最新刊期
卷 0 ， 期 0 ， 2020
- 摘要：Holistic concept is major characteristics of thinking of the Chinese nation.Chinese language carries the unique thinking of our nation in Chinese history for thousands years.Chinese language and the way of thinking of Chinese traditional culture,science and technology impact each other.TCM holistic concept reflected in the unity of heaven and man is closely related to the holistic thinking of Chinese language,which reflects the people-oriented spirit of the Chinese nation.Although TCM holistic thinking has the weakness of indistinct,it has a very rich organic or systemic holism,the feature of dialectical thinking,and profound methodology and epistemology sense.It can play an important role in the concordance process of modern holistic methodology.关键词：Chinese language;traditional Chinese medicine;holistic thinking
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发布时间：2021-05-20 - 摘要：<正>"洞泄"这一古病证名称,散见于传世本《黄帝内经》。然考察古今学者相关注解,不难发现诸家对于"泄"为"泄利""泄泻"之义绝无争议,而对于"洞"字含义为何多置之不理,现有的解释也远未能在学术界达成共识。"洞"字含义不明,这必然会妨碍我们对洞泄的理解,故笔者尝试从《内经》文本出关键词：黄帝内经;洞泄;迵风;风邪
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发布时间：2021-05-20 - 摘要：<正>本草学术的发展一般由该时期的本草著作状况来反映。民国时期（1912年1月—1949年9月）作为一个独立的社会历史时期,在中国近代史乃至整个中国历史上有着重要的影响。由于仅有38年历史的民国一直处于军阀割据、战争频繁、政局动荡、经济衰退的特殊年代,学术界一般认为民国时期的时代背景对关键词：民国时期;本草著作;出版;馆藏
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发布时间：2021-05-20 - 摘要：Objective To study the characteristics of sound frequency in women with different constitutional types.Methods The sound frequency was detected in the women with normal constitution,cold constitution or heat constitution through 5-tone analysis and 25-tone analysis by using 25-tone analyzer.Results The sound frequency in the normal constitution group transited from Zheng tone or Yu tone to Jiao tone with the increase of age.In 36-50 age group and compared with the normal constitution group,the sound frequency decreased（373.76 Hz） in the cold constitution group,and increased in the heat constitution group（394.99 Hz）.In the Jiao tong area,the frequency of occurrence of the cold constitution group was the highest（28.88%）,and in Yu tong area,that of the heat constitution group was the highest（29.78%）.Conclusion The women with different constitutional types have different sound characteristics.The analysis on sound frequency may provide an objective base for the differentiation of TCM cold or heat constitution.关键词：woman;constitution;cold-heat syndrome differentiation;five tones;sound frequency
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发布时间：2021-05-20 - 摘要：Objective To clear the correlation between HPLC spectrum and antipyretic effect of Huangqin（Radix Scutellariae）,and to characterize the efficacy material basis of active principles of Huangqin.Methods The rat model of fever was established with dried yeast and then was given extractive of Huangqin.The peak areas of all component peaks in HPLC spectrum were connected to the data of antipyretic effect by using grey relation statistic method.The spectrum-effect correlation was studied and the material basis of Huangqin’s antipyretic effect was found out.Results The antipyretic effect was not characterized only by baicalin,and the contribution of baicalein and other flavonoids should not be neglected.The contribution degrees of flavonoids in Huangqin like baicalin and baicalein were determined by using grey correlation analysis according to the correlation degrees.Conclusion It is an effective way for characterizing Chinese medicinal-efficacy correlation to study HPLC spectrum features and spectrum-effect relationship of effective components of Chinese medicinal.关键词：Huangqin（Radix Scutellariae）;HPLC spectrum;antipyretic effect;spectrum-effect relationship
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发布时间：2021-05-20 - 摘要：Objective To investigate the absorption mechanism and the factors influencing the absorption taken andrographolide microemulsion as the object.Methods The test of in situ perfusion was used for studying the influences of carrier inhibitor,energy inhibitor and P-glycoprotein inhibitor on the absorption behavior of andrographolide microemulsion in rat small intestine.Results The absorption of andrographolide microemulsion needed carrier in the small intestine,and which was influenced by the exocytosis of P-glycoprotein and might have no energy consumption.Conclusion There may be two absorption mechanisms of microemulsion in the small intestine,one is passive transportation and the other is lymphatic absorption.关键词：andrographolide;microemulsion;absorption;mechanism;in situ perfusion;rats
