最新刊期
卷 35 ， 期 9 ， 2012
- 摘要：The concept of construction history of TCM theory is proposed.The relative literature has been tidied in the perspective of medical though history taking an example of qi being in charge of exhaling misquoted as qi being in charge of warming in Nanjing: The Twenty-Second Nan.The authors indicated that the misquotation is related to the requirement of theoretical construction of qi being in charge of warming,which,however,has connection with the background of integrating Chinese and Western medicine.The construction of modern TCM theory is facing a dilemma whether to defer to ancient meaning or absorb new knowledge.Citing ancient words and changing their meaning cannot offer solutions.The paper,finally,put forward the ideas of restoring to the original,clarifying TCM system and making original innovation for promoting the development of TCM theory.
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发布时间：2021-05-20 - 摘要：Object Through similarity comparison methods of informatics,to calculate the similarity among these formulas and screen special formulas for treating asthma.Methods The similarity among the formulas for treating asthma was analyzed by using three-layer comparison method.The first layer was to analyze the similarity of Chinese medicinal composition in these formulas by using Jaccard method,the second layer was to analyze the similarity of dose of Chinese medicinals in these formulas by using angle cosine method,and the third layer was to analyze the similarity of effects of these formulas by using angle cosine method.Results There were some special formulas screened,and among them 557 with special medicinal composition,16 with special dose and no one with special effect.Conclusion The most of formulas for treating asthma are designed on the base of previous foundation and there are a few formulas with originality.关键词：formulas;similarity;set;angle cosine;asthma
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发布时间：2021-05-20 - 摘要：It is one of basic concepts in TCM theory that heart governs memory and thinking.The formation reason of heart governing thinking instead of brain in TCM theory was traced back in the paper according to the concepts of holism and viscera inside must manifesting themselves externally through investigating relative TCM classics.The locations of heart and brain in the holism of TCM,the comprehension to the functions of heart and brain by ancient TCM doctors,and the necessity of the concept of heart governs memory and thinking in TCM diagnosis were analyzed.关键词：heart governing thinking instead of brain;theoretical origin;textual research
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发布时间：2021-05-20 - 摘要：Objective: To establish the animal model of urinary tract infection（UTI） during menopause.Methods All experimental mice were ovariectomized and infected in urinary tracts,and then the results of UTI were reviewed by using vaginal smears,vaginal keratinocytic method,observation on serum estradiol 2（E2） level,and bladder germiculture and bladder pathological grading.Results The vaginal smears showed and maintained diestrous manifestations in infection group and non-infection group 5 days after ovariectomizing,while those maintained periodic variation in sham-operation infection group and sham-operation non-infection group.The cornification index of exfoliative vaginal cells decreased significantly in infection group and non-infection group than that in sham-operation infection group and sham-operation non-infection group.The level of E2 was significantly lower in infection group and non-infection group after ovariectomizing than that in sham-operation infection group and sham-operation non-infection group（P<0.01）.The results of bladder urine culture and pathological section showed that the mice were all infected in infection group and sham-operation infection group,while the results were all negative in non-infection group and sham-operation non-infection group.Conclusion Mice are infected in bladder after ovariectomizing and they initially meet the requirement of animal model of UTI during menopause.关键词：urinary infection;menopause;animal model;mice
