increase the expressions of HGF and c-Met-mRNA after hepatic fibrosis occurred.关键词：hepatocyte growth factors;hepatic fibrosis;Ruanganshengbai Granules;mice
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发布时间：2021-05-20 - 摘要：Objective To determine whether chlorogenic acid（CA） could be taken as a hapten to induce allergic reaction.Methods The artificial antigen was synthesized by conjugating CA and bovine serum albumin（BSA） in vitro,which was then mixed with Freund’s complete adjuvant.Kunming mice were injected hypodermically with the mixture（immune group）,and IgG（CA antibody） and its titer were detected in the serum after 14 days.The mice in the blank control group were injected hypodermically with equivalent Freund’s complete adjuvant.After 20 days the immune group was attacked by CA and then the outcomes of active systemic anaphylaxis（ASA） test and passive cutaneous anaphylaxis（PCA） test were observed.Results In the immune group there were 5 samples of effective serum,of 8 samples,showing IgG positive and the titer of CA IgG was 1∶80 in the mixed serum.In ASA test all mice of the immune group（n=10） had allergic reaction in varying degrees and there was only one mouse having suspect allergic reaction in the blank control group.In PCA test OD value of Evansblue（610 nm） was 0.099±0.023 in the immune group and 0.076±0.013 in the blank control group（P=0.000 4,P<0.01）.The difference was significant statistically.Conclusion CA can be used as a kind of hapten to stimulate the immunologic response and induce allergic reaction in mice.关键词：chlorogenic acid;hapten;allergenicity;mice
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发布时间：2021-05-20 - 摘要：Objective To determine the content of butyrophenone and stilbene constituents in different varieties of medicinal material of Dahuang（Radix et Rhizoma Rhei） produced from different areas.Methods The content of trans-3,5,4′-3-hydroxy-vinyl-4′-O-β-D-glucopyranoside（a）,4′-hydroxy-phenyl-2-butanone（b） and 4′-hydroxy-phenyl-2-butanone-4′-O-β-D-（6″galloyl）-glucopyranoside（c） in Dahuang were determined by HPLC at 35℃.The mobile phase was methanol-1% acetic acid water solution（20∶80）.The detection wavelength was 280 nm and flow velocity was 1.0 mL/min.Results In identified material of Dahuang three constituents were detected.The content of a was higher in Zhangye Dahuang（Rheum palmatum L.） than that in Tanggute Dahuang（Rheum tanguticum Maxim.ex Balf.） and in medicinal Dahuang.It was the lowest in spurious Tu Dahuang（Rumex madaio Makino） and counted for 4% of that in Zhangye Dahuan.The content of b and c were similar in Zhangye Dahuan and Tanggute Dahuang and lower in medicinal Dahuang.There was no c in spurious Tu Dahuang.Conclusion These three constituents can be taken as the indicators of quality evaluation of Dahuang,which enrich the method of quality evaluation of Dahuang material.关键词：Dahuang（Radix et Rhizoma Rhei）;butyrophenone;stilbene;quantitative determination
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发布时间：2021-05-20 - 摘要：Objective To establish a method for quantitative determination of tetrahydropalmatine in Xiaohuahuangjin（Corydalis racemosa） by HPLC.Methods The HPLC procedure was performed on the chromatographic column of Gemini C18（250 mm×4.6 mm,5 μm） at 25 ℃,the mobile phase was methanol-0.1% phosphoric acid water solution（75∶25）.The flow velocity was 1.0 mL/min and the detection wavelength was 280 nm.Results The average content of tetrahydropalmatine in Xiaohuahuangjin was 0.160%.Tetrahydropalmatine showed a good linear relationship at a range from 0.193 μg to 2.128 μg.The average recovery was 98.55%（RSD=1.67%,n=6）.Conclusion The method was simple and reliable with a good repeatability,which can be used for the quantitative determination of tetrahydropalmatine in Xiaohuahuangjin.关键词：Xiaohuahuangjin（Corydalis racemosa）;tetrahydropalmatine;quantitative determination;HPLC
