最新刊期
卷 36 ， 期 12 ， 2013
- 摘要：Objective To study the correlation between the incidence of typhoid /paratyphoid and meteorological factors in the same year and three years ago based on TCM theory of five circuits and six qi,and establish a medical meteorological forecast model of artificial neural network. Methods The data of the incidence of typhoid / paratyphoid and meteorological factors were extracted from 1970 to 2004（ 35 years） in Beijing, and the correlation between the incidence of typhoid/paratyphoid and meteorological factors in the same year and three years ago was investigated by applying descriptive statistical analysis,Spearman correlation analysis and BP artificial neural network analysis. Results The incidence of typhoid / paratyphoid showed a disproportion distribution in each year, and occurred frequently during the periods of third qi and fourth qi. The incidence of typhoid / paratyphoid was significantly correlated to average temperature,average wind speed and average relative humidity（ P <0. 05） in the same year and three years ago. In the meteorological forecast model,average wind speed and average relative humidity three years ago and average relative humidity in the same year were important influence factors. Conclusion The incidence of typhoid / paratyphoid is certainly correlated to the meteorological factors in the same year and three years ago,which can be established a forecast model. The theory of five circuits and six qi has value in in-depth study of predicting the incidence of epidemic diseases.关键词：meteorological factors;typhoid/paratyphoid;pestilence occurring after three years;five circuits and six qi;BP artificial neural network
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发布时间：2021-05-20 - 摘要：The thought of He（ harmoniousness） in Neijing has become one of the guiding ideology of clinical TCM. He（ harmoniousness） is considered to be the essence of human health. Shihe（ inharmoniousness） plays a major role in the pathogenesis of bronchial asthma,manifesting as inharmoniousness between ascending and descending, inharmoniousness among viscera, emotional disharmony,inharmoniousness between yin and yang and inharmoniousness between qi and blood. Only keep the principle of balance and harmoniousness,can we be free from excess and deficiency and avoid leaning to either side.关键词：Neijing;He（harmoniousness）;bronchial asthma
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发布时间：2021-05-20 - 摘要：The pathogenesis changes of Parkinson’s disease were studied to provide ideas for syndrome differentiation and treatment in clinic. Through analyzing the pathogenesis and clinical features of Parkinson’s disease,the authors not only revealed that the pathogenesis foundation of Parkinson ’s disease was "qi deficiency"and deficiency of liver and kidney（ deficient qi）,but also indicated the important pathological links including qi stagnation,phlegm-turbidity,blood stasis,internal wind and damage by toxin（ retention）. Deficient qi and retention influence the occurrence,development and changes of Parkinson’s disease. Therefore,the main preventive and treatment rule of Parkinson ’s disease is to treat deficiency with tonifying therapies and remove stasis,which is significant for guiding clinical practice.关键词：deficient qi retention;Parkinson’s disease;pathogenesis
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发布时间：2021-05-20 - 摘要：Objective To explore the administration laws and characteristics of couplet medicinal in Shanghanlun. Methods The formulas（ except of one-medicinal formulas） in Shanghanlun were divided into two groups and support degree and confidence of couplet medicinal were found out,and the couplet medicinal with support degree and confidence over 0. 05 were determined by applying association rules of data mining method. Results In group 1,the first 6 couplet medicinal were Guizhi（ Ramulus Cinnamomi） and Shaoyao（ Radix Paeoniae）,Guizhi and Mahuang（ Herba Ephedrae）,Ganjiang（ Rhizoma Zingiberis） and Fuzi（ Radix Aconiti Lateralis praeparata）,Renshen（ Radix Ginseng） and Banxia（ Rhizoma Pinelliae）,Renshen and Ganjiang,and Huangqin（ Radix Scutellariae） and Huanglian（ Rhizoma Coptidis）. In group 2,the first 6 couplet medicinal were Guizhi and Gancao（ Radix Glycyrrhizae）,Dazao（ Fructus Ziziphi Jujubae） and Shengjiang（ Rhizoma Zingiberis Recens）,Dazao and Gancao,Gancao and Shengjiang,Dazao and Guizhi,and Guizhi and Shengjiang. Conclusion The first6 couplet medicinal in group 1 are the major medicinal in the basic formulas for six-meridian diseases,and those in group 2 reflect that ZHANG Zhong-jing made good uses of Shengjiang,Gancao and Dazao for protecting stomach qi.关键词：Shanghanlun;couplet medicinal;association rules
