最新刊期
卷 36 ， 期 11 ， 2013
- 摘要：The current research on the dosage of Chinese medicinal are mostly focused on the dose of a single medicinal,while the dosages of whole decoctions were seldomly mentioned. The authors have studied the dosages of whole decoctions,numbers of medicinal and quantity of added water of formulas in Waitai Miyao. The conclusion is as follows: the general dosage range of whole decoctions are from 131 g to 331 g,numbers of medicinal were from 4 to 8,and the range of quantity of added water is from 1 200 mL to 1 800 mL. This calculated result indicates that the characteristics of specialized medicinal with powerful actions in Shanghan Zabing Lun have been inherited by most physicians in the Han and Tang dynasties. The quantity of added water depends on different formulas and different medicinal for the best curative effect and maximum decocted volume.关键词：Waitai Miyao;dosage of whole decoction;numbers of medicinal;quantity of added water
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发布时间：2021-05-20 - 摘要：<正>2013年9月27日,中国科学技术信息研究所（ISTIC）在北京召开中国科技论文统计结果发布会,《北京中医药大学学报》荣获2012年"百种中国杰出学术期刊"称号（见封二）。这是《北京中医药大学学报》继2008年、2011年进入"中国精品科技期刊"后首次获得"百种中国杰出学术期刊"称号。中国科学技术信息研究所每年出版的《中国科技期刊引证报告》（核心版）,发布当年中国科技论文与引文数据库收录的中国科技论文核心期刊科学计量指标。中国科技期刊综合评价指标体系,采用层次分析法,
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发布时间：2021-05-20 - 摘要：From the angle of theory of fluid being related to humor,the paper has discussed the essence of the theory of lung and large intestine being interior-exteriorly related. The lung is the upper source of water and has the function of regulating waterways,and large intestine is an organ being in charge of transportation and governs body fluid. They are closely correlated to and supplement each other. Discussion on the theory of fluid being related to humor will deepen understanding of the connotation of the theory of lung and large intestine being interior-exteriorly related,and will enhance its application in clinic.关键词：fluid being related to humor;regulating waterways;large intestine governing fluid;basic theory of TCM
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发布时间：2021-05-20 - 摘要：Embodied mind,which prevalent gradually since the 1980s,is the second generation of ideological trend in Western cognitive science. Under the premise of monism,its core idea can be summarized in three characteristics of the mind,including embodiment,situatedness and enaction. Concrete thinking theory is an innovative viewpoint about thinking outlook on development in TCM scientific field in the 1990s,based on the overall concept of "holism of body and mind",this theory expanded the concept of thinking and put forward a new pathway of the thinking development process. In this 21stcentury,if we ponder deeply over the intersection of embodied mind and concrete thinking from the perspective of cognitive science,maybe we can get important inspiration about how to explore mind theory more deeply under the background which Eastern and Western culture are infiltrated mutually.关键词：mind;embodied mind;concrete thinking;cognitive science
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发布时间：2021-05-20 - 摘要：There are a lot of Chinese medicinal named in the word-form of"× qi",and the plants named in this word-form mostly refer to medicinal plants. The medicinal parts of these plants are mainly root and hair. In the producing areas of the plants named as " × qi",the pronunciations of qi and xu are very similar to each other,so qi with fewer strokes is becoming more prevalent. The word-form of " × qi"is complicated in naming,borrowing of characters and developing of pronunciation.关键词：× qi;names of Chinese medicinal;names of plants
