最新刊期
卷 35 ， 期 5 ， 2012
- 摘要：Objective To investigate the application of data mining in the study on inheritance laws of Chinese medicinal administration,and provide new ideas for finding and spreading of TCM tacit knowledge.Methods The clinical prescriptions were collected from Professor WANG Qing-guo,a disciple of Professor LIU Du-zhou,and the frequency and correlation analyses were carried out after standardization.The Professor WANG’s laws of medicinal administration were summed up and compared with those of Professor LIU’s.Results The frequency analysis obtained the common Chinese medicinal in Professor WANG’s prescriptions in clinic.The correlation analysis showed that the characteristic medicinal combination in Professor WANG’s prescriptions were aligned with the classic formulas in Shanghan Lun and common formulas of Professor LIU’s,especially Xiaochaihu Tang,Xiexin Tang and Cgaihu Guizhi Ganjiang Tang.The support of frequent itemset of Huangqi（Radix Astragali）,Danggui（Radix Angelicae Sinensis） and Baishao（Radix Paeoniae Alba） were over 20%,and support of coupled medicinal [Huangqi,Danggui and Baishao coupling with Chaihu（Radix Bupleuri）,Huangqin（Radix Scutellariae）,Zhigancao（prepared Radix Glycyrrhizae） and Shengsaishen（dry Radix Ginseng） respectively] was also very high.The results indicated that Professor WANG is very concerned about the integration of Chinese medicinal with the actions of tonifying qi and activating blood in application of classic formulas.Conclusion The analysis of data mining has found that Professor WANG is good at application of formulas with Chaihu and Xiexin Tang-like formulas in clinic.He has inherited Professor LIU’s academic thought-harmonizing and releasing Shaoyang pivot,and has new breakthrough in administration of formulas and Chinese medicinal.The study demonstrates that data mining can reveal the trace of TCM academic inheritance to some extent,and enlighten the research on inheritance laws of TCM sciences.关键词：data mining;academic inheritance;laws of Chinese medicinal administration
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发布时间：2021-05-20 - 摘要：Objective To study the therapeutic laws of Chinese and Western medicinal in treatment of hand-foot-mouth disease（HFMD）.Methods The literature data of treatment of HFMD were collected from Chinese biomedicine literature service system.The syndromes,symptoms,and Chinese medicinal with centralized data,and laws of Chinese patent medicines combining Western medicinal were mined by applying data hierarchy algorithm based on frequency statistics of sensitive key words.All results were demonstrated through one-dimensional frequency and building network graphs.Results The syndromes of HFMD were mostly related to heat,phlegm and toxin and core symptoms included fever,herpes and mouth ulcer.The Chinese medicinal as core ones for treating HFMD were mainly Jinyinhua（Flos Lonicerae）,Lianqiao（Fructus Forsythiae）,Shengshigao（crude Gypsum Fibrosum）,Zhuye（Lophatheri）,Danzhuye（Herba Lophatheri）,Gancao（Radix Glycyrrhizae）,Daqingye（Folium Isatidis） and Huangqin（Radix Scutellariae）.The most common Chinese patent medicines were Qingkailing Injection,Shuanghuanglian Injection and Tanreqing Injection,and Kangfuxin Oral Solution was generally used for mouth ulcer.Western medicinal was used mainly for anti-virus and the most common one was ribavirin.The most common combination of Chinese and Western medicinal were ribavirin combining Tanreqing Injection.Conclusion Text mining is a new exploration and trial in the treatment of HFMD with Chinese and Western medicinal.关键词：text mining;data hierarchy algorithm;hand-foot-mouth disease;syndromes;Chinese medicinal
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发布时间：2021-05-20 - 摘要：<正>《肘后备急方》简称《肘后方》,是现存最早的古代急救手册,所载方药治法在魏晋南北朝医学史及道教史上均占有重要地位。《肘后方》从成书到定型的过程十分复杂,共经过四个阶段。《肘后方》系东晋道士葛洪所撰,原书3卷,载方86首。梁代道士陶弘景加以补充,仍为3卷,收方101首,称为《肘关键词：《肘后备急方》;唐代增订;证据
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发布时间：2021-05-20 - 摘要：<正>清代医家戈直哉《伤寒指归》从绘制"表里阴阳六经图"阐述六经之实质以及阴阳气液开阖之状态等方面,对人体"六经"结构做出了描述。认为人体阴阳有"开阖枢"运动,而阴阳"开阖枢"运动中所产生的6种病理状态,就是伤寒六经病。其运行演变规律,即为仲景《伤寒论》之结构。"开阖枢,谓阴阳关键词：清代;戈直哉;伤寒指归