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发布时间：2021-05-20 - 摘要：Objective To review the characteristics of major syndrome factors of hypercholesterolemia.Methods The latent tree structure chart of 419 cases of hypercholesterolemia was established by applying multidimensional hierarchical clustering,and quantitative data,including latent probability,conditional probability,mutual information and cumulative information coverage rate,were analyzed. The characteristics of major syndrome factors of hypercholesterolemia were interpreted by using artificial recognition method. Results When taking cumulative information coverage rate reached 95% as the criterion,419 cases had moderate and severe symptoms / syndromes（ latent probability was 33% and 67%respectively）. The syndrome factors were mainly qi deficiency,qi stagnation,fire-heat,phlegm-damp,static blood and yin deficiency,and the targets of syndrome factors were mainly heart,liver,spleen and kidney. Conclusion A latent structure model can directly display the latent tree structures of observed variables（ symptoms） and latent variables（ syndrome factors）,as well as quantify the correlation degree and occurrence probability of variables,and it is an ideal method to review syndrome factors.关键词：Latent structure model;syndrome factors;hypercholesterolemia
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发布时间：2021-05-20 - 摘要：Objective To study the mechanism of Zhuanggu Zhitong Fang in the treatment of osteoporosis by applying proteomics method. Methods The rat model of osteoporosis was established through ovariectomy. All rats were divided into Zhuanggu Zhitong Fang group,model group and sham-operation group. After successful modeling for 13 weeks,the samples of femoral tissue protein were collected and separated with two-dimensional electrophoresis（ 2-DE）. The anatomy atlas of total femoral protein molecule was obtained,and then the different protein spots were analyzed by using imagine software. All proteins were initially identified by using MAIDI-TOF-MS combining Marx Science Ltd Database. Results There were three different proteins identified,including insulin receptor protein（ X1）,heat shock cognate 71KD protein（ X2） and secretogranins II（ X3）. Conclusion X1,X2 and X3 play an important regulative role in the treatment of osteoporosis with Zhuanggu Zhitong Fang.关键词：Zhuanggu Zhitong Fang;proteomics;osteoporosis;two-dimensional electrophoresis;rats
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发布时间：2021-05-20 - 摘要：Objective To compare the immune function changes in three rat models of liver depression syndrome,spleen deficiency syndrome and syndrome of liver depression and spleen deficiency. Methods Male Wistar rats were randomly divided into normal group（ N group）,liver depression group（ L group）,spleen deficiency group（ S group） and liver depression and spleen deficiency group（ LS group,each n =10）. Except of N group,L group was given chronic restraint,S group was given over fatigue + improper diet,and LS group was given chronic restraint + over fatigue + improper diet for establishing the models for 4 weeks. On the 29th day,the levels of serum interleukin-1（ IL-1）,interleukin-2（ IL-2）,interleukin-6（ IL-6） and tumor necrosis factor-α（ TNF-α）,proliferation rates of T and B lymphocytes,and thymus and spleen indexes were detected in all groups. Results The levels of IL-2 and IL-6 and thymus and spleen indexes decreased significantly in L group,S group and LS group compared with N group（ P < 0. 05）. The level of IL-1 decreased significantly（ P < 0. 05） and TNF-α increased significantly（ P < 0. 05） in L group. The proliferation rate of T lymphocytes decreased significantly（ P < 0. 05） and level of IL-1 increased significantly（ P < 0. 05） in S group. The levels of TNF-α and IL-1 increased significantly（ P < 0. 05） and proliferation rate of T lymphocytes decreased significantly（ P < 0. 05） in LS group. Conclusion There are some abnormal changes of immune functions in all three rat models of liver depression syndrome,spleen deficiency syndrome and syndrome of liver depression and spleen deficiency,while liver depression syndrome mainly involves the decrease of thymus function and insufficient release of cytokines at early immune response stage,spleen deficiency syndrome involves the inhibition of cellular immunity,and syndrome of liver depression and spleen deficiency further involves the inhibition of humoral immunity besides of the same abnormal changes of immune functions as the other two syndromes.关键词：liver depression syndrome;spleen deficiency syndrome;syndrome of liver depression and spleen deficiency;interleukin;proliferation rates of T/ B lymphocytes;rats
