最新刊期
卷 0 ， 期 0 ， 2020
- 摘要：The TCM theory of Shaoyang includes triple energizer of Hand-Shaoyang and gallbladder of Foot-Shaoyang,and they connect each other closely both in physiology and pathology.The concept of triple energizer is relatively obscure and abstract.Triple energizer membrane system is raised on the base of summarizing and refining author’s clinical experience for several decades,which tries to explain the meaning of triple energizer and makes it become from abstract to concrete.The physiological and pathological characteristics of triple energizer membrane system were proofed according to the words in Neijing,Nanjing and Shanghanlun.The author thinks that triple energizer membrane system can be divided into two systems,outside connective membrane system and inside connective membrane system.The formation and structure of triple energizer membrane system are closely related to not only the functions of kidney,heart,lung,liver and gallbladder,but also qi movement,circulation of nutrient and blood,and attacking and hiding of pathogens.They influence on each other and develop in syndromes at all levels through triple energizer membrane system.The concept of triple energizer membrane system is commonly used to analyse and sum up the pathogenesis of complicated syndromes.External pathogens attack firstly the outside connective membrane system,and then the inside connective membrane system in course of time to induce the obstruction of blood circulation and disorder of heart and liver.The damage of triple energizer membrane system is both beginning and terminal point of development of a disease.关键词：Shaoyang;triple energizer;membrane system;pathogenesis
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发布时间：2021-05-20 - 摘要：<正>燥、湿二气的病因、病机学说起源于秦汉,发展于金元,争鸣于明清。清.黄元御《四圣心源》"医家识燥湿之消长,则仲景之堂奥可阶而升",强调辨别燥湿为辨证论治的捷径与升堂入室的台阶,将燥湿之辨提高到纲领的地位。清代新安医家余国珮创造了一套独具特色的"燥、湿"理法方药思想,其后石寿棠大加阐发。关键词：新安;余国珮;燥;湿
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发布时间：2021-05-20 - 摘要：The thinking train of treatment of ulcerative colitis from lung was expounded based on the theory of lung and large intestine being interior-exteriorly related.The author indicated that the location of ulcerative colitis was in the large intestine and at blood aspect,and it was induced by qi stagnation and blood stasis involving lung.This disease should be treated by tonifying lung and supplementing qi from interior to exterior,dispersing lung-qi,harmonizing qi and blood,transporting body fluid,considering spleen and stomach,and preventing it transmission and development.The paper has provided a new thinking train and method for the treatment of ulcerative colitis with Chinese medicine.关键词：ulcerative colitis;treatment from lung;lung and large intestine being interior-exteriorly related
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发布时间：2021-05-20 - 摘要：The acute stage of ischemic stroke is the crucial period in its development.Chinese medicine plays an important role in the treatment of ischemic stroke of acute stage.Through analyzing clinical and experimental researches and combining TCM theory,the author believed that the main pathogenesis of ischemic stroke of acute stage was heat-toxin and blood stasis,and the therapy for it was to clear heat,remove toxin and activate blood circulation.关键词：ischemic stroke of acute stage;clearing heat and removing toxin;activating blood circulation;Qingkailing
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发布时间：2021-05-20 - 摘要：<正>《正续一切经音义》（以下简称《音义》）是唐释慧琳《一切经音义》一百卷（以下简称《慧琳音义》）和辽释希麟《续一切经音义》十卷（以下简称《希麟音义》）的合刊本,书中保存了丰富的医学资料。本文就其中的病证名进行了搜集整理并以"癫痫"和"痰饮"为例进行探讨。关键词：正续一切经音义;病证名;癫痫;痰饮
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发布时间：2021-05-20 - 摘要：<正>《四库全书》是中国古代最大的丛书,编撰于清代乾隆年间。其医家类收书百余种（含附）,共1800多卷,可以说历代医学名著要籍基本上都被选入。它的编订首先要归功于全书的总纂官纪昀。不过,纪昀要宏观负责四部书籍,虽亦参与所选医籍内容提要的撰写,但具体编纂的主要协关键词：劳树棠;四库全书总目;医家类
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发布时间：2021-05-20 - 摘要：<正>年鉴是年度性的工具书。年鉴的英文是year-book,由年和书组成,意思是一个年度的书,我国译为年鉴。年鉴以年为期,一年一鉴,收录上一个年度1月1日至12月31日完整的信息。北京中医药大学年鉴条目编撰的主要任务是记录学校上一年度教育教学的基本情况、重要工作和重大事件,反映学校教育教学改革和发展中的突出成绩和基本经验,为关键词：年鉴;条目;北京中医药大学年鉴
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发布时间：2021-05-20 - 摘要：<正>王玉川教授为人谦和儒雅,平时言语不多,他对中医理论研究之深,对中医学术评析之严谨,不是一般学者所能相比,其文章笔锋犀利,思想敏锐,分析入理,展示了一代国医大师的风范,现将他的学术思想作一探讨分析。1承古而不泥于古,立足于创新王玉川教授1941年师从于当时的中医名家戴关键词：国医大师;王玉川;学术思想