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发布时间：2021-05-20 - 摘要：Objective To announce initially the connotation of lung and large intestine being interior-exteriorly related from the aspect of respiratory changes influencing digestion and metabolism for studing the biological basis of lung and large intestine being interior-exteriorly related.Methods How the amount of qing-qi inhaled by lung influencing the metabolism and changes of diet,food essence and dreg was observed based on anatomy and histology of lung and intestine in rats.Results Hyperoxia had an obvious influence on water-intake and urine output manifesting as the increase of initial water-intake and urine output.Hypoxia had an obvious influence on body weight,food-intake,water-intake and urine output manifesting as inhibition.From the 5th day,anatomy and histological lesions began to appear in the lung and large intestine in both hyperoxia group and hypoxia group.Conclusion The amount of qing-qi can influence on,besides the respiration,the motion,metabolism of food and water,blood flow and tissue of the lung and intestine.It has proofed initially that there is a relationship between the lung and large intestine.关键词：lung and large intestine being interior-exteriorly related;hyperoxia;hypoxia;metabolism of food and water;qing-qi;rats
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发布时间：2021-05-20 - 摘要：Objective To probe into the development trends of post-stroke mental symptoms based on the changes of post-stroke mental symptom group in rats and the interventional effect of Yi Nao Jie Yu Fang with the actions of replenishing kidney and regulating qi.Methods Male Wistar rats,after open-field ethology scoring,were randomly divided into the normal group,sham-operation group,multiple cerebral infarction（MCI） group,Chinese medicinal group,Western medicinal group,post-stroke depression（PSD） group and vascular dementia（VD） group.The normal group was fed normally,sham-operation group was injected normal saline solution（0.3 mL） through the external carotid artery and given distilled water intragastrically,and other groups were injected homogenous heterophile thromboembolus through the external carotid artery by using the injection of homogenous microembolus in vitro.The Chinese medicinal group was given Yi Nao Jie Yu Fang and Western medicinal group was given nimodipine all for 4 weeks after modeling.After the operation for 7 days,the PSD group was given chronic unpredictable mild stress（CUMS） and isolation rearing for 21 days for duplicating PSD model.After the operation for 28 days,the VD group was selected by Morris water maze and then put into the test.On the 4th week after successfully modeling,the characterization observation was carried out in rats including the changes of hair and eyes,average food intake and body weight.At the same time the ethological detection was conducted including consumption test of sucrose water,open-field test,and test of shuttle box.Results The characterization observation showed that the average food intake decreased in the MCI group,PSD group and VD group,especially in the latter two groups,and the change trend of body weight was similar.The ethological detection showed that the interest and ability of memory decreased significantly in the MCI group,PSD group and VD group.The consumption test of sucrose water and open-field test indicated that decrease was mainly in interest in the PSD group and the test of shuttle box active avoidance response indicated that decrease was mainly in ability of memory and learning in the VD group.Chinese medicinal slowed the decrease trends of characterization and ability of memory and learning.Conclusion There are changes of mental symptom group in rats after cerebrovascular diseases and treads of developing to PSD and VD.Yi Nao Jie Yu Fang can slowdown this development.关键词：cerebral stroke;post-stroke depression;vascular dementia;mental symptoms group;Yi Nao Jie Yu Fang;rats
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发布时间：2021-05-20 - 摘要：<正>为提高编辑办公自动化水平,提高办公效率,实现网上资源共享,北京中医药大学主办的学术刊物,包括《北京中医药大学学报》《中医教育》《北京中医药大学学报（中医临床版）》已于2010年6月统一试行网络采编系统,包含作者网上投稿查询、编辑网上审编、专家网上审稿、网上通知等功能,网址:http://www.