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发布时间：2021-05-20 - 摘要：Objective To study the distributions features of TCM syndrome types and tongue manifestations in patients with chronic heart failure（CHF） with different cardiac functional grades.Methods The clinical materials were collected from 612 CHF patients through the survey of multiple center clinical epidemiology.The types of TCM syndrome and data of tongue manifestations were given descriptive and statistical analysis,and the distribution laws were studied in the patients with different cardiac functional grades.Results In CHF patients with cardiac functional grade Ⅱ,the most common syndrome type was syndrome of qi deficiency and blood stasis（27.6%）,and tongue manifestations showed as pink tongue（21.2%）,red tongue（21.2%）,thin and white tongue fur（78.2%） and lavender sublingual collateral vessels（27.6%）.In CHF patients with cardiac functional grade Ⅲ,the most common syndrome type was syndrome of qi deficiency and blood stasis（17.5%）,and tongue manifestations showed as dark red tongue（27.8%）,thin and white tongue fur（78.2%） and blue sublingual collateral vessels（26.3%）.In CHF patients with cardiac functional grade Ⅳ,the most common syndrome type was syndrome of yang deficiency with water flood combining syndrome of phlegm accumulating with stasis,and tongue manifestations showed as dark red tongue（25.7%）,slightly thick and white tongue fur（35.3%） and blue sublingual collateral vessels（40.4%）.Conclusion The syndrome types have a tendency transforming gradually from syndrome of qi deficiency and blood stasis to syndrome of yang deficiency with water flood combining syndrome of phlegm accumulating with stasis as the increase of cardiac functional grades.The color of tongue transforms from pink to dark red,tongue fur,from thin to slightly thick,and color of sublingual collateral vessels,from lavender to blue.The study results indicate that the degree of blood stasis is aggravating as the deterioration of cardiac function in CHF patients.The tongue manifestations trend to become abnormal or reflect the nature of qi deficiency and blood stasis,and deficiency complicated with excessiveness.关键词：chronic heart failure;TCM syndrome types;tongue manifestations;cardiac functional grading
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发布时间：2021-05-20 - 摘要：Objective To study the influences of coupled medicinal-Shechuangzi（Fructus Cnidii） and Buguzhi（Fructus Psoraleae） on survival time,activity of osteoclast and bone injury in nude mice with breast cancer with bone metastasis,and discuss the best combination of the coupled medicinal in the treatment of breast cancer with bone metastasis.Methods The model of nude mouse was established by using left ventricle injection of MDA-MB-231BO cells.The effect of coupled medicinal-Shechuangzi and Buguzhi（2.56 g/mouse） was observed taking zoledronic acid as a positive control medicinal.All nude mice（n=84） were randomly divided into（0.2 mg/kg） group A and group B（each n=42）,and each group were randomly divided again into model group,zoledronic acid group,4 parts Shechuangzi to 0 part Buguzhi group（4 to 0 group）,0 part Shechuangzi to 4 parts Buguzhi group（0 to 4 group）,1 part Shechuangzi to 3 parts Buguzhi group（1 to 3 group）,2 parts Shechuangzi to 2 parts Buguzhi group（2 to 2 group）,3 parts Shechuangzi to 1 parts Buguzhi group（3 to 1 group,each n=6）.A normal group（n=6） was additionally set into group B.The survival time was observed in group A after intervention by different proportions of medicinal.The samples were collected 6 weeks after intervention by different proportions of medicinal in group B.The changes of morphology and quantity of osteoclasts were observed after TRACP staining,and the expressions of genes and proteins of M-CSF and PTHrP were detected in bone metastasis focus.Results The survival time was significantly prolonged in all intervention groups in nude mouse model（P<0.05,P<0.01）,and the effect was the best in 2 to 2 group,which was almost as the same as that in zoledronic acid group.The activity of osteoclasts was inhibited to some extent in all intervention groups（P<0.05,P<0.01）,and the effect was the best in 2 to 2 group,which was almost as the same as that in zoledronic acid group.The expressions of genes and proteins of M-CSF and PTHrP were down-regulated to some extent in all intervention groups（P<0.05,P<0.01）,and the effect was the best in 2 to 2 group.Conclusion The coupled medicinal-Shechuangzi and Buguzhi with the action of warming kidney can inhibit breast cancer with bone metastasis,and their proportion of two to two may be the best proportion with the best curative effect.关键词：breast cancer;bone metastasis;coupled medicinal;Shechuangzi（Fructus Cnidii） and Buguzhi（Fructus Psoraleae）;mice