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发布时间：2021-05-20 - 摘要：Objective To study the changes of expressions of cerebral interferon-γ（IFN-γ） and interleukin-4（IL-4） in spleen-deficiency rat model,and the interventional effects of Chinese medicinal with actions of replenishing qi and reinforce the healthy qi.MethodsAll rats（n=40） were randomly divided into the normal group,model group,treatment group 1（T group 1,treated with Sijunzi Decoction） and treatment group 2（T group 2,treated with Yupingfeng Powder,each n=10）.The spleen-deficiency model was established in rats by using the methods of purgation,improper diet and over strain.The indexes of immune organs were detected by applying weighing method.The expressions of cerebral IFN-γ,IL-4 and IFN-γ-mRNA in the ventral nucleus of hypothalamus and CA1 zone of hippocampus,and therapeutic effects of Sijunzi Decoction and Yupingfeng Powder were detected by applying immunohistochemistrical assay and in situ hybridization.ResultsIn the model group the indexes of thymus and spleen,and IFN-γ expression decreased significantly,and IL-4 expression increased significantly in the ventral nucleus of hypothalamus and CA1 zone of hippocampus.In T group 1 and T group 2 the indexes of thymus and spleen,and IFN-γ and IFN-γ-mRNA expressions increased significantly,while LI-4 expression decreased significantly.ConclusionSijunzi Decoction and Yupingfeng Powder,with the actions of replenishing qi and reinforce the healthy qi,can regulate the immunologic function of the body through influencing immune organs and controlling the expressions of brain IFN-γ and IL-4.关键词：spleen-deficiency rats;cytokines;interferon-γ;interleukin-4;Chinese medicinal with actions of replenishing qi and reinforce the healthy qi
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发布时间：2021-05-20 - 摘要：Objective To observe the influences of astragalus polysaccharides（APS） on genetic transcription of P-selectin and E-selectin in human cardiac microvascular endothelial cells（HCMEC） after ischemia-reperfusion injury,and explore the protective mechanism of APS to myocardium injured by ischemia-reperfusion.MethodsHCMEC cultured from primary to fifth generation were divided into the normal group,model group,low-dose APS group（25 mg/L）,high-dose APS group（100 mg/L） and PDTC group（50 μmol/L）.The model of ischemia-reperfusion injury was established by using the methods of oxygen-glucose deprivation and oxygen-glucose recovery.The genetic transcription of P-selectin and E-selectin was detected by applying real time fluorescent quantitative polymerase chain reaction（RT-PCR）.ResultsThe mRNA transcriptions of P-selectin and E-selectin increased significantly in the model group compared with the normal group（P<0.01）,and decreased significantly in the low-dose APS group and high-dose APS group compared with the model group（P<0.05）.ConclusionAPS can inhibit the genetic transcription of P-selectin and E-selectin in HCMEC after ischemia-reperfusion injury,and prevent microvascular endothelial cells injured by ischemia-reperfusion from inflammatory adhesion.关键词：astragalus polysaccharides;P-selectin;E-selectin;ischemia-reperfusion injury
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发布时间：2021-05-20 - 摘要：Objective To study the influences of acupuncture in acupoints and non-acupoints on brain resting state function network by applying functional magnetic resonance imaging（fMRI）,and to provide scientific evidence for exploring further the neural mechanism of acupuncture.MethodsTwenty health university students were selected and divided randomly into the acupoint group and non-acupoint group.The acupoint group was given acupuncture in Baihui（GV20）,Fengchi（GB20,both sides） and Neiguan（PC6,both sides）,while the non-acupoint group was given acupuncture in the sites 1.5 cm to 2.0 cm asides of the above mentioned acupoints.After 30 minutes,all students were given immediate fMRI scan for collecting fMRI data.The different brain regions of regional homogeneity（ReHo） were obtained through ReHo computing,which were then taken as seed points to compute the functional connectivity（FC） between them and other brain voxels.ResultsThe difference of brain resting state between two groups demonstrated mainly in left fusiform gyrus,left inferior temporal gyrus and left insula with statistical significance.The analysis of FC at the seed point of left insula showed that the influences of acupoint-needling and non-acupoint-needling on brain FC mode were different,which was stronger in left insula and right middle frontal gyrus in the acupoint group.ConclusionThe influences of acupuncture in GV20,GB20 and PC6 on brain resting state function network showed the specific of acupoints.The effects of acupuncture in GV20,GB20 and PC6 for improving intelligence,awakening consciousness and improving memory may be related to that acupuncture can strengthen the activities of left fusiform gyrus,inferior temporal gyrus and insula at resting functional state,such as promoting the functional connection of memory-related or learning-related cerebral regions through the significant increase of FC in left insula and right middle frontal gyrus.关键词：functional magnetic resonance imaging;resting state;acupuncture;acupoints
