最新刊期
卷 34 ， 期 1 ， 2011
- 摘要：The orientation of traditional Chinese medicine（TCM） discipline has changed along with the development of science and technology in the 21st century,and the changes have influenced deeply the thinking and behaviors of TCM scholars.The development orient will be,according to the reform demand of TCM discipline,medical procedure guided by natural philosophy,major diseases diagnosed and treated by TCM and Chinese medicinal,and personalized medicine with syndrome differentiation and treatment as main body.The author thought that the evaluation system of TCM curative effect should be completed continuously to obtain common understanding evidences of evidence-based medicine（EBM） and improve the scientificity and technologic accessibility of TCM theory.The accepted standards of TCM industry popularized in Chinese and overseas should be established for promoting the international academic influence of TCM.One of innovation ways of TCM discipline is to learn and apply hermeneutics and EBM.The training of talent and the improvement of academic innovation ability should be paid attention to and science and humanity should be integrated organically.The academic leaders of TCM will know culture and history,perceive metabolomics,pay regard to the observation and experience on characterization and interwoven of multi-disciplines with each other,and lay the foundation for united new medicine and new pharmacology.关键词：Chinese medical sciences;academic development;academic reform;academic innovation
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发布时间：2021-05-20 - 摘要：Atrophy syndrome in Chinese medicine consists of a variety of diseases characterized by flaccidity of hands and feet.The causes include six excesses,seven emotions,improper diet and overstrain.Atrophy syndrome is also named Weibi,Weiyi,Weijue and Jieyi in ancient time.There is a specific chapter-Weilun in Neijing,which emphasizes five zang-viscera,and underlines atrophy syndrome originating from scorched lung and the therapeutic method being to needle only in Yangming Meridians.The doctors of later ages have developed the above-mentioned theory and they focused on three opinions: the first one moved the main point from acupuncture to Chinese medicinal though they abiding by the therapeutic method of needling only in Yangming Meridians.The second one took the therapy of tonifying kidney as core because kidney governing tendons and bones.The third one differentiated the therapeutic methods for atrophy syndrome from impediment syndrome.The essential of treatment of atrophy syndrome is invigoration but not dispelling wind and the essential of treatment of impediment syndrome is dispelling wind but not tonifying deficiency.The therapeutic method of needling only in Yangming Meridians in Neijing stressed acupuncture in Yangming Meridians for clearing Ying and tonifying Shu,regulating qi and blood of the whole body,and helping ancestral sinew to control bones and joints.The doctors of later ages have paid more attention to administrating medicinal for regulating spleen and stomach,strengthening healthy qi,removing dampness and heat,helping transportation and transformation,recovering ascending and descending movement of qi,and supplying more resources for qi and blood.The method of tonifying liver and kidney is a major one in the treatment of atrophy syndrome with medicinal,which can strength tendons and bones.The author believed that acupuncture and medicinal should be integrated in the treatment of atrophy syndrome,i.e.needling in Yangming Meridians combining with tonifying liver and kidney according to syndrome differentiation.The names of Weibi or Weijue were all originated from clinical practice and still have practical significance nowadays.So the opinion that atrophy syndrome should be tonified while impediment syndrome should be purged is improper.关键词：atrophy syndrome;needling in Yangming Meridian;tonigying liver and kidney;Chinese medicine;acupuncture