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发布时间：2021-05-20 - 摘要：Objective To investigate the influences of medicinal serum of Sumu（Lignum Sappan） and Chuanxiong（Rhizoma Ligutici） on the proliferation of human highly metastasis PG cells cultured in normoxia and hypoxia conditions,screen the suitable concentration of medicinal serum and determine the best acting time.Methods The medicinal serum samples of Sumu and Chuanxiong were prepared and used to intervene PG cells cultured in normoxia and hypoxia conditions.The samples were then divided into 6 groups according to the concentration of medicinal serum and a control group was set.The influences of medicinal serum of Sumu and Chuanxiong on the proliferation of PG cells were observed by using MTT method.Results In normoxia condition,the differences among different concentration of medicinal serum of Sumu（except of 0.625%） and medicinal serum of Chuanxiong（except of 1.25%） had statistical significance（P<0.05）.In hypoxia condition,the differences among different concentration of medicinal serum of Sumu and medicinal serum of Chuanxiong had no statistical significance（P>0.05）.Conclusion The medicinal serum of Sumu or Chuanxiong can inhibit PG cell proliferation in normoxia condition after intervening for 24 hours and shows a dose-dependence.The higher the concentration of the serum is,the more obvious its inhibitory effect is.But in hypoxia condition,the medicinal serum can improve PG cell proliferation.With its action time increasing（48 h and 72 h）,the medicinal serum has the action of promoting PG cell proliferation（being the most significant at 72 h） in normoxia and hypoxia conditions,and shows a dose-dependence.The higher the concentration of the serum is,the more significant PG cell proliferation is（being the most obvious in concentration of 20%）.The condition of hypoxia is more beneficial to the proliferation of PG cells promoted by the medicinal serum of Sumu or Chuanxiong.
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发布时间：2021-05-20 - 摘要：Objective To discuss the pathogenesis of blood stasis syndrome of preeclampsia combining the mouse model of preeclampsia induced by the injection of phosphatidylserine/phosphatidylcholine（PS/PC） micelle.Methods The total of 27 pregnancy ICR mice were randomly divided into model group and control group.The model group was injected continuously PS/PC（1 mg/d） and control group,normal saline solution（0.1 mL/d） from the 5.5th to 16.5th day after pregnancy.The changes of systolic blood pressure（SBP）,urine protein（UP）,fetal weight,placental weight,number of absorbed embryos and dead fetuses,platelet count,content of plasma antithrombin III（AT-Ⅲ） and D-dimmer,and thrombin time were observed in two groups.The fibrin deposition of placenta and expression of placental vascular TM were analyzed.Results Compared with control group,model group showed a higher SBP（129.467 mmHg vs.101.560 mmHg,P<0.001）,increase of UP（732.700 mg/L vs.186.200 mg/L,P<0.001）,inhibition of fetal orthotonic intrauterine growth（0.983 g vs.1.119 g,P<0.05）,increase of occurrence rate of absorbed embryos and dead fetuses,formation of extensive fibrin deposition of placenta（2.333 vs.1.267,P<0.001）,and increase of the expression of placental TM（0.193 vs.0.088,P<0.01）.In model group,the content of plasma AT-Ⅲ decreased（89.384 mg/L vs.135.373 mg/L,P<0.001）,content of D-dimer increased（6.992 mg/L vs.0.317 mg/L,P<0.005）,platelet count decreased（83.650×1010 L-1 vs.117.000×1010 L-1,P<0.001）,and thrombin time was shortened（15.942 s vs.18.207 s,P<0.001）.Conclusion The intravenous injection of PS/PC micelle can induce abnormal hemostatic function in pregnancy ICR mice accompanied by the formation of extensive fibrin deposition of placenta,which will lead preeclamptic-like performances（blood stasis syndrome）.The status of blood stasis of placenta may be one of important mechanisms of preeclampsia.关键词：phosphatidylserine;phosphatidylcholine;mice;preeclampsia;hemostatic function;blood stasis syndrome
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发布时间：2021-05-20 - 摘要：Objective To obtain the visible evidence of electroacupuncture regulating injured cerebral function in liver-qi depression syndrome by applying positron emission tomography（PET） of cerebral function,and explore the mechanism of its effect on nerve center.Methods Wistar rats（n=20） were divided into model group of liver-qi depression syndrome（model group） and treatment group of electroacupuncture（treatment group） according to body weight.The two groups were given 18F fluorodeoxyglucose（18F-FDG） PET imaging scanning respectively before and after modeling.The data of two groups before and after modeling were treated with two-sample t-test（P<0.001） by using SPM2 imagine analysis software,and the regions with brain glucose metabolism changes in liver-qi depression syndrome regulated by electroacupuncture were obtained.Results The visible evidence of electroacupuncture regulating injured cerebral function in liver-qi depression syndrome has been obtained initially.Compared with model group,the cerebral regions with decreased glucose metabolism in treatment group included left frontal lobe,parietal lobe,paracentral lobule,supracallosal gyrus,thalamus and hypothalamus,and the regions with increased glucose metabolism included left basal ganglion,temporal lobe,right frontal lobe and subthalamus besides left frontal lobe and parietal lobe.Conclusion The glucose metabolism in different cerebral regions can be influenced after electroacupuncture in Ganshu（BL18） and Qimen（LR14）.关键词：electroacupuncture;rats;liver-qi depression syndrome;positron emission tomography