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发布时间：2021-05-20 - 摘要：Objective To discuss the role of lateral intracerebroventricular injection of substance P（SP） in the treatment of focal cerebral ischemia with electroacupuncture.MethodsAll 50 modeled Wister rats were randomly divided into the model group,normal saline solution group（NS group）,SP group,electroacupuncture group（EA group） and SP and EA group（SP+EA group） and a control group was set additionally（each n=10）.The rat model of focal cerebral ischemia was established by using middle cerebral artery occlusion（MCAO）.The NS group and SP group were given lateral intracerebroventricular injection of NS or SP respectively after MCAO.The EA group was given electroacupuncture at the same time of MCAO.The SP+EA group was given intracerebroventricular injection of SP on the base of electroacupuncture after MCAO.The Zea Longa graded approach of 6 grades was used for neuroethology scoring.The cerebral ischemia area was detected by applying staining of triphenyl tetrazolium chloride（TTC） and immunohistochemistry was used to detect SP expression in brain tissue.ResultsCompared with the model group and NS group,the neuroethology scores decreased significantly in the EA group 24 hours after MCAO（P<0.05）,and were significantly lower in the SP+EA group than those in other groups（P<0.01）.Compared with the model group and NS group,the cerebral ischemia area was reduced significantly in the EA group and SP+EA group 24 hours after MCAO（P<0.01）.The content of SP in cerebral cortex and hippocampus were significantly higher in the SP+EA group than those in the model group（P<0.01,P<0.05）.ConclusionThe lateral intracerebroventricular injection of SP can improve the curative effect of electroacupuncture in the treatment of focal cerebral ischemia.关键词：focal cerebral ischemia;substance P;lateral intracerebroventricular injection;electroacupuncture;rats
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发布时间：2021-05-20 - 摘要：Objective To establish a determination method of HPLC for plasma concentration of naringin,neosperidin and saikosaponin b2 in effective fraction of Weineng Formula in rats.MethodsThe protein in plasma samples were precipitated with methanol and HPLC was used for determine the plasma concentration.The procedure of HPLC was performed on the chromatographic column of Agilent Eclipse XDB-C18（4.6 mm×250 mm,5 μm）,and the mobile phase was acetonitrile-0.1% phosphoric acid solution in the gradient elution.The flow velocity was 1 mL/min and detection wavelength was 280 nm and 254 nm.ResultsThe lowest limit of detection concentration of all constituents was ranged from 0.067 to 0.272 mg/L.The average recovery was higher than 85% and RSD of intra-day and RSD of inter-day were all below 10%.ConclusionThe method was simple and accurate,which can be used in the quantitative analysis for plasma concentration of 3 constituents,including naringin,in effective fraction of Weineng Formula.关键词：naringin;neosperidin;saikosaponin b2;HPLC;quantitative determination;plasma concentration;rats
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发布时间：2021-05-20 - 摘要：Objective To verify the rationality of genuine producing areas recorded in literature through comparing and studying the content of active principles in Danshen（Radix Salviae Miltiorrhizae） from 5 genuine producing areas and 3 non-genuine producing areas recorded in herbal literature.MethodsThe material of Danshen of 12 batches were collected from 5 genuine producing areas and 3 non-genuine producing areas and the quantitative determination of 3 active principles,salvianic acid A sodium,cryptotanshinone and tanshinone ⅡA,was carried out by using HPLC.ResultsThe content of active principles were higher in Danshen from the genuine producing areas including Shanxi（S1）,Henan（S2,S8） and Shandong（S6）,and lower in Danshen from 2 genuine producing areas including Hubei（S9） and Sichuan（S11） and 2 non-genuine producing areas including Hebei（S3） and Beijing（S12）.ConclusionThe study has verified partially the rationality of genuine producing areas of Danshen recorded in literature,and laid a foundation for further study.关键词：herbal literature;genuine producing area;Danshen（Radix Salviae Miltiorrhizae）;HPLC