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发布时间：2021-05-20 - 摘要：Objective To study the effect of low-frequency ultrasound for enhancing percutaneous permeation of Chinese medicinal with macromolecule,and provide the experimental evidence for the clinical application of phonophoresis. Methods Taking rabbits as objects,the effect of enhancing permeation of low-frequency ultrasound for 5% extract liquor of Guizhi（ Ramulus Cinnamomi） was observed through experiment in vitro and experiment in vivo. In experiment in vitro,rabbits were divided into control group in vitro and ultrasound group in vitro. The control group in vitro was give nature penetration method and ultrasound group in vitro,phonophoresis. The content of cinnamic aldehyde was detected by using high performance liquid chromatography（ HPLC） at different time points and the outcomes from two groups were statistically analyzed. In experiment in vivo,rabbits were divided into control group in vivo and ultrasound group in vivo. The control group in vivo was give hot compress of Chinese medicinal and ultrasound group in vivo,phonophoresis. The content of cinnamic aldehyde in different tissues（ including synovial fluid,synovium,muscle and skin） was detected by using HPLC and the outcomes from two groups were statistically analyzed. Results The content of cinnamic aldehyde in experiment in vitro increased over time,which was higher in ultrasound groups at different time points. The difference between ultrasound groups and control groups had statistical significance（ P < 0. 05）. In experiment in vivo,cinnamic aldehyde was detected in synovial fluid,synovium,muscle and skin,and its content was higher in ultrasound group in vivo than that in control group in vivo（ P < 0. 05）. Conclusion Low-frequency ultrasound can improve the permeability of skin and enhance the permeation of Chinese medicinal with macromolecule. It is worth further studing in clinic.关键词：phonophoresis;high performance liquid chromatography;cinnamic aldehyde;rabbits
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发布时间：2021-05-20 - 摘要：Objective To discuss the correlation between degranulation of RBL-2H3 cells induced by Qingkailing Injection and calcium ion. Methods Taking RBL-2H3 cell line as objects,which were divided into normal group,positive control group and treatment group. IC50 of Qingkailing Injection was detected by using MTT assay. The rate of cell degranulation and fluorescence intensity of intracellular calcium ion were detected by using flow cytometry after the cells were incubated with Qingkailing Injection in certain concentration for 30 minutes. The fluorescence intensity of intracellular calcium ion and the changes of cytoskeletons were detected by using laser scanning confocal microscope. Results Qingkailing Injection（ 40 mL / L） could induce the degranulation of RBL-2H3 cells accompanied by the increase of fluorescence intensity of intracellular calcium ion and changes of cytoskeletons at the same time. Conclusion The process of degranulation of RBL-2H3 cells induced by Qingkailing Injection is correlated to calcium ion.关键词：Qingkailing Injection;RBL-2H3 cells;calcium ion;cytoskeleton