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发布时间：2021-05-20 - 摘要：Objective To investigate the protective effect of pretreatment with scarring moxibustion with incense stick in rats with cerebral ischemia-reperfusion injury.Methods SD rats（n=40） were randomly divided into control group,model group,pretreatment group with scarring moxibustion with moxa cone（moxa cone group） and pretreatment group with scarring moxibustion with incense stick（incense stick group）.The rat model of middle cerebral artery occlusion（MCAO） and reperfusion was established by using thread approach.The moxa cone group and incense stick group were given the pretreatment of scarring moxibustion with moxa cone or incense stick on Zusanli（ST36） 3 days before ischemia-reperfusion.The rats were sacrificed after ischemia for 3 hours and reperfusion for 24 hours.The control group and model group were not given the pretreatment.The content changes of superoxide dismutase（SOD）,malondialdehyde（MDA）,nitric oxide（NO） and lactic acid（LD） were observed in all groups.Results The content of NO,LD and MDA decreased significantly,and content of SOD increased significantly in incense stick group compared with model group（P<0.05,P<0.01）.The content of LD decreased significantly and content of SOD increased significantly in moxa cone group compared with model group（P<0.05,P<0.01）.The content of LD decreased significantly in incense stick group compared with moxa cone group（P<0.05）.The content of NO,MDA and SOD had no differences between incense stick group and moxa cone group（P>0.05）.Conclusion The pretreatment of scarring moxibustion with incense stick and that with moxa cone can promote antioxidation in cells,reduce neurotoxicity mediated by NO and improve the energy metabolism in brain cells,and have significant protective effect in rats with cerebral ischemia-reperfusion.The effect of pretreatment of scarring moxibustion with incense stick is better than that of pretreatment of scarring moxibustion with moxa cone.关键词：cerebral ischemia/reperfusion;pretreatment;Scarring moxibustion;Protection;rabbits
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发布时间：2021-05-20 - 摘要：<正>针灸学是一门起源于中国的古老而神奇的医学。随着社会的不断进步、发展,针灸在维护人类健康方面的重要性越来越受到国际社会的关注和重视。2010年11月16日联合国教科文组织保护非物质文化遗产政府间委员会第五次会议审议通过,将"中医针灸"正式列入《人类非物质文化遗产代表作名录》[1]。此次针灸"申遗"成功,说明世界对针灸的认关键词：期刊;针灸;论文
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发布时间：2021-05-20 - 摘要：Objective To determine the crocins in the fruits of Gardenia jasminoides.Methods The chromatographic condition was as follows: HPLC procedure was performed on the chromatographic column of Dikma Diamonsil C18（4.6 mm×250 mm,5 μm） at 30 ℃,and the mobile phase was 0.15% formic acid solution-methanol in gradient elution.The flow velocity was 0.6 mL/min and the detection wavelength was 440 nm.The mass spectrometry condition was as follows: source of electrospray ionization（ESI）,detection of negative ion mode and scan rang being m/z=100-1400.The structure of crocins was determined combining the analysis on characteristics of ultraviolet-visible absorption spectra and MS/MS dissociation.Results There were 31 crocins identified from the fruits of Gardenia jasminoides by using HPLC-DAD-MS/MS,and 23 chemical constituents deduced according to the laws of MS/MS dissociation.Conclusion HPLC-DAD-MS/MS can be used for rapid screening and identifying crocins from the fruits of Gardenia jasminoides.关键词：fruits of Gardenia jasminoides;crocins;HPLC-DAD-MS/MS;constituent identification
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发布时间：2021-05-20 - 摘要：<正>为了更好地服务作者、读者,提高工作效率,《北京中医药大学学报》编辑部自2011年1月1日起开通网上采编系统（http://xb.bucm.edu.cn）,请广大作者和读者登陆本刊网址,随时通过此系统投稿、查稿、修改稿件或浏览最新目录等,首次登陆需先行注册。2010—2011年杂志及现刊内容已在网上全文刊出,可在线
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发布时间：2021-05-20 - 摘要：Objective To study the triterpenoid saponins constituents in Altai Chaihu（Altai Radix Bupleuri）.Methods Altai Chaihu was isolated and purified by using chromatography technology and its structure was identified according to its physicochemical property and wave spectrum data.Results There were 5 compounds isolated and identified,including saikosaponin a,saikosaponin d,saikosaponin c,saikosaponin f and saikosaponin b3.Conclusion These five compounds are all isolated from Altai Chaihu for the first time.关键词：Altai Chaihu（Altai Radix Bupleuri）;triterpenoid saponins;isolation;identification