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发布时间：2021-05-20 - 摘要：Objective To observe the preventive and therapeutic effects of Fulin Granules on urinary infection in mice after castration. Methods The minimum inhibitory concentration（ MIC） of Fulin Granules was determined on Staphylococcus aureus（ 26076）,beta streptococcus（ 32204）,Escherichia coli,Pseudomonas aeruginosa（ 10105）,Klebsiella Pneumoniae（ 46108） and Candida albicans by applying in vitro bacteriostasis test. The model of experimental urinary infection was established through the intravesical injection of pathogenic Escherichia coli in female castrated mice. Fulin Granules（ 22、11、 5. 5 g / kg） was orally administrated in all groups for 11 days,and the changes of vaginal smears,vaginal keratinized cells,serum level of estradiol（ E 2） and bladder histopathology were observed. Results Fulin Granules has inhibitory or killing effects in varying degrees on Staphylococcus aureus（ 26076）,beta streptococcus（ 32204）,Escherichia coli,Pseudomonas aeruginosa（ 10105）,Klebsiella Pneumoniae （ 46108） and Candida albicans,and its MIC value was much lower than that in Sanjin Pian group. The results of vaginal smears showed that there were proestrus performances in mid-dose group and high-dose group. The level of serum E 2 was reduced in high-dose group and mid-dose group（ P < 0. 01,P < 0. 05）,and the changes of bladder histopathology were significantly relieved in high-dose group, mid-dose group and low-dose group but there was no significant difference among these three groups. Conclusion Fulin Granules has certain therapeutic effect on menopausal urinary infection in mice.关键词：Fulin Granules;urinary infection;menopause;mice
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发布时间：2021-05-20 - 摘要：Objective To review systemically the curative effect and safety of the therapy of supplementing qi and activating blood in treatment of syndrome of qi deficiency and blood stasis of acute cerebral ischemic stroke（ ACIS）. Methods The databases,including PubMed,Springer,China Journal Full-Text Database（ CJFD） and WanFang Database,were retrieved for collecting the literature about clinical randomized controlled trials（ RCT） involved the treatment of ACIS with the therapy of supplementing qi and activating blood. The quality of collected literature was reviewed according to the Jadad scoring method recommended by Cochrane Collaboration,and RevMan 4. 2. 3 software was used in Meta-analysis. Results There were 28 literature included involved 2 385 cases,among them 1 251 in treatment group（ treated with therapy of supplementing qi and activating blood combining Western medicinal） and 1 134 in control group（ treated only with Western medicinal）. The baseline data was comparable in all trials. The results of Meta-analysis showed that the treatment group was better than control group in improving total curative effect [RR = 4. 24,95% CI（ 2. 26,5. 51） ],decreasing NIHSS [WMD =-3. 13,95% CI（- 4. 01,- 2. 26） ],reducing TCM syndrome integrals [WMD =-5. 23, 95% CI（- 8. 53,- 1. 93） ],improving activity of daily living [WMD = 12. 79,95% CI（ 4. 29,21. 29） ] and reducing plasma viscosity [WMD =- 0. 54,95% CI（- 0. 90,- 0. 17） ]. Conclusion The curative effect is better in treatment group than that in control group. As the limitation of literature quality and quantity,more multiple-center and large-sample clinical RCT with higher quality are required for further identifying the results.关键词：supplementing qi and activating blood;acute ischemic stroke;randomized controlled trials;Meta-analysis
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发布时间：2021-05-20 - 摘要：Objective To observe the influences of Huannao Yicong Fang on learning and memory ability,hippocampal pathomorphology and content of cerebral oxidative stress and inflammatory factors in rapid aging SAMP8 mice. Methods Male rapid aging SAMP8 mice were randomly divided into model group,positive drug group（ donepezil hydrochloride,0. 65mg / kg） and high-dose（ 21. 84 g / kg）,middose（ 10. 92 g / kg） and low-dose（ 5. 46 g / kg） Huannao Yicong Fang groups（ high-dose group,middose group and low-dose group,each n = 10）,and all groups were intragastrically given corresponding medicinal continuously. The changes of mouse ethology were observed by applying Morris water maze. The content and activity of hippocampal and cortex superoxide dismutase（ SOD）,malondialdehyde（ MDA）,glutathione and glutathione peroxidease（ GSH-PX） were detected by using chromatoptometry. The levels of interleukin-1（ IL-1） and interleukin-6（ IL-6） were detected by using radioimmunoassay. Results Compared with model group,Huannao Yicong Fang increased the number of passing platform,prolonged the distance and time in the fourth quadrant（ P < 0. 