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发布时间：2021-05-20 - 摘要：Objective To analyse the gene expression characteristics of pituitary signal pathway of G protein and functional hormones in the tumor-bearing mice with different syndromes of same disease.Methods The characteristics of gene expressions related to pituitary signal pathway of G protein and functional hormones were observed in normal mice（normal group）,tumor-bearing mice with syndrome of pathogenic toxin stagnation at early stage（pathogenic toxin group） and tumor-bearing mice with qi deficiency syndrome（qi deficiency group） by applying measurementized four diagnosis and syndrome differentiation methods and the technology of GeneChip Mouse Exon 1.0 ST Array.Results The expressive trends of PP2B and Calm1 genes of signal pathway of pituitary G protein were not different between the pathogenic toxin group and qi deficiency group,but the absolute expression was lower in the pathogenic toxin group than that in the qi deficiency group.The ras genes of signal pathway of pituitary G protein were active in the qi deficiency group but not stable in the pathogenic toxin group,especially Kras gene and its expression was in the pathogenic toxin group only 55% of that in the qi deficiency group.Compared with the normal group,the expressions of pituitary Lhb and Tshb increased,expressions of Fshb,Cga and Prl decreased and expressions of Pomc and Gh had no changes in the pathogenic toxin group,while all these gene expressions were up-regulated in the qi deficiency group.Conclusion The gene expressions related to pituitary signal pathway of G protein and functional hormones show a upward trend after tumor generation,but which are lower in the tumor-bearing mice with the syndrome of pathogenic toxin stagnation than those in the tumor-bearing mice with the qi deficiency syndrome.It may be related to that the tumor-bearing mice with the syndrome of pathogenic toxin stagnation have poorer prognosis.关键词：tumor;different syndromes of same disease;syndromes;pituitary;G protein;hormones;signal pathway;mice
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发布时间：2021-05-20 - 摘要：Objective To observe the influence of Jiang Tang Bu Shen Fang on the expression of I kappa β kinase（IKKβ） mRNA in muscular tissue in diabetic rats induced by low-dose streptozotocin（STZ） and high-fat diet（HFD）.Methods Male SD rats were fed HFD for 4 weeks,and then injected low-dose STZ.After one week the level of fasting plasma glucose was detected in rats and those with higher than 11.1 mmol/L of level of fasting plasma glucose were successfully modeled.The rats were randomly divided into the model group,low-dose,mid-dose and high-dose Jiang Tang Bu Shen Fang groups（low-dose,mid-dose and high-dose groups）,aspirin group and blank group.All groups were intervened by relevant medicinal for 4 weeks.The expression of IKKβ mRNA in muscular tissue was detected by using reverse transcription polymerase chain reaction（RT-PCR）.Results The expression of IKKβ mRNA in the model group was significantly higher than that in the blank group（5.098 times,P<0.01）.The expression of IKKβ mRNA in the aspirin group,high-dose and mid-dose groups was 2.814 times,3.246 times or 3.770 times,respectively lower than that in the blank group and showed P<0.01 compared with that in the model group.In the low-dose group,the expression of IKKβ mRNA was 4.974 times lower than that in the blank group and showed P>0.05 compared with that in the model group.Conclusion Jiang Tang Bu Shen Fang can inhibit IKKβ mRNA to some extent in diabetic rats,which may be one of mechanisms of the formula in the treatment of diabetes by inhibiting the conduction of inflammation signal pathway and improving insulin resistance.关键词：Jiang Tang Bu Shen Fang;diabetic rats;I kappa β kinase
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发布时间：2021-05-20 - 摘要：Objective To screen the best genuine material of Danshen（Radix Salviae Miltiorrhizae）,verify the rationality of genuine producing areas recorded in herbal literature,and define the best genuine producing areas through comparing HPLC characteristic chromatograms of Danshen from 5 genuine procuding areas.Methods The cultivars of 8 batches of Danshen from 5 genuine producing areas recorded in herbal literature,and material of 11 batches of Danshen（3 varieties） from 2 non-genuine producing areas were collected and their characteristic chromatograms were analyzed.Results The similarity was over 0.9 with larger HPLC peak area and the best quality in the Danshen produced from 2 genuine producing areas of Henan and Shanxi.The similarity was over 0.9 but with smaller HPLC peak area and lower quality in the Danshen produced from 2 genuine producing areas of Sichuan and Hubei,and also in shallow rooted Danshen produced from Hebei.The Danshen produced from the genuine producing area of Shandong had larger HPLC peak area but the similarity was below 0.9 and the quality was poor.Conclusion The results of analysis on HPLC characteristic chromatograms proved to some extent the rationality of records in herbal literature.The study has verified initially that the quality of Danshen was the best produced from the genuine producing areas of Henan and Shanxi and was poor from Shandong,which still need larger sample for further confirm.