最新刊期
卷 0 ， 期 0 ， 2020
- 摘要：TCM has experienced for thousands of years and derived many academic schools.Inheritance of TCM academic schools has played an important role in promoting development of TCM theory and. practice.In the positive development of TCM academic schools,the main content of inheritance includes dao,fa and shu,which are key parts guarantying not only inheritance quality but also integrity and continuity of TCM academy.This paper tried to excavate,induct and generalize common regularities of the inheritance of academic schools based on deep consideration and discussion,so as to develop and strengthen inheritance of academic schools,and to highlight academic characteristics of TCM.关键词：TCM;inheritance of academic schools;key factors
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发布时间：2021-05-20 - 摘要：<正>为了更好地服务作者、读者,提高工作效率,《北京中医药大学学报》编辑部自2011年1月1日起开通网上采编系统（http://xb.bucm.edu.cn）,请广大作者和读者登陆本刊网址,随时通过此系统投稿、查稿、修改稿件或浏览最新目录等,首次登陆需先行注册。2010一2012年杂志及现刊内容已在网上全文刊出,可在线全文阅读。
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发布时间：2021-05-20 - 摘要：Objective To establish a image acquisition method of quail tongue while awake and a digital quantification method based on computer technology,which would lay foundation for research on basic theories of TCM and pharmacological mechanism of Chinese medicinal.Methods Tongue images of healthy quails while awake were collected by using digital camera.Tongue images and standard 24 color cards were analyzed by using Image-Pro Plus software.Scores of hue（H）,saturation（S）,intensity（I）,red（R）,green（G） and blue（B） were extracted from images,and values of red intensity（r）, green intensity（g） and blue intensity（b） were calculated.Tongue area,red tongue area and red tongue area ratio were also analyzed by using software.Results Relative standard deviation（RSD） of HIS color space,RGB color vector and values of rgb were all less than 10%in different periods.Imaging conditions and analysis process had sound stability and reproducibility.Scores of HIS color space and RGB color vector,and values of rgb were successfully detected in tongue images of quails.The results of red intensity and red tongue area were consistent to those of human visual observations,and reflected red degree of quail tongue manifestation.Conclusion In this study a method to detect tongue manifestation of quails while awake is successfully built up,which makes standardization analysis and digital quantitative analysis possible with advantage of non-invasion.This method can be used to follow the dynamic changes of quail tongue manifestation and provide certain reference for diagnosing symptom types of quails.关键词：tongue manifestation;quails;symptoms;standard;quantitative analysis
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发布时间：2021-05-20 - 摘要：Objective To observe the influences of Qufeng Xuanfei Fang on cough and airway responsiveness in guinea pigs with airway hypersensitivity.Methods Male Hartley guinea pigs（n =40） were intraperitoneally injected cyclophosphamide（30 mg/kg）,and ovalbumin（2 mg） and aluminium hydroxide（100 mg/kg） 2 days later,and ovalbumin（0.01 mg） and aluminium hydroxide（100 mg/ kg） 3 weeks later for boosting immunization and sensitization.After 3 weeks,guinea pigs were given aerosol inhalation of ovalbumin solution（10 mg/mL） for 60 seconds to provoke cough.All guinea pigs were divided into control group,model group,Chinese medicinal group and Western medicinal group. Chinese medicinal group was orally given Qufeng Xuanfei Fang and Western medicinal group was orally given montelukast sodium for continuous 10 days.Then counting of cough,airway responsiveness,and counting and differentiation of white blood cell（WBC） in bronchoalveolar lavage fluid were detected in all groups.Results Counting of cough increased significantly in model group compared with control group（P<0.05）,decreased in Chinese medicine group and montelukast sodium group compared with model group（P<0.05）,and decreased in Chinese medicinal group compared with Western medicinal group（P<0.05）.Airway resistance in all groups increased after provoking cough.The value of airway resistance in model group was relatively higher than those in other groups（P<0.05）,was lower in Chinese medicinal group and Western medicinal group than that in other groups（P<0.05）,and was lower in Chinese medicinal group than that in Western medicinal group（P<0.05）.In the aspect of counting and differentiation of WBC in bronchoalveolar lavage fluid,total cells counting,monocyte counting and eosinophils counting were more in model group than those in control group（P<0.05）, were less in Chinese medicinal group and Western medicinal group than those in model group（P< 0.05）,and were less in Chinese medicinal group than those in Western medicinal group（P<0.05）. Conclusion Qufeng Xuanfei Fang has a satisfactory curative effect on guinea pigs with airway hypersensitivity,and the mechanism may be related to alleviating airway inflammation and relieving airway hypersensitivity.关键词：guinea pigs;coughing;airway responsiveness;airway resistence;Qufeng Xuanfei Fang