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发布时间：2021-05-20 - 摘要：Objective To investigate the attitude of most residents to Chinese medicine,and supply relative information to decision-makers,researchers and clinical physicians in TCM field.Methods A simple survey was carried out in the objective views to TCM among Beijing residents who took part in the activities related to TCM.The method of simple anonymous questionnaire,combined with foreign literature,was applied and analysed.There were 224 participants selected to fill in the questionnaire.The questionnaire consisted of 10 simple questions and the participants selected options to answer according to their objective impression.Results Among 224 participants,male accounted to 42.41% and female,to 57.59%.In 33 options of 10 questions there was no statistical difference between male and female,but there was statistical difference in 2 options between participants aged over 60 and those aged below 60.The people group aged below 60 were more interested in TCM and thought Western medicine was more convenient than TCM in practice.Conclusion The results of the survey can make some implications to future strict and large-scale research although it is simple and plain.Because of the popularization of TCM,most of people group have a supportive and positive attitude to it.It is an important orient to transform this attitude into the information being conductive to decision-makers,researchers and clinical physicians in TCM field.关键词：attitude;questionnaire;Chinese medicine
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发布时间：2021-05-20 - 摘要：<正>尊敬的各位专家、学者:由世界中医药学会联合会主办的第四届国际中医心理学学术大会暨第三届中国国际睡眠医学学术大会拟于2011年5月6—8日（星期五星期日）在中国首都北京举行。我们诚挚欢迎各相关领域专家学者积极
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发布时间：2021-05-20 - 摘要：Objective To find an approach that can differentiate TCM symptomatic units from their corresponding normal life manifestations.Methods Twenty electronic works were chosen from Superstar Digital Library after establishing the definite inclusive rules.The normal life manifestation corresponding to every symptomatic unit was classified and found artificially based on 427 symptomatic units extracted from the database of TCM case records of past dynasties,and the characteristics of normal life manifestations differentiating themselves from symptomatic units.Results The normal life manifestations corresponding to TCM symptomatic units could be classified into 25 categories according to the locations and physical functional states.These manifestations had 5 characteristics,showing as short duration,unserious,low frequency,having special physiological stage and definite inducing factor.Conclusion The study will be conducive for collecting the symptomatic units with diagnostic significance and defining the connotation of symptomatic units.关键词：symptomatic units;normal life manifestations;diagnosis of Chinese medicine
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发布时间：2021-05-20 - 摘要：The concepts of eighteen incompatible medicinal and nineteen medicinal of mutual antagonism are the synonym for prohibited combination of Chinese medicinal,which have been believed by physicians of all times.There were,however,literature and clinical records about contrary medicinal used together in formula designing,and the essential of combination of contrary medicinal has been a focus study.Instructions of China Pharmacopoeia Application is one of assorted series of China National Pharmacopoeia and has being indispensable reference for Chinese medical workers in reasonable administration of all types of medicinal,which records the formulas containing couplet medicinal of incompatible medicinal.Instructions of China Pharmacopoeia Application·Chinese medicine Volume（Edition 2005） records totally 1 423 patent formulas,among them there are 18 formulas containing couplet medicinal of incompatible medicinal including 9 containing couplet medicinal of eighteen incompatible medicinal and 9 containing couplet medicinal of nineteen medicinal of mutual antagonism.The frequency of couplet medicinal of contrary medicinal in above-mentioned formulas was analysed,and the functions,dosage forms,usages and ingredients of these formulas were summarized in the paper aiming at studying the usage laws of contrary medicinal combination in clinical practice and guiding reasonable application of eighteen incompatible medicinal and nineteen medicinal of mutual antagonism.关键词：Instructions of China Pharmacopoeia Application;formulas of Chinese medicinal;eighteen incompatible medicinal;nineteen medicinal of mutual antagonism
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发布时间：2021-05-20 - 摘要：<正>《内经》曰:"六府者,传化物而不藏,故实而不能满也。"六腑"实而不满"的运动特点决定其"以通为用"的治疗特点。善治脾胃病并以补气升阳见长关键词：李东垣;腑病;通腑法
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发布时间：2021-05-20 - 摘要：<正>《肘后备急方》是东晋葛洪撰写的一部医书。现存本《肘后备急方》已非葛氏之书原貌,而是历经3人之手而成。葛洪先编写了《玉函》一书,从书中选取其要,成《肘后救卒》三卷,共八十六首。梁代关键词：附广肘后方;杨用道;官职
