最新刊期
卷 0 ， 期 0 ， 2020
- 摘要：on: The theory of transformation of five minds into fire means that it may course the imbalances of yin,yang,qi,blood and zang-fu organs in the body when emotion is stimulated.The imbalance will course depression of qi movement and generation of internal fire.Inflammatory factors are different cytokines involving in inflammatory responses,and the inflammation is essentially an objective reflection of general struggle between human body and inflammatory factors.The authors have found out the correlation between transformation of five minds into fire and inflammatory factors and explored theoretical foundation through long time clinical observation and retrieving,referring to and summarizing relevant domestic and foreign literature.关键词：transformation of five minds into fire;inflammatory factors;theoretical foundation
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发布时间：2021-05-20 - 摘要：The study on TCM academic inheritance is very important to talent training and TCM academic innovation.The paper introduced the concept of tacit knowledge and pointed out that there are a lot of tacit knowledge and corresponding inheritance strategies in TCM knowledge hierarchy.The introduction of tacit knowledge theory will influence the conception innovation of TCM academic inheritance and provide useful guidance of epistemology and methodology.And modern information technology can become an important tool for the acquisition,transformation and conversion in TCM academic inheritance.It was explored how to use the theory and method of tacit knowledge to improve the inheritance of TCM sciences in the paper.关键词：inheritance of TCM sciences;tacit knowledge;master-apprentice education
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发布时间：2021-05-20 - 摘要：The dose-effect relationship of TCM compound formulas shares the common characteristics with other medications,and it is influenced by place of origin,processing,combination,chemical components,syndrome differentiation and treatment,and other multiple factors,which presents a huge challenge for clinical research.The study on the dose-effect relationship of TCM compound formulas consists of whole formula research,sovereign mediocinal study,dose-effect relationship of TCM patent medicine,and relationship study of effectiveness and different doses of individual medicinal.Explanatory randomized controlled trial,single-case randomized controlled trial and prospective cohort study can be employed in clinical research on whole formula,sovereign medicinal study,and dose-effect relationship of TCM patent medicine,however,the design of research plan has to be facilitated with characteristics of the dose-effect relationship of Chinese medicinal.It is difficult to conduct the researches on relationship of effectiveness and different doses of each medicinal in a compound formula from clinical perspective.According to the original characteristics of dose-effect relationship of traditional Chinese medicine and TCM compound formulas,it is encouraged to explore and improve methodology in clinical studies,and therefore to scientifically evaluate dose-effect relationship of TCM compound formulas.关键词：TCM compound formulas;dose-effect relationship;clinical research methods;evidence-based medicine
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发布时间：2021-05-20 - 摘要：<正>中医色诊,以青、赤、黄、白、黑五色推演于五行内合于五脏,进行疾病的临床诊断与辨证,其临床应用价值及理论意义为历代医家所推崇。邓铁涛国医大师与刘颂豪院士提出中医学与光学的交叉学科建设时,就以中医望诊作为突破口,建议应用光子学技关键词：色诊;望诊;舌诊;色度学;色差;光谱测色;定量度量
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发布时间：2021-05-20 - 摘要：Objective To discuss TCM constitutional features and correlation between constitution and syndrome type in patients（Han nationality or Uyghur nationality） with coronary heart disease（CHD） in Xinjiang,and provide basis for preventing and treating CHD in clinic.Methods From Oct.2009 to Oct.2010 and in 10 hospital in 5 prefectures including Akesu of Xinjiang,660 hospitalized patients,who grew up or have lived in Xinjiang for more than 20 years and diagnosed firstly as CHD by Western medicine and/or as chest impediment by Chinese medicine,were selected by using cross-sectional survey.Their TCM constitutional types and syndrome types were identified by applying standardized scale of 9 TCM constitutional types.The relationship between TCM constitutional types and syndrome types was analyzed.Results ①The constitutional types are mainly qi-deficiency constitution,phlegm-damp constitution and blood-stasis constitution in both Han and Uyghur patients with CHD,while there was statistical difference in phlegm-damp constitution and damp-heat constitution between Han and Uyghur patients（P<0.01）.