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发布时间：2021-05-20 - 摘要：Objective To explore the mechanism of Yisuishengxue Formula in the treatment of thalassemia.MethodsThe changes of hemoglobin（Hb）,red blood cell count（RBC）,reticulocyte count（Ret） and fetal hemoglobin（HbF） were observed before and after treatment in 30 children patients treated with Yisuishengxue Formula.The influences of Yisuishengxue Formula on the gene expressions of transcriptions,including GATA-binding protein-1（GATA-1）,GATA-2,erythroid Krüppel-like factor（EKLF）,Krüppel-like transcription factor（FKLF） and nuclear factor erythriod 2（NF-E2） in karyocytes were detected in 10 children patients by using real-time fluorescence quantitative polymerase chain reaction（RT-PCR）.ResultsAfter the treatment,all hematologic parameters were improved in the patients and were significant（P<0.01） compared with those before the treatment.The gene expressions of GATA-1,GATA-2 and NF-E2 increased and were significant compared with those before the treatment（P<0.01,P-<0.05）.The differences in gene expressions of EKLF and FKLF were no significant before and after the treatment.ConclusionYisuishengxue Formula can relieve the symptoms of the patients with thalassemia.It controls the expression of globin gene cluster and improves the generation of effective erythrocytes through regulating the expressions of erythroid specific trans-acting factors,which is one of molecular mechanisms of its therapeutic effect.关键词：thalassemia;Yisuishengxue Formula;erythroid specific trans-acting factors;gene expression
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发布时间：2021-05-20 - 摘要：Objective To investigate the syndrome rules of chronic severe hepatitis B.MethodsThe patients with chronic severe hepatitis B（n=260） were selected from 10 hospitals and the patients with chronic hepatitis B（n=113） were selected as control.A symptological survery was conducted and the rules of syndrome distribution were explored.ResultsThe common syndrome types of pathogen excessiveness included blood stasis in liver and spleen（66.2%）,internal accumulation of water turbidity（41.5%）,obstruction of damp turbidity（37.3%）,accumulation of damp-toxin（27.6%）,flourishing of heat-toxin（21.5%）,and heat in blood（11.9%）.The common syndrome types of deficiency of the root included liver-kidney yin deficiency（50.0%）,spleen-qi deficiency（33.4%）,kidney-qi deficiency（29.6%）,liver-yang deficiency（25.7%）,spleen-kidney yang deficiency（22.3%）,and liver-qi deficiency（20.7%）.Two major syndrome types were internal accumulation of yin-toxin and internal domination of yang-toxin,and the syndrome of internal accumulation of yin-toxin accompanying by internal domination of yang-toxin was concurrent of yin-toxin and yang-toxin.In the combination of multiple syndromes,the percentage of syndrome of blood stasis in liver and spleen,liver-spleen-kidney qi deficiency,and liver-spleen-kidney yang deficiency were all higher in internal accumulation of yin-toxin,second in concurrent of yin-toxin and yang-toxin and less in internal domination of yang-toxin,and the comparison was significant（P<0.05）.The percentage of liver-kidney yin deficiency was higher in concurrent of yin-toxin and yang-toxin,second in internal accumulation of yin-toxin and less in internal domination of yang-toxin.ConclusionThe patients with chronic severe hepatitis B can be differentiated to the syndrome of internal accumulation of yin-toxin,internal domination of yang-toxin,and concurrent of yin-toxin and yang-toxin.The combinations of multiple syndromes are mainly blood stasis in liver and spleen,liver-kidney yin deficiency,liver-spleen-kidney qi deficiency,and liver-spleen-kidney yang deficiency.The thinking train in syndrome differentiation of yin-toxin and yang-toxin syndrome of chronic severe hepatitis B takes toxin,stasis and deficiency as the core of pathogenesis,and yin and yang as principle.关键词：chronic severe hepatitis;hepatitis B;disease causes and pathogenesis;syndrome rules
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发布时间：2021-05-20 - 摘要：Objective To observe the curative effect of modified Yueju Decoction on impaired glucose tolerance（IGT） of type of qi stagnation and phlegm retention.MethodsThe patients of IGT of qi stagnation and phlegm retention（n=90） were randomly divided into the blank group（n=30）,Chinese medicinal group（n=30） and Western medicinal group（n=30）,and was,respectively,given the basic treatment,basic treatment and Yueju Decoction and basic treatment and acarbose.The changes of plasma glucose,glycated hemoglobin（HbA1c）,insulin function,lipid metabolism and body mass index（BMI） were observed,and the outcomes of three groups were reviewed after the treatment.ResultsCompared with the blank group,the levels of 2-hour postprandial blood glucose（PBG） and HbA1c decreased significantly and insulin（INS） increased（P<0.01）,and the indexes of triglyceride（TG）,total cholesterol（TC）,low-density lipoprotein（LDL） and BMI were improved significantly（P<0.05） in the Chinese medicinal group and Western medicinal group.The transformation rate of normal glucose tolerance（NGT） was higher in the Chinese medicinal group and Western medicinal group than that in the blank group（P<0.05）.ConclusionModified Yueju Decoction can relieve IGT,improve insulin function and correct the disorder of lipid metabolism.It can reverse IGT to normal glucose tolerance to a certain degree and the curative effect is as same as acarbose.关键词：impaired glucose tolerance;intervention with Chinese medicinal;Yueju Decoction
