最新刊期
卷 36 ， 期 1 ， 2013
- 摘要：The process design and decision knowledge of traditional Chinese medicine（TCM） clinical pathway were integrated,open modeling concept was introduced into the development of TCM clinical pathway system,and a mode chart of TCM clinical pathway workflow has been drawn.The mode is different from traditional clinical pathway-order sheet,emphasizes integrating clinical data,interlinking decision knowledge,building complex cognitive network and providing clinical materials for subsequent methodological evaluation through applying dynamical-sequential process.The integration of TCM with complex science is a kind of collision in thinking field,and complex model and visualized technology are the media for inheriting and supporting the sparks from this collision.In the practice of clinical pathway,origin and reasonable thinking with humanity flavor are needed at thinking level,rigorous methodological design and process quality control are needed at organization level,and adjustment of medical standards,reduction of medical cost and emergence of advantage therapies are needed at policy and regulation level.关键词：clinical pathway;information technology;complex network;evidence system;clinical workflows
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发布时间：2021-05-20 - 摘要：Suwen Yipian stresses three aspects: heaven,human and pathogen in discussion of pathogenesis of epidemic diseases,which is important for understanding the pathogenesis of epidemic diseases and guiding the prevention and treatment.Human’s vital qi is the base of prevention and should be taken care of.Pathogen with infectivity（"poisonous qi","pathogenic ghost"） is pathological causes and should be dodged in prevention and eliminated in treatment.The disorder of heaven’s qi will induce epidemic diseases and determine the nature and trend of diseases,which should be avoided.关键词：Suwen Yipian;epidemic diseases;pathogenesis
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发布时间：2021-05-20 - 摘要：Objective Objective To probe into automatic extractive method of tongue images based on the combination of visual attention mechanism and support vector machine（SVM）,and offer a new thinking train for applying pattern recognition method in tongue image segmentation.Methods After visual feature extraction and Gaussian pyramid multi-scale transformation,tongue images were created to saliency maps and then given binarization according to multi-feature merge strategy.The positive training samples and negative training samples were randomly selected from significant and non-significant areas without manual intervention,and SVM classifier was generated through sample automatic learning.Finally,the trainined SVM classifier was used to segment complete tongue images.Results This method had good segmentation effect on normal tongue,fissured tongue and teeth-marked tongue and anti-noise ability,and feature data was not lost.Conclusion The automatic segmentation method of tongue images based on visual attention and SVM has a stable segmentation effect in the condition without any priori knowledge,which is an initial exploration to pattern recognition application in tongue image segmentation.关键词：tongue image segmentation;visual attention;support vector machine;pattern recognition
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发布时间：2021-05-20 - 摘要：Forming yang with the pungent and sweet is one of combination reactions of Chinese medicinals,and it is originated in Huangdi Neijing,applied by ZHANG Zhong-jing,developed in dynasties of Jin,Yuan and Ming,and presented by ZHENG Qin-an in Qing Dynasty.Forming yang with the pungent and sweet is more than dispersing wind-cold and warm tonifying yang-qi,so the understand should be put on specific formulas and medicinals from the angle of yin-yang attributes.The kernel of forming yang with the pungent and sweet lies in the characteristics of yang: outward,warm and active,including pungent-sweet dispersing and pungent-sweet warm draining.The formulas and medicinals with actions of pungent-sweet dispersing have outward features,such as formulas and medicinals of dispersing wind-cold,dispersing wind-heat,outthrusting pathogen and clearing qi aspect heat.The formulas and medicinals with actions of pungent-sweet warm draining have warm and active features,such as formulas and medicinals of warming interior,nourishing,moving qi,activating blood,dispelling dampness,eliminating phlegm,helping digestion and purgation.关键词：forming yang with the pungent and sweet;dispersing;warm draining;yin-yang attributes;essence