②Among 660 CHD patients,there were 387 with syndrome of dirty-turbid phlegm obstruction（58.63%）,and 273 without this syndrome（41.37%）.③The syndrome of dirty-turbid phlegm obstruction was mainly related to combined constitution and mixture constitution of deficiency and excess,and the comparison in yin-deficiency constitution,phlegm-damp constitution,damp-heat constitution and blood-stasis constitution showed statistical significance between two groups（P<0.01）.④The syndrome of dirty-turbid phlegm obstruction was significantly correlated to phlegm-damp constitution,qi-deficiency constitution,damp-heat constitution and blood-stasis constitution（all P<0.05）.Conclusion Diet custom is an important factor influencing constitutional types and syndrome types.The syndrome of dirty-turbid phlegm obstruction was mainly related to deflective constitution and combined constitution of deficiency and excess,and was correlated to qi-deficiency constitution,phlegm-damp constitution,damp-heat constitution and blood-stasis constitution.关键词：coronary heart disease;Han nationality;Uyghur nationality;TCM constitution;TCM syndrome types
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发布时间：2021-05-20 - 摘要：Objective To explore the application of analytical hierarchy process（AHP） in TCM etiology research,and establish an AHP model of TCM etiology of coronary heart disease（CHD） taken CHD as a carrier.Methods TCM pathogenic factors of CHD were summed up and an AHP model of TCM etiology of CHD was established initially through literature analysis,expert demonstration and clinical investigation.Results The model was divided into three levels including objective level,criterion level and factor level.The objective level was for mastering TCM etiology of CHD and determine the importance ranking of different factors,and criterion level and factor level included natural factors（climate and regions）,living factors（diet,work and rest,smoking and drinking）,emotional factors（survive,work,interpersonal relationship and family）,physical factors（weak,sickly and obesity） and other factors（age,gender and family history）.Conclusion TCM etiology is a complicated and multi-factor system.The research on TCM etiology of CHD by using analytical hierarchy process is available,but further argument and perfection are needed for model content and methodology.关键词：coronary heart disease;TCM etiology;analytical hierarchy process
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发布时间：2021-05-20 - 摘要：<正>《伤寒杂病论》这部古籍之所以能影响中医学1700多年之久,是因为灵活使用了辨证思维和科学研究的基本方法,形成了一种认识疾病的规律。清代医家徐灵胎说:"医者之学问,全在伤寒之理,则万病皆通。"所谓"伤寒之理"从某种意义上说,即该书研究关键词：中医眼科;伤寒杂病论;临证思维;辨证论治
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发布时间：2021-05-20 - 摘要：Objective To discuss the elimination effect of Shuanghuanglian Injectable Powder and Qingkailing Injection on R plasmids of Escherichia coli（E.coli） producing super broad-spectrum β-lactamase（ESBLs） and influence on the activity of ESBLs.Methods E.coli with ESBLs positive were colleted from clinic and R plasmids were extracted with plasmid kit.The elimination of R plasmids was analyzed by using agarose gel electrophoresis and UV gel imager before and after the administration of Chinese medicinal.The extracting solution of ESBLs was collected by using ultrasonication and protein quantified by using Bradford method.The activity of ESBLs was determined taking Nitrocefin as substrate.Results Before and after the administration of Shuanghuanglian Injectable Powder and Qingkailing Injection,the comparison of plasmid maps showed that a plasmid band was lost.The activity of ESBLs was,respectively,（13.43 0.40） U/mg,（3.49 0.12） U/mg,（3.54 0.27） U/mg and（3.35 0.12） U/mg in broth group,Sulbactam group,Shuanghuanglian group and Qingkailing group.The activity of ESBLs decreased in Shuanghuanglian group and Qingkailing group compared with broth group（P<0.01） and was similar to that in Sulbactam group.Conclusion Shuanghuanglian Injectable Powder and Qingkailing Injection have some elimination effects on R plasmids of drug-resistant E.coli and can inhibit the activity of ESBLs.关键词：Qingkailing Injection;Shuanghuanglian Injectable Powder;Escherichia coli producing super broad-spectrum β-lactamase;R plasmids;β-lactamase