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发布时间：2021-05-20 - 摘要：Objective To study the improvement effect of practicing Baduanjin on the life quality in people group of fatigue-predominant sub-health.MethodsThe cohort method was used to divide the subjects into the Baduanjin cohort and control cohort,and they were observed for 6 weeks.On the first day and the end of 6th week,the questionnaires（SF-36） were used respectively to survey the healthy state of the subjects and compare the changes of life quality in two cohorts.ResultsAmong 129 subjects,there were 62 in the Baduanjin cohort and 67 in the control cohort.The comparison between the data of end of 6th week and baseline data showed that the scores of general health（GH）,physiological function（PF）,role-physiology（RP）,role-emotion（RE）,vitality（VT） and mental health（MH） all increased significantly in the Baduanjin cohort,and only the score of GH increased significantly in the control cohort.The score of bodily painful（BP） decreased significantly in two groups.The difference comparison between the data of end of 6th week and baseline data showed that the differences of PF,RP and RE were positive in the Baduanjin cohort,and higher significantly that those in the control cohort.In the Baduanjin cohort the difference of BP score at the end of 6th week was negative and lower significantly than that in the control cohort.ConclusionPracticing Baduanjin can improve the life quality of people of fatigue-predominant sub-health.关键词：baduanjin;fatigue-predominant sub-health;life quality
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发布时间：2021-05-20 - 摘要：Objective To get know the cognitive level and management of chronic obstructive pulmonary disease（COPD） in community doctors in Beijing urban.MethodsA questionnaire of COPD was designed under the guideline of COPD experts,and then used in the community doctors who had taken part in the continuing education classes for 4 times held by the Beijing Community Health Association from Jan.to June in 2010.The survey content included the cognitive level of COPD,knowledge on medicinal used in treatment,cognition on the education and management of COPD at stable stage by community doctors,their desire or ability for taking care COPD patients,and the expectation on COPD special training and improvement of community health stations.ResultsAmong 865 doctors 72.9% of them thought that COPD should be listed into community management of chronic diseases,54.6% believed that community stations could manage COPD patient well,55.8% have not accepted COPD special training,34%-40% knew COPD nature,23% understood the standard of COPD severity grades,only 74 doctors（8.6%） believed that they have been aware of current and common inhalation and its usages,80% thought that the patients with COPD at stable stage were needed long-term treatment,but 76.1% did not know the therapeutic plan and could not give standardized treatment,and over 70% understood the importance of health education,no-smoking,nutrition status and psychological counseling towards the recovery of the patients,but only 40% have given the health education to the patients.ConclusionMost of community doctors know the importance of management of COPD at stable stage,and are willing to improve the management.Currently the community management of COPD patients has not been carried out effectively due to limited special knowledge and shortage of manpower.It is request to promote the levels of cognition and management of COPD in community doctors.关键词：chronic obstructive pulmonary disease;community doctors;cognitive level;community management;survey
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发布时间：2021-05-20 - 摘要：<正>北京中医药大学主办学术刊物的网上采编系统已开通,包括《北京中医药大学学报》（http://xb.bucm.edu.cn）、《中医教育》（http://zyjy.bucm.edu.cn）、《北京中医药大学学报（中医临床版）》（http://xblc.bucm.edu.cn）。请广大作者和读者登录相应网址投稿、査稿或阅读最新目录,欢迎在使用系统过程中提出
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发布时间：2021-05-20
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