关键词：herbal literature;genuine producing areas;Danshen（Radix Salviae Miltiorrhizae）;characteristic chromatograms
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发布时间：2021-05-20 - 摘要：Objective To establish the characteristic chromatograms of serum of Kai Xin San,and analyze and identify its chemical compositions absorbed into blood.Methods SD rats were orally given Kai Xin San and water extractive of each single ingredient.The medicinal serum were separated and detected with HPLC.The analysis methods of HPLC characteristic chromatograms of Kai Xin San and medicinal serum were established.The characteristic chromatograms of the whole formula of Kai Xin San,single ingredient and medicinal serum were analyzed,and the chemical compositions,original crude medicinal and metabolites in blood were compared and identified.Results There were 24 chemical compositions absorbed into blood in the medicinal serum,among them 14 were original compositions and 10 were metabolites.The results of HPLC showed that 15 peaks came from Yuanzhi（Radix Polygalae）,7 from Shichangpu（Rhizoma Acori Graminei） and 2 from Yuanzhi and Shichangpu.The original compositions were came from sibricose A5,sibricose A6,xanthone III or 3,6’-disinapoylsucrose of Yuanzhi,and β-asarone of Shichangpu.Conclusion The chemical compositions and metabolites in blood may be the drug-like compositions with the direct actions in vivo,which come from the ingredients of Kai Xin San.关键词：Kai Xin San;characteristic chromatograms;chemical composition;serum;rats
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发布时间：2021-05-20 - 摘要：Objective To study the quality evaluation method of decocting pieces of Juemingzi（Semen Casiae） based on the processing principle of the decocting pieces.Methods The study on the quality evaluation standard for the crude pieces and stir-fried pieces of Juemingzi was conducted based on the quality identification by TCL and HPLC fingerprints and quantitative determination according to the significant changes of 5 constituents before and after processing.Results The method of TLC taken buranol-acetic acid-water as opening system was used simply and intuitively in the identification of the crude pieces and stir-fried pieces of Juemingzi.The changes of main chemical compositions of decocting pieces of Juemingzi before and after processing were reflected by 2 fingerprints of detecting wavelength and content changes of 2 naphtha-pyrone glycosides and 3 anthraquinone aglycons.Conclusion After processing,the internal material basis will change essentially in decocting pieces.The quality evaluation standard should be established and perfected gradually,which is identified by traditional experience combining with quality determination of fingerprints,quantitative determination of multi-index constituents and characters of decocting pieces aiming at the scientific evaluation of different processing products of the same Chinese medicinal.关键词：processing principle;Juemingzi（Semen Casiae）;quality evaluation
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发布时间：2021-05-20 - 摘要：Objective To investigate the distribution laws of syndrome factors of senile dementia.Methods The modern documents about senile dementia from 1994 to 2009 were retrieved and a database was established.The data was counted,described and analyzed by using SPSS13.0 software.Results There were 42 qualified documents colleted.The common syndrome types of senile dementia included liver-kidney yin deficiency,blood stasis due to qi stagnation,phlegm-turbidity obstructing orifices and deficiency of sea of marrow.There were totally 11 syndrome factors withdrew including mainly phlegm,qi deficiency and blood stasis,the cumulative constructive ratio was 54.3%,and their major targets were kidney,spleen,liver and brain.There were mainly 4 forms of syndrome-factor combination and the form of single syndrome factor and form of two syndrome factors were common.Among the forms of single syndrome factor,the most common ones were qi deficiency and yin deficiency,and secondary ones were phlegm and blood stasis,and their major targets included kidney and brain（orifice）.Among the forms of two syndrome factors,the most common one was qi stagnation combined with blood stasis,and secondary ones were phlegm combined with blood stasis and qi deficiency combined with essence deficiency,and their targets included kidney,spleen and brain orifice.Conclusion The disease location of senile dementia is brain,and the dysfunction of zang-fu organs is mainly kidney deficiency and involves spleen and heart.The pathological factors are mainly phlegm-urbidity and blood stasis.关键词：senile dementia;syndrome factors;syndrome types