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发布时间：2021-05-20 - 摘要：Objective To observe the influence of Huangqi Injection on the epithelial-myofibroblast transdifferentiation（EMT） induced by transforming growth factor β1（TGF-β1） in human renal tubular epithelial cells（HK-2） cultured in vitro,and reveal the detail effective mechanism in the treatment of renal interstitial fibrosis（RIF）.Methods HK-2 cells were divided into 3 groups,and in normal group HK-2 cells were normally cultured,in model group,stimulated with TGF-β1（8×10-9 mg/L） for 48 hours,and in treatment group,cultured together with TGF-β1（8×10-9 mg/L） and Huangqi Injection（8×10-6 mg/L） for 48 hours.The morphologic changes of HK-2 were observed with the inverted phase contrast microscope,and expressions of E-cadherin and a-smooth muscle actin（a-SMA） were observed by using immunohistochemistry assay.Results The observation results of the inverted phase contrast microscope showed that the morphologic changes experienced from epithelial-like transform to fibroblast-like transform in model group,and fibroblasts decreased and a lot of epithelioid cells were observed in treatment group.The results of immunohistochemistry assay showed that the expression of a-SMA increased and expression of E-cadherin decreased in model group compared with normal group,while in treatment group,expression of E-cadherin increased and expression of a-SMA decreased compared with model group.Conclusion Huangqi Injection can inhibit to a certain extent the phenotypic alternation induced by TGF-β1 in HK-2 cells,reduce the expression of a-SMA,improve the expression of E-cadherin,and block or reverse EMT progress.关键词：human renal tubular epithelial cells;epithelial-myofibroblast transdifferentiation;Huangqi Injection
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发布时间：2021-05-20 - 摘要：Objective To observe the influence of Yixin Jiedu Fang on hemorrheology in miniature pigs with cardiac insufficiency induced by Ameroid constricting ring.Methods The model of chronic myocardial ischemia cardiac insufficiency was established in Bama miniature pigs（n=32） by applying Ameroid constricting ring in left anterior descending coronary artery.The pigs were randomly divided into model group,Qishen Yiqi Diwan group and Yixin Jiedu Fang group（each n=6）,and other 4 pigs were prepared as sham-operation group.The whole blood viscosity（WBV）,whole blood reduced viscosity（WBRV）,plasma viscosity,hematocrit（Hct）,red blood cell deformation index（RBCDI） and red blood cell aggregation index（RBCAI） were detected.Results Before medicinal administration,WBV（1/5） increased significantly in model group,Qishen Yiqi Diwan group and Yixin Jiedu Fang group compared with sham-operation group（P<0.01 or P<0.05）.After 2 weeks,4 weeks and 8 weeks,WBV（1/150,1/10 and 1/5）,WBRV（1/38,1/10 and 1/5）,Hct,RBCAI and RBCDI all increased significantly in model group compared with sham-operation group（P<0.01 or P<0.05）,while they decreased significantly in Qishen Yiqi Diwan group and Yixin Jiedu Fang group at all time points.WBRV（1/38） after 2 weeks and 4 weeks and Hct after 8 weeks decreased significantly in Qishen Yiqi Diwan group and Yixin Jiedu Fang group compared with model group（P<0.01 or P<0.05）,and all indexes after 8 weeks was not significantly different in Yixin Jiedu Fang group compared with sham-operation group.Conclusion Yixin Jiedu Fang can significantly improve the indexes of hemorrheology in miniature pigs with myocardial ischemia cardiac insufficiency induced by Ameroid constricting ring.关键词：Yixin Jiedu Fang;cardiac insufficiency;blood stasis syndrome;hemorrheology;miniature pigs
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发布时间：2021-05-20 - 摘要：Objective To observe the influence of component formula of Suanzaoren Tang on hippocampus monoamine neurotransmitters and their metabolites in rats in elevated plus maze test（EPM）,and discuss its effective components and mechanism of anti-anxiety.Methods The influence of component formula of Suanzaoren Tang on rat ethology was observed by using international common-used anxiety animal model in EPM.The levels of monoamine neurotransmitters including noradrenaline（NE）,5-hydroxytryptamine（5-HT） and dopamine（DA） and their metabolites were detected by applying HPLC.Results Compared with blank group,the ratio of entering times and retention time ratio in open arm increased significantly in whole component formula group（whole CF group）,effective component formula group（effective CF group） and diazepam group（P<0.01 or P<0.05）.The level of 5-HT decreased significantly in effective CF group and diazepam group,and showed a decreasing trend in whole CF group.The level of hippocampus homovanillic acid（HVA） increased significantly in effective CF group（P<0.01）.Conclusion The whole component formula and effective component formula of Suanzaoren Tang are similar to diazepam in anti-anxiety mechanism to some extent,which may involve the decrease of hippocampus 5-HT level.The whole component formula and effective component formula have different influences on the metabolism of hippocampus monoamine neurotransmitters in rats.关键词：Suanzaoren Tang;effective components;anti-anxiety;elevated plus maze;monoamine neurotransmitters;rats