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发布时间：2021-05-20 - 摘要：Objective To observe the influences of Chinese medicinals with actions of dispersing lung（modified Jiegeng Tang） on investine transmission function and content of neurokinin A（NKA） and vasoactive intestinal peptide（VIP） in lung and intestine in mice with slow transit constipation（STC）,and discuss the connecting mechanism of lung associating with large intestine from the angle of neuropeptides.Methods Mice（n=40） were randomly divided into normal group,model group,model treatment group and normal treatment group.STC model was established with the intragastrical method combining self-feces and compound diphenoxylate.Model treatment group and normal treatment group were given modified Jiegeng Tang intragastrically for 7 days,and normal group and model group was given distilled water intragastrically for 7 days.The defecation of mice was observed and content of NKA and VIP were detected in lung and intestine.Results Compared with normal group,in model group the time of the first melena was prolonged,number and weight of 4-hour melena decreased significantly,and NKA increased significantly and VIP decreased significantly in lung and intestine.Compared with model group,in model treatment group the time of the first melena was shortened,number and weight of 4-hour melena increased,and NKA decreased significantly in lung and intestine and VIP increased significantly in lung.Conclusion Modified Jiegeng Tang can improve the intestine transmission function in STC mice,and the mechanism may be related to the regulation of the content of NKA and VIP in lung and intestine.关键词：modified Jiegeng Tang;dispersing lung;slow transit constipation;lung associating with large intestine;neuropeptides;mice
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发布时间：2021-05-20 - 摘要：<正>《北京中医药大学学报》已入编《中国学术期刊（光盘版）》。为此郑重声明如下:一、凡在《北京中医药大学学报》发表的文章,如作者事先未表示异议,则相应地被编入《中国学术期刊（光盘版）》。《中国学术期刊（光盘版）》免收作者版面费。
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发布时间：2021-05-20 - 摘要：Objective To study the characteristics of chronic severe hepatitis B（syndrome of exuberance of internal yang toxin）.Methods The pictures of face,lips,palms and tongue manifestations（tongue body,tongue fur and sublingual collateral vessels） were taken by using digital photographing technology,and then their RGB values（R was red,G was green and B was blue） were detected by applying the System of TCM Experts of Tongue Inspection.The mean values of two samples [syndrome of exuberance of internal yang toxin（group 1） and syndrome of non-exuberance of internal yang toxin（group 2）] were compared.Results RGB values of face were all higher in group 1 than those in group 2.The difference in RG values of face was greatly significant between two groups（P<0.01）,and that in B value was significant（P<0.05）.RGB values of lips were all higher in group 1 than those in group 2.The difference in RGB values of lips was greatly significant between two groups（P<0.01）.RGB values of tongue body were all higher in group 1 than those in group 2.The difference in R value of tongue body was greatly significant between two groups（P<0.01）,and that in GB values was significant（P<0.05）.Conclusion The changes of RGB values of face,lips and tongue body can be taken as the reference indexes for the diagnosis of chronic severe hepatitis B（syndrome of exuberance of internal yang toxin）.关键词：chronic severe hepatitis;hepatitis B;syndrome of exuberance of internal yang toxin;color inspection;objectification
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发布时间：2021-05-20 - 摘要：Objective To observe the influence of Jingzhi Qingkailing Injection on blood fat in rats with experimental hyperlipidemia.Methods Normal rats and rat model of hyperlipidemia induced by self-made high fat fodder were used to observe the influences of Jingzhi Qingkailing（containing 4.4 g/L baicalin,0.4 g/L geniposide,3.0 g/L cholic acid and 2.6 g/L deoxycholic acid）on normal rats and rats with hyperlipidemia.SD rats（n=66） were randomly divided into normal group,model group,group with low-dose Jingzhi Qingkailing Injection（1.5 mL/kg,low-dose group）,mid-dose of Jingzhi Qingkailing Injection（3.0 mL/kg,mid-dose group）,high-dose of Jingzhi Injection（6.0 mL/kg,high-dose group） and Jiangzhi Tongluo Capsules group（30 mg/kg,JTC group,each n=11）.All rats were respectively given normal or high fat fodder for 45 days,and then intragastrically given medicinals for 15 days.The level of blood fat was detected before and after the treatment.Results Compared with normal group,the levels of serum total cholesterol（TC）,triglyceride（TG）,low-density lipoprotein（LDL） and high-density lipoprotein（HDL） increased significantly in model group（P<0.01）.Compared with model group,the levels of serum TC,TG and LDL decreased significantly in low-dose group,mid-dose group and high-dose group（P<0.01 or P<0.05）,and HDL level increased significantly.Conclusion Jingzhi Qingkailing Injection has significant effect of reducing blood fat in rats with hyperlipidemia.关键词：Jingzhi Qingkailing;hyperlipidemia;rats
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发布时间：2021-05-20 - 摘要：<正>《北京中医药大学学报》系中央级的高级中医药学术刊物,1959年创刊,由教育部主管、北京中医药大学主办。现分别属于中国自然科学核心期刊、中国中文核心期刊、全国中医药优秀期刊、全国优秀科技期刊、中国科学引文数据库首批入选的315种期刊之一、北京高校自然科学学报系统及全国高等医药院校学报系统优秀学报等。