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发布时间：2021-05-20 - 摘要：<正>2013年9月27日,中国科学技术信息研究所（ISTIC）在北京召开中国科技论文统计结果发布会,《北京中医药大学学报》荣获2012年"百种中国杰出学术期刊"称号（封二）。这是《北京中医药大学学报》继2008年、2011年进入"中国精品科技期刊"后首次获得"百种中国杰出学术期刊"称号。2012年《中国科技期刊引证报告》（核心版）共收录中国科技核心期刊1994种,《北京中医药大学学报》
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发布时间：2021-05-20 - 摘要：Objective To investigate molecular genetic mechanism of epidermal growth factor receptor（EGFR）polymorphism influencing on tongue coatings in the patients with gastric cancer（GC）.Methods A hospital-based case-control study was conducted,in which patients（n=387） with GC were enrolled in GC group and healthy subjects（n=392） in control group.The tongue coating color and coating texture were observed.Eleven single nucleotide polymorphisms（SNPs） in EGFR were detected by using ligase detection reaction.Correlations among the coating color,coating texture and SNPs in EGFR were statistically analyzed by using SPSS 16.0 software.Results T allele was detected only in mismatched SNP rs28384375.The incidence of GC increased in the patients who were carrying SNP rs763317 GA/ AA genotype and white coating.SNP rsl050171 GG genotype and rs2293347 could significantly affect coating color（P<0.05）,and SNP rsl7337023 TA/TT genotype,rsl050171 and rs2293347 could significantly affect coating texture（P<0.05）.Conclusion There is a correlation between the changes of tongue coating and polymorphism in EGFR in GC patients.关键词：gastric cancer;tongue coating;epidermal growth factor receptor;single nucleotide polymorphism
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发布时间：2021-05-20 - 摘要：Objective To observe gene expressions of nephrin and podocin in renal tissue in rats with diabetic nephropathy,and to discuss the interaction of nephrin and podocin on proteinuria of diabetic nephropathy.Methods Male Sprague-Dawley（SD） rats were randomly divided into nephrectomy group,model group,irbesartan group,high-dose,mid-dose and low dose Chinese medicinal groups（high-dose group,mid-dose group and low-dose group）.All groups were given relevant medicinal intragastrically.At the end of the 6th week,the levels of 24-hour urinary protein（U Pro） Scr and BUN were detected in rats of all groups,and expressions of nephrin and podocin in renal cortex were detected by using reverse transcription polymerase chain reaction（RT-PCR）.Results The level of U Pro decreased significantly in irbesatan group,low-dose group and mid-dose group compared with that in model group（P<0.05）.The levels of Scr and BUN were improved and the expressions of nephrin and podocin increased significantly in all treatment groups compared with those in model group（P<0.05）. The results demonstrated a negative correlation between 24-hour U Pro and expressions of nephrin and podocin,and a positive correlation between expression of nephrin and that of podocin.Conclusion The decrease of expressions of nephrin and podocin in glomerular epithelial cells may be one of proteinuria mechanisms of diabetic nephropathy in rats with diabetes.关键词：rats with diabetes;Chinese medicinal with actions of replenishing qi and nourishing yin,and resolving mass and freeing collateral vessels;nephrin;podocin;proteinuria
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发布时间：2021-05-20 - 摘要：Objectives To observe the influences of wind-dispelling and tonifying Chinese medicinals in Houshihei San on the expressions of glial fibrillary acidic protein（GFAP） and aquaporin-4（AQP-4） in lateral ventricle in rats with cerebral ischemia.Methods The model of focal cerebral ischemia was established by using thread approach to occlude middle cerebral artery in rats.The effects of winddispelling,tonifying and combining Chinese medicinals in Houshihei San on expressions of GFAP and AQP-4 were observed at three time points（6 hours,24 hours and 48 hours after cerebral ischemia）. Results After ischemia