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发布时间：2021-05-20 - 摘要：Objective To analyse the volatile oil constituents from three kinds of processed Zhishi（Fructus Aurantii Immaturus）.Methods The volatile oil constituents were extracted from three kinds of processed Zhishi including crude Zhishi,vinegar-baking Zhishi and bran-stirring Zhishi by applying steam distillation,and then were analysed by using GC-MS.The relative content of different constituents in volatile oil from three kinds of processed Zhishi were determined by applying the chromatographic area normalization method.Results There were totally 53 constituents of volatile oil identified from three kinds of processed Zhishi and among them the major one was limonene,which was accounted for 64% in crude Zhishi and 33.0% in bran-stirring Zhishi.There were 26 volatile oil constituents in crude Zhishi,37 in vinegar-baking Zhishi and 48 in bran-stirring Zhishi.The content of limonene had a decreasing tendency in Zhishi processed by different methods,but the varieties and quantity increased in varying degrees.Conclusion The content of volatile oil are different in processed Zhishi by different methods and quantity of chemical constituents were different too,but a part of chemical constituents are the same.The method can be used in the analysis of chemical constituents of volatile oil in Zhishi.关键词：Zhishi（Fructus Aurantii Immaturus）;processed medicinal;volatile oil;GC-MS
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发布时间：2021-05-20 - 摘要：Objective To determine the content of trace elements-Mn,Fe,Ca,Mg,Cu,Zn and Cd in Gancao（Radix Glycyrrhizae） from different places in northwest China,and to provide a reliable method for the scientific evaluation and effective control on the quality of Gancao.Method The content of Mn,Fe,Ca,Mg,Cu,Zn and Cd in Gancao were detected by using flame atomic absorption method.Result The order of the content of these trace elements in Cancao in northwest China,from high to low,was Ca,Fe,Zn,Mg,Mn,Cu and Cd.There was a difference in the content of these trace elements among Gancao produced from different places.Gancao produced in Qin’an contained Cd and Gancao produced other places had no Cd.Conclusion The content of trace elements has reference value in the quality evaluation and control of Gancao.The wild Gancao produced in Qin’an contains Cd so it is not suitable to be used as medicinal.关键词：different places in northwest China;Gancao（Radix Glycyrrhizae）;trace elements;quantitative determination
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发布时间：2021-05-20 - 摘要：Objective To study the correlation between TCM syndromes and types of Oxfordshire community stroke project（OCSP） in the acute stage of ischemic stroke by applying sequence.Methods The patients（n=846） in the acute stage of ischemic stroke were divided into types according to OCSP.The first time（stroke onset for 1 to 3 days）,the 5th day,7th day,10th day and 14th day were taken as the key time points of syndrome development.The syndromes were reviewed by using Ischemic Stroke TCM Syndrome Factor Diagnostic Scale and the clinical data were analysed by applying sequence in 4230 cases.Results There were 40 rules obtained after searching the development laws of core syndromes from 4 OCSP types gone through 5 time points.The similarity and characteristics of each OCSP type were found out through comparing the core syndromes at the first,middle and final time points of 4 OCSP types.Conclusion There is a correlation between TCM syndromes and OCSP types in the acute stage of ischemic stroke,which reflects the idea of disease-syndrome combination.The study provides the data basis for physicians to grasp the development laws of a disease through patient’s syndromes.关键词：disease-syndrome combination;sequence;ischemic stroke;syndromes;OCSP types
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发布时间：2021-05-20 - 摘要：Objective To evaluate the preventive effect of TCM preventive plan on influenza in community people group,and to provide the base of evidence-based medicine for controlling influenza with Chinese medicine.Methods Among 3166 natural persons from Dongcheng District of Beijing after collecting completed materials,there were 3078 enclosed into final statistical analysis.All persons were randomly divided into adult intervention group,adult control group,senile intervention group and senile control group according to the age and will.The two intervention groups were given oral TCM preventive formula for adult or aged,and the control groups were not given any intervention medicinal.The occurrence of influenza were observed.Results After statistical analysis,the morbidity of influenza was lower