05）, ameliorated the cerebral pathomorphology,increased the activity of SOD and GSH-PX（ P < 0. 05,P < 0. 01）,and decreased the levels of IL-1 and IL-6（ P < 0. 05,P < 0. 01）. Conclusion Huannao Yicong Fang can improve the abilities of space recognition,learning and memory through inhibiting oxidative stress and inflammatory reactions and protecting the morphology of cerebral hippocampus and cortex in rapid aging SAMP8 mice.关键词：Huannao Yicong Fang;rapid aging SAMP8 mice;cognitive impairment;oxidative stress;inflammatory reaction
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发布时间：2021-05-20 - 摘要：Objective To explore the mechanism of moxibustion in intervening inflammatory injury of Helicobacter pylori（ Hp） gastritis and protecting gastric mucosa. Methods Health SD rats（ n = 50） were randomly divided into blank group,Hp model group,acupoint moxibustion group,non-acupoint moxibustion group and electroacupuncture group（ each n = 10）. The rat model of Hp gastritis was established by intragastrically giving of Hp. The content of tumor necrosis factor-α（ TNF-α）, interleukin-1β（ IL-1β）,interleukin-12（ IL-12） and interleukin-10（ IL-10） in gastric homogenate were detected by applying enzyme-linked immunosorbent assay（ ELISA）. Results The pretreatment of moxibustion reduced gastric mucosal injury index（ P < 0. 01）,decreased the content of TNF-α,IL-1β and IL-12（ P < 0. 05 or P < 0. 01）,and increased the content of IL-10（ P < 0. 01） compared with Hp model group,acupoint moxibustion group and electroacupuncture group. Conclusion The pretreatment of moxibustion can relieve the gastric mucosal injury of Hp gastritis,and the mechanism may be related to inhibiting the release of pro-inflammatory cytokines（ TNF-α,IL-1β and IL-12） and improving the release of anti-inflammatory cytokines（ IL-10） for relieving the inflammatory reaction and protecting gastric mucosa.关键词：moxibustion;Helicobacter pylori gastritis;tumor necrosis factor-α;interleukin-1β;interleukin-12;interleukin-10;rats
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发布时间：2021-05-20 - 摘要：Objective To observe the influences of effective monomers in Huoxue Huayu Fang on the proliferation of activated renal fibroblast cell line（ NRK-49F） and mesangial cell line（ HBZY-1）. Methods NRK-49F and HBZY-1 were cultured in vitro and then divided into blank group,model group（ TGF-β 1,5 mg/L）,high-dose group（ TGF-β 1,5 mg/L + Chinese medicinal,10 mg/L） and low-dose group（ TGF-β 1,5 mg/L + Chinese medicinal,1 mg/L）. NRK-49F and HBZY-1 were digested with 205 g / Ltrypsin-0. 2 g / L EDTA for making single cell suspension,and the suspension was inoculated to 96well plates. After the synchronization of cell growth,TGF-β 1 was added for 24 hours,then the cultural medium was removed,and finally the monomers of Chinese medicinal was added. After culturing for 24 hours,the effects of Chinese medicinal on NRK-49F and HBZY-1 were observed by using methyl thiazolyl tetrazolium test（ MTT）, and the secretion of TGF-β was observed by using enzyme-linked immunosorbent assay（ ELISA）. Results Compared with blank group,TGF-β 1-stimulating factor improved the activation of NRK-49F and HBZY-1（ P < 0. 05） and secretion of TGF-β（ P < 0. 01）. After adding the monomers of Chinese medicinal,the proliferation of activated NRK-49F and HBZY-1 and secretion of TGF-β were inhibited（ P < 0. 05 or P < 0. 01）. Salvianolic acid B had the best inhibitory effect,and followed by salvianolic acid A,chrysophanol and rhein. Conclusion The monomers of Huoxue Huayu Fang can inhibit the proliferation of activated NRK-49F and HBZY-1 and prevent renal fibrosis,and the possible mechanism is related to the inhibition of TGF-β secretion.关键词：fibroblast cell line;mesangial cell line;culturing in vitro;Huoxue Huayu Fang;monomers of Chinese medicinal;transforming growth factor-β