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发布时间：2021-05-20 - 摘要：Objective: To study the effect of Cigu Xiaozhi Wan on serum adiponectin（ APN） and tumor necrosis factor（ TNF-α） in rats with alcoholic fatty liver disease（ AFLD）, and to discuss the mechanism. Methods The rat model of AFLD was established by feeding high fat diet and intragastrically giving ethanol. All rats were randomly divided into normal group,model group,high-dose group,mid-dose group,low-dose group and positive control group. After 4 weeks of treatment with Cigu Xiaozhi Wan on model rats,histopathological changes of liver were observed; serum liver function and levels of APN and TNF-α were detected. Results In model group,there were steatosis in hepatic lobule,infiltration of a large number of inflammatory cells and spotty necrosis of partial hepatocytes in portal area. The levels of ALT,AST and TNF-α increased and the level of APN decreased significantly in model group compared with those in normal group. In high-dose,mid-dose and low-dose groups,steatosis and inflammation in liver were relieved in varying degrees. Cigu Xiaozhi Wan could decrease the levels of ALT,AST and TNF-α of model rats,and ameliorate the level of APN significantly,the differences of which were statistically significant（ P < 0. 05- 0. 01）. Conclusion Cigu Xiaozhi Wan has the effects of ameliorating liver function,regulating the levels of TNF-α and APN and relieving steatosis of hepatocytes,so as to be used in treatment on AFLD.关键词：Cigu Xiaozhi Wan;alcoholic fatty liver disease;TNF-α;APN;rats
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发布时间：2021-05-20 - 摘要：Objective Through studying the effect of Xuesaitong Soft Capsules（ Xuesaitong） in intervening myocardial remodeling in rats with acute myocardial infraction（ AMI） and its influence on TGF-β1 / Smads,to discuss the mechanism of Xuesaitong in intervening myocardial remodeling after AMI,and provide experimental basis for treating myocardial remodeling after AMI with Xuesaitong Soft Capsules. Methods Male Wistar rats（ n = 50,specific pathogen free） were randomly divided into normal group,model group,sham-operation group,Xuesaitong group and AMD3100 group（ each n =10）. Xuesaitong group were given medicine once a day 3 days before operation. After 7 days,the expressions of TGF-β1 mRNA,Smad3 mRNA and Smad7 mRNA were detected by using real-time fluorescence quantitative polymerase chain reaction（ RT-PCR）,collagen content was analyzed in noninfracted myocardial tissue in all groups,and myocardial tissue was observed by applying HE staining.Results The expressions of TGF-β1 mRNA and Smad3 mRNA increased（ P < 0. 05）,and expression of Smad7 mRNA decreased（ P < 0. 05） in model group compared with those in sham-operation group. The expressions of TGF-β1 mRNA and Smad3 mRNA decreased（ P < 0. 05）,expression of Smad7 mRNA increased（ P < 0. 05）,myocardial collagen content decreased,and myocardial pathological lesion was alleviated in Xuesaitong group compared with those in model group. There were no significant differences in expressions of TGF-β1 mRNA,Smad3 mRNA and Smad7 mRNA between Xuesaitong group and AMD3100 group（ P > 0. 05）. Conclusion Xuesaitong has an inhibitory effect on myocardial remodeling after AMI.关键词：Xuesaitong Soft Capsules;acute myocardial infraction;myocardial remodeling;TGF-β1/Smads;rats
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发布时间：2021-05-20 - 摘要：Objective To investigate the quality of raw decoction pieces of Yinyanghuo（ Herba Epimedii） sold in the market. Methods The content of impurities,moisture,extractum and total flavones were determined according to the Chinese Pharmacopeia（ 2010）. The content of icariin,epimedin C and baohuoside I were determined simultaneously by applying high performance liquid chromatography（ HPLC）. Results The study on impurities,moisture and extractum of 16 batches of raw decoction pieces revealed that 13 batches completely conformed to the requirements of the pharmacopoeia. The content ranges of total flavones,icariin,epimedin C and baohuoside I were 2. 7-15. 2%,0. 08- 1. 99%,0. 05- 2. 34% and 0. 02- 0. 38%,respectively. Conclusion There is a huge difference among different batches of raw decoction pieces of Yinyanghuo sold in the market. Taking icariin as the only index to evaluate the quality of Yinyanghuo collected from multiple sources has certain limitations. The standards of quality evaluation of decoction pieces should be improved.关键词：Yinyanghuo（Herba Epimedii）;decoction pieces;quality
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发布时间：2021-05-20 - 摘要：Objective To study the best technology conditions of smashing extraction for extracting paeoniflorin from Baishao（ Paeonia Lactiflora Pall）. Methods The influence factors on the smashing extraction were investigated by using orthogonal design taking the extraction rate of paeoniflorin as the index. The extractive rate,extraction time and electricity consumption were compared with other methods reported in literature. Results The best technique of the smashing extraction was as follows: 40%ethanol was taken as solvent,the ratio of liquid and material was 20: 1,time was 1 minute. Conclusion This method is simple and economic with a higher extraction rate,which can be used for the exploitation and utilization of Baishao.关键词：smashing extraction;Baishao（Paeonia Lactiflora Pall）;paeoniflorin;orthogonal test