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发布时间：2021-05-20 - 摘要：Object To investigate the syndrome types of depression and used medicinal from the angle of experts’experience.Methods The expert questionnaire was established by using Delphi method according to literature and results of previous survey on TCM syndrome types in the patients with depression.The questionnaire was given out to 75 experts selected from the whole country.The positive degree,concentrative degree,coordination degree and authority degree of obtained data were counted and reviewed.Results The reclamation rate of the first round questionnaire was 93.20%.Among 9 syndrome types of depression,there were 6 items（66.67%） with higher importance.Among 12 common formulas for treating depression,there were 7 items（58.30%） with higher importance.There were 8 syndrome types with variation coefficient being less than 0.25,6 common formulas and 9 common medicinal.The average value of authority degree was 0.82.Conclusion The common syndrome types of depression include syndrome of liver depression and qi stagnation,syndrome of liver depression and phlegm obstruction,syndrome of liver depression and spleen deficiency,and syndrome of depressed liver qi transforming into fire.The common formulas for treating depression include Xiaoyao San,Chaihu Shugan San,Wendan Tang,Chaihu and Lumu Tang,Sini San and Xuefu Zhuyu Tang.关键词：depression;Delphi method;expert questionnaire;formulas
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发布时间：2021-05-20 - 摘要：Objective To analyze the nature of unknown pain by using infrared thermal imaging technology and sum up the pathogenesis and types of pain.Methods Infrared thermal imaging technology was used and compared with rheumatic factor and results of X-ray and CT to observe health people（n=40） and patients（n=40） with cold-damp pain,pain induce by disorder of blood circulation or aseptic inflammation,pain due to qi stagnation and blood stasis,and mixed pain（cold combining stasis）.Half patients were male and half were female aged from 23 years old to 65 years old.Results The temperature of thermograms of pain areas was lower in patients with cold-damp pain than that in other patients and the thermograms showed color of dark blue.The temperature of thermograms was higher in the patients with pain induce by disorder of blood circulation than that in patients with cold-damp pain and the thermograms showed color of blue.The temperature of thermograms was higher in patients with pain induce by aseptic inflammation than that in other patients and the thermograms showed color of dark red.The temperature of thermograms had high area as well as low area in patients with mixed pain,and high area was closed to that in patients with pain due to qi stagnation and blood stasis and low area was closed to that in patients with pain induce by disorder of blood circulation.The temperature of thermograms was lower in the patients with pain due to qi stagnation and blood stasis than that in the patients with pain induce by aseptic inflammation,and higher than that in health people and other patients.The thermograms were larger and showed as scattered and stellate red area in the patients with pain due to qi stagnation and blood stasis,while those were centered and flaky in other patients.The characteristics of thermograms were prominent in all patients and the difference was significant（P<0.05） after statistical handling.Conclusion Infrared thermograms can be taken as the objective index,from both visible images and data proofs,in syndrome differentiation and treatment in clinic,which provide a reliable base and guidance for the treatment of unknown pain.关键词：infrared thermal imaging;pain;mechanism and typing
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发布时间：2021-05-20 - 摘要：The ideas and methods for treating chemotherapy-induced leucopenia with Chinese medicine were summed up through the study on literature of formulas,Chinese medicinal and acupuncture.Analyzing the adverse reactions of chemotherapy from the aspect of Chinese medicine,the pathogeneses of chemotherapy-induced leucopenia were dual deficiency of spleen and kidney,and deficiency of qi and blood.The corresponding therapies included fortifying spleen and kidney,tonifying qi and replenishing blood,harmonizing stomach and calming adverse-rising qi,clearing heat and removing toxicity,and activating blood circulation and removing stasis.关键词：leucopenia;chemotherapy;fortifying spleen and kidney;tonifying qi and replenishing blood
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发布时间：2021-05-20
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