in the adult intervention group compared with that in the adult control group,the group without inoculation of Influenza A Vaccine and the group without ordinary inoculation of influenza vaccine.The difference was statistically significant.In the adult groups（with the body index below 30） the morbidity was lower in the adult intervention group compared with that in the adult control group and the difference was statistically significant,but that in the adult groups（with the body index above 30） was not statistically significant.The comparison in the morbidity,inoculation of influenza vaccine and body index between the aged intervention group and aged control group showed that there was no statistical difference.Conclusion The study has proved initially that TCM intervention has the effect of preventing the occurrence of influenza.关键词：influenza;TCM prevention;intervention plan
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发布时间：2021-05-20 - 摘要：Objective To discuss the characteristics,distribution and development laws of TCM syndromes of diabetic nephropathy（DN）.Methods The multicenter,stratified and cross-sectional study was conducted on TCM syndromes based on clinical data collection platform.Results The common TCM syndromes of DN included lassitude of spirit and fatigue,dry throat and mouth,dropsy of face and foot,purplish or dark purplish lips and tongue with stasis maculae,and purple and engorgement of sublingual collateral vessels.The constituent ratio of qi-deficiency syndrome and blood-stasis syndrome in three phases of DN were all over 60%,that of yin-deficiency syndrome tended to decrease and that of yang-deficiency syndrome tended to increase.Dampness-turbidity syndrome was observed in IV and V phases of DN.The constituent ratio of blood-deficiency syndrome was 80% in V phase of DN.The combination of syndrome factors reached dozens and showed the trend as follows: from less to more and from simple to complex.Conclusion TCM syndromes of DN have the characteristics of deficiency complicated with excessiveness,and syndrome factor combination,but the syndrome distribution and development has some regularity.关键词：diabetic nephropathy;TCM syndromes;distribution laws
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发布时间：2021-05-20 - 摘要：Objective To investigate the distribution characteristics of common TCM syndromes and syndrome factors of chronic obstructive pulmonary disease（COPD） in stable stage.Methods The data related to the information of four examinations and syndrome differentiation based on experiences were collected from the patients with COPD in stable stage through multicenter,clinical and epidemiological survey.The data were analysed with descriptive statistics.Results There were 774 cases collected,among them there were 269 pattern types of syndrome differentiation based on experiences.After standardization of names,there were 155 pattern types,of them,there were 20 common syndromes（with the occurrence rate over 1%,similarly hereinafter）.On the basis of syndrome standardization,there were 10 syndrome factors of disease location extracted and common ones were lung,kidney and spleen.There were 16 syndrome factors of disease nature extracted and common ones were phlegm,qi deficiency,fire（heat）,blood stasis,yin deficiency and yang deficiency.Conclusion There are nonstandard descriptions in the names of syndrome differentiation based on experiences in the patients with COPD in stable stage.The pattern types can be summed up as qi deficiency taking deficiency of lung-qi,kidney-qi and spleen-qi as principal ones,deficiency syndrome taking yin deficiency as principal one,excess syndrome taking phlegm,dampness（turbidity）,heat and stasis intertwined with each other in lung as principal ones,and mixture syndrome of deficiency and excess taking deficiency of lung-qi and kidney-qi combined with phlegm-heat obstructing lung as principal ones.It is advantageous to study the syndromes of COPD in stable stage from the angle of syndrome factors.关键词：chronic obstructive pulmonary disease;stable stage;syndromes;syndrome factors;clinical research