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发布时间：2021-05-20 - 摘要：Objective To develop a standardized measuring tool for evaluating TCM syndromes of sub-health state.Methods Through determining the concept of sub-health state and TCM basic syndromes,constructing questionnaire frame and item pool,making questions and answers,carrying out pre-investigation,testing the reliability and validity,and revising the questionnaire,the questionnaire for evaluating TCM basic syndromes of sub-health state was developed according to the principles and steps of questionnaire design combining with literature research,expert consultation and TCM basic theory.Results A questionnaire was developed combined with self-assessment and interviews,which included 9 dimensions-liver depression syndrome,liver-qi deficiency syndrome,spleen-qi deficiency syndrome,liver-fire syndrome,heart-fire syndrome,stomach-fire syndrome,heart-qi deficiency syndrome,lung-qi deficiency syndrome and dampness syndrome,and 66 items（50 items of them for five-class quantization）.Conclusion The questionnaire can quantize the TCM syndromes in sub-health population to some extent,find out the characteristics of TCM basic syndromes of sub-health state through epidemiological investigation in high-risk people group,and supply a standardized tool for syndrome classification study in sub-health people group.关键词：sub-health;syndromes;questionnaire;factor analysis;correlation analysis;rank test
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发布时间：2021-05-20 - 摘要：Objective To reveal the promoting mechanism of Naomaitong on cerebral angiogenesis after cerebral ischemia/reperfusion（I/R） in aged rats based on the expressions of fetal liver kianse-1（Flk-1）.Methods Male and aged SD rats were randomly divided into the sham-operation group,model group,nimodipine group and Naomaitong group.The microvessel density（MVD） of brain tissue,area of vascular field,and expressions of Flk-1 and Flk-1-mRNA were detected by using immunohistochemistry and hybridization in situ.Results Compared with the model group at the same time point,both MVD [ischemia（I） for 3 h,and I/R for 1 d,3 d and 12 d] and area of vascular field（I for 3 h,and I/R for 3 d,6 d and 12 d） in the Naomaitong group were increased（P<0.05,P<0.01）.Compared with the nimodipine group,both MVD（I/R for 12 d） and the area of vascular field（I for 3h） in Naomaitong group were increased（P<0.01）.In the model group MVD lasted to descend from I for 3 h to I/R for 12 d,the are of vascular field reached peak after I/R for 1 d,then decreased quickly,and reached the lowest level after I/R for 12 d.The area of vascular field（I/R for 1 d） reached peak,then decreased quickly and to the lowest level after 12 days.In the Naomaitong group MVD increased significantly after I for 3 h,reached peak after I/R for 1 d,then started to decrease after,reached the lowest level after I/R for 6 d,and increased significantly after I/R for 12 d,and the area of vascular field increased significantly after I for 3 h,decreased to the lowest level after I/R for 1 d,increased a little after I/R for 3 d,decreased again after I/R for 6 d,and then increased again and recovered to the level of I/R for 3 d after I/R for 12 d.The expressions of Flk-1 in the Naomaitong group at all time points increased compared with the model group（P<0.05,P<0.01）.Compared with the nimodipine group,expressions of Flk-1 in the Naomaitong group after I/R for 1 d,6 d and 12 d increased（P<0.05,P<0.01）,while decreased after I/R for 3 d（P<0.01）.In the model group the expression of Flk-1 began to increase after I for 3 h,reached peak after I/R for 1 d,and decreased rapidly after I/R from 1 d to 12 d.In the Naomaitong group the expression of Flk-1 performed better after I for 3 h,reached peak after I/R for 3 d,then decreased a little,but still kept a higher level after I/R for 12 d.Compared with the model group at the same time point,expression of Flk-1-mRNA increased（P<0.01） in the Naomaitong group,and increased after I/R for 6 d and 12 d（P<0.01） compared with the nimodipine group.In the model group the expression of Flk-1-mRNA reached peak after I/R for 1 d and decreased fast after I/R from 1 d to 12 d.In the Naomaitong group the expression of Flk-1-mRNA was higher after I for 3 h,reached peak after I/R for 1 d,then decreased gradually,and still kept a higher level after I/R for 12 d.Conclusion Naomaitong can promote angiogenesis after cerebral ischemia/ reperfusion in the aged,and the mechanism of which may be related to the increase of expressions of Flk-1 and Flk-1-mRNA.关键词：Naomaitong;aged;cerebral ischemia/reperfusion;angiogenesis;fetal liver kianse-1;rats
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发布时间：2021-05-20 - 摘要：<正>北京中医药大学主办学术刊物的网上采编系统已开通,包括《北京中医药大学学报》(http://xb.bucm.