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发布时间：2021-05-20 - 摘要：Objective To observe the curative effect of Huatan Tongluo Fang on collagen-induced arthritis（CIA） in rats.Methods The CIA model was established through choosing bovine collagen II as immunogen,and then modeled rats（n=40） were randomly divided into normal saline group（group A）,Huatan Tongluo Fang group（group B）,methotrexate group（group C） and Huatan Tongluo Fang+MTX group（group D,each n=10）.A therapeutic course was 30 days.The degree of CIA was scored by using arthritis index（AI） scoring.The levels of serum matrix metalloproteinase-3（MMP-3） and vascular endothelial growth factor（VEGF） were detected by using enzyme-linked immunosorbent assay（ELISA）.The integrals of synovitis index were reviewed based on synovial pathology.Results The scores of AI increased significantly in group A（P<0.01）,had no changes in group B（P>0.05） and decreased significantly in group C and D（P<0.01）.The scores of AI was significantly lower in group B,C and D than those in group A（P<0.05）,and significantly lower in group D than in group B（P<0.05）.The levels of VEGF and MMP-3 were lower in group B,C and D than those in group A（P<0.01）,and lower significantly in group D than in group B（P<0.05）.The difference between group B and C,or between group C and D was not significant（P>0.05）.The integrals of synovitis index were lower significantly in group B,C and D than those in group A,and lower in group D than in group B（P<0.05）,lower in group D than in group C,and lower in group C than in group B but the difference was not significant（P>0.05）.Conclusion Huatan Tongluo Fang can relieve CIA inflammation and reduce significantly the levels of serum VEGF and MMP-3.Its curative effect will be enhanced when it combined with MTX.关键词：resolving phlegm;activating blood circulation;arthritis;collagen inductivity;rats
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发布时间：2021-05-20 - 摘要：Objective To optimize the best proportion of matrix recipe of paeonol cataplasm to prepare good cataplasm.Methods The composition proportion of cataplasm matrix was optimized taking matrix uniformity,ductility,membrane rescue,skin following,viscosity and peeling strength as comprehensive indexes and raw materials of recipe as factors by using response surface design.Results Through the analysis on the data of factorial experiment,climbing experiment and Box-Behnken experiment,the best recipe proportion was as follows: EDTA: dihydroxyaluminii Aminoacetate: tartaric acid:K-90: glycerin:XL-10: NP-800 was 0.20: 0.20: 0.10: 1.00: 28.62: 1.95: 5.88.Conclusion The matrix recipe obtained in the experiment was better,and prepared paeonol cataplasm accorded with the requirements of pharmaceutics.关键词：paeonol;cataplasm;matrix;response surface experiment
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发布时间：2021-05-20 - 摘要：Airway remodeling is the key pathological progress of chronic obstructive pulmonary disease（COPD）.The paper stated the correlation and uniformity between airway remodeling of COPD and micro-accumulation in lung collateral vessels in cause,pathogenesis,location,course and prognosis based on the TCM doctrine of collateral disease and accumulation theory.The occurrence and development of airway remodeling is induced by improper treatment to COPD,so lung-qi is consumed,body fluid coagulates into phlegm,blood stagnates into blood stasis,phlegm and stasis glue together in lung collaterals and then micro-accumulation is formed and blocks lung collateral vessels gradually.The paper also proposed resolving accumulation and freeing collateral vessels as major therapeutic principle.This theory has enriched the TCM theory about lung disease and provides a new idea for improving clinical effect.关键词：lung collateral vessels;micro-accumulation;chronic obstructive pulmonary disease;airway remodeling