for 6 hours to 48 hours,astrocytes in lateral ventricle were markedly swollen in model group,and expressions of GFAP and AQP-4 increased significantly in model group compared with those in sham-operation group（P<0.01）.After ischemia for 6 hours,wind-dispelling and combining Chinese medicinal significantly regulated downwards AQP-4 expression,which showed a significant difference compared with that in model group（P<0.05）.After ischemia for 24 hours,AQP-4 expression in lateral ventricle decreased significantly in tonifying group and combining group compared with that in model group（P<0.05）.After ischemia for 48 hours,wind-dispelling Chinese medicinal reduced significantly the expression of GFAP,and tonifying Chinese medicinals significantly regulated downwards the expressions of GFAP and AQP-4,which showed a significant difference compared with those in model group（P<0.05）.Conclusion Wind-dispelling Chinese medicinal and tonifying Chinese medicinal have positive protective effects on ischemic brain by controlling the expressions of GFAP and AQP-4 and reducing edema of astrocytes.关键词：cerebral ischemia;glial fibrillary acidic protein;aquaporin-4;wind-dispelling Chinese medicinals;tonifying Chinese medicinals;rats
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发布时间：2021-05-20 - 摘要：Objective To discuss the influence of Shoutai Wan on expression of annexin A2 in decidual tissues in mice with recurrent abortion.Methods The model of normal pregnancy was established based on mating of female strain CBA/J mice and male strain BALB/C mice.The model of recurrent abortion was established based on mating of female strain CBA/J mice and male strain DBA/2 mice.The mice with recurrent abortion were randomly divided into model group,high-dose,mid-dose and low dose Shoutai Wan groups（high-dose group,mid-dose group and low-dose group） according to order of pregnancy.All groups were given medicinal intragastrically from the 1th day of pregnancy,and killed on the 14th day.The expression of annexin A2 in decidual tissues in all groups was detected by using immunohistochemical method and Western blot.Results The expression of annexin A2 decreased significantly in model group compared with that in control group,and the difference between the two groups was significant（P<0.01）.The expressions of annexin A2 increased in high-dose group,mid-dose group and low-dose group compared with that in model group,and difference was significant（P< 0.01）.The expression of annexin A2 increased significantly in high-dose group compared with that in mid-dose group and low-dose group,and difference was significant（P<0.01）.Conclusion Shoutai Wan can regulate upwards the expression of annexin A2 in decidual tissues to maintain pregnancy in mice with recurrent abortion,which may be one of its mechanisms to prevent miscarriage.关键词：Shoutai Wan;recurrent abortion;decidua;annexin A2;mice
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发布时间：2021-05-20 - 摘要：Objective Perceptual thinking is a thinking pattern with unique TCM characteristics.This experiment is aiming at studying characteristics of surface electromyogram amplitudes while in perceptual thinking state and proposing indicators which can be used to distinguish perceptual thinking from abstract thinking and imagery thinking.Methods By using the method of " two-way layout,correlated detection and mutual paraphrase" in this experimental study,the surface electromyogram signals were collected from subjects who were thinking of the same topic while in abstract thinking state,imagery thinking state and perceptual thinking state,and exported amplitude data was statistically analyzed.Results Amplitude range and standard deviation of surface electromyogram signals data in perceptual thinking state had significant differences compared with those in other thinking state.Non-parametric test was introduced in this study then.Mean value,standard deviation and range of amplitude of surface electromyogram signals had no significant differences in abstract thinking state and imagery thinking state compared with those in resting state.Mean value and mean rank of amplitude of surface electromyogram signals had no significant differences in perceptual thinking state compared with those in resting state（P>0.05）,and range of amplitude had significant difference in perceptual thinking state compared with that in resting state（P> 0.05）.Conclusion Comparative analysis and statistical results indicated that electromyogram signals in perceptual thinking state fluctuated greatly compared with those in resting state,while electromyogram signals in abstract thinking state and imagery thinking state showed no such fluctuations.Psychology in perceptual thinking state would change accompanying the changes of physiological indexes,while psychology in abstract thinking state and imagery thinking state showed no such changes.Different from abstract thinking and imagery thinking,perceptual thinking is a unique thinking pattern which combines spirit and body.关键词：perceptual thinking;surface electromyogram signal;amplitude characteristic;fluctuation