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发布时间：2021-05-20 -
Promoting effect of 3′-daidzein sulfonate sodium on apoptosis of human breast cancer cell line MCF-7
摘要：Objective To study the promoting effect of 3′-daidzein sulfonate sodium on apoptosis of human breast cancer cell line MCF-7.Methods Three breast cancer cell lines（MCF-7,MDA-MB-231 and SK-BR-3） were incubated with 3′-daidzein sulfonate sodium of different concentrations for 24 hours.The cell viability was detected by using MTT assay and apoptosis was detected by applying flow cytometry and Hoechst 33258 staining.Results The growth of three breast cancer cell lines（MCF-7,MDA-MB-231 and SK-BR-3） were inhibited by 3′-daidzein sulfonate sodium and IC50 were,respectively,656 μmol/L,798 μmol/L and 735 μmol/L.The analysis on MCF-7 by Hoechst 33258 staining and flow cytometry showed the same results.The apoptosis rates of MCF-7 induced by 3′-daidzein sulfonate sodium in the concentrations of 656 μmol/L and 900 μmol/L) were,respectively,（16.4%±3.2%） and（38.0%±4.1%）.Conclusion 3′-daidzein sulfonate sodium can inhibit the proliferation of human breast cancer cell line MCF-7 and induce its apoptosis.关键词：3′-daidzein sulfonate sodium;apoptosis;breast cancer;tumor cells- 12
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发布时间：2021-05-20 - 摘要：Objective To study the influence of curcumin（Cur） on chromosomal aberration induced by cyclophosphamide（CTX,chemotherapeutics）.Methods Kunming mice were randomly divided into the normal group,Cur group（100 mg/kg）,model group,and group of CTX+low-dose Cur（low-dose group,50 mg/kg）,group of CTX+mid-dose Cur（mid-dose group,100 mg/kg）,group of CTX+high-dose Cur（high-dose group,200 mg/kg）.The normal group（negative control group） was fed basic forage.The model was established by intraperitoneal injection of CTX for 2 times in the dose of 50 mg/kg with 24 hours interval between 2 times.The model group was injected only CTX,and the Cur group,low-dose group,mid-dose group and high-dose group were given relevant medicinal intragastrically once a day 4 weeks before CTX injection.All mice were sacrificed 24 hours after the last CTX injection.The mice were injected intraperitoneally with 0.04% colchicine（0.1 mL/10 g wt） 2 or 3 hours before sacrifice for accumulating mitotic figures.The femoral bones from the mice were collected to prepare chromosomal samples.The situation of chromosomal aberration,the total aberration rate and aberration rate of different chromosome types were observed by using Giemsa staining.Results Cur decreased significantly the deletion of chromosomal ends and formation of chromosomal fragments induced by CTX.The comparison between the Cur group and normal group showed no difference and Cur had no teratogenicity.The aberration rate was significantly lower in the low-dose group,mid-dose group and high-dose group than that in the model group（P<0.05,P<0.01）,and was,respectively,19.65%,37.08% and 17.22% showing the most significant influence in the mid-dose group.The deletion rate of chromosomal ends decreased significantly in the Cur groups of different doses（P<0.05）,and there was no difference in the formation of polyploidy compared with the model group.The formation rate of chromosomal fragments was reduced significantly in the mid-dose group（P<0.01）.Conclusion The results showed that Cur can reduce the chromosomal aberration induced by CTX,and has a significant preventive effect on chromosomal damage.关键词：curcumin;cyclophosphamide;chromosomal aberration;mice
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发布时间：2021-05-20 - 摘要：<正>据中国科学技术信息研究所发布的《2010中国国内科技论文产出状况》报道,《北京中医药大学学报》2005年28卷第4期刊登的王琦教授学术论文——"9种基本中医体质类型的分类及其诊断表述依据",入选
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发布时间：2021-05-20 - 摘要：Objective To study the chemical constituents of volatile oil in the aerial part and underground part of Gansong（Rhizoma Nardostachydis）.Method The chemical constituents of volatile oil were extracted from the aerial part and underground part of Gansong by applying steam distillation.The chemical constituents were analysed and identified by using gas chromatography-mass spectrometry（GC-MS）.Result The volatile oil in the aerial part of Gansong was extracted for the first time and from which 40 compounds were identified（77.32% of the total volatile oil）,and from the underground part of Gansong 36 compounds were identified（88.02% of the total volatile oil）.There were 20 common compounds in both parts and accounted for 57.69% and 85.06% of the total volatile oil,respectively.The main compounds of volatile oil in both parts of Gansong all included calarene,β-maaliene,α-gurjenene,aristolene,patachouli alcohol,and [1R-（1.alpha.,4a.bata.,8a.alpha.）]-decahydro-1,4a-dimethyl-7-（1-methylethylidene）-1-naphthalenol.Ledene oxide（Ⅱ） was only extracted from the underground part of Gansong and its content was just next to that of calarene.Conclusion The result of the study shows that the main constituents of both parts of Gansong are almost the same,but there are a little difference in kinds and content.The result can be taken as a base for the further development and utility of Gansong.关键词：Gansong（Rhizoma Nardostachydis）;aerial part;underground part;volatile oil;gas chromatography-mass spectrometry