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发布时间：2021-05-20 - 摘要：Objective To establish a HPLC method for quantitative determination of rutin and narcissoside in Shuxuening Injection. Methods The HPLC procedure was performed on the chromatographic column of DIKMA Diamonsil-C 18（ 250 mm ×4. 6 mm,5 μm） at 35 ℃,the mobile phase was methanol-0. 4% phosphoric acid solution（ 35: 65） with the flow velocity of 0. 1 mL / min,and the detection wavelength was 360 nm. Results Rutin showed a linear relationship at a range from 0. 101 μg to 0. 756 μg（ r = 0. 999 5） and the recovery was 101. 1 %. Narcissoside showed a linear relationship at a range from 0. 100 μg to 0. 752 μg（ r = 0. 999 5） and the recovery was 102. 0%. Conclusion The method is simple,accurate with high sensitivity and good repeatability,and can be used for the quality control of rutin and narcissoside in Shuxuening Injections.关键词：Shuxuening Injection;rutin;narcissoside;high performance liquid chromatography;quantitative determination
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发布时间：2021-05-20 - 摘要：Objective To investigate the influence of disassembled Simiao Yong ’an Tang on the extraction rate of glycyrrhizic acid. Methods After Simiao Yong’an Tang was disassembled,the RPHPLC procedure was performed on the chromatographic column of SunFireTMC 18（ 150 mm ×4. 6 mm,5 μm） at 35℃,the mobile phase was acetonitrile-phosphoric acid water solution（ 0. 1%） in gradient elution with the flow velocity of 0. 1 mL / min, and the detection wavelength was 250 nm. The quantification of glycyrrhizic acid was analyzed and its extraction rate was calculated. Results The quantification of glycyrrhizic acid was detected in 8 simples and the extraction rate was calculated. The regression equation was Y = 793 318 X- 1 161. 3,which showed a linear relationship at a range from 0. 036 24 to 0. 253 7 μg（ r = 0. 999 6,n = 7） and the average recovery was 101. 10%（ RSD = 2. 88%, n = 6）. Conclusion Compared with Gancao（ Radix Glycyrrhizae）,the extraction rate of glycyrrhizic acid can be significantly reduced by two-herb combination, three-herb combination and four-herb combination among Gancao and other 3 herbs in Simiao Yong ’an Tang,including Jinyinhua（ Flos Ionicerae）,Xuanshen（ Radix Scrophulariae） and Danggui（ Radix Angelicae Sinensis）,which showed a decrease at a range from 50% to 74. 12%. These changes may be related to different pH values in water extract in the procedure to get extracts from different disassembled formula samples.关键词：Simiao Yong ’an Tang;disassembled formulas;combination;glycyrrhizic acid;extraction rate
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发布时间：2021-05-20 - 摘要：Objective To observe the influences of Huangqi（ Radix Astragali seu Hedysari） on serum liver fibrosis markers and expressions of tissue inhibitor of metalloproteinase-1（ TIMP-1） and matrix metalloproteinase-1（ MMP-1） in liver tissues in rat model of immune liver fibrosis induced by pig serum. Methods Wistar rats（ n = 40） were randomly divided into normal group,model group,Huangqi group and colchicinum group. Excepting normal group,other groups were injected intraperitoneally sterile pig blood twice a week for 12 weeks. Meanwhile,normal group and model group were intragastrically given distilled water every day,and other groups were intragastrically given corresponding drugs. The changes of liver function,liver fibrosis markers including serum hyaluronic acid（ HA）,laminin（ LN）,collagen Ⅳ（ C Ⅳ） and pro-collagen Ⅲ（ PC Ⅲ）,and TIMP-1 and MMP-1 levels were detected by using biochemical assay,radioimmunoassay and ELISA. Results The levels of serum HA and C Ⅳ,and level of TIMP-1 decreased significantly,and the level of MMP-1 in increased significantly in Huangqi group compared with those in model group（ P < 0. 01）. Conclusion Huangqi can effectively reduce the levels of serum indexes of liver fibrosis,and remarkably ameliorate the degree of liver fibrosis. The mechanism may be related to that it can increase MMP-1 expression, decrease TIMP-1 expression, improve extracellular matrix（ ECM） degradation and decrease ECM synthesis,so as to suppress the accumulation of ECM and ameliorate the fibrosis degree of liver tissues.