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发布时间：2021-05-20 - 摘要：Objective To discuss the influences of Qishen Granules combining exercise therapy on cardiac function and left ventricular remodeling in rats with heart failure.Methods The model of heart failure induced by acute myocardial infarction was established by using thread approach of left anterior descending coronary artery（LAD） in Sprague-Dawley（SD） rats.Then the rats were randomly divided into model group,Qishen Granules treatment group（Qishen Granules group）,Qishen Granules combining exercise therapy group（combining group） and exercise therapy group（exercise group） 5 weeks after operation,which were given relevant treatment.At the end of 8th week after operation, cardiac functions were detected by using echocardiogram and cardiac histomorphological changes were observed in all groups.Results Left ventricular ejection fraction（LVEF） decreased significantly,left ventricular end-diastolic dimension（LVEDD） and LVEDs increased significantly（P<0.01）,LVFS shortened significantly（P<0.01）,left ventricular weight index,heart weight index,and left ventricular perimeter and area increased significantly（P<0.01） in model group compared with those in shamoperation group.The pathological characteristics of left ventricular remodeling in model group were remarkable.LVEF,LVEDs and other indexes decreased significantly（P<0.05,P<0.01）,left ventricular perimeter and area decreased significantly（P<0.01） in Qishen Granules group and combing group compared with those in model group.The pathological changes were alleviated in Qishen Granules group and combing group.Conclusion Qishen Granules combining exercise therapy can improve cardiac functions and postpone the formation and development of left ventricular remodeling in rats with heart failure induced by acute myocardial infarction.关键词：heart failure;cardiac function;Qishen Granules;exercise therapy;left ventricular remodeling;rats
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发布时间：2021-05-20 - 摘要：Objective To observe the regulatory effect of acupoint catgut embedding therapy on liver insulin JNK1 signal pathway in rats with nonalcoholic fatty liver.Methods Male SD rats were feed with fatty food for 12 weeks for establishing rat model of nonalcoholic fatty liver.After treatment with cupoint catgut embedding therapy for 8 weeks,the changes of liver index were compared between model group and embedding group.The expression changes of liver insulin receptor,phosphorylation of insulin receptor substrate 1（p-IRS1,Ser307 loci）,C-Jun N-terminal kinase 1（JNK1） and C-phosphorylation of Jun N-terminal kinase 1（p-JNKl） were detected by using Western blot method before and after treatment.The mechanism of cupoint catgut embedding therapy in influencing JNK1 expression and activating and regulating main signal molecules of insulin pathway was analyzed.Results The liver index was significantly lower in embedding group than that in model group（P<0.05）.The changes of liver insulin receptor were not significant（P<0.05）,and the expressions of pVIRS1,JNK1 and p-JNKl were significantly lower in embedding group than those in model group（P<0.05）.Conclusion Acupoint catgut embedding therapy has therapeutic effect on nonalcoholic fatty liver.The mechanism may be related to that it can decrease JNK1 expression,inhibit phosporylation of JNK1 and further inhibit the phosporylation of Ser307,and relieve insulin resistance.关键词：C-Jun N-terminal kinase;nonalcoholic fatty liver;insulin resistance;acupoint catgut embedding;rats