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发布时间：2021-05-20 - 摘要：Objective To observe the curative effect of Huangxiong Kangshuan Capsules on acute-stage cerebral infarction（ type of wind-phlegm obstruction）,and discuss its mechanism in relieving insulin resistance（ IR）. Methods The patients（ n = 60） diagnosed as acute-stage cerebral infarction for the first time were chosen and divided into two groups according to random block method. The two groups were given basic treatment and treatment group was given additionally Huangxiong Kangshuan Capsules.The recovery of neurological impairment and changes of relative biochemical indexes were observed and analyzed statistically by using SPSS17. 0 software. Results The curative effect was better in treatment group than that in control group（ P < 0. 05） after 21 days. There were differences in the scores of CSS, NIHSS BI and MRS between two groups before and after treatment,and the curative effect was more significant in treatment group. In treatment group,the scores of CSS,NIHSS,BI and MRS all had significant difference,and in control group,only the scores of CSS and MRS. Huangxiong Kangshuan Capsules improved significantly the scores of CSS and BI. The levels of TC,TG and LDI-C decreased in treatment group with significant difference before and after treatment,and only TC level decreased in control group（ P < 0. 05）. After treatment,the levels of fasting plasma glucose（ FPG）,serum insulin and insulin resistance index（ IRI） decreased and insulin sensitivity index（ ISI） increased,and treatment group was significantly superior to control group（ P < 0. 05,P < 0. 01）. Conclusion Huangxiong Kangshuan Capsules can relieve the symptoms of neurological impairment and IR in the patients with acute-stage cerebral infarction（ type of wind-phlegm obstruction）,and the latter may be its effective mechanism in treating acute cerebral infarction.关键词：Huangxiong Kangshuan Capsules;acute-stage cerebral infarction;wind-phlegm obstruction;insulin resistance;clinical study
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发布时间：2021-05-20 - 摘要：Objective To discuss the relationship between large and small artery disease of ischemic stroke and stroke prognosis. Methods The patients with acute ischemic stroke（ n = 207） were divided into large artery disease group（ n = 87） and small artery disease group（ n = 120） according to the differentiation diagnostic criterion of Trial of Org 10172 in Acute Stroke Treatment（ TOAST） combining with imageology. The scores of NIH stroke scale（ NIHSS）,modified Rankin scale（ MRS） and activities of daily living（ ADL） scale were compared dynamicly between two groups. Results ①The regularity of NIHSS scores was similar to that of syndrome scores at 6 time points（ 1 day and 2,3,7,14 and 28days） after stroke. The curve of large artery disease ascended firstly and then descended,while the curve of small artery disease descended firstly,then ascended and descended again. A trough of wave appeared on the second day,and peaks of wave showed on the third to seventh days. ②For the prognosis of large and small artery disease,the MRS scores and NIHSS scores were significantly higher in large artery disease group than those in small artery disease group,which indicated that the prognosis was poorer in large artery disease group than that in small artery disease group. There was no significant difference in ADL between two groups. Conclusion There is difference in prognosis regulation between large and small artery disease of ischemic stroke. The prognosis is poorer in large artery disease group than that in small artery disease group.关键词：ischemic stroke;large and small artery disease;prognosis
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发布时间：2021-05-20 - 摘要：<正>2013年9月27日,中国科学技术信息研究所（ISTIC）在北京召开中国科技论文统计结果发布会,《北京中医药大学学报》荣获2012年"百种中国杰出学术期刊"称号（见封二）。这是《北京中医药大学学报》继2008年、2011年进入"中国精品科技期刊"后首次获得"百种中国杰出学术期刊"称号。