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发布时间：2021-05-20 - 摘要：Objective To analyze concrete thinking with oriental characteristics by using electroencephalogram（EEG） examination,and discover the independence characteristics based on the changes of power spectrum in α-frequency range.Methods After training of mental tasks,69 students from universities were selected,and their EEG changes were detected during the processes of concrete thinking,Abstract thinking and thinking in images.The relative power was extracted from α-frequency range（including α1-frequency range and α2-frequency range） by applying power spectrum analysis.The three thinking forms were compared with common static state.Results In α1-frequency range,the comparison in distribution among concrete thinking,common static state,thinking in images and Abstract thinking showed greatly significant difference（P<0.001）.The three thinking forms had higher power than common static state,and showed parallel arrangement distribution and clear boundaries without linear cross.The characteristics of spatial distribution of concrete thinking showed Fz high power,lead O1 and lead F7 tending to consistency,and lead C3 showing high power reaction.In α2-frequency range,the comparison between concrete thinking and common static state showed greatly significant difference（P<0.001）,and showed no significant difference compared with thinking in images and Abstract thinking（P>0.05）.The relative power values of the three thinking forms had no significant difference,but had significant difference compared with common static state.The spatial distribution of concrete thinking showed lead O2 and lead T6 having high power.Conclusion From different angles and in varying degrees,α-frequency range shows the difference among the three thinking forms and independent characteristics of concrete thinking.关键词：concrete thinking;α-frequency range;electroencephalogram;specificity
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发布时间：2021-05-20 - 摘要：Objective To review the curative effect of Liangxue Tongyu Fang on acute-phase cerebral hemorrhage.Methods All patients（n=337） were randomly divided into treatment group（n=168） and control group（n=169）.The two groups were given routine therapies of Western internal medicine,and treatment group was given Liangxue Tongyu Fang at the same time.A therapeutic course was 21 days.The comprehensive curative effect,diagnostic scores of stroke,absorption of cerebral hemorrhage,haematoma grading and scores of Glasgow outcome score（GOS） were counted and compared in two groups.Results The total effective rate was 88.0% in treatment group,which was higher than that（77.5%） in control group（P<0.05）.The diagnostic scores of stroke and GOS decreased significantly in two groups after the treatment than before（P<0.01）,which was more significant in treatment group than that in control group（P<0.05 or P<0.01）.Conclusion Liangxue Tongyu Fang can significantly improve the curative effect and outcomes in the treatment of acute cerebral hemorrhage.关键词：acute cerebral hemorrhage;Liangxue Tongyu Fang;clinical research;Glasgow outcome score
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发布时间：2021-05-20 - 摘要：Objective To observe the influence of medicinals with actions of clearing heat and tonifying qi on the level of plasma glucose,insulin sensitive index（ISI） and pathomorphology of liver in KKay mice with early type 2 diabetes.Methods Male KKay mice with early type 2 diabetes（10 weeks old,n=27） were divided into model group,rosiglitazone group（0.67 g/kg·d） and Chinese medicinal group（8.3 g/kg·d） according to the value of plasma glucose.Other male C57BL/6J mice（10 weeks old,n=9） were selected as normal group.All groups were intragastrically given corresponding medicinals for 4 weeks and then the levels of random blood sugar（RBS）,fasting plasma glucose（FPG） and isuline were detected.The histomorphologic changes of liver were observed by using HE staining of liver section.Results Compared with normal group,ISI decreased significantly（P<0.01）,the levels of FPG and RBS increased significantly（P<0.01） and liver tissue had obvious adipose degeneration in model group.Compared with model group,ISI increased（P<0.01）,FPG decreased（P<0.01） and RBS decreased but without statistical significance（P>0.05） in Chinese medicinal group.The histomorphologic structure of liver was better in Chinese medicinal group than that in model group.Conclusion Medicinals with actions of clearing heat and tonifying qi can alleviate the insulin resistance,improve insulin sensitivity,regulate the level of blood sugar and protect the histomorphologic structure of live in KKay mice with early type 2 diabetes.关键词：medicinals with actions of clearing heat and tonifying qi;Huangqi（Radix Astragali seu Hedysari）;Fanbaicao（Herba Potentilla Discoloris）;type 2 diabetes;KKAy mice;insulin sensitivity