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发布时间：2021-05-20 - 摘要：Objective To observe the distribution and functional changes of mastocyte（MCs） in acupoint areas after injection of antibody of monocyte chemotactic protein-1（anti-MCP-1） in stomach acupoints in rats,and study the influences of anti-MCP-1 and electroacupuncture on activity of MCs.Methods All rats were randomly divided into control group,electroacupuncture group（EA group）,anti-MCP-1 group and combining group（each n=10）.EA group was given electroacupuncture in left stomach acupoints for 25 minutes,anti-MCP-1 group was injected anti-MCP-1 in left stomach acupoints,and combining group was firstly injected anti-MCP-1 and then given electroacupuncture in left stomach acupoints for 25 minutes.The tissue samples of acupoint areas were collected for detecting and comparing the content of MCP-1,and at the same time,stained by cetylcholine esterase（AchE） and counterstaining by toluidine blue（TB） for observing the distribution of MCs in acupoint areas and comparing the differences in MCS count and degranulation among all groups.Results The content of MCP-1 and MCs count were significantly lower in combining group and anti-MCP-1 group than those in control group and EA group（P<0.05）.The rate of MCs degranulation was significantly lower in anti-MCP-1 group than that in EA group（P<0.05）.Conclusion After the injection of anti-MCP-1 and electroacupuncture in acupoint areas,MCs count and degranulation decrease significantly.MCs count is correlated to the content of MCP-1,and MCP-1 has an improving effect in the course of MCs migrating and recruiting to acupoint areas promoted by electroacupuncture.关键词：monocyte chemotactic protein-1;mastocytes;electroacupuncture;injection in acupoints;rats
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发布时间：2021-05-20 - 摘要：Objective To investigate the therapeutic effect of Huabianlian（HBL） extract on rats with type 1 complex regional pain syndrome（CRPS1） and the mechanism when it was used as glucocorticoid（GC）-sparing agent.Methods The influences of GC and HBL extract in different doses and combining treatment on hind leg swelling and pain,and activities of macrophage migration inhibiting factor（MMIF） and MIF tauromerase were compared in rats with CRPS1.Results In HBL group,hind leg pain was relieved,activity of MIF tauromerase was significantly inhibited,and secretion of serum MIF was slightly inhibited（P<0.05）.In low-dose GC group,the pain threshold had no changes in rats,but after combining HBL extract,the pain threshold was effectively improved and the curative effect was similar to that in high-dose GC group.Conclusion HBL extract has anti-inflammatory and analgesic effects as well as can be used as GC sensitization agent for enhancing the curative effect of low-dose GC on CRPS1.The mechanism may be related to that it can eliminate the antagonism of MIF to GC and improve the sensitivity of CRPS to GC through inhibiting the activity of MIF tauromerase.
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发布时间：2021-05-20 - 摘要：Objective To evaluate the curative effect and anti-recurrence effect of Chinese compound formula with the actions of tonifying qi,activating blood and resolving toxin on chronic recurrent ulcerative colitis（UC） at active phase and chronic persistent phase.Methods Randomized and positive control method was applied and clinical and hospitalized patients were taken as study objects,60 patients with chronic recurrent UC at active phase and chronic persistent UC were selected.The treatment group was given Chinese medicinals with the actions of tonifying qi,activating blood and resolving toxin and control group was given sulfasalazine（SASP,4～6 g/d）.A therapeutic course was 3 months and the cases with curative effect were followed up for 6 months.The clinical comprehensive curative effect,recurrent rate,curative effect on TCM syndromes,and changes of clinical activity index and endoscopic index were observed.Results After treatment for 3 months,the clinical comprehensive curative effect was higher in treatment group than that in control group.The complete remission rate and total effective rate had significant difference between two groups after statistical test.The 6-month recurrent rate was significantly lower in treatment group than that in control group.The short-term and long-term improvement of TCM syndrome integral,clinical activity index,endoscopic index and short-term and long-term curative effects were all better in treatment group than those in control group.Conclusion Chinese compound formula with the actions of tonifying qi,activating blood and resolving toxin has a reliable curative effect on UC,especially in anti-recurrent effect,it is much better than SASP.关键词：ulcerative colitis;recurrence;therapy of tonifying qi,activating blood and resolving toxin
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发布时间：2021-05-20 - 摘要：Objective To extract the syndrome factors of gestational diabetes mellitus（GDM）,analyze the distribution and combination laws of these syndrome factors,and explore the ideas of TCM syndrome differentiation for GDM.Methods A questionnaire of TCM syndromes of GDM was designed and 204 patients were selected and given syndrome differentiation for deciding disease location and disease nature.The distribution and combination laws of GDM syndrome factors were studied by using frequency analysis and factor analysis.Results The disease-location factors of GDM included kidney,mind,spleen and stomach,and kidney had the highest occurrence frequency（63.73%）.The disease-natures factors of GDM included qi deficiency,yin deficiency,yang deficiency,heat,dampness,blood deficiency and yang hyperactivity,and qi deficiency had the highest occurrence frequency（91.67%） and yin deficiency