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发布时间：2021-05-20 - 摘要：Objective To have preliminary understanding on TCM syndrome characteristics and laws of syndrome factor distribution in the patients with simple obesity based on literature research and clinical investigation. Methods The patients with simple obesity（ n = 245）,who visited hospital from Jan.2011 to Aug. 2012, were divided into stomach heat with dampness obstruction syndrome, duel spleen-kidney deficiency syndrome,liver depression with qi stagnation syndrome,yin deficiency with internal heat syndrome and spleen deficiency with dampness obstruction syndrome according to the results of questionnaire for discussing the distribution characteristics of TCM syndromes. The statistics about gender,age and body mass index（ BMI） were made and the results were generalized and compared in the patients with different syndromes,so that the laws of TCM syndrome distribution and syndrome factor distribution of simple obesity were achieved. Results The syndrome distribution of simple obesity showed a descending order as follows: stomach heat with dampness obstruction syndrome, liver depression with qi stagnation syndrome,duel spleen-kidney deficiency syndrome,yin deficiency with internal heat syndrome and spleen deficiency with dampness obstruction syndrome. The proportion of stomach heat with dampness obstruction syndrome（ n = 103,42%） was the highest. The syndrome distribution in male patients showed that the proportions of duel spleen-kidney deficiency syndrome（ 64%） and stomach heat with dampness obstruction syndrome（ 68%） were notable. The syndrome distribution in female patients showed that the proportions of yin deficiency with internal heat syndrome（ 71%） and spleen deficiency with dampness obstruction syndrome（ 69%） were higher than those of other syndromes. In overweight male patients,stomach heat with dampness obstruction syndrome（ 54%） was notable,while in overweight female patients,the proportion of yin deficiency with internal heat syndrome（ 57%） was the highest. In obese male and female patients,the proportion of spleen deficiency with dampness obstruction syndrome（ 23%,31%） was the highest. Conclusion The TCM syndrome distribution of simple obesity has certain laws,which is related to gender,age and living habits.关键词：simple obesity;syndrome;distribution characteristics
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发布时间：2021-05-20 - 摘要：Objective To investigate the laws of syndrome differentiation and formula administration in the treatment of optic atrophy by the ophthalmologists in the Eye Hospital of China Academy of Chinese Medical Sciences. Methods The formulas of Chinese medicinal decoctions were analyzed administrated in the patients with optic atrophy in 2006 by applying computer information technology based on TCM theory. The purpose was to find out the laws and characteristics of medicinal administration.Results The first three types of Chinese medicinal,used for treating optic atrophy,were medicinal with the actions of activating blood and resolving stasis,tonifying qi and tonifying blood,and they were commonly accompanied by Gegen（ Radix Puerariae） and Shichangpu（ Rhizoma Acori Graminei） for opening orifices and improving vision. The formulas used commonly included Siwu Tang,Danggui Buxue Tang,Liuwei Dihuang Tang and Wuzi Yanzong Tang with the actions of nourishing liver and kidney,and Buyang Huanwu Tang and Taohong Siwu Tang with the actions of activating blood and resolving stasis.The nature of these medicinal was warm,and the flavor was mainly sweet. The flavors of the medicinal with the actions of activating blood and resolving stasis were mainly pungency and bitterness. The analysis on medicinal meridian entry showed that the medicinal for optic atrophy mostly entered into the meridians of liver and kidney,which verified the theory of liver opening at eyes and homogeny of liver and kidney.Conclusion The treatment of optic atrophy with Chinese medicine has internal laws in clinical practice.关键词：database;optic atrophy;administration laws of Chinese medicinal;TCM ophthalmology;clinical Chinese pharmacy
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发布时间：2021-05-20 - 摘要：<正>《北京中医药大学学报》系中央级的高级中医药学术刊物,1959年创刊,由教育部主管、北京中医药大学主办。现分别属于中国自然科学核心期刊、中国中文核心期刊、全国中医药优秀期刊、全国优秀科技期刊、中国科学引文数据库首批入选的315种期刊之一、北京高校自然科学学报系统及全国高等医药院校学报系统
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发布时间：2021-05-20
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