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发布时间：2021-05-20 - 摘要：Objective To investigate the intervention of medicated serum of Yinyanghuo（Herba Epimedii） to the expression of PPARγ mRNA in mesenchymal stem cells（MSCs） after adipogenic differentiation in rats with postmenopausal osteoporosis.Methods MSCs were separated and cultured in aseptic condition for three generations in female SPF SD rats（n=15）,and then the collected cells were randomly divided into model group,adipogenic induction group（AI group）,Western medicine group（WM group）,adipogenic and Western medicine group（AWM group）,Chinese medicine group（CM group）,adipogenic and high-dose Chinese medicine group（AI and high-dose CM group）,adipogenic and mid-dose Chinese medicine group（AI and mid-dose CM group）,and adipogenic and low-dose Chinese medicine group（AI and low-dose CM group）.The adipogenic inducers were prepared by using calf serum,high-dose,mid-dose and low-dose of medicated serum of Yinyanghuo and nilestriol serum,and then they were respectively used to intervene MSCs.The expression of PPARγ mRNA was observed in all groups 7 days after the intervention.Results Compared with model group,the expression of PPARγ mRNA decreased in WM group,AWM group and AI and high-dose CM group（P<0.05）,and decreased significantly in AI and low-dose CM group（P<0.01）.Compared with AI group,the expression of PPARγ mRNA decreased significantly in AI and low-dose CM group（P<0.01） and decreased in AI and high-dose CM group（P<0.05）.The expression of PPARγ mRNA was inhibited most significantly in AI and low-dose CM group（P<0.01,P<0.05）,and AI and high-dose CM group followed behind（P<0.05）.Conclusion After the intervention for 7 days,the expression of PPARγ mRNA can be observed in all groups,while it is the most significant in model group.The inhibitory effect on the expression of PPARγ mRNA was the highest in AI and low-dose CM group and AI and high-dose CM group.关键词：medicated serum of Yinyanghuo（Herba Epimedii）;mesenchymal stem cells;adipogenic differentiation;PPARγ;rats
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发布时间：2021-05-20 - 摘要：Objectives To observe the influence and long-term effect of therapies of regulating and supplementing lung and kidney（tonifying lung and spleen,tonifying lung and replenishing kidney,and replenishing qi and enriching kidney） on collagen and matrix metalloproteinase（MMP） in lung tissue in rats with chronic obstructive pulmonary disease（COPD）.Methods All rats were randomly divided into normal group,model group,tonifying lung and spleen group（treatment group 1）,tonifying lung and replenishing kidney group（treatment group 2）,replenishing qi and enriching kidney group（treatment group 3） and aminophyline group.The model of stable COPD was established by using the method of cigarette inhalation combining bacterial infection.From the 9th week all groups were respectively given corresponding medicinals until to the 20th week.The samples were collected on the 20th and 32nd week respectively.The pathological changes of lung tissue and expressions of MMP-9,MMP-2,TIMP-1,collagen I,collagen III and collagen IV were observed.Results In model group there were obvious pathological injuries was observed in lung tissue,and on the 20th week this injuries,including thickening of bronchial wall,bronchial stenosis,alveolar disruption and fusion,and thickening of pulmonary arteriolar wall,were relieved significantly in treatment group 1,treatment group 2 and treatment group 3（P<0.05 or P<0.01）.The expressions of MMP-9,MMP-2,TIMP-1,collagen I,collagen III and collagen IV were reduced（P<0.05 or P<0.01）,which still were significant on the 32nd week（P<0.05 or P<0.01） and were more significant than those in aminophyline group（P<0.05 or P<0.01）.Conclusion The therapies of tonifying lung and spleen,tonifying lung and replenishing kidney,and replenishing qi and enriching kidney can obviously relieve the impairments of lung tissue induced by COPD,reduce the expressions of collagen and matrix metalloproteinase with a good long-term effect.关键词：tonifying lung and spleen;tonifying lung and replenishing kidney;replenishing qi and enriching kidney;chronic obstructive pulmonary disease;collagen;matrix metalloproteinase;long-term effect;rats
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发布时间：2021-05-20 - 摘要：Objective To study whether Daotan Tang can interfere carotid atherosclerosis through regulating intercellular adhesion molecular-1（ICAM-1） and p38 pathway.Methods New Zealand rabbits were randomly divided into control group,model group and treatment groups with Daotan Tang in different doses [high-dose group（10 mL/kg）,mid-dose group（8 mL/kg） and low-dose group（6 mL/kg） given intragastrically].The influences of Daotan Tang on the expressions of ICAM-1 and p38 were observed by using immunohistochemistry technique.Results In model group,the expressions of ICAM-1 and p38 showed strong positive in endochylema of endothelial cells of vessel wall,which were significantly higher than those in control group（P<0.01）.The positive expressions of ICAM-1 and p38 were significantly lower in treatment groups than those in model group（P<0.01）,and this inhibitory effect increased as the dose of Daotan Tang increased.The activity of p38 was significantly correlated to ICAM-1 level（r=0.757,P<0.01）.Conclusion Daotan Tang can effectively inhibit the expressions of ICAM-1 and p38 in vessel endothelial cells in rabbits with carotid atherosclerosis.关键词：Daotan Tang;carotid atherosclerosis;intercellular adhesion molecular-1;p38;rabbits