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发布时间：2021-05-20 - 摘要：Objective To investigate the basic syndromes and characteristics of acute exacerbation of chronic obstructive pulmonary disease（COPD）.Methods The materials of COPD patients were collected and the statistical description and Logistic regression analysis were conducted by applying SPSS13.0 statistic package.Results Among 1046 COPD cases,there were 18 basic syndromes were observed,and the frequency and constituent ratio of phlegm-heat syndrome reached the highest（60.2% and 12.44% respectively）,those of lung-qi deficiency syndrome and phlegm turbidity syndrome were secondly（46.2% and 9.55%,45.5% and 9.40%,respectively）,and those of heart-yang deficiency syndrome were lowest（5.5% and 1.14% respectively）.The common basic syndromes of acute exacerbation of COPD included phlegm-heat syndrome,phlegm turbidity syndrome,cold fluid-retention syndrome,blood stasis syndrome,lung-qi deficiency syndrome,spleen-qi deficiency syndrome,kidney-qi deficiency syndrome,lung-yin deficiency syndrome,and kidney-yin deficiency syndrome.Conclusion There were 9 common basic syndromes in acute exacerbation of COPD,and the most common one was phlegm-heat syndrome.关键词：chronic obstructive pulmonary disease;acute exacerbation;basic syndromes
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发布时间：2021-05-20 - 摘要：Objective To discuss the curative effect of TCM therapy of clearing away heat,moistening lung and controlling cough and its action for correcting unbalance of type Ⅰ helper T cell/ type Ⅱ helper T cell（Th1/Th2） in patients with cough variant asthma（CVA）.Methods The CVA patients with the syndrome of consumption of body fluid due to lung-heat（n=58） were selected and divided into the treatment group and control group according to randomized,single blind and parallel controlled principle.The treatment group（n=31） was given Qingrerunfeizhike Formula（a dose two times daily） orally for 2 weeks,and the control group was given procaterol（25 ug two times daily） for 2 weeks.The curative effects and the levels of serum interleukin-2（IL-2）,interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α） were observed and compared.Results After 7 days the curative effect on TCM syndromes of the control group was better than that of the treatment group,but after 14 days the curative effect of the treatment group was better than that of the control group.The level of IL-2 increased in the treatment group but not in the control group.The level of IL-6 decreased in two groups and there was no difference between two groups.The level of TNF-α decreased in the treatment group but not in the control group.Conclusion The curative effect on TCM syndromes was better in the treatment group than that in the control group.The mechanism of the therapy of clearing away heat,moistening lung and controlling cough is to stop the cascade of inflammatory mediator through increasing IL-2 level,inhibiting the production and activities of TNF-α and IL-6,and to make the unbalanced Th1/Th2 move to Th1 and relief the inflammatory reaction of air passage.关键词：therapy of clearing away heat,moistening lung and controlling cough;cough variant asthma;type Ⅰ helper T cell;type Ⅱ helper T cell
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发布时间：2021-05-20 - 摘要：Objective To explore the effects of acupuncture on insulin and resistin in rats with type 2 diabetes.Methods All modeled rats were randomly divided into the acupuncture group,Western medicinal group and model group,and other general feeding rats were assigned as the normal group（each n=8）.The acupuncture group was given acupuncture treatment by needling in the acupoints of Housanli[Zusanli（ST36）],Neiting（ST44） and Yishu,the Western medicinal group was given Rosiglitazone orally and the model group,double-distilled water orally,once daily for 4 weeks.The levels of serum insulin and resistin were detected at the end of the experiment.Results In the acupuncture group the level of plasma glucose and blood fat decreased significantly,at the same time,the levels of serum insulin and resistin decreased significantly too.Conclusion Acupuncture can obviously reduce the levels of serum insulin and resistin in rats with type 2 diabetes in order to attenuate insulin resistance.关键词：type 2 diabetes;insulin resistance;insulin;resistin;acupuncture;rats
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发布时间：2021-05-20
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