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发布时间：2021-05-20 - 摘要：<正>更年期综合征是指妇女在绝经前后出现的月经紊乱、烘热汗出、五心烦热、头晕耳鸣、心悸失眠、烦躁易怒、腰酸骨楚、皮肤麻木刺痒或有蚁爬感、记忆力下降、浮肿便溏甚或情志异常等与绝经有关的症状。西医学认为,女性绝经前后性腺发生退行性改变,使下丘脑-垂体-性腺轴之间的平衡制约关系失调,进而导致机体自主神经功能紊乱、性功能障关键词：更年期;中医辨治;临床经验
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发布时间：2021-05-20 - 摘要：<正>复发性阿弗它性口腔溃疡是临床最常见的口腔黏膜病,其病因尚不明确,多与遗传、免疫力降低、微循环损伤、微量元素缺乏、内分泌失调等因素有关。本病可发生于任何年龄,以青壮年多见,有反复发作的特点。中医谓本病为"口疮""口疳""口糜""口破",多因心脾积热或肾阴虚,阴虚火旺灼伤关键词：口腔溃疡;吴茱萸;贴敷疗法;涌泉穴
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发布时间：2021-05-20 - 摘要：Objective To discuss the immuno-regulatory effects and mechanism of balance acupuncture for anti-inflammatory and analgesia in rats with discogenic radiculagia.Methods The symptoms of discogenic radiculagia was simulated and the acupoints of lumbo-pain and hip-pain,common in clinic,were taken as the stimulation points of balance acupuncture.The pain tolerant threshold and pathological changes of radicular tissue and the content changes of hypothalamus β-EP and serum IL-1β were observed in rats with discogenic radiculagia treated with balance acupuncture.Results The pain tolerant threshold decreased in the pain side and then increased after the treatment of balance acupuncture.The balance acupuncture relieved significantly the edema of nerve roots,myelinolysis and other symptoms induced by discogenic radiculagia.The content of hypothalamus β-EP and serum IL-1β increased significantly in the rat model and decreased significantly after the treatment.Conclusion The balance acupuncture has the effects of anti-inflammatory and analgesia on the symptoms of herniated intervertebral disc disease.It can enable the body to set up a new equilibrium state through needling in the stimulation points,changing the excitability of nerve system,starting nerve-endocrine-immune system and inducing generalized anti-inflammatory and analgesic effects.It regulates further physiological function of body,alleviates the edema of nerve roots and local inflammation for final repair of injured nerve roots.关键词：balance acupuncture;discogenic radiculagia;rats
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发布时间：2021-05-20 - 摘要：Objective To observe the curative effect of electroacupuncture in Tinggong（SI19） on tinnitus,and analyse the influence factors on the curative effect.Methods The patients with subjective tinnitus（n=120） were selected from clinic.The patients were given acupuncture vertically in Tinggong（SI19） of tinnitus side for 1.2-1.3 cun until they had local aching,tingling and distending pain.Then the end of needle was connected with pulse therapeutic device G6805O-2A with stimulation of continuous wave at repetition frequency of 30 Hz for 15 minutes.The treatment was given to the patients once a day and one therapeutic course included 20 times.The curative effect and influence factors were reviewed and analysed according to the evaluation standard and the method of multiple linear regression.Results ①The patients with tinnitus were aged mainly from 30 years old to 65 years old,and the proportion of male to female was 1 to 1.3.The shortest disease course was 7 days and the longest was 10 years.②There were 10 cases cured,41 with obvious effect,43 with effect and 26 without any curative effect.The total effective rate was 78.4%.The curative effect was definite.③The results of regression showed that the curative effect was negatively correlated to the age and duration of tinnitus,and correlated to tinnitus severity（P=0.000）.There was no statistical correlation between the curative effect and sex,tinnitus loudness,primary basic diseases and hearing.Conclusion The stimulation of electroacupuncture in Tinggong（SI19） had a reliable curative effect.The younger patients with more severe tinnitus and shorter disease course have better prognosis without considering tinnitus cause.关键词：tinnitus;treatment;acupuncture;influence factors;attribution analysis
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发布时间：2021-05-20
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