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发布时间：2021-05-20 - 摘要：Objective To establish a quality control system of Zhishi（Fructus Auranlii Immaturus） based on effective substance basis.Methods Thin layer chromatography（TLC） was used to qualitatively identify dihydroflavone and volatile oils in Zhishi,and HPLC was used to quantitatively determine the effective index constituents including naringin,hesperidin and neogesperidin.Results The qualitative identification with TLC of dihydroflavone and volatile oils in Zhishi was specific.Naringin showed a good linear relationship at a range from 0.652 5μg to 5.22μg（r=0.999 9） and the average recovery was 96.98%（RSD=1.74%）.Hesperidin showed a good linear relationship at a range from 0.037μg to 0.296μg（r=0.999 5） and the average recovery was 97.70%（RSD=1.89%）.Neogesperidin showed a good linear relationship at a range from 0.507 5μg to 4.06μg（r=0.999 9） and the average recovery was 98.22%（RSD=1.81%）.Conclusion The applied TLC is simple and feasible in the qualitative identification of dihydroflavone and volatile oils in Zhishi.The established HPLC quantitative determination of 17 batches of Zhishi material is easy and accurate.The quality control sgstem develop and evaluated in the paper canbe used as an effective substance basis related to natural properties of Zhishi.关键词：volatile oils;dihydroflavone;Zhishi（Fructus Aurantii Immaturus）;quality control system;effective substance basis
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发布时间：2021-05-20 - 摘要：Objective To develop a method for determining the entrapment efficiency of glycyrrhetinic acid-tanshinone IIA compound liposomes（GT-Lip）.Methods Sephadex filtration and low-speed centrifugation were used for separating GT-Lip and free drugs.The determination results of these two methods for the entrapment efficiency were compared taken HPLC as analysis approach.Results Sephadex filtration G-50（M） absorbed some GT-Lip,which was not good for the determination of the entrapment efficiency of GT-Lip.The low-speed centrifugation separated effectively GT-Lip and free drugs,and the average entrapment efficiency of tanshinone IIA reached to（81.50 ±0.76）%and that of glycyrrhetinic acid reached to（98.63±0.90）%after HPLC determination.Conclusion HPLC combining low-speed centrifugation can applied for the effective determination of the entrapment efficiency of GT-Lip,which is quick and accurate.关键词：glycyrrhetinic acid;tanshinone ⅡA;entrapment efficiency;low-speed centrifugation;Sephadex filtration
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发布时间：2021-05-20 - 摘要：Objective To study the technology of macroporous resin in the purification of the total flavonoids in Duoye Jidou（Oxytropis myriophylla）.Methods Taken the content and adsorptiondesorption rate of the total flavonoids as the indicators,the adsorption ability of 5 kinds of macroporous resins to the total flavonoids were observed,and resin D4006 was determined to be used in purification for optimizing the conditions of adsorption,impurity removing and elution in purification technology.Results The best purification conditions were as follows;the concentration of sample was 0.05 g/mL,maximum sample volume was 24 BV,adsorption flow velocity was 3 BV/h,and ratio of diameter to height was 1:9. After adsorption,5%ethanol was used in elution（9 BV） for impurity removing and then 50%ethanol was used in elution（8 BV,3 BV/h） again.The content of the total flavonoids reached to 54%after the purification with resin D4006.Conclusion The developed technology has good separation effectiveness and is simple with higher repeatability,which can be used for separating and enriching the total flavonoids in Duoye Jidou.关键词：Duoye Jidou（Oxytropis myriophylla）;total flavonoids;macroporous resin;purification
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发布时间：2021-05-20 - 摘要：Objective To get know the distribution laws of TCM syndrome types in 281 patients with cervical intraepithelial neoplasia（CIN） through cluster analysis.Methods By applying multicenter clinical trials,94 symptom items from 281 CIN patients were inputted into SPSS17.0 software,and the data was given cluster analysis by using R-cluster method in hierarchical clustering.The names of syndrome types were determined by expert group according to clustering results.Results The syndrome types in 281 CIN patients included spleen deficiency and dampness exuberance,kidney-yang deficiency, damp-heat accumulating in the interior,heat-turbidity binding,yin deficiency combining phlegm and liver depression and qi stagnation.There were 109 patients with mainly CIN Ⅰ and spleen deficiency and dampness exuberance and secondly kidney-yang deficiency,77 with CIN Ⅱ and mainly damp-heat accumulating in the interior and secondly kidney-yang deficiency,and 