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发布时间：2021-05-20 - 摘要：Objective To determine the minimum pre-freezing temperature of Danshen（Radix Salviae Miltiorrhizae） liquid in different concentrations.Method The eutectic points of Danshen liquid in different concentrations were detected by using resistance method,and the pre-freezing temperature was determined.Result The eutectic points of Danshen liquid in 100 g/L,150 g/L and 200 g/L were,respectively,-19 ℃,-23 ℃ and-28.8 ℃,and the corresponding minimum pre-freezing temperature was,respectively,-24 ℃ to-29 ℃,-28 ℃ to-33 ℃ and-33.8 ℃ to-38.8 ℃.Conclusion The properties of lyophilized powder of Danshen is good at the minimum temperature determined in this test,and the content of index constituents accord with the quality standard.关键词：lyophilized powder of Danshen（Radix Salviae Miltiorrhizae）;temperature of eutectic point;resistance;pre-freezing temperature
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发布时间：2021-05-20 - 摘要：Objective To optimize the penetrating agents for Gushang Gel Paste,and study their percutaneous absorption behavior and release rate in vitro.Methods Franzs diffusion cell test and HPLC were applied to optimize the penetrating agents for Gushang Gel Paste and their percutaneous absorption and release rate were detected taken normal saline water as reception liquid,and 24-hour accumulative osmosis dose and anatonosis times of naringin as indexes.Results When taking azone and propylene glycol as penetrating agents the percutaneous absorption was good,and finally the ratio of azone to propylene glycol was set at 1∶1 with a dose of 5%.The accumulative release rate of naringin was 83.48% and accumulative percutaneous absorption was 46.59%.The release in vitro and percutaneous absorption all accorded with Weibull distribution equation.Conclusion When azone and propylene glycol are added into Gushang Gel Paste,the percutaneous absorption of which is increased significantly,and the percutaneous absorption and release rate are favorable.关键词：gel paste;penetrating agents;percutaneous absorption;release in vitro
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发布时间：2021-05-20 - 摘要：Objective To study the correlation between stroke syndrome factors of stroke and neurological impairment scores.Methods The patients with acute cerebral infarction（n=163） were chosen and the information of TCM four diagnostic methods was collected.The syndrome factors were extracted according to the Stroke Syndrome Diagnostic Criteria,and neurological impairment was scored according to the National Institutes of Health Stroke Scale（NIHSS）.Results The scores of fire,phlegm and qi-deficiency were correlated to the scores of NIHSS.The scores of NIHSS increased gradually as the number of concurrent syndrome factors increasing and the correlation coefficient（r） between them was 0.218（P<0.05）.Most patients were those with wind,phlegm and blood stasis when they just hospitalized,and after the treatment the numbers of patients with wind or blood stasis decreased significantly but those with other syndrome factors had no changes.The scores of NIHSS had no significant difference in the patients with one of syndrome factors when they just hospitalized and hospitalized for 14 days.After hospitalized for 14 days the most of the patients had less scores of syndrome factors and NIHSS but the changes of syndrome factor scores and NIHSS scores had no statistical difference.Conclusion The scores and concurrent of syndrome factors are correlated to neurological impairment.The complexity and diversity of scores and combination of stroke syndrome factors can reflect the severity of stroke to a certain extent.关键词：stroke;syndrome factors;neurological impairment scores;correlation
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发布时间：2021-05-20 - 摘要：<正>《北京中医药大学学报》是由教育部主管、北京中医药大学主办的中央级的高级中医药学术期刊,主编为中国中医界学术权威王永炎院士。本刊分别属
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发布时间：2021-05-20
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