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发布时间：2021-05-20 - 摘要：Objective To discuss the evolution laws of TCM syndromes of diabetes complicating cerebrovascular disease at acute stage.Methods The patients with diabetes complicating cerebrovascular disease（n=137,complicating group） and those without diabetes complicating cerebrovascular disease（n=158,other disease group） were selected.The TCM syndrome factors included wind,fire,phlegm,blood stasis,qi deficiency and yin deficiency with yang hyperactivity,and they were collected,reviewed and compared at four time points（hospitalized day,7th day,14th day and 28th day）.Results The evolution laws of TCM syndromes in complicating group were from syndrome of wind stirring due to yin deficiency to phlegm-fire syndrome to phlegm-stasis syndrome to qi deficiency and blood stasis syndrome,and that in other disease group,from wind-phlegm syndrome to phlegm-fire syndrome to phlegm-stasis syndrome to phlegm-stasis syndrome.Conclusion The different evolution laws in diabetes complicating cerebrovascular disease and other diseases provide theoretical basis for treating stroke with TCM at different stages.关键词：diabetes complicating acute cerebrovascular disease;TCM syndromes;evolution laws
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发布时间：2021-05-20 - 摘要：Objective To discuss the curative effect of tap therapy of electric plum-blossom needle on child amblyopia and its influence on pattern-visual evoked potential（P-VEP）.Methods The child patients with amblyopia aged from 4 to 12 years old were selected（n=38,69 eyes） and randomly divided into experimental group and control group on the base of ametropia after glasses rectification.The experimental group was treated with comprehensive therapy of Western medicine and tap therapy of electric plum-blossom needle,and control group with comprehensive therapy of Western medicine only.All patients in two groups were given examinations of P-VEP and vision correction before and after the treatment,and those in experimental group were given examination of P-VEP respectively before and after one time of tap therapy of electric plum-blossom needle.Results The results of P-VEP examination showed that in experimental group the instant effect and P100 wave peak latency were significantly shortened（P<0.05）,but amplitude had no significant difference compared with control group.In experimental group after one course of treatment compared with before the treatment,P100 wave peak latency was significantly shortened（P<0.05）,but amplitude had no significant difference.The results of visual acuity examination showed that in experimental group the visual acuity of 32 eyes among 36 eyes（88.9%） and in control group,that of 24 among 33 eyes（72.7%） were increased two or more lines in visual chart.The total effective rate was higher in experimental group than that in control group according to the analysis on age,and degree and types of amblyopia and curative effect.Conclusion The tap therapy of electric plum-blossom needle can shorten P100 wave peak latency of P-VEP in amblyopia children and improve their visual acuity.It has a bright application prospect in clinic.关键词：amblyopia;electric plum-blossom needle;pattern-visual evoked potential
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发布时间：2021-05-20 - 摘要：Objective To compare and observe the influences of pre-warming acu-moxibustion and warm acu-moxibustion in Shenmen（HT7） on the activities of serum creatine kinase（CK） and lactate dehydrogenase（LDH） in rats with ischemia arrhythmia.Methods Wistar rats were randomly divided into normal group,model group,pre-warming acu-moxibustion group and warm acu-moxibustion group（each=9）.The model of ischemia arrhythmia was established by sublingual injection of barium chloride.The influences of pre-warming acu-moxibustion and warm acu-moxibustion in HT7 on heart rate,QRS wave and recovery time of heart rate were observed by ECG,and those on the activities of serum CK and LDH were detected by using biochemistry assay.Results Pre-warming acu-moxibustion and warm acu-moxibustion corrected variant QRS wave,and warm acu-moxibustion decreased heart rate,shortened recovery time of heart rate and reduced the activities of serum CK and LDH in rats with ischemia arrhythmia.Conclusion Warm acu-moxibustion can prevent myocardial injury at the same time of relieving ischemia arrhythmia,but pre-warming acu-moxibustion is not stable.It is necessary to study further on the mechanism of difference in curative effect of two therapies.关键词：pre-warming acu-moxibustion;warm acu-moxibustion;Shenmen（HT7）;ischemic arrhythmia;rats
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发布时间：2021-05-20
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