had the secondary highest frequency（74.51%）.There were 25 combinations of syndrome factors and commonly were 2-factor combination,3-factor combination and 4-factor combination.There were 3 principal components selected from 11 syndrome factors after factor analysis on principal components.The first principal component Z1 was closely correlated to syndrome factors of kidney,qi deficiency and yang deficiency,the second principal component Z2 was closely correlated to syndrome factors of qi deficiency and yin deficiency,and the third principal component Z3 was closely correlated to syndrome factors of kidney,yin deficiency and heat.The total contribution degree was 70.91%.Conclusion The major disease-location factor of GDM is kidney,and disease-nature factors include mainly qi deficiency and yin deficiency.The most common syndrome types are kidney qi deficiency,dual deficiency of qi and yin and kidney yin deficiency.Qi deficiency and yin deficiency are the key pathogenesis of GDM.关键词：gestational diabetes mellitus;syndrome factors;syndrome differentiation
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发布时间：2021-05-20 - 摘要：Objective To observe the preventive effect of Yiqi Huoxue Fang on lower extremity deep vein thrombosis（DVT） after surgery of hip fracture,and discuss the clinical application values.Methods The patients（n=146） were randomly divided into two groups,and Chinese medicinal group（n=73） was orally given Yiqi Huoxue Fang and control group（n=73） was given injection of low molecular heparin calcium.After continue medication for 3 weeks,the patients were given D-dimer test and double lower extremity vascular color Doppler ultrasonography.The changes of D-dimer values were compared before and after treatment,bleeding tendency was observed after the surgery and occurrence of DVT was counted.Results The values of D-dimer were all decreased significantly in two groups（P<0.05） before and after medication.There were no adverse events in Chinese medicinal group,and there was one case of mild cerebral hemorrhage and one case of extensive subcutaneous hemorrhage in control group.Conclusion The occurrence rate of DVT effectively decreases in two groups,so Yiqi Huoxue Fang is safe and effective in the prevention of DVT.关键词：Yiqi Huoxue Fang;surgery of hip fracture;lower extremity deep vein thrombosis;therapy of Chinese medicinals;prevention
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发布时间：2021-05-20 - 摘要：Objective To give the molecular identification to Shuizhi（Hirudo）,Mahuang（Whitmania pigra）,Liuyemahuang（Whitmania acranulata Whitman） and common adulterants by applying COI sequences,and investigate a rapid and accurate method for identifying Shuizhi（Hirudo） and its adulterants.Methods Qualified Shuizhi,Mahuang,Liuyemahuang and five kinds of adulterants were collected from the whole county（12 samples）,and the DNA was extracted for obtaining COI sequences.The softwares of ContigExpress,DNAMAN,EDIT SEQUENCE and MEGA 5 were used to analyze variable sites and build up N-J trees of qualified Shuizhi and its adulterants.Results There were many variable sites between qualified sources of Shuizhi（Mahuang,Shuizhi and Liuyemahuang） and its adulterants.The N-J trees showed that congeneric species got together and different species formed relative independent branches.Conclusion The technology of DNA barcodes based on COI sequences can be used for identifying Shuizhi and its adulterants excellently.关键词：Shuizhi（Hirudo）;COI sequences;DNA barcodes
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发布时间：2021-05-20 - 摘要：A large number of processing methods of Chinese medicinals was recorded in Shanghanlun as footnote,and they are indispensable part of formula design.According to clinical syndromes,ZHANG Zhong-jing combined the purpose of formula design to choose different processing methods of Chinese medicinals that showed both normatively and flexibly.It will help us to understand ZHANG Zhong-jing’ s academic spirit to explore the clinical significance of processing methods of Chinese medicinals in Shanghanlun from the perspective of clinical application,syndromes and purpose of formula design.关键词：Shanghanlun;processing of Chinese medicinals;clinical significance
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发布时间：2021-05-20 - 摘要：The data of articles published on the Journal of Beijing University of Traditional Chinese Medicine（JBUTCM） were retrieved from SciFinder Scholar database from 1999 to 2011 aiming at to know about the collection situation of JBUTCM by American Chemical Abstracts.The inclusion amount,total inclusion proportion,scientific classification and sum and proportion of funds were counted and analyzed.The results showed that JBUTCM has kept a higher quality through strict screening of articles and reasonable and stable structure of submitted articles.关键词：Journal of Beijing University of Traditional Chinese Medicine;American Chemical Abstracts;inclusion;analysis
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发布时间：2021-05-20 - 摘要：<正>《北京中医药大学学报》是由教育部主管、北京中医药大学主办的中央级的高级中医药学术期刊,主编为中国中医界学术权威王永炎院士。本刊分别属于中国自然科学核心期刊
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发布时间：2021-05-20
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