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发布时间：2021-05-20 - 摘要：Objective To observe the influence of Liuwei Buqi Capsule on the expression of lung dendritic cells（ DCs） in rat model of chronic obstructive pulmonary disease（ COPD）（ type of lung qi deficiency syndrome）. Methods The rat model of COPD（ type of lung qi deficiency syndrome） was established by using cigarette smoking and intratracheal instillation of LPS. The expression of lung DCs in all groups was observed after being treated with Liuwei Buqi Capsule. Results The positive area of DCs and average optical density increased in model group compared with those in normal group（ P < 0. 01）. The positive area of DCs decreased in all treatment groups compared with that in model group（ P < 0. 01, P < 0. 05）,and average optical density in all treatment groups decreased to varying degrees. The differences among all treatment groups were not significant. Conclusion The expression of lung DCs in rat model of COPD（ type of lung qi deficiency syndrome） increases,which can be reduced by Liuwei Buqi Capsule.关键词：Liuwei Buqi Capsule;chronic obstructive pulmonary disease;lung qi deficiency syndrome;dendritic cells;rats
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发布时间：2021-05-20 - 摘要：Objective To explore the distribution differences of TCM syndromes of chronic atrophic gastritis（ CAG） between south and north areas of China,so as to provide some references for treatment of CAG and basis for further study on treatment in accordance with local conditions. Methods The literature research was conducted to collect the documents about TCM treatment on CAG in recent 20 years. The south and north areas of China were divided according to the China ’s north and south boundary map,which was based on GIS data evaluation. The difference in syndromes of CAG was analyzed between the south and north areas of China by using SPSS software. Results In 89 documents,the syndromes of CAG with high frequency in south area of China were syndrome of spleen and stomach weakness,stomach yin deficiency syndrome and syndrome of dampness-heat in spleen and stomach,and those in north area of China were syndrome of liver-stomach disharmony and syndrome of blood stasis in stomach collateral（ P < 0. 05）. Conclusion It is indicated that climatic conditions,dietary habits and living habits in south and north areas of China have appreciable effects on the syndrome distribution of CAG.关键词：chronic atrophic gastritis;TCM syndromes;south and north areas of China
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发布时间：2021-05-20 - 摘要：Object To objectively review the correlation between changes of coagulation indexes and symptom scoring of blood stasis syndrome in patients with advanced gastric cancer. Methods The coagulation indexes,including prothrombin time（ PT）,activated partial thromboplastin time（ APTT）,fibrinogen（ FIB）,thrombin time（ TT） and D-dimer（ DD）,were retrospectively analyzed in 80 patients, and compared with those in normal people. The symptoms and signs of patients were graded and scored according to scoring standard of clinical symptoms of blood stasis syndrome. Results The percentage of the patients with abnormally higher FIB and DD increased（ P < 0. 05）. The patients with blood stasis syndrome accounted for 63. 7% after TCM syndrome differentiation,which was correlated to abnormal coagulation indexes（ P < 0. 05）. Conclusion Most of patients with advanced gastric cancer have abnormal coagulation indexes and symptoms of blood stasis syndrome,which are correlated to each other.关键词：advanced gastric cancer;coagulation indexes;blood stasis syndrome
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发布时间：2021-05-20 - 摘要：Objective To discuss GRACE predictive integrals of all-cause mortality in the emergency patients with chest impediment,and to improve the ability to identify risk degrees. Methods The patients with chest impediment（ n = 381） were given syndrome differentiation and divided into qi stagnation and blood stasis group,turbid phlegm obstruction group,yin and blood deficiency group and yang qi deficiency group. The related items of GRACE predictive integrals of all-cause mortality in the patients were recorded. All data were statistically analyzed. Results The average GRACE predictive integral was（ 163. 28 ± 38. 69） in turbid phlegm obstruction group,（ 167. 41 ± 35. 66） in qi stagnation and blood stasis group,（ 199. 80 ± 42. 13） in yang qi deficiency group and（ 192. 88 ± 43. 70） in yin and blood deficiency group. GRACE predictive integrals were higher in yang qi deficiency group and yin and blood deficiency group than those in turbid phlegm obstruction group and qi stagnation and blood stasis group respectively（ P < 0. 01）. The ascending levels of WBC and CK-M were risk factors for increasing mortality in the patients with yang qi deficiency syndrome. Conclusion The most dangerous syndrome is yang qi deficiency syndrome in the patients with chest impediment and heart pain. The increased levels of WBC and CK-MB indicate the dead risk in the patients with yang qi deficiency syndrome,which should be paid more attention to.关键词：chest impediment;syndrome differentiation and classification;all-cause mortality;GRACE predictive integrals
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发布时间：2021-05-20
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