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发布时间：2021-05-20 - 摘要：Objective To discuss the mechanism of acupoint application of Xioachuan Gao in the prevention and treatment of asthma.Methods The asthma model was induced by egg albumin in rats.Xioachuan Gao was applied on double Feishu（BL13）,double Xinshu（BL15） and double Ganshu（BL18）.The changes of cytokines interferon-γ（IFN-γ）/interleukin-4（IL-4） of Th1/Th2 were observed in serum and bronchoalveolar lavage fluid（BLAF）,and the pulmonary pathological changes were analyzed.Results Compared with model group,the cytokine IFN-γ of Th1 increased significantly（P < 0.05） in serum and BLAF and cytokine IL-4 of Th2 decreased significantly（P < 0.05） in Xiaochuan Gao group after the acupoint application with Xiaochuan Gao,and the pulmonary pathological changes showed that inflammatory infiltration and glandular hyperplasia were significantly alleviated.Conclusion The acupoint application with Xiaochuan Gao has a significant regulative effect on the disorder of Th1/Th2 and can relieve the symptoms of asthma.关键词：Xiaochuan Gao;acupoint application;interferon-γ;interleukin-4;rats
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发布时间：2021-05-20 - 摘要：Objective To observe the influence of Xingnaojing microemulsion after nasal administration on rats’behaviors and morphology of nasal mucusa,and develop new kind of compound preparation.Methods Health SD rats（n=125） were randomly divided into blank microemulsion group（blank group 1）,blank solvent group（blank group 2）,Xingnaojing microemulsion group（Xingnaojing group 1,84.4 g/L）,Xngnaojing naristillae group（Xingnaojing group 2,84.4 g/L） and normal saline solution group（saline group,each n=25）.Each group was given corresponding medicinal（50 μL） to every nostril each time and three times a day for 7 days.The samples of nasal septum mucosa were collected respectively after 1,4 and 7 days and 1 and 2 weeks after stoping medicinal administration for preparing paraffin sections,which were given HE staining and observed under light microscope.The ethological changes were observed in rats.Results After nasal administration of medicinals in all groups,the rats had behavioral reactions in varying degrees.The results of section observation showed that blank group 1,blank group 2 and Xingnaojing group 1 had certain irritating effect on nasal mucosa 7 days after medicinal administration and the irritation was equivalent（P>0.05）,but the injury of nasal mucosa was recovered one week after stopping medicinal administration.The irritation to nasal mucosa was significantly higher in Xingnaojing group 2 than that in Xingnaojing group 1（P<0.05） after 7 days.Conclusion The medicinals in Xingnaojing have irritation to nasal mucosa in rats,while when Xingnaojing is prepared as microemulsion,the irritation is reduced and the injury of nasal mucosa is recovered after one week.关键词：Xingnaojing;microemulsion;nasal medication of medicinals;nasal mucosa;irritation;rats
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发布时间：2021-05-20 - 摘要：Objective To analyze the correlation between the emotional symptoms of menopausal syndrome and 5-serotonin（5-HT）,estradiol（E2）,follicle-stimulating hormone（FSH） and luteinizing hormone（LH）.Methods The patients with diagnosed menopausal syndrome were asked to fill a observation table of clinical symptoms.The levels of serum 5-HT,E2,FSH and LH were detected and treated by using SAS statistical software package.The correlation between the emotional symptoms and levels of serum 5-HT,E2,FSH and LH was analyzed.Results The scores of emotional symptoms including irritability,vexation and palpitations were taken as abscissa,and the levels of 5-HT,FSH,LH and E2 were taken as ordinate for making scatter diagram.The analysis showed that 5-HT had centrostigma area in low-value area with significant tropism,and E2 had centrostigma area in low-value area with significant tropism.Conclusion The occurrence of emotional symptoms of menopausal syndrome is correlated to the levels of serum 5-HT and E2,and has no significant correlation to the levels of serum FSH and LH.关键词：menopausal syndrome;5-serotonin;sex hormones;emotional symptoms;correlation