95 with CIN Ⅲ and mainly dampheat accumulating in the interior and secondly heat-turbidity binding and spleen deficiency and dampness exuberance.Conclusion It is found that spleen deficiency and kidney-yang deficiency are common syndrome types of CIN Ⅰ,which indicates healthy qi deficiency,and damp-heat accumulating in the interior are common syndrome types of CIN Ⅱ and CIN Ⅲ,which indicates the struggle between the healthy qi and pathogenic qi and deficiency of the root and excess of the tip.The incidence trend of CIN is from healthy qi deficiency at first developing to deficiency complicated with excessiveness关键词：cervical intraepithelial neoplasia;cluster analysis;TCM syndrome types
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发布时间：2021-05-20 - 摘要：Objective To investigate the curative effect of acupuncture on female overactive bladder（OAB）.Methods The female patients（re=60） with OAB were randomly divide into acupuncture group and solifenacin group.The symptoms of OAB were quantified with the questionnaire（Chinese version） of OAB symptom scores（OABSS） for reviewing the severity of OAB.The average frequency of urgency to urination in 24 hours,daytime urination frequency,nighttime urination frequency,urine volume of every time and median of uroclepsia frequency were recorded with urination diary for observing curative effect.The solifenacin group（n=30） was orally given solifenacin（5 mg） per day for 4 weeks,and acupuncture group（n=30） was needled in Guanyuan（CV4）,Shenshu（BL23）,Zuwuli（LR10）, Yinlingquan（SP9）,Shuidao（ST28）,Zhongji（CV3）,Zhonglvshu（BL29）,Pangguangshu（BL28） and Ciliao（BL32） once a day for 4 weeks.All data was treated by using SPSS 13.0 software and the curative effect was analyzed.Results The total effective rate was 90%in acupuncture group and 86.9%in solifenacin group（P>0.05）.After treatment the average frequency of urgency to urination in 24 hours,daytime urination frequency,nighttime urination frequency,urine volume of every time and median of uroclepsia frequency were all decreased in two groups than before（P<0.05）.The curative effect on urgency to urination was better in acupuncture group than that in solifenacin group（P<0.05）, and had no statistical significance in the comparison of daytime urination frequency,nighttime urination frequency,urine volume of every time and median of uroclepsia frequency between two groups（P> 0.05）.The difference in OABSS had significance in two groups before and after treatment（P<0.05） and had no significance after treatment（P>0.05）.Conclusion Acupuncture can relieve safely and effectively the symptoms of OAB in female patients.关键词：overactive bladder;acupuncture;solifenacin;clinical research
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发布时间：2021-05-20 - 摘要：Objective To analyze the correlation between TCM constitutional types and chronic low back pain in elderly patients.Methods The method of cluster sampling was used to chose elderly patients aged from 60 to 69 in Lishui City,Zhejiang Province.The status of chronic low back pain was surveyed at site and TCM constitutional types were determined in the elderly patents.Results The tendentiousness of chronic low back pain in the elderly patents was significantly correlated to normal constitution（rs= 0.205,P=0.000）,qi-deficiency constitution（rs=-0.114,P=0.018）,yang-deficiency constitution（rs=-0.124,P=0.009）,phlegm-damp constitution（rs=-0.122,P=0.011） and blood-stasis constitution（rs=-0.121,P=0.012）.The Oswestry disability index of the patients with chronic low back pain was significantly correlated normal constitution（rs=0.260,P=0.000）,qi-deficiency constitution（rs=-0.170,P=0.000）,yang-deficiency constitution（rs=-0.7324,P=0.000）, phlegm-damp constitution（rs=-0.140,P=0.004）,blood-stasis constitution（rs=-0.130,P= 0.007） and qi-depression constitution（rs=-0.100,P=0.038）.Conclusion The tendentiousness of chronic low back pain in elderly patients is significantly correlated to qi-deficiency constitution,yangdeficiency constitution,phlegm-damp constitution and blood-stasis constitution.Qi-deficiency constitution,yang-deficiency constitution,phlegm-damp constitution,blood-stasis constitution and qidepression constitution are closely correlated to the degree of disability induced by chronic low back pain in elderly patients.关键词：elderly people;TCM constitutional types;chronic low back pain;correlation
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发布时间：2021-05-20
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