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发布时间：2021-05-20 - 摘要：Objective To observe the changes of neurotransmitter-related indexes before and after the treatment of climacteric hypertension with Xuzao Gengping San and study the mechanism.Methods The patients（n=66） with climacteric hypertension（syndrome of yin deficiency and internal dryness） were randomly divided into treatment group（n=30） and control group（n=36）.The changes of blood pressue,neusopeptide Y（NPY）,neurotensin（NT） and noradrenalin（NE） were detected,analyzed and compared.Results The levels of NPY and NE decreased in treatment group and control group（P<0.05） than before the treatment and the change of NT level had no statistical significance（P>0.05）.The levels of NPY and NE decreased in treatment group compared with control group（P<0.05）.Conclusion Xuzao Gengping San used for treating climacteric hypertension has decreased the levels of plasma NPY and NE,which indicates that Xuzao Gengping San has a regulative effect on the neurotransmitters relating to climacteric hypertension.关键词：climacteric hypertension;Xuzao Gengping San;neuropeptide Y;neurotensin;noradrenalin
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发布时间：2021-05-20 - 摘要：Objective To study the influence of body differentiation and regulation combining Jinqi Jiangtang Pian on outcomes of impaired glucose tolerance（IGT）.Methods The people groups were intervened with body differentiation and regulation combining Jinqi Jiangtang Pian,dietary therapy and exercise therapy.Results In treatment group,the number of patients transformed to diabetes was lower,obvious effective rate was higher and depravation rate was lower compared with control group（P<0.05）.The comparison in fasting blood glucose（FBG）,2-hour postprandial blood glucose（PBG）,fasting insulin（FINS）,2-hour postprandial insnlin（PINS）,glycated hemoglobin（HbA1c）,and insulin resistance index（IRI） showed significance（P<0.05） between treatment and control group after the treatment.Conclusion At the same time of orally taking Jinqi Jiangtang Pian,IGT patients are recuperated according their constitutional types.The incidence of IGT transforming to diabetes can be reduced,and the therapy has an active effect on IGT reversing to normal glucose toherance（NGT） and decrease of diabetes incidence in clinic.关键词：body differentiation;body regulation;impaired glucose tolerance;clinical research
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发布时间：2021-05-20 - 摘要：Objective To observe the curative effect of electroacupuncture and pricking blood therapy on chronic whiplash injury and ameliorative effect on anxiety-depression.Methods The patients（n=40） were randomly divided into electricacupuncture group（EA group,n=20） and electricacupuncture combined with blood-letting group（EAPB group,n=20）.The two groups were respectively given corresponding treatment,and the ameliorative rate of symptoms and changes of anxiety-depression index were observed.Results There was a significant difference in the ameliorative rate of symptoms（P<0.05） between two groups,but no difference in the amelioration of anxiety.Conclusion Electroacupuncture and pricking blood therapy has a cooperative effect on chronic whiplash injury and the clinical curative effect can be improved significantly.关键词：electroacupuncture;pricking blood therapy;whiplash injury;anxiety-depression index
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发布时间：2021-05-20 - 摘要：Objective To investigate the curative effect of Qizao Yangxin Tang on child viral myocarditis.Methods The patients（n=100） with child viral myocarditis were randomly divided into treatment group and control group.The treatment group was given basic treatment and Qizao Yangxin Tang,and control group was given basic treatment and Shengmai Yin.The curative effect was compared between two groups before and after the treatment.Results Before and after the treatment,the improvement of TCM symptom integrals（P<0.05）,and the improvement of lactate dehydrogenase（LDH）,creatine kinase（CK） and CK-MB were better in treatment than those in control group（P<0.05）.In the improvement of ECG there was no statistical significance between two groups（P>0.05）.Conclusion Qizao Yangxin Tang has a obvious curative effect on child viral myocarditis.关键词：Qizao Yangxin Tang;child viral myocarditis;dual deficiency of qi and yin syndrome;clinical